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fatiga&#44; cefalea&#44; ansiedad&#44; &#171;niebla mental&#187;&#44; insomnio&#44; tos&#44; disnea&#44; dolor tor&#225;cico&#44; artralgias&#44; mialgias y diarrea &#40;entre otros&#41;&#44; todos ellos fluctuantes y heterog&#233;neos en caracter&#237;sticas e intensidad<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A este conjunto de s&#237;ntomas y signos presentes tras la COVID-19 se lo ha denominado a lo largo del &#250;ltimo a&#241;o de diferentes maneras&#58; s&#237;ndrome pos-COVID-19&#44; condiciones pos-COVID&#44; <span class="elsevierStyleItalic">long-COVID</span>&#44; COVID-persistente&#44; COVID-19 posaguda&#44; secuelas posagudas de la COVID-19&#44; portadores a largo plazo de COVID y s&#237;ndrome pos-COVID cr&#243;nico&#44; por citar las m&#225;s relevantes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Entonces&#44; &#191;de qu&#233; hablamos cuando hablamos de manifestaciones &#171;pos-COVID-19&#187;&#63; Las primeras gu&#237;as publicadas utilizan la designaci&#243;n de &#171;s&#237;ndrome pos-COVID-19&#187; considerando los signos y s&#237;ntomas que se desarrollan durante o despu&#233;s de la infecci&#243;n&#44; que contin&#250;an durante m&#225;s de 12 semanas y no se pueden explicar con un diagn&#243;stico alternativo&#46; Utilizan adem&#225;s el t&#233;rmino <span class="elsevierStyleItalic">long-COVID</span> para designar el cuadro cl&#237;nico que sigue a la fase aguda &#40;4 semanas&#41; y se prolonga m&#225;s all&#225; de las 12 semanas &#40;abarcando al s&#237;ndrome pos-COVID-19&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Posteriormente&#44; la Organizaci&#243;n Mundial de la Salud y los Centers for Diseases Control and Prevention utilizaron el t&#233;rmino &#171;condiciones&#187; para designar las manifestaciones pos-COVID-19&#44; asignando la Organizaci&#243;n Mundial de la Salud el c&#243;digo U09&#46;9 en el CID-10 para <span class="elsevierStyleItalic">post-COVID conditions</span>&#46; De forma m&#225;s reciente&#44; diferentes asociaciones cient&#237;ficas y de pacientes han utilizado los t&#233;rminos &#171;long-COVID&#187; y &#171;COVID persistente&#187;&#44; sin el prefijo pos-&#44; ya que alude a una enfermedad superada&#44; hecho contrapuesto con la hip&#243;tesis patog&#233;nica de la existencia de reservorios con persistencia viral<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ninguno de los t&#233;rminos propuestos es correcto por completo&#58; todos tienen fortalezas y debilidades y a&#250;n no se llega a un acuerdo en c&#243;mo definir esta situaci&#243;n&#46; Est&#225;n sin definir&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">El nombre que mejor los identifica&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Los plazos temporales para considerar su comienzo &#40;3&#44; 4&#44; 12&#44; 24 semanas&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los s&#237;ntomas y signos que se han de incluir&#44; ya que en la etiopatogenia debe esclarecerse la presencia de&#58; 1&#41; secuelas por fibrosis y tromboembolia&#44; 2&#41; inflamaci&#243;n persistente&#44; 3&#41; reacciones autoinmunes y 4&#41; persistencia de reservorios virales intestinales&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Si deben considerarse entidades confirmadas&#44; probables o posibles&#44; en funci&#243;n del tipo de estudio que verifica la presencia de la infecci&#243;n por SARS-CoV-2 &#40;RT-PCR&#44; test de detecci&#243;n de ant&#237;genos&#44; detecci&#243;n de anticuerpos&#41;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p></li></ul></p><p id="par0055" class="elsevierStylePara elsevierViewall">Desde el punto de vista cl&#237;nico-patog&#233;nico&#44; se superpone la coexistencia de manifestaciones originadas por&#58; a&#41; secuelas inducidas por SARS-CoV-2 &#40;fibrosis&#44; trombosis&#41;&#59; b&#41; manifestaciones relacionadas con actividad inflamatoria persistente &#40;inflamaci&#243;n sist&#233;mica&#44; reacciones autoinmunes o persistencia del SARS-CoV-2&#41; y c&#41; secuelas de la internaci&#243;n&#44; principalmente en quienes requirieron asistencia en unidades de cuidados intensivos &#40;UCI&#41;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Considerando esta variabilidad&#44; ser&#237;a posible distinguir los siguientes fenotipos