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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La diabetes mellitus tipo 2 &#40;DM2&#41; y la insuficiencia cardiaca &#40;IC&#41; son 2 enfermedades muy prevalentes&#44; especialmente en los pacientes mayores de 65 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a>&#46; La DM2 es un factor claramente asociado con la morbimortalidad de pacientes con IC cr&#243;nica<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;3</span></a>&#46; Sin embargo&#44; no existe tanta evidencia respecto a su implicaci&#243;n como factor predictivo de mortalidad en los episodios de IC aguda &#40;ICA&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A partir de la informaci&#243;n aportada por una base de datos prospectiva&#44; desarrollada en nuestro centro&#44; hemos analizado 294 pacientes mayores de 50 a&#241;os ingresados por ICA de cualquier tipo &#40;<span class="elsevierStyleItalic">de novo</span> o cr&#243;nica descompensada&#44; definida de acuerdo a los criterios de la Sociedad Europea de Cardiolog&#237;a&#41; atendidos por el equipo a cargo del estudio durante un periodo de 2 a&#241;os consecutivos&#46; Se excluyeron aquellos con enfermedades en fase terminal o en tratamiento paliativo&#46; Se recogieron los datos demogr&#225;ficos&#44; cl&#237;nicos y de tratamiento de estos pacientes&#44; dividi&#233;ndolos en 2 grupos&#44; en funci&#243;n de la existencia de un diagn&#243;stico de DM2 previo al ingreso&#44; y comparando sus caracter&#237;sticas basales y evolutivas&#46; Se calcul&#243; la tasa de mortalidad global intrahospitalaria en ambos grupos y su asociaci&#243;n con las variables presentes al ingreso&#44; mediante m&#233;todos de regresi&#243;n log&#237;stica&#46; El nivel de significaci&#243;n estad&#237;stica se estableci&#243; en p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Para el an&#225;lisis de los datos se utiliz&#243; el paquete estad&#237;stico IBM SPSS<span class="elsevierStyleSup">&#174;</span> versi&#243;n 21&#46; El comit&#233; de &#233;tica asistencial de nuestro centro aprob&#243; el protocolo de recogida de datos y se obtuvo el consentimiento informado de todos los pacientes incluidos&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Del total de 294 pacientes&#44; 158 &#40;54&#37;&#41; eran mujeres&#44; con una edad promedio de 74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 a&#241;os&#44; un &#237;ndice de Charlson medio de 2&#44;6 puntos y un leve predominio &#40;52&#37;&#41; de ICA con fracci&#243;n de eyecci&#243;n preservada &#40;&#62;<span class="elsevierStyleHsp" style=""></span>45&#37;&#41;&#46; En 115 pacientes &#40;39&#44;1&#37;&#41; exist&#237;a un diagn&#243;stico previo de DM2&#46; La <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> muestra las diferencias basales entre los pacientes con y sin DM2&#46; En el an&#225;lisis multivariable la presencia de DM2 previa al episodio de ICA se asoci&#243; significativamente con el g&#233;nero femenino &#40;OR&#58; 3&#44;340&#59; IC 95&#37;&#58; 1&#44;879-5&#44;936&#41;&#44; el diagn&#243;stico previo de hipertensi&#243;n arterial &#40;OR&#58; 2&#44;673&#59; IC 95&#37;&#58; 1&#44;497-4&#44;774&#41; y dislipidemia &#40;OR&#58; 2&#44;965&#59; IC 95&#37;&#58; 1&#44;609-5&#44;463&#41; y la etiolog&#237;a isqu&#233;mica de la IC &#40;OR&#58; 1&#44;779&#59; IC 95&#37;&#58; 1&#44;009-3&#44;134&#41;&#46; Durante el ingreso 36 pacientes &#40;12&#44;2&#37;&#41; fallecieron&#44; sin que existieran diferencias significativas en funci&#243;n de un diagn&#243;stico previo de DM2 &#40;9&#44;6&#37; en ausencia vs&#46; 14&#37; en presencia de DM2&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;347&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">La relaci&#243;n entre DM2 y la mortalidad o el reingreso por IC a largo plazo es un hecho constatado en diferentes estudios<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">4&#8211;6</span></a>&#46; Sin embargo&#44; los datos son m&#225;s heterog&#233;neos cuando se analiza la relaci&#243;n entre DM2 e ICA&#46; Nuestros resultados son concordantes con los de algunos estudios previos en los que la mortalidad no se vi&#243; afectada durante el ingreso por ICA en pacientes que presentaban simult&#225;neamente DM2<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">7&#44;8</span></a>&#46; No obstante&#44; otros estudios han detectado una disminuci&#243;n de la supervivencia en pacientes diab&#233;ticos ingresados por ICA<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a>&#46; La falta de asociaci&#243;n objetivada en nuestro estudio podr&#237;a en parte ser debida a cuestiones estrictamente metodol&#243;gicas tales como el peque&#241;o tama&#241;o de la muestra&#44; o bien a la presencia de comorbilidades asociadas o a la elevada proporci&#243;n de pacientes con fracci&#243;n de eyecci&#243;n preservada&#46; Asimismo&#44; no recogimos la tasa de reingresos ni datos relacionados con la gravedad de la DM2 &#40;duraci&#243;n de la enfermedad&#44; complicaciones asociadas&#44; tipo e intensidad del tratamiento previo&#41;&#46; Tampoco se obtuvo informaci&#243;n sobre el grado de control gluc&#233;mico en el momento del ingreso o el tratamiento utilizado durante la hospitalizaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">10&#44;11</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">En definitiva&#44; la DM2 es una comorbilidad muy prevalente en pacientes no seleccionados que experimentan un episodio de ICA de cualquier causa&#44; y se asocia significativamente a la presencia de otros factores de riesgo cardiovascular&#46; Sin embargo&#44; la presencia de DM2 no parece conferir un mayor riesgo de mortalidad intrahospitalaria durante un ingreso por ICA en esta poblaci&#243;n con elevada carga de pluripatolog&#237;a y polifarmacia&#46;</p></span>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#44;91 &#40;19&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;241&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">94 &#40;32&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72 &#40;40&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">122&#44;7 &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;3 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;729&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;21&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas basales cl&#237;nicas y anal&#237;ticas de los pacientes con insuficiencia cardiaca aguda&#44; seg&#250;n presencia o no de diabetes mellitus</p>"
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                      "titulo" => "Diabetes in heart failure&#58; Prevalence and impact on outcome in the population"
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                            0 => "A&#46;M&#46; From"
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                    0 => array:1 [
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                      "titulo" => "Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure&#58; Findings from the EVEREST trial"
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                      "titulo" => "Association between type-2 diabetes mellitus and post-discharge outcomes in heart failure patients&#58; Findings from the RICA registry"
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                      "titulo" => "Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure"
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                      "titulo" => "Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure&#58; A report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with heart Failure &#40;OPTIMIZE-HF&#41;"
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Correspondencia
Riesgo de mortalidad en pacientes con diabetes mellitus tipo 2 hospitalizados por insuficiencia cardiaca aguda
Mortality in type 2 diabetes patients admitted because of acute heart failure
P. Cerdà
Autor para correspondencia
, J. Franco, D. Chivite, F. Formiga
Servicio de Medicina Interna, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, España

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