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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis multivariado de la asociaci&#243;n de cada droga con la presencia de dolor tor&#225;cico ajustado por edad y sexo &#40;OR e IC del 95&#37;&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El dolor tor&#225;cico &#40;DT&#41;&#44; s&#237;ntoma frecuente en los servicios de urgencias hospitalarias &#40;SUH&#41;&#44; est&#225; relacionado en ocasiones con el consumo de drogas<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a>&#46; La asociaci&#243;n de cuadros coronarios con el consumo reciente o cr&#243;nico de coca&#237;na est&#225; bien establecida<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a>&#44; consider&#225;ndose ello como un factor de riesgo cardiovascular<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La mayor&#237;a de los estudios sobre drogas y DT se basan en series de pacientes con diagn&#243;stico de isquemia cardiaca&#44; pero existe poca informaci&#243;n tanto sobre el DT como motivo de consulta sin diagn&#243;stico final cardiol&#243;gico&#44; como sobre la asociaci&#243;n del DT con el consumo aislado o conjunto de drogas distintas de la coca&#237;na &#40;anfetaminas&#44; cannabis&#44; etc&#46;&#41;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a>&#46; Adem&#225;s&#44; es preciso disponer de datos actualizados en el cambiante mundo de las drogas&#44; debido al incremento de la potencia de alguna de ellas &#40;caso del cannabis&#41;&#44; al uso de adulterantes no conocidos&#44; etc&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El objetivo de este trabajo es conocer la relaci&#243;n y las caracter&#237;sticas cl&#237;nicas entre el consumo agudo de drogas y la presencia de dolor tor&#225;cico en pacientes que consultan a los SUH espa&#241;oles&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">El registro Red de estudio de drogas en urgencias hospitalarias en Espa&#241;a &#40;REDUrHE&#41; es un registro multic&#233;ntrico y prospectivo&#44; en el que participaron 11 SUH de 6<span class="elsevierStyleHsp" style=""></span>comunidades aut&#243;nomas espa&#241;olas&#44; realizado durante 2 a&#241;os &#40;agosto del 2017-julio del 2019&#41;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Los criterios de inclusi&#243;n fueron el consumo reciente de drogas &#40;atribuci&#243;n de dicho consumo por el paciente al motivo de la consulta&#41;&#44; signos o s&#237;ntomas indicativos de consumo agudo de drogas y presentar un an&#225;lisis toxicol&#243;gico positivo junto a s&#237;ntomas compatibles con los efectos secundarios del consumo de drogas&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Se recogieron variables demogr&#225;ficas &#40;edad&#44; sexo y forma de acceso a urgencias &#8212;ambulancia&#47;otros&#8212;&#41;&#44; tipo de drogas implicadas &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; consumo concomitante de alcohol &#40;excluy&#233;ndose las intoxicaciones exclusivamente et&#237;licas&#41;&#44; constantes vitales&#44; manifestaciones cl&#237;nicas&#44; tratamiento inicial&#44; tiempo de asistencia y destino final del paciente&#46; Se defini&#243; como indicador primario de gravedad el evento adverso combinado formado por intubaci&#243;n orotraqueal&#44; parada cardiorrespiratoria&#44; necesidad de ingreso en cuidados intensivos y muerte por cualquier causa&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Las drogas consumidas se determinaron bien por la historia cl&#237;nica &#40;indicadas por el enfermo o su entorno&#41; o bien por la anal&#237;tica toxicol&#243;gica &#40;determinaci&#243;n de drogas en orina con t&#233;cnicas de enzimoinmunoan&#225;lisis&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Los casos del registro REDUrHE se dividieron en funci&#243;n de si acud&#237;an por DT o no como motivo de consulta&#46; Los pacientes reincidentes se incluyeron tantas veces como acudieron al SUH&#46; De los 4&#46;526 casos del registro se descartaron 89&#44; en los que el dato de DT no se hab&#237;a consignado&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Las variables cuantitativas se expresan con media y desviaci&#243;n est&#225;ndar&#44; utiliz&#225;ndose la U de Mann-Whitney para muestras independientes&#46; Las variables cualitativas se expresaron en cifras absolutas y porcentuales&#44; compar&#225;ndose mediante la prueba de la chi cuadrado o el test exacto de Fisher&#44; seg&#250;n procediera&#46; Se consider&#243; estad&#237;sticamente significativo un valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Tambi&#233;n se utiliz&#243; el paquete estad&#237;stico SPSS v&#46;28&#46;0&#46;1 &#40;IBM&#44; Armonk&#44; Nueva York&#44; EE&#46; UU&#46;&#41;&#46; El estudio fue aprobado por el Comit&#233; de &#201;tica de la Investigaci&#243;n del Hospital Universitario de Canarias &#40;Tenerife&#41;&#44; referencia 2016-71&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">Los resultados de las diferentes variables se presentan en la &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; De los 4&#46;437 pacientes del registro&#44; 398 &#40;8&#44;97&#37;&#41; presentaban DT&#44; con una edad media de 34&#44;2 a&#241;os &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;81&#41; y un 82&#44;9&#37; de varones &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Las drogas m&#225;s frecuentes fueron la coca&#237;na &#40;69&#44;8&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; el cannabis &#40;35&#44;7&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y las anfetaminas y derivados &#40;21&#44;4&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;06&#41;&#46; En el 50&#44;1&#37; de los pacientes con DT hubo coingesta de etanol y en el 36&#44;7&#37;&#44; consumo de varias drogas&#46; Consumieron una sola sustancia el 63&#44;3&#37; de los pacientes con DT&#44; mezcla de 2<span class="elsevierStyleHsp" style=""></span>sustancias el 28&#44;4&#37;&#44; 3<span class="elsevierStyleHsp" style=""></span>drogas el 8&#37; y 4<span class="elsevierStyleHsp" style=""></span>el 0&#44;3&#37;&#44; sin diferencias significativas con los pacientes sin DT &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;17&#41;&#46; Hubo relaci&#243;n significativa entre consumo de drogas y menos presencia de DT&#44; en el caso del consumo de cannabis &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; de benzodiacepinas &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; opi&#225;ceos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#44; GHB &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41; y sustancias desconocidas &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">En el an&#225;lisis multivariante&#44; ajustado por edad y sexo&#44; la coca&#237;na aument&#243; 2&#44;7 veces la probabilidad de dolor tor&#225;cico &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44;875&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44;229-3&#44;48&#41;&#46; Tambi&#233;n en sentido contrario&#44; el consumo de cannabis &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;672&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;543-0&#44;833&#41;&#44; GHB &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;394&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;193-0&#44;804&#41;&#44; opioides &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;566&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;348-0&#44;921&#41;&#44; benzodiacepinas &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;333&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;190-0&#44;584&#41;&#44; y sustancias desconocidas &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;403&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;212-0&#44;764&#41;&#44; obtuvieron menos probabilidad de asociarse al DT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Los pacientes con DT acudieron a urgencias con menor frecuencia en ambulancia&#44; respecto al resto &#40;38&#44;9&#37; vs&#46; 57&#44;7&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; En las constantes vitales no se hallaron diferencias significativas entre ambos grupos&#44; si bien la frecuencia respiratoria no se consign&#243; en el 81&#44;4&#37; y la temperatura en el 35&#37;&#46; Como s&#237;ntomas diferenciales&#44; el DT se asoci&#243; de forma significativa a palpitaciones &#40;45&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; hipertensi&#243;n &#40;13&#44;6&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; ansiedad &#40;42&#44;5&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y arritmias &#40;5&#44;9&#37;&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Los pacientes con DT recibieron m&#225;s tratamientos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; si bien no hubo diferencias en cuanto al uso de sedaci&#243;n&#44; intubaci&#243;n orotraqueal o maniobras de reanimaci&#243;n cardiopulmonar&#46; Tampoco hubo diferencias en la presencia del evento adverso combinado&#44; el cual se dio en el 2&#44;3&#37; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0&#41;&#46; Ingresaron m&#225;s los pacientes sin DT &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;00&#41;&#44; fundamentalmente a expensas de hacerlo en salas de Psiquiatr&#237;a &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;00&#41;&#46; En sentido contrario&#44; los pacientes con DT presentaron una estancia en urgencias mayor &#40;13&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>61&#44;05 vs&#46; 8&#44;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>27&#44;52&#44; aunque sin significaci&#243;n estad&#237;stica &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#41;&#46; Fallecieron 12 pacientes de la serie&#44; sin relaci&#243;n significativa con el DT &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;35&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discusi&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Este trabajo ayuda a mejorar el conocimiento epidemiol&#243;gico y cl&#237;nico de la relaci&#243;n entre el consumo de drogas recreacionales y la consulta a urgencias por DT&#44; en una serie de casos amplia&#44; prospectiva y reciente&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Dado que Espa&#241;a es uno de los pa&#237;ses con m&#225;s consumidores de coca&#237;na de Europa<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a>&#44; no es de extra&#241;ar tanto desde una perspectiva fisiopatol&#243;gica como epidemiol&#243;gica que en nuestra serie la coca&#237;na sea la droga m&#225;s frecuente&#44; tanto inicialmente como tras su ajuste por edad y sexo&#46; Sin embargo&#44; otras drogas cuya prevalencia ha aumentado tambi&#233;n pueden ocasionar DT como efecto secundario tras su consumo&#46; En el registro europeo EURO-DEN&#44; sobre 17&#46;104 pacientes que