cl&#237;nicos&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">a&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Patr&#243;n predominantemente respiratorio &#40;asistidos en UCI&#44; fibrosis pulmonar&#44; neumon&#237;a organizada&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">b&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Patr&#243;n cardiorrespiratorio con s&#237;ntomas cardiovasculares y da&#241;o pulmonar de menor magnitud &#40;pacientes no hospitalizados&#44; dolor tor&#225;cico&#44; taquicardia&#44; s&#237;ndrome de taquicardia postural ortost&#225;tica&#44; estudios de imagenolog&#237;a y funci&#243;n pulmonar sin da&#241;o significativo&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">c&#46;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Patr&#243;n psiconeurocognitivo &#40;alteraci&#243;n de la memoria&#44; &#171;niebla mental&#187;&#44; insomnio&#44; ansiedad&#44; depresi&#243;n&#44; cefalea&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">d&#46;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Patr&#243;n con actividad inflamatoria persistente&#44; as&#237; como la concomitancia de este con los patrones previos<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">Es posible que el s&#237;ndrome pos-COVID-19&#44; <span class="elsevierStyleItalic">long-COVID</span>&#44; COVID persistente y otras denominaciones utilizadas en la bibliograf&#237;a representen m&#250;ltiples s&#237;ndromes&#44; resultado de procesos patog&#233;nicos pasados o persistentes&#44; de los cuales resulta imprescindible conocer la etiopatogenia&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">De momento&#44; cabe utilizar un t&#233;rmino &#171;paraguas&#187; que abarque las manifestaciones pos-COVID-19 y entenderlo&#44; al menos por ahora&#44; como un concepto o varios conceptos en construcci&#243;n&#44; con certezas&#44; dudas y superposiciones&#44; a la espera de que se pueda redefinir a la luz de evidencia cient&#237;fica concluyente&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Las respuestas vendr&#225;n de la investigaci&#243;n&#44; 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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">COVID-19&#58; <span class="elsevierStyleItalic">coronavirus disease-19</span>&#59; SARS-CoV-2&#58; <span class="elsevierStyleItalic">severe acute respiratory syndrome coronavirus-2&#46;</span></p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Definici&#243;n en castellano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Definici&#243;n utilizada en la publicaci&#243;n original&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tiempos considerados en la definici&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Otras definiciones consideradas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">National Institute for Health and Care Excellence &#40;NICE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ndrome pos-COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-COVID-19 syndrome</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 12 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID sintom&#225;tico en curso &#40;<span class="elsevierStyleItalic">ongoing symptomatic COVI</span>D&#41;&#58; 4 a 12 semanas&#46; COVID prolongado <span class="elsevierStyleItalic">&#40;long-COVID&#41;</span>&#58; 4 semanas en adelante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID-19 rapid guideline&#58; managing the long-term effects of COVID-19&#46; <span class="elsevierStyleInterRef" id="intr0005" href="http://www.nice.org.uk/guidance/ng188">www&#46;nice&#46;org&#46;uk&#47;guidance&#47;ng188</span> diciembre de 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Organizaci&#243;n Mundial de la Salud &#40;OMS &#8211; WHO&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Condiciones pos-COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-COVID-19 conditions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tras 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Corto plazo &#40;4 a 8 semanas&#41;&#44; medio plazo &#40;2 a 6 meses&#41;&#44; largo plazo &#40;m&#225;s de 6 meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Expanding our understanding of post COVID-19 condition&#46; Report of a WHO webinar&#46; <span class="elsevierStyleInterRef" id="intr0010" href="http://www.who.int/standards/classifications">www&#46;who&#46;int&#47;standards&#47;classifications</span> febrero de 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Centers for Diseases Control and Prevention &#40;CDC&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Condiciones pos-COVID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-COVID conditions</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuelas de la COVID posaguda &#40;<span class="elsevierStyleItalic">post-acute sequelae COVID</span>&#44; PASC&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleInterRef" id="intr0015" href="http://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions">www&#46;cdc&#46;gov&#47;coronavirus&#47;2019-ncov&#47;hcp&#47;clinical-care&#47;post-covid-conditions</span> abril de 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sociedad Espa&#241;ola de M&#233;dicos Generales y de Familia &#40;SEMG&#41; y LongCovidACTS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Long-COVID</span>&#47;COVID persistente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Long COVID &#47; COVID persistente</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ndrome pos-COVID-19&#58; corresponde a secuelas de la COVID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gu&#237;a cl&#237;nica para la atenci&#243;n al paciente <span class="elsevierStyleItalic">long COVID</span>&#47;COVID persistente&#46; Versi&#243;n 1&#46;0&#46; <span class="elsevierStyleInterRef" id="intr0020" href="http://www.semg.es/index.php/consensos-guias-y-protocolos">www&#46;semg&#46;es&#47;index&#46;php&#47;consensos-guias-y-protocolos</span> mayo de 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nalbandian A&#44; Sehgal K&#44; Gupta A&#44; Madhavan MV&#44; McGroder C&#44; Stevens JS&#44; et al&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID-19 posaguda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-acute COVID-19</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID-19 subagudo &#40;<span class="elsevierStyleItalic">subacute &#8211; ongoing symptomatic COVID-19</span>&#41; y COVID-19 cr&#243;nico o s&#237;ndrome pos-COVID-19 &#40;<span class="elsevierStyleItalic">chronic o post-COVID-19 syndrome</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nature Medicine&#46; April 2021&#59; 27&#58; 601-615&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Al-Aly Z&#44; Xle Y&#44; Bowe B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuelas posagudas de la COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-cute sequalae of COVID-19</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 30 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">High-dimensional characterization of post-acute sequalae of COVID-19&#46;</span> Nature&#46; 2021 Jun&#59; 594&#58;259-64&#46;doi&#46;org&#47;10&#46;1038&#47;s41586-021-03553-9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Datta SD&#44; Talwar A&#44; Lee JT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuelas tard&#237;as de la infecci&#243;n por SARS-CoV-2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Late sequelae of SARS-CoV-2 infection</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Portadores de largo plazo de SARS-CoV-2 &#40;<span class="elsevierStyleItalic">SARS-CoV-2 long haulers</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">A proposed framework and timeline of the spectrum disease due to SARS-CoV-2 infection&#46; Illnes beyond acute infection and public health implications</span>&#46; JAMA&#46; 2020&#59;324&#58;2251-2&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nath A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Portador de largo plazo COVID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Long-Haul COVID</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 100 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID de cola larga &#40;o &#171;coletazo del COVID&#187;&#41; &#40;<span class="elsevierStyleItalic">long-tail COVID</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Long-haul COVID</span>&#46; Neurology&#46; 2020&#59;95&#58;559-60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fern&#225;ndez de Las Pe&#241;as C&#44; Palacios Ce&#241;a D&#44; G&#243;mez Mayordomo V&#44; Cuadrado ML&#44; Florencio L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ntomas pos-COVID agudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Acute post-COVID symptoms</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">S&#237;ntomas prolongados pos-COVID &#40;<span class="elsevierStyleItalic">long post-COVID symptoms</span>&#41;&#59; s&#237;ntomas persistentes pos-COVID &#40;<span class="elsevierStyleItalic">persistent post-COVID symptoms</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Defining post-COVID symptoms &#40;post-acute COVID&#44; long COVID&#44; persisten pos-COVID&#41;&#58; An integrative classification&#46;</span> Int J Environ Res Public Health&#46; 2021&#59;18&#58;2621&#46; doi&#46;org&#47;10&#46;3390&#47;ijerph18052621&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">S&#237;ndrome post-COVID agudo&#44; menos de 12 semanas &#40;<span class="elsevierStyleItalic">acute post-COVID syndrome</span>&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Characteristics and predictors of acute and chronic post-COVID syndrome&#58; a systematic review and meta-analysis&#46;</span> EClin Med&#46; 2021&#59;24&#59;36&#58;100899doi&#46;org&#47;10&#46;1016&#47;j&#46;eclinm&#46;2021&#46;100899&nbsp;\t\t\t\t\t\t\n
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CORRESPONDENCIA
¿De qué hablamos cuando hablamos de pos-COVID-19?
What are we talking about when we talk about post-COVID-19?
E. Cairolia,b,c
a Unidad Pos-COVID-19, Centro Asistencial del Sindicato Médico del Uruguay (CASMU) y Unidad de Seguimiento Pos-COVID-19, Cooperativa Regional de Asistencia Médica Integral (CRAMI), Montevideo, Uruguay
b Unidad de Enfermedades Autoinmunes, Centro Asistencial del Sindicato Médico del Uruguay (CASMU) y Hospital Evangélico, Montevideo, Uruguay
c Laboratorio de Inmunorregulación e Inflamación, Institut Pasteur de Montevideo, Montevideo, Uruguay
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            "entidad" => "Unidad Pos-COVID-19&#44; Centro Asistencial del Sindicato M&#233;dico del Uruguay &#40;CASMU&#41; y Unidad de Seguimiento Pos-COVID-19&#44; Cooperativa Regional de Asistencia M&#233;dica Integral &#40;CRAMI&#41;&#44; Montevideo&#44; Uruguay"
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        "titulo" => "What are we talking about when we talk about post-COVID-19&#63;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">El virus SARS-CoV-2 &#40;<span class="elsevierStyleItalic">severe acute respiratory syndrome coronavirus-2</span>&#41; agente etiol&#243;gico de la COVID-19 &#40;<span class="elsevierStyleItalic">coronavirus disease-19</span>&#41; provoc&#243; una pandemia de tal magnitud que llev&#243; al colapso sanitario y a una fractura econ&#243;mica y social&#44; y ha instalado el t&#233;rmino &#171;pos-COVID-19&#187; en expresiones cotidianas en m&#250;ltiples &#243;rdenes de la vida&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En t&#233;rminos de salud&#44; la expresi&#243;n &#171;pos-COVID-19&#187; se utiliza para hacer referencia a la persistencia de s&#237;ntomas y signos en personas que cursaron la fase aguda de la infecci&#243;n&#46; Una vez superada esta&#44; se estima que entre el 10 y el 20&#37; de estas personas persistir&#225;n con un conjunto de s&#237;ntomas tales como&#58; fatiga&#44; cefalea&#44; ansiedad&#44; &#171;niebla mental&#187;&#44; insomnio&#44; tos&#44; disnea&#44; dolor tor&#225;cico&#44; artralgias&#44; mialgias y diarrea &#40;entre otros&#41;&#44; todos ellos fluctuantes y heterog&#233;neos en caracter&#237;sticas e intensidad<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A este conjunto de s&#237;ntomas y signos presentes tras la COVID-19 se lo ha denominado a lo largo del &#250;ltimo a&#241;o de diferentes maneras&#58; s&#237;ndrome pos-COVID-19&#44; condiciones pos-COVID&#44; <span class="elsevierStyleItalic">long-COVID</span>&#44; COVID-persistente&#44; COVID-19 posaguda&#44; secuelas posagudas de la COVID-19&#44; portadores a largo plazo de COVID y s&#237;ndrome pos-COVID cr&#243;nico&#44; por citar las m&#225;s relevantes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Entonces&#44; &#191;de qu&#233; hablamos cuando hablamos de manifestaciones &#171;pos-COVID-19&#187;&#63; Las primeras gu&#237;as publicadas utilizan la designaci&#243;n de &#171;s&#237;ndrome pos-COVID-19&#187; considerando los signos y s&#237;ntomas que se desarrollan durante o despu&#233;s de la infecci&#243;n&#44; que contin&#250;an durante m&#225;s de 12 semanas y no se pueden explicar con un diagn&#243;stico alternativo&#46; Utilizan adem&#225;s el t&#233;rmino <span class="elsevierStyleItalic">long-COVID</span> para designar el cuadro cl&#237;nico que sigue a la fase aguda &#40;4 semanas&#41; y se prolonga m&#225;s all&#225; de las 12 semanas &#40;abarcando al s&#237;ndrome pos-COVID-19&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Posteriormente&#44; la Organizaci&#243;n Mundial de la Salud y los Centers for Diseases Control and Prevention utilizaron el t&#233;rmino &#171;condiciones&#187; para designar las manifestaciones pos-COVID-19&#44; asignando la Organizaci&#243;n Mundial de la Salud el c&#243;digo U09&#46;9 en el CID-10 para <span class="elsevierStyleItalic">post-COVID conditions</span>&#46; De forma m&#225;s reciente&#44; diferentes asociaciones cient&#237;ficas y de pacientes han utilizado los t&#233;rminos &#171;long-COVID&#187; y &#171;COVID persistente&#187;&#44; sin el prefijo pos-&#44; ya que alude a una enfermedad superada&#44; hecho contrapuesto con la hip&#243;tesis patog&#233;nica de la existencia de reservorios con persistencia viral<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ninguno de los t&#233;rminos propuestos es correcto por completo&#58; todos tienen fortalezas y debilidades y a&#250;n no se llega a un acuerdo en c&#243;mo definir esta situaci&#243;n&#46; Est&#225;n sin definir&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">El nombre que mejor los identifica&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Los plazos temporales para considerar su comienzo &#40;3&#44; 4&#44; 12&#44; 24 semanas&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los s&#237;ntomas y signos que se han de incluir&#44; ya que en la etiopatogenia debe esclarecerse la presencia de&#58; 1&#41; secuelas por fibrosis y tromboembolia&#44; 2&#41; inflamaci&#243;n persistente&#44; 3&#41; reacciones autoinmunes y 4&#41; persistencia de reservorios virales intestinales&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Si deben considerarse entidades confirmadas&#44; probables o posibles&#44; en funci&#243;n del tipo de estudio que verifica la presencia de la infecci&#243;n por SARS-CoV-2 &#40;RT-PCR&#44; test de detecci&#243;n de ant&#237;genos&#44; detecci&#243;n de anticuerpos&#41;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p></li></ul></p><p id="par0055" class="elsevierStylePara elsevierViewall">Desde el punto de vista cl&#237;nico-patog&#233;nico&#44; se superpone la coexistencia de manifestaciones originadas por&#58; a&#41; secuelas inducidas por SARS-CoV-2 &#40;fibrosis&#44; trombosis&#41;&#59; b&#41; manifestaciones relacionadas con actividad inflamatoria persistente &#40;inflamaci&#243;n sist&#233;mica&#44; reacciones autoinmunes o persistencia del SARS-CoV-2&#41; y c&#41; secuelas de la internaci&#243;n&#44; principalmente en quienes requirieron asistencia en unidades de cuidados intensivos &#40;UCI&#41;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Considerando esta variabilidad&#44; ser&#237;a posible distinguir los siguientes fenotipos cl&#237;nicos&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">a&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Patr&#243;n predominantemente respiratorio &#40;asistidos en UCI&#44; fibrosis pulmonar&#44; neumon&#237;a organizada&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">b&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Patr&#243;n cardiorrespiratorio con s&#237;ntomas cardiovasculares y da&#241;o pulmonar de menor magnitud &#40;pacientes no hospitalizados&#44; dolor tor&#225;cico&#44; taquicardia&#44; s&#237;ndrome de taquicardia postural ortost&#225;tica&#44; estudios de imagenolog&#237;a y funci&#243;n pulmonar sin da&#241;o significativo&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">c&#46;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Patr&#243;n psiconeurocognitivo &#40;alteraci&#243;n de la memoria&#44; &#171;niebla mental&#187;&#44; insomnio&#44; ansiedad&#44; depresi&#243;n&#44; cefalea&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">d&#46;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Patr&#243;n con actividad inflamatoria persistente&#44; as&#237; como la concomitancia de este con los patrones previos<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">Es posible que el s&#237;ndrome pos-COVID-19&#44; <span class="elsevierStyleItalic">long-COVID</span>&#44; COVID persistente y otras denominaciones utilizadas en la bibliograf&#237;a representen m&#250;ltiples s&#237;ndromes&#44; resultado de procesos patog&#233;nicos pasados o persistentes&#44; de los cuales resulta imprescindible conocer la etiopatogenia&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">De momento&#44; cabe utilizar un t&#233;rmino &#171;paraguas&#187; que abarque las manifestaciones pos-COVID-19 y entenderlo&#44; al menos por ahora&#44; como un concepto o varios conceptos en construcci&#243;n&#44; con certezas&#44; dudas y superposiciones&#44; a la espera de que se pueda redefinir a la luz de evidencia cient&#237;fica concluyente&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Las respuestas vendr&#225;n de la investigaci&#243;n&#44; la cual debe nutrirse desde la pr&#225;ctica cl&#237;nica con el surgimiento de grupos&#44; unidades o policl&#237;nicas de pos-COVID-19 multidisciplinares&#44; que posibiliten conocer en profundidad todos los perfiles cl&#237;nicos e interroguen el modelo para identificar fenotipos que permitan establecer mejor el pron&#243;stico y utilizar tratamientos ajustados a cada perfil cl&#237;nico&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financiaci&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicto de intereses</span><p id="par0105" class="elsevierStylePara elsevierViewall">El autor declara no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">COVID-19&#58; <span class="elsevierStyleItalic">coronavirus disease-19</span>&#59; SARS-CoV-2&#58; <span class="elsevierStyleItalic">severe acute respiratory syndrome coronavirus-2&#46;</span></p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autores&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Definici&#243;n en castellano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Definici&#243;n utilizada en la publicaci&#243;n original&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tiempos considerados en la definici&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Otras definiciones consideradas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">National Institute for Health and Care Excellence &#40;NICE&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ndrome pos-COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-COVID-19 syndrome</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 12 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID sintom&#225;tico en curso &#40;<span class="elsevierStyleItalic">ongoing symptomatic COVI</span>D&#41;&#58; 4 a 12 semanas&#46; COVID prolongado <span class="elsevierStyleItalic">&#40;long-COVID&#41;</span>&#58; 4 semanas en adelante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID-19 rapid guideline&#58; managing the long-term effects of COVID-19&#46; <span class="elsevierStyleInterRef" id="intr0005" href="http://www.nice.org.uk/guidance/ng188">www&#46;nice&#46;org&#46;uk&#47;guidance&#47;ng188</span> diciembre de 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Organizaci&#243;n Mundial de la Salud &#40;OMS &#8211; WHO&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Condiciones pos-COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-COVID-19 conditions&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Tras 4 semanas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Corto plazo &#40;4 a 8 semanas&#41;&#44; medio plazo &#40;2 a 6 meses&#41;&#44; largo plazo &#40;m&#225;s de 6 meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Expanding our understanding of post COVID-19 condition&#46; Report of a WHO webinar&#46; <span class="elsevierStyleInterRef" id="intr0010" href="http://www.who.int/standards/classifications">www&#46;who&#46;int&#47;standards&#47;classifications</span> febrero de 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Centers for Diseases Control and Prevention &#40;CDC&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Condiciones pos-COVID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Post-COVID conditions</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Secuelas de la COVID posaguda &#40;<span class="elsevierStyleItalic">post-acute sequelae COVID</span>&#44; PASC&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleInterRef" id="intr0015" href="http://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions">www&#46;cdc&#46;gov&#47;coronavirus&#47;2019-ncov&#47;hcp&#47;clinical-care&#47;post-covid-conditions</span> abril de 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Sociedad Espa&#241;ola de M&#233;dicos Generales y de Familia &#40;SEMG&#41; y LongCovidACTS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Long-COVID</span>&#47;COVID persistente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Long COVID &#47; COVID persistente</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ndrome pos-COVID-19&#58; corresponde a secuelas de la COVID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gu&#237;a cl&#237;nica para la atenci&#243;n al paciente <span class="elsevierStyleItalic">long COVID</span>&#47;COVID persistente&#46; Versi&#243;n 1&#46;0&#46; <span class="elsevierStyleInterRef" id="intr0020" href="http://www.semg.es/index.php/consensos-guias-y-protocolos">www&#46;semg&#46;es&#47;index&#46;php&#47;consensos-guias-y-protocolos</span> mayo de 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nalbandian A&#44; Sehgal K&#44; Gupta A&#44; Madhavan MV&#44; McGroder C&#44; Stevens JS&#44; et al&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID-19 posaguda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-acute COVID-19</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID-19 subagudo &#40;<span class="elsevierStyleItalic">subacute &#8211; ongoing symptomatic COVID-19</span>&#41; y COVID-19 cr&#243;nico o s&#237;ndrome pos-COVID-19 &#40;<span class="elsevierStyleItalic">chronic o post-COVID-19 syndrome</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nature Medicine&#46; April 2021&#59; 27&#58; 601-615&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Al-Aly Z&#44; Xle Y&#44; Bowe B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuelas posagudas de la COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Post-cute sequalae of COVID-19</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 30 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">High-dimensional characterization of post-acute sequalae of COVID-19&#46;</span> Nature&#46; 2021 Jun&#59; 594&#58;259-64&#46;doi&#46;org&#47;10&#46;1038&#47;s41586-021-03553-9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Datta SD&#44; Talwar A&#44; Lee JT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuelas tard&#237;as de la infecci&#243;n por SARS-CoV-2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Late sequelae of SARS-CoV-2 infection</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Portadores de largo plazo de SARS-CoV-2 &#40;<span class="elsevierStyleItalic">SARS-CoV-2 long haulers</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">A proposed framework and timeline of the spectrum disease due to SARS-CoV-2 infection&#46; Illnes beyond acute infection and public health implications</span>&#46; JAMA&#46; 2020&#59;324&#58;2251-2&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nath A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Portador de largo plazo COVID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Long-Haul COVID</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 100 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COVID de cola larga &#40;o &#171;coletazo del COVID&#187;&#41; &#40;<span class="elsevierStyleItalic">long-tail COVID</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Long-haul COVID</span>&#46; Neurology&#46; 2020&#59;95&#58;559-60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fern&#225;ndez de Las Pe&#241;as C&#44; Palacios Ce&#241;a D&#44; G&#243;mez Mayordomo V&#44; Cuadrado ML&#44; Florencio L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ntomas pos-COVID agudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Acute post-COVID symptoms</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ntomas prolongados pos-COVID &#40;<span class="elsevierStyleItalic">long post-COVID symptoms</span>&#41;&#59; s&#237;ntomas persistentes pos-COVID &#40;<span class="elsevierStyleItalic">persistent post-COVID symptoms</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Defining post-COVID symptoms &#40;post-acute COVID&#44; long COVID&#44; persisten pos-COVID&#41;&#58; An integrative classification&#46;</span> Int J Environ Res Public Health&#46; 2021&#59;18&#58;2621&#46; doi&#46;org&#47;10&#46;3390&#47;ijerph18052621&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Iqbal FM&#44; Lam K&#44; Sounderajah V&#44; Clarke JM&#44; Ashrafian H&#44; Drazi A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ndrome pos-COVID cr&#243;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Chronic post-COVID syndrome</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#225;s de 12 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;ndrome post-COVID agudo&#44; menos de 12 semanas &#40;<span class="elsevierStyleItalic">acute post-COVID syndrome</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Characteristics and predictors of acute and chronic post-COVID syndrome&#58; a systematic review and meta-analysis&#46;</span> EClin Med&#46; 2021&#59;24&#59;36&#58;100899doi&#46;org&#47;10&#46;1016&#47;j&#46;eclinm&#46;2021&#46;100899&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Definiciones utilizadas en la bibliograf&#237;a cient&#237;fica sobre las manifestaciones cl&#237;nicas presentes tras la fase aguda de la COVID-19</p>"
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      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:4 [
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              "identificador" => "bib0025"
              "etiqueta" => "1"
              "referencia" => array:1 [
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                  "referenciaCompleta" => "COVID-19 rapid guideline&#58; Managing the long-term effects of COVID-19&#46; National Institute for Health and Care Excellence &#40;NICE&#41;&#46; 18 Dic 2020 &#91;consultado 18 de junio de 2021&#93;&#46; Disponible en&#58; www&#46;nice&#46;org&#46;uk&#47;guidance&#47;ng188&#46;"
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            1 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "2"
              "referencia" => array:1 [
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                  "referenciaCompleta" => "Gu&#237;a cl&#237;nica para la atenci&#243;n al paciente long COVID&#47;COVID persistente&#46; SEMG &#40;Sociedad Espa&#241;ola de M&#233;dicos Generales y de Familia&#41;&#46; LongCovidACTS &#40;Autonomous Communities Together Spain&#41;&#46; Documento colaborativo entre colectivos de pacientes y sociedades cient&#237;ficas Versi&#243;n 1&#46;0&#46; &#40;01&#47;05&#47;2021&#41; &#91;consultado 5 de mayo de 2021&#93;&#46; Disponible en&#58; https&#58;&#47;&#47;www&#46;semg&#46;es&#47;index&#46;php&#63;option<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>com&#95;content&#38;view<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>article&#38;id<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>363&#46;"
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              "identificador" => "bib0035"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long COVID or post-COVID-19 syndrome&#58; Putative pathophysiology&#44; risk factors and treatments &#91;published online ahead of print&#44; 2021 May 22&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;J&#46; Yong"
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                    0 => array:2 [
                      "doi" => "10.1080/23744235.2021.1924397"
                      "Revista" => array:4 [
                        "tituloSerie" => "Infect Dis"
                        "fecha" => "2021"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
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                    0 => array:2 [
                      "titulo" => "Defining post-COVID symptoms &#40;post-acute COVID&#44; long COVID persistent post-COVID&#41;&#58; An integrative classification"
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                      "doi" => "10.3390/ijerph18052621"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Environ Res Public Health"
                        "fecha" => "2021"
                        "volumen" => "18"
                        "paginaInicial" => "2621"
                        "link" => array:1 [
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Información del artículo
ISSN: 00142565
Idioma original: Español
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