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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El c&#225;ncer de pulm&#243;n representa un problema de salud p&#250;blica a escala mundial y sigue siendo el c&#225;ncer m&#225;s letal del mundo&#46; Seg&#250;n estimaciones de GLOBOCAN&#44; en 2018 se diagnosticaron unos 2&#44;1&#160;millones de casos y se produjeron aproximadamente 1&#44;8&#160;millones de muertes por c&#225;ncer de pulm&#243;n<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El c&#225;ncer de pulm&#243;n puede dividirse en c&#225;ncer de pulm&#243;n no microc&#237;tico &#40;CPNM&#41; y c&#225;ncer de pulm&#243;n microc&#237;tico &#40;CPM&#41;&#46; El CPNM es la forma m&#225;s frecuente &#40;aproximadamente el 85&#160;&#37;&#41; y tiene dos subtipos histol&#243;gicos frecuentes&#58; adenocarcinoma pulmonar y carcinoma epidermoide<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;3</span></a>&#46; Aunque las estrategias terap&#233;uticas &#40;es decir&#44; cirug&#237;a&#44; quimioterapia&#44; radioterapia&#44; tratamiento dirigido e inmunoterapia&#41; han conseguido algunas mejoras significativas&#44; el pron&#243;stico del c&#225;ncer de pulm&#243;n sigue siendo desfavorable&#44; con una tasa de supervivencia a 5&#160;a&#241;os de aproximadamente el 15&#160;&#37;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">4&#44;5</span></a>&#46; Por tanto&#44; es necesario investigar m&#225;s a fondo el potencial de biomarcadores que sean &#250;tiles en el pron&#243;stico del c&#225;ncer de pulm&#243;n&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">En varios estudios se ha descrito la presencia de c&#233;lulas madre cancerosas en los tumores&#46; Las c&#233;lulas madre cancerosas intervienen en la funci&#243;n de autorrenovaci&#243;n&#44; proliferaci&#243;n incontrolada y diferenciaci&#243;n celulares<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">6</span></a>&#46; Tambi&#233;n son responsables de la progresi&#243;n&#44; el pron&#243;stico&#44; la radiorresistencia y la quimiorresistencia del c&#225;ncer<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">7&#44;8</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La prote&#237;na Y-box&#160;2 &#40;SOX2&#41; de la regi&#243;n determinante del sexo&#44; un factor de transcripci&#243;n fundamental&#44; controla las propiedades de autorrenovaci&#243;n y pluripotencia de las c&#233;lulas madre<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">9&#44;10</span></a>&#46; SOX2 desempe&#241;a una funci&#243;n esencial en el mantenimiento del fenotipo de c&#233;lula madre de las c&#233;lulas tumorales y una funci&#243;n importante en el destino y la diferenciaci&#243;n celulares&#44; la migraci&#243;n&#44; invasi&#243;n y proliferaci&#243;n de las c&#233;lulas cancerosas&#44; as&#237; como en la formaci&#243;n de colonias y esferas y la apoptosis<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">11&#44;12</span></a>&#46; SOX2 est&#225; relacionada con el crecimiento celular&#44; la oncogenicidad&#44; la farmacorresistencia&#44; la agresividad tumoral y las met&#225;stasis<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">11&#44;13&#44;14</span></a>&#44; y su expresi&#243;n tambi&#233;n se correlaciona con una mala supervivencia global en tumores s&#243;lidos humanos<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">15</span></a>&#46; Algunos estudios han demostrado que SOX2 se expresa en el c&#225;ncer de pulm&#243;n<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">16&#8211;18</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Se ha descrito la sobreexpresi&#243;n de SOX2 en diferentes tipos de c&#225;ncer de pulm&#243;n&#44; como el CPM y el carcinoma epidermoide&#44; pero tambi&#233;n en el adenocarcinoma<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#44; lo que respalda la funci&#243;n oncog&#233;nica de SOX2 en estos tejidos&#46; Sin embargo&#44; existe informaci&#243;n contradictoria sobre la utilidad pron&#243;stica de la expresi&#243;n de SOX2 en el c&#225;ncer de pulm&#243;n&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Bas&#225;ndose en un an&#225;lisis de regresi&#243;n multivariante de Cox&#44; Liu et al&#46; comunicaron que la expresi&#243;n de SOX2 no se correlacionaba con la supervivencia global en el CPNM<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">17</span></a>&#46; Por otro lado&#44; Velcheti et al&#46; describieron que la expresi&#243;n de SOX2 se asociaba a una mejor supervivencia global en el CPNM<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a>&#46; La expresi&#243;n de SOX2 se ha correlacionado con una escasa supervivencia global tanto en el CPNM como en el CPM<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">18&#44;21</span></a>&#46; Por consiguiente&#44; con el fin de conocer plenamente la utilidad de la expresi&#243;n de SOX2 en la supervivencia en el c&#225;ncer de pulm&#243;n&#44; se llev&#243; a cabo un metaan&#225;lisis para analizar la relaci&#243;n entre la expresi&#243;n de SOX2 y el pron&#243;stico de los pacientes con c&#225;ncer de pulm&#243;n&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materiales y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Revisi&#243;n bibliogr&#225;fica</span><p id="par0035" class="elsevierStylePara elsevierViewall">El presente metaan&#225;lisis se llev&#243; a cabo bas&#225;ndose en la declaraci&#243;n PRISMA &#40;Elementos de informe preferidos para revisiones sist&#233;micas y metaan&#225;lisis&#44; <span class="elsevierStyleItalic">Preferred reporting items for systematic reviews and meta-analyses</span>&#41;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">22</span></a>&#46; Se realizaron b&#250;squedas sistem&#225;ticas en bases de datos destacadas&#44; como PubMed&#44; Embase y Web of Science&#44; para identificar publicaciones anteriores al 19 de junio de 2021&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se utilizaron las siguientes palabras clave y estrategia de recuperaci&#243;n&#58; &#171;SOX2 OR Sex determining region Y-box 2 OR SOX-2 OR SRY-Related HMG-Box Gene 2&#187;&#44; &#171;lung OR pulmonary&#187; &#171;cancer OR carcinoma OR tumor OR neoplasm OR malignancy&#187; y &#171;survival OR prognosis OR prognostic OR outcome&#187;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; se realizaron b&#250;squedas manuales en las bibliograf&#237;as de los art&#237;culos aceptables para obtener m&#225;s estudios&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Selecci&#243;n de los estudios</span><p id="par0050" class="elsevierStylePara elsevierViewall">Los estudios considerados aceptables para este metaan&#225;lisis cumpl&#237;an los siguientes criterios de inclusi&#243;n&#58; 1&#41; se diagnosticaron muestras de c&#225;ncer de pulm&#243;n humano&#59; 2&#41; se notific&#243; la expresi&#243;n de SOX2 en los art&#237;culos originales&#59; 3&#41; los estudios aportaban informaci&#243;n sobre la supervivencia basada en an&#225;lisis de regresi&#243;n multivariante de Cox&#44; y 4&#41; cuando los autores hab&#237;an publicado m&#225;s de un art&#237;culo basado en la poblaci&#243;n de pacientes coincidente&#44; solo se seleccionaba el estudio m&#225;s reciente o el m&#225;s completo para el metaan&#225;lisis actual&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Los criterios de exclusi&#243;n fueron los siguientes&#58; 1&#41; casos cl&#237;nicos&#44; actas de conferencias&#44; revisiones&#44; cartas al director&#59; 2&#41; estudios con c&#233;lulas o con animales&#44; y 3&#41; art&#237;culos en los que se publicaron datos insuficientes o estudios en los que se utiliz&#243; un an&#225;lisis univariante de Cox&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Extracci&#243;n de datos</span><p id="par0060" class="elsevierStylePara elsevierViewall">De cada estudio se extrajo la siguiente informaci&#243;n&#58; autor principal&#44; pa&#237;s&#44; a&#241;o de publicaci&#243;n&#44; origen &#233;tnico&#44; histolog&#237;a&#44; estadio de la enfermedad&#44; m&#233;todo de detecci&#243;n&#44; frecuencia de expresi&#243;n elevada de SOX2 y datos de supervivencia&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Se incluyeron datos pron&#243;sticos como supervivencia global&#44; supervivencia sin recidiva&#44; tiempo hasta la progresi&#243;n y supervivencia sin progresi&#243;n&#46; Dos revisores realizaron de forma independiente la extracci&#243;n de datos y la selecci&#243;n de los estudios y todas las discrepancias se resolvieron mediante consulta con un tercer revisor&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">An&#225;lisis estad&#237;stico</span><p id="par0070" class="elsevierStylePara elsevierViewall">Los datos se obtuvieron a partir de los estudios originales&#46; Seg&#250;n el an&#225;lisis multivariante de Cox&#44; se calcularon las razones de riesgos instant&#225;neos &#40;HR&#41; agrupadas con los intervalos de confianza &#40;IC&#41; del 95&#160;&#37; correspondientes para determinar la utilidad pron&#243;stica de la expresi&#243;n de SOX2 en pacientes con c&#225;ncer de pulm&#243;n&#46; Una HR observada con un IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1 era indicativa del peor pron&#243;stico&#46; Una HR observada con un IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1 era indicativa de una mayor supervivencia&#46; Se aplic&#243; al estudio el modelo de efectos aleatorios&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La heterogeneidad del estudio se investig&#243; mediante la prueba Q de Cochran<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">23</span></a> y se consider&#243; que exist&#237;a una heterogeneidad significativa cuando la prueba Q &#40;valor de p&#41; era<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;10&#46; En los casos en que se observ&#243; una heterogeneidad considerable&#44; se realizaron an&#225;lisis de sensibilidad para estimar la estabilidad de las HR recalculadas eliminando uno o varios estudios&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El sesgo de publicaci&#243;n se determin&#243; mediante la prueba de Egger para m&#225;s de cinco estudios<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">24</span></a>&#46; El an&#225;lisis de los datos se realiz&#243; con el programa Stata &#40;versi&#243;n&#160;12&#46;0&#44; Stata Corporation&#44; College Station&#44; TX&#44; EE&#46;&#160;UU&#46;&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">An&#225;lisis funcional</span><p id="par0085" class="elsevierStylePara elsevierViewall">La correlaci&#243;n entre SOX2 y los genes del c&#225;ncer de pulm&#243;n se aplic&#243; a partir de la base de datos GEPIA2 &#40;An&#225;lisis interactivo de perfiles de expresi&#243;n g&#233;nica&#160;2&#44; <span class="elsevierStyleItalic">Gene expression profiling interactive analysis 2&#44;</span> https&#58;&#47;&#47;gepia2&#46;cancer-pku&#46;cn&#47;&#41;&#46; Se seleccionaron coeficientes de correlaci&#243;n<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;4&#46; Finalmente&#44; se encontr&#243; una asociaci&#243;n significativa de 1000&#160;genes con SOX2&#46; Metascape &#40;<a href="https://metascape.org/">https&#58;&#47;&#47;metascape&#46;org&#47;</a>&#41; es una herramienta eficaz que proporciona un recurso de an&#225;lisis sistem&#225;tico para el enriquecimiento funcional y la anotaci&#243;n g&#233;nica<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">25</span></a>&#46; Se cargaron los genes significativos junto con el an&#225;lisis de enriquecimiento&#46; Los t&#233;rminos de enriquecimiento con p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01 se consideraron estad&#237;sticamente significativos&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Caracter&#237;sticas de los estudios</span><p id="par0090" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> se muestra el diagrama de flujo del procedimiento de selecci&#243;n&#46; Seg&#250;n los criterios de inclusi&#243;n&#44; 13&#160;estudios definitivos descritos en 11&#160;art&#237;culos publicados entre 2010 y 2016 fueron aceptables para este metaan&#225;lisis<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">16&#8211;18&#44;20&#44;21&#44;26&#8211;31</span></a>&#46; Se incluyeron un total de 2008&#160;pacientes con c&#225;ncer de pulm&#243;n&#46; Se realiz&#243; un an&#225;lisis de supervivencia de la expresi&#243;n de SOX2 en el c&#225;ncer de pulm&#243;n mediante un an&#225;lisis multivariante de Cox&#46; Los estudios incluidos se llevaron a cabo en el Reino Unido&#44; Estados Unidos&#44; China&#44; Jap&#243;n y Eslovenia&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran las caracter&#237;sticas b&#225;sicas de diez de los estudios aceptables con datos disponibles&#46; La frecuencia de expresi&#243;n de SOX2 en el CPM y el CPNM fue del 49&#44;4&#160;&#37; y el 56&#44;6&#160;&#37;&#44; respectivamente&#46; Se observ&#243; expresi&#243;n de SOX2 en aproximadamente el 50&#44;4&#160;&#37; de los carcinomas epidermoides y el 50&#160;&#37; de los adenocarcinomas&#46; Adem&#225;s&#44; en los otros tres art&#237;culos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>428&#41; se inform&#243; de que la expresi&#243;n de SOX2 no ten&#237;a un efecto estad&#237;sticamente significativo en la supervivencia global en el CPNM<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#44;29&#44;30</span></a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Expresi&#243;n de SOX2 y supervivencia global</span><p id="par0100" class="elsevierStylePara elsevierViewall">En siete estudios con 1163&#160;casos se demostr&#243; que la expresi&#243;n de SOX2 no se asociaba a la supervivencia global en el c&#225;ncer de pulm&#243;n &#40;HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;26&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;78-2&#44;05&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;350&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>A&#41; y se observ&#243; una heterogeneidad significativa &#40;I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>85&#44;6&#160;&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">El an&#225;lisis de subgrupos seg&#250;n la histolog&#237;a del tumor puso de manifiesto que no se observaba ninguna asociaci&#243;n significativa entre la expresi&#243;n de SOX2 y la supervivencia global en el CPNM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5 estudios con 891&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;06&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;58-1&#44;92&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;858&#41; y CPM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#160;estudios con 272&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;95&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;85-4&#44;46&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;116&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>B&#41;&#46; Tambi&#233;n se detect&#243; una heterogeneidad considerable en el an&#225;lisis de subgrupos &#40;CPNM&#58; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>84&#44;3&#160;&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#59; CPM&#58; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#44;8&#160;&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;034&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; en tres estudios con 428&#160;casos tambi&#233;n se comunic&#243; que la expresi&#243;n de SOX2 no mostraba una correlaci&#243;n significativa con la supervivencia global en el CPNM<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#44;29&#44;30</span></a>&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Expresi&#243;n de SOX2 en relaci&#243;n con los otros criterios de valoraci&#243;n pron&#243;sticos</span><p id="par0115" class="elsevierStylePara elsevierViewall">La expresi&#243;n de SOX2 no se correlacion&#243; con la supervivencia en el c&#225;ncer de pulm&#243;n &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#160;estudios con 272&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;95&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;85-4&#44;46&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;302&#41; y hubo indicios evidentes de heterogeneidad &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#46; La expresi&#243;n de SOX2 se asoci&#243; notablemente a peores resultados en el tiempo hasta la progresi&#243;n &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#160;estudios con 104&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44;50&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;34-9&#44;15&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;010&#41; y la supervivencia sin recidiva &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#160;estudios con 335&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;45&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;12-1&#44;87&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41; en el CPNM &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>C&#41;&#44; sin que se observara heterogeneidad significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;1&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Sesgo de publicaci&#243;n</span><p id="par0120" class="elsevierStylePara elsevierViewall">No se observ&#243; ning&#250;n sesgo de publicaci&#243;n significativo entre SOX2 y la supervivencia global &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;325<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">An&#225;lisis funcional de SOX2</span><p id="par0125" class="elsevierStylePara elsevierViewall">Los an&#225;lisis de v&#237;as y procesos biol&#243;gicos demostraron que SOX2 participaba en numerosas funciones biol&#243;gicas&#44; como el s&#237;ndrome de microduplicaci&#243;n&#44; la reparaci&#243;n del ADN&#44; el ciclo celular&#44; la regulaci&#243;n del proceso metab&#243;lico del ADN&#44; la divisi&#243;n celular&#44; la diferenciaci&#243;n del endodermo&#44; la diferenciaci&#243;n de las c&#233;lulas madre&#44; la regulaci&#243;n del mantenimiento de la poblaci&#243;n de c&#233;lulas madre&#44; la v&#237;a NRF2 y la v&#237;a de se&#241;alizaci&#243;n Hippo &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discusi&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Este trabajo es un metaan&#225;lisis sistem&#225;tico en el que se utiliz&#243; una extensa poblaci&#243;n de estudios en los que se evalu&#243; el efecto de la expresi&#243;n de SOX2 sobre la supervivencia en el c&#225;ncer de pulm&#243;n&#46; En metaan&#225;lisis previos se public&#243; que la expresi&#243;n de SOX2 se asociaba a una supervivencia global favorable en el CPNM<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">32&#44;33</span></a>&#46; Los estudios aceptables de estos metaan&#225;lisis se incluyeron antes de enero de 2021&#44; y en numerosos estudios aceptables se utiliz&#243; un an&#225;lisis univariante de la supervivencia con los datos pron&#243;sticos&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">En el presente estudio se evalu&#243; el efecto de la expresi&#243;n de SOX2 sobre la supervivencia en el c&#225;ncer de pulm&#243;n utilizando diferentes criterios de valoraci&#243;n pron&#243;sticos&#46; A partir de los datos de un an&#225;lisis de regresi&#243;n multivariante de Cox&#44; se encontr&#243; que la expresi&#243;n de SOX2 no se asociaba a la supervivencia global en el c&#225;ncer de pulm&#243;n&#46; La estratificaci&#243;n adicional seg&#250;n la histolog&#237;a no revel&#243; ninguna asociaci&#243;n entre la expresi&#243;n de SOX2 y la supervivencia global en el CPM y el CPNM&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Los resultados de la supervivencia global coincidieron con los estudios publicados anteriormente sobre el CPNM<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">17&#44;26&#44;29&#44;30</span></a>&#46; Se observ&#243; que la expresi&#243;n de SOX2 se asociaba a peores resultados en el tiempo hasta la progresi&#243;n &#40;HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44;50&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; y la supervivencia sin recidiva &#40;HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;45&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41; en el CPNM&#46; Los resultados fueron coherentes con los estudios publicados previamente sobre la supervivencia sin recidiva<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">27&#44;28</span></a>&#46; Dado que algunos de los an&#225;lisis &#40;tiempo hasta la progresi&#243;n y supervivencia sin recidiva en el c&#225;ncer de pulm&#243;n y supervivencia global en el CPM&#41; incluyeron solo uno o dos estudios&#44; los resultados deben considerarse con precauci&#243;n&#46; Se necesitan numerosos estudios para demostrar la importancia predictiva de SOX2 en el futuro&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">El an&#225;lisis funcional indic&#243; que SOX2 estaba relacionado con el s&#237;ndrome de microduplicaci&#243;n&#44; la reparaci&#243;n del ADN&#44; el ciclo celular&#44; la regulaci&#243;n del proceso metab&#243;lico del ADN&#44; la divisi&#243;n celular&#44; la diferenciaci&#243;n del endodermo&#44; la diferenciaci&#243;n de las c&#233;lulas madre&#44; la regulaci&#243;n del mantenimiento de la poblaci&#243;n de c&#233;lulas madre&#44; la v&#237;a NRF2 y la v&#237;a de se&#241;alizaci&#243;n Hippo&#46; Por ejemplo&#44; SOX2 influye en la apoptosis y la reparaci&#243;n del ADN<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">34</span></a> e interviene en la progresi&#243;n del ciclo celular en las c&#233;lulas DU145<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">35</span></a>&#46; SOX2 desempe&#241;a una funci&#243;n esencial en el mantenimiento de la poblaci&#243;n de c&#233;lulas madre y favorece la diferenciaci&#243;n de las c&#233;lulas madre embrionarias<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">36&#44;37</span></a>&#46; Tambi&#233;n puede interferir en la v&#237;a de los supresores tumorales Hippo para mantener las propiedades de pluripotencia de las c&#233;lulas madre<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">38</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Estos an&#225;lisis demuestran que SOX2 puede ser un biomarcador pron&#243;stico para predecir un peor tiempo hasta la progresi&#243;n y una peor supervivencia sin recidiva y podr&#237;a representar un objetivo terap&#233;utico eficaz para el tratamiento del c&#225;ncer de pulm&#243;n&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Este metaan&#225;lisis presenta algunas limitaciones&#46; En primer lugar&#44; las poblaciones de los estudios estaban formadas &#250;nicamente por participantes europeos y asi&#225;ticos&#59; faltaban otros grupos &#233;tnicos&#44; como los africanos&#46; En segundo lugar&#44; solo se dispon&#237;a de datos relativos a SOX2 y a los otros criterios de valoraci&#243;n pron&#243;sticos &#40;tiempo hasta la progresi&#243;n y supervivencia sin recidiva&#41; para una poblaci&#243;n peque&#241;a&#46; Es fundamental y necesario realizar m&#225;s estudios cl&#237;nicos en el futuro para confirmar los resultados pron&#243;sticos de SOX2 en el CPM&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conclusiones</span><p id="par0160" class="elsevierStylePara elsevierViewall">La expresi&#243;n de SOX2 no se asoci&#243; a la supervivencia global en el CPNM ni en el CPM y se relacion&#243; con un peor pron&#243;stico en el tiempo hasta la progresi&#243;n y la supervivencia sin recidiva en el CPNM&#46; SOX2 podr&#237;a ser un objetivo terap&#233;utico &#250;til&#46; Estos resultados deber&#237;an confirmarse en m&#225;s estudios prospectivos&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Financiaci&#243;n</span><p id="par0170" class="elsevierStylePara elsevierViewall">Esta investigaci&#243;n no ha recibido financiaci&#243;n espec&#237;fica de entidades de sectores p&#250;blicos&#44; comerciales ni sin &#225;nimo de lucro&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicto de intereses</span><p id="par0165" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la relaci&#243;n entre SOX2 y el pron&#243;stico del c&#225;ncer de pulm&#243;n mediante la selecci&#243;n de estudios con informaci&#243;n disponible sobre la supervivencia basada en un an&#225;lisis de regresi&#243;n multivariante de Cox&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materiales y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realizaron b&#250;squedas en las bases de datos PubMed&#44; Embase y Web of Science para identificar estudios aceptables anteriores al 19 de junio de 2021&#46; Se calcularon las razones de riesgos instant&#225;neos o <span class="elsevierStyleItalic">hazard ratio</span> &#40;HR&#41; con intervalos de confianza &#40;IC&#41; del 95&#160;&#37; para evaluar el efecto pron&#243;stico de SOX2 bas&#225;ndose en un an&#225;lisis de regresi&#243;n multivariante de Cox&#46; Se utiliz&#243; un sesgo de publicaci&#243;n para evaluar el riesgo de sesgo&#46; Tambi&#233;n se realiz&#243; un an&#225;lisis funcional de SOX2&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 13&#160;estudios con un total de 2008&#160;pacientes con c&#225;ncer de pulm&#243;n&#46; La expresi&#243;n de SOX2 no se correlacion&#243; con la supervivencia global en el c&#225;ncer de pulm&#243;n &#40;10&#160;estudios con 1591&#160;casos&#41;&#46; Se observ&#243; heterogeneidad entre los estudios &#40;I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>85&#44;6&#160;&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El an&#225;lisis de subgrupos indic&#243; que no exist&#237;a correlaci&#243;n entre la expresi&#243;n de SOX2 y la supervivencia global en el c&#225;ncer de pulm&#243;n no microc&#237;tico &#40;ocho estudios con 1319&#160;casos&#41; ni el c&#225;ncer de pulm&#243;n microc&#237;tico &#40;dos estudios con 272&#160;casos&#41;&#46; La expresi&#243;n de SOX2 se asoci&#243; de forma significativa a peores resultados en el tiempo hasta la progresi&#243;n &#40;dos estudios con 104&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44;50&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;34-9&#44;15&#41; y la supervivencia sin recidiva &#40;dos estudios con 335&#160;casos&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;45&#44; IC del 95&#160;&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;12-1&#44;87&#41; en el c&#225;ncer de pulm&#243;n no microc&#237;tico&#46; El an&#225;lisis funcional demostr&#243; que SOX2 interviene en la reparaci&#243;n del ADN&#44; el ciclo celular&#44; la regulaci&#243;n del mantenimiento de la poblaci&#243;n de c&#233;lulas madre y la v&#237;a de se&#241;alizaci&#243;n Hippo&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">SOX2 puede ser un factor pron&#243;stico independiente para el tiempo hasta la progresi&#243;n y la supervivencia sin recidiva y puede convertirse en un objetivo terap&#233;utico prometedor&#46; Es necesario realizar m&#225;s estudios para profundizar en nuestros resultados&#46;</p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the association of SOX2 with the prognosis in lung cancer&#44; studies providing survival information were selected based on multivariate Cox regression analysis&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">PubMed&#44; Embase&#44; and Web of Science databases were searched to identify eligible studiesbefore June 19&#44; 2021&#46; The hazard ratios &#40;HR&#41; with 95&#37; confidence intervals &#40;CI&#41; were calculated to assess the prognostic impact of SOX2 based on multivariate Cox regression analysis&#46; Publication bias was used to assess the risk of bias&#46; Functional analysis of SOX2 was also conducted&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">13 studies with a total of 2008 patients with lung cancer were included&#46; SOX2 expression was not correlated with overall survival in lung cancer &#40;10 studies with 1591 cases&#41;&#46; Between-study heterogeneity was noted &#40;<span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>85&#46;6&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#41;&#46; Subgroup analysis suggested that no correlation was found between SOX2 expression and overall survival in non-small cell lung cancer &#40;eight studies with 1319 cases&#41; and small-cell lung cancer &#40;two studies with 272 cases&#41;&#46; SOX2 expression was significantly associated with worse time-to-progression &#40;two studies with 104 cases&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;50&#44; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;34-9&#46;15&#41; and recurrence-free survival &#40;two studies with 335 cases&#58; HR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;45&#44; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;12-1&#46;87&#41; in non-small cell lung cancer&#46; Function analysis demonstrated that SOX2 was involved in DNA repair&#44; cell cycle&#44; regulation of stem cell population maintenance&#44; and Hippo signaling pathway&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">SOX2 may be an independent prognostic factor in time-to-progression and recurrence-free survival and may become a promising therapeutic target&#46; More studies are essential to further our findings&#46;</p></span>"
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A&#41; Diagrama de bosque de SOX2 y supervivencia global en el c&#225;ncer de pulm&#243;n&#46; B&#41; Diagrama de bosque del an&#225;lisis de SOX2 y supervivencia global en el c&#225;ncer de pulm&#243;n en funci&#243;n del subgrupo de histolog&#237;a tumoral&#46; C&#41; Diagrama de bosque de SOX2 y los otros criterios de valoraci&#243;n pron&#243;sticos en el c&#225;ncer de pulm&#243;n&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">CPM&#58; c&#225;ncer de pulm&#243;n microc&#237;tico&#59; CPNM&#58; c&#225;ncer de pulm&#243;n no microc&#237;tico&#59; SSR&#58; supervivencia sin recidiva&#59; THP&#58; tiempo hasta la progresi&#243;n&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 3856
            "Ancho" => 2508
            "Tamanyo" => 1391367
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis funcional de SOX2 en el c&#225;ncer de pulm&#243;n&#46;</p>"
        ]
      ]
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        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">AD&#58; adenocarcinoma&#59; AM&#58; an&#225;lisis de regresi&#243;n multivariante de Cox&#59; CPM&#58; c&#225;ncer de pulm&#243;n microc&#237;tico&#59; CPNM&#58; c&#225;ncer de pulm&#243;n no microc&#237;tico&#59; DE&#58; desviaci&#243;n est&#225;ndar&#59; E<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#58; expresi&#243;n positiva&#59; ELISA&#58; ensayo por inmunoabsorci&#243;n ligado a enzimas <span class="elsevierStyleItalic">&#40;enzyme-linked immunosorbent assay&#41;</span>&#59; HR&#58; hazard ratio&#59; IC&#58; intervalo de confianza&#59; IFC&#58; inmunofluorescencia cuantitativa&#59; IHQ&#58; immunohistoqu&#237;mica&#59; N&#58; n&#250;mero de la poblaci&#243;n que se ha estudiado&#59; NA&#58; no se aplica&#59; SG&#58; supervivencia global&#59; SSR&#58; supervivencia sin recidiva&#59; TaqMan qPCR&#58; TaqMan PCR cuantitativa&#59; THP&#58; tiempo hasta la progresi&#243;n&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autor principal</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pa&#237;s</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Origen &#233;tnico</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Edad</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">M&#233;todo de detecci&#243;n</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estadio de la enfermedad</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Histolog&#237;a</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ab</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tinci&#243;n</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Corte</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Caso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pron&#243;stico-AM &#40;HR con IC del 95&#37;&#41;</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;E<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maddison 2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reino Unido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ELISA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;5 DE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">177 &#40;29&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Supervivencia&#58; 0&#44;97 &#40;0&#44;64-1&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sholl 2010 &#40;cohorte masculina&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EE&#46; UU&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IHQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPNM &#40;AD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;60&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">THP&#58; 5&#44;6 &#40;2&#44;3&#8211;13&#44;8&#41;&#59; SG&#58; 2&#44;5 &#40;1&#44;2&#8211;5&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sholl 2010 &#40;cohorte femenina&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EE&#46; UU&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IHQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPNM &#40;AD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;43&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">THP&#58; 2&#44;1 &#40;0&#44;8&#8211;5&#44;7&#41;&#59; SG&#58; 1&#44;6 &#40;0&#44;8&#8211;3&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Velcheti 2013 &#40;cohorte de formaci&#243;n&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EE&#46; UU&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IFC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPNM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Puntuaci&#243;n de 193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340 &#40;72&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SG&#58; 0&#44;429 &#40;0&#44;295-0&#44;663&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Velcheti 2013 &#40;cohorte de validaci&#243;n&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EE&#46; UU&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IFC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPNM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Puntuaci&#243;n de 193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">307 &#40;56&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SG&#58; 0&#44;734 &#40;0&#44;502-1&#44;075&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yang 2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">China&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IHQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Puntuaci&#243;n de 55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">222 &#40;55&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SSR&#58; 1&#44;365 &#40;1&#44;017-1&#44;831&#41;&#59; SG&#58; 1&#44;359 &#40;1&#44;016-1&#44;818&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Udagawa 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jap&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IHQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mediana puntuaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">113 &#40;50&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SSR&#58; 1&#44;736 &#40;1&#44;055&#8211;2&#44;901&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sodja 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eslovenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TaqMan qPCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mediana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;92&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SG&#58; 3&#44;205 &#40;1&#44;536-6&#44;711&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liu 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">China&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IHQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPNM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">140 &#40;48&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SG&#58; 1&#44;341 &#40;0&#44;744&#8211;2&#44;417&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ying 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">China&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IHQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1-3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CPNM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SOX2 anticuerpos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nuclear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; y &#40;&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;35&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Supervivencia&#58; 0&#44;380 &#40;0&#44;223-0&#44;649&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
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