visitaron urgencias por consumo de drogas &#40;1&#46;186 casos de Espa&#241;a&#41;&#44; se hall&#243; que&#44; en nuestro pa&#237;s&#44; hubo m&#225;s urgencias por coca&#237;na &#40;48&#44;4&#37;&#41; y menos por opi&#225;ceos &#40;12&#44;4&#37;&#41; que en el resto de Europa<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">8</span></a>&#46; Otros estudios recientes europeos han hallado prevalencias similares de consumo de coca&#237;na en pacientes con DT&#44; as&#237; como en la preponderancia del sexo masculino y en la coingesta de etanol&#44; sin observarse cambios importantes de tendencia en los &#250;ltimos a&#241;os<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Aunque otros autores espa&#241;oles ya hab&#237;an observado la asociaci&#243;n entre cannabis y DT<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">10</span></a>&#44; que esta asociaci&#243;n sea del 36&#37; es un dato a considerar&#46; Por un lado&#44; puede deberse al aumento de consumidores de cannabis<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">7</span></a>&#44; pero tambi&#233;n al aumento de la potencia de los preparados a base de cannabis que actualmente se utilizan en Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a>&#46; Conoci&#233;ndose ya a nivel fisiopatol&#243;gico los efectos secundarios cardiovasculares del cannabis&#44; tanto agudos<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">10&#44;11</span></a> como cr&#243;nicos<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">12</span></a>&#44; creemos que es necesario en el <span class="elsevierStyleItalic">screening</span> toxicol&#243;gico a pacientes con s&#237;ndrome coronario agudo incluir su detecci&#243;n<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">13</span></a>&#46; Adem&#225;s&#44; es destacable que consuman m&#225;s de una sustancia el 39&#37; de los pacientes del estudio<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Los s&#237;ntomas que acompa&#241;aban al DT&#44; como era de esperar&#44; fueron los simpaticomim&#233;ticos y la ansiedad&#44; mientras que los de tipo neurol&#243;gico y psiqui&#225;trico se asociaron de forma inversa&#46; Datos similares se han obtenido en otras series<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a>&#46; Sin embargo&#44; no se encontraron diferencias significativas en las constantes vitales a la llegada entre ambos grupos&#44; como cabr&#237;a esperar desde un punto de vista fisiopatol&#243;gico&#46; Es probable que la ausencia de datos en un m&#237;nimo del 11&#37; de los casos y el escaso registro de la frecuencia respiratoria y de la temperatura hagan que deba tomarse con cautela estos resultados&#46; Estudios previos han obtenido los mismos porcentajes de registro de estas 2<span class="elsevierStyleHsp" style=""></span>constantes<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">8&#44;10</span></a>&#44; existiendo margen de mejora en estos &#237;tems probablemente no solo en enfermedad toxicol&#243;gica&#44; sino en la asistencia urgente en general&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">A pesar de permanecer los pacientes con DT m&#225;s tiempo en urgencias &#40;de forma no significativa&#41;&#44; no hubo diferencias en cuanto a procedimientos de soporte vital avanzado&#44; evento adverso combinado o ingresos en el hospital&#46; Este aspecto tambi&#233;n se ha hallado en otras series espa&#241;olas&#44; con porcentajes similares en cuanto a las unidades de ingreso y el destino final de los pacientes dados de alta desde urgencias<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">8&#44;9</span></a>&#46; Esta mayor estancia en urgencias quiz&#225;s se deba a la necesidad de seriar en el tiempo los niveles de troponinas&#44; lo que ocasiona estancias iniciales m&#225;s prolongadas&#44; pero menos ingresos&#44; al descartarse el origen isqu&#233;mico del dolor tor&#225;cico&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">En cuanto a las limitaciones de este trabajo&#44; la distribuci&#243;n de los hospitales no fue homog&#233;nea&#44; con infrarrepresentaci&#243;n de algunas comunidades aut&#243;nomas&#46; Existe adem&#225;s cierto sesgo en la identificaci&#243;n de sustancias&#44; debido a que el diagn&#243;stico de drogas fue realizado mediante la historia cl&#237;nica y test de drogas en orina&#46; No obstante&#44; esto se asemeja a la pr&#225;ctica cl&#237;nica habitual en urgencias&#46; De la misma forma&#44; tampoco se solicit&#243; etanolemia de forma generalizada&#46; Al tratarse de un registro multiprop&#243;sito&#44; no se registraron determinados datos que pueden ser relevantes en el DT&#44; tales como el diagn&#243;stico final del paciente &#40;para diferenciar en motivos finales cardiol&#243;gicos o no&#41;&#44; los casos reincidentes &#40;que se consideraron como nuevos casos&#41;&#44; los niveles de troponinas y otros datos de laboratorio&#46; Con todo&#44; conocer las drogas asociadas al DT&#44; adem&#225;s de datos epidemiol&#243;gicos&#44; permite instaurar programas de prevenci&#243;n de factores de riesgo cardiovascular<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">15&#44;16</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Como conclusi&#243;n&#44; en la actualidad el DT tras el consumo de drogas&#44; supone el 9&#37; de las visitas a urgencias hospitalarias&#46; Los t&#243;xicos asociados a ello son los de tipo simpaticomim&#233;tico &#40;coca&#237;na y &#233;xtasis&#41;&#44; aunque se observa un aumento del cannabis como causante de DT&#44; lo cual deber&#237;a tenerse en cuenta en futuros estudios&#44; dado sus efectos t&#243;xicos cardiovasculares<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">16</span></a>&#46; Si bien no hallamos peores resultados cl&#237;nicos en los pacientes con DT&#44; su estancia en urgencias es mayor&#44; posiblemente por la necesidad de descartar cuadros cardiol&#243;gicos agudos susceptibles de tratamiento urgente<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">17&#44;18</span></a>&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financiaci&#243;n</span><p id="par0110" class="elsevierStylePara elsevierViewall">Estudio financiado por la Delegaci&#243;n del Gobierno para el Plan Nacional sobre Drogas&#44; Ministerio de Sanidad&#44; ref&#46; 2016&#47;072&#44; en su convocatoria de proyectos de investigaci&#243;n de 2016&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicto de intereses</span><p id="par0115" class="elsevierStylePara elsevierViewall">Los autores declaran no tener conflicto de intereses&#46;</p></span></span>"
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          "identificador" => "xpalclavsec1750831"
          "titulo" => "Keywords"
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          "titulo" => "Introducci&#243;n"
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          "identificador" => "sec0030"
          "titulo" => "Conflicto de intereses"
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        10 => array:1 [
          "titulo" => "Bibliograf&#237;a"
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    "tienePdf" => true
    "fechaRecibido" => "2023-02-06"
    "fechaAceptado" => "2023-05-08"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1750830"
          "palabras" => array:5 [
            0 => "Dolor tor&#225;cico"
            1 => "Drogas ilegales"
            2 => "Coca&#237;na"
            3 => "Cannabis"
            4 => "Urgencias hospitalarias"
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        0 => array:4 [
          "clase" => "keyword"
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            0 => "Chest pain"
            1 => "Illicit drugs"
            2 => "Cocaine"
            3 => "Cannabis"
            4 => "Emergency department"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer las caracter&#237;sticas de los pacientes con dolor tor&#225;cico &#40;DT&#41; asociado al consumo reciente de drogas&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de los casos del Registro REUrHE atendidos en urgencias de 11 hospitales espa&#241;oles por DT tras el consumo de drogas de uso recreacional&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El DT supuso el 8&#44;97&#37; de las asistencias &#40;varones 82&#44;9&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; La coca&#237;na estaba presente en el 70&#37; de los casos&#44; seguida del cannabis &#40;35&#44;7&#37;&#41; y las anfetaminas y derivados &#40;21&#44;4&#37;&#41;&#46; La cl&#237;nica inicial m&#225;s frecuente fue&#58; palpitaciones &#40;45&#44;5&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; ansiedad &#40;42&#44;5&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; hipertensi&#243;n &#40;13&#44;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y arritmias &#40;5&#44;9&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Recibieron m&#225;s tratamiento los pacientes con DT &#40;81&#44;9&#37; vs&#46; 74&#44;1&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; aunque ingresaron menos &#40;7&#44;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;0&#41;&#44; sin diferencias en cuanto a maniobras de reanimaci&#243;n cardiopulmonar&#44; sedaci&#243;n&#44; intubaci&#243;n&#44; o ingreso en cuidados intensivos &#40;1&#44;9&#37;&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En el DT tras una intoxicaci&#243;n aguda por drogas predomina el uso de la coca&#237;na&#44; aunque aumentan los casos por consumo de cannabis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "M&#233;todo"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the characteristics of patients with chest pain &#40;CP&#41; associated with recent drug use&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Study of cases from the REUrHE registry attended in the emergency department of 11 Spanish hospitals for CP following recreational drug use&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">CP accounted for 8&#46;97&#37; of attendances &#40;males 82&#46;9&#37;&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Cocaine was present in 70&#37; of cases&#44; followed by cannabis &#40;35&#46;7&#37;&#41; and amphetamines and derivatives &#40;21&#46;4&#37;&#41;&#46; The most frequent initial symptoms were&#58; palpitations &#40;45&#46;5&#37;&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; anxiety &#40;42&#46;5&#37;&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; hypertension &#40;13&#46;6&#37;&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and arrhythmias &#40;5&#46;9&#37;&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Patients with TD received more treatment &#40;81&#46;9&#37; vs&#46; 74&#46;1&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; although they were admitted less &#40;7&#46;6&#37;&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;0&#41;&#44; with no differences in terms of CPR manoeuvres&#44; sedation&#44; intubation&#44; or admission to intensive care &#40;1&#46;9&#37;&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In CP following acute drug intoxication&#44; cocaine use predominates&#44; although cases of cannabis use are increasing&#46;</p></span>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis multivariado de la asociaci&#243;n de cada droga con la presencia de dolor tor&#225;cico ajustado por edad y sexo &#40;OR e IC del 95&#37;&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; GHB&#58; gama-hidroxi-butirato&#59; LSD&#58; &#225;cido diacetil lis&#233;rgico&#59; RCP&#58; reanimaci&#243;n cardiopulmonar&#46;</p>"
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coingesta de etanol&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">854 &#40;19&#44;24&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;249 &#40;59&#44;53&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">172 &#40;50&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingesta de m&#250;ltiples drogas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1736 &#40;39&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1590 &#40;39&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Drogas</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coca&#237;na y derivados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cannabis y derivados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anfetaminas y derivados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">85 &#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Benzodiacepinas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">372 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Opi&#225;ceos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">350 &#40;7&#44;88&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">312 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>GHB y derivados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">208 &#40;4&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">200 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;008&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ketamina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">168 &#40;3&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">148 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;17&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>F&#225;rmacos psicotr&#243;picos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">63 &#40;1&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LSD y otros alucin&#243;genos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">31 &#40;0&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">29&#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nuevas drogas psicoactivas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;0&#44;31&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sustancia desconocida&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">253 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">243&#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10&#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Constantes vitales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia cardiaca&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">528 &#40;11&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94&#44;25 &#40;23&#44;91&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">98&#44;84 &#40;24&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">557 &#40;12&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">126&#44;45 &#40;19&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">125&#44;35 &#40;19&#44;34&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">135&#44;82 &#40;21&#44;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial diast&#243;lica&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">561 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">76&#44;73 &#40;14&#44;96&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">76&#44;12 &#40;14&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81&#44;6 &#40;14&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia respiratoria&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;682 &#40;81&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&#44;7 &#40;5&#44;65&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&#44;64 &#40;5&#44;712&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19&#44;43 &#40;5&#44;35&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Temperatura&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;582 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">36&#44;18 &#40;0&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36&#44;165 &#40;0&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36&#44;28 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cl&#237;nica cardiol&#243;gica</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Palpitaciones&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;0&#44;02&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">728 &#40;16&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">547 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">181 &#40;45&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arritmias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">79 &#40;1&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">123 &#40;2&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">100 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">23 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;0&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">242 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">188 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">54 &#40;13&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipotensi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">34 &#40;0&#44;76&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">93 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">87 &#40;2&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">6 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Otros s&#237;ntomas</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Agitaci&#243;n&#47;agresi&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ansiedad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">974 &#40;24&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V&#243;mitos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">527 &#40;11&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertermia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disminuci&#243;n nivel de consciencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">147 &#40;3&#44;31&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">807 &#40;18&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">799 &#40;20&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Convulsiones&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">398 &#40;8&#44;97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;1&#44;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">275 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;0&#44;75&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;ntomas cerebelosos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17 &#40;0&#44;38&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;0&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;0&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="6" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Manejo del paciente</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alg&#250;n tratamiento&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;0&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;317 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">326 &#40;81&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Test de drogas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;391&#40;76&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;099 &#40;76&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">292 &#40;73&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ant&#237;doto&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;0&#44;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">350 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">342 &#40;8&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Naloxona&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;0&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sedaci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Evento adverso combinado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso Unidad m&#233;dica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso Unidad intensivos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso Psiquiatr&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alta m&#233;dica&nbsp;\t\t\t\t\t\t\n
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Vol. 223. Núm. 7.
Páginas 450-455 (agosto - septiembre 2023)
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Vol. 223. Núm. 7.
Páginas 450-455 (agosto - septiembre 2023)
ORIGINAL BREVE
Dolor torácico secundario al consumo de drogas atendido en urgencias hospitalarias en España
Chest pain secondary to drug use treated in hospital emergency departments in Spain
Visitas
70
D. Ibrahim-Achia,b, S. Pelizzolo-Vegaa, J. Puiguriguerc, A. Supervíad, M. Galiciae, A. Domínguez-Rodríguezf,g, O. Miróe,h, G. Burillo-Putzeg,h,
Autor para correspondencia
gburillo@telefonica.net

Autor para correspondencia.
a Facultad de Ciencias de la Salud, Universidad de La Laguna, Tenerife, Santa Cruz de Tenerife, España
b Servicio de Urgencias, Hospital Universitario de Canarias, Tenerife, Santa Cruz de Tenerife, España
c Servicio de Urgencias, Unidad de Toxicología Clínica, Hospital Son Espases, Palma de Mallorca, Baleares, España
d Servicio de Urgencias, Unidad de Toxicología Clínica, Hospital del Mar, Barcelona, España
e Servicio de Urgencias, Hospital Clínic, Barcelona, España
f Servicio de Cardiología, Hospital Universitario de Canarias, Tenerife, Santa Cruz de Tenerife, España
g Departamento de Ciencias de la Salud, Universidad Europea de Canarias, Tenerife, Santa Cruz de Tenerife, España
h Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Barcelona, España
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Tabla 1. Características demográficas, grupos de drogas implicadas y aspectos clínico-asistenciales de los pacientes incluidos en el estudio
Resumen
Objetivo

Conocer las características de los pacientes con dolor torácico (DT) asociado al consumo reciente de drogas.

Método

Estudio de los casos del Registro REUrHE atendidos en urgencias de 11 hospitales españoles por DT tras el consumo de drogas de uso recreacional.

Resultados

El DT supuso el 8,97% de las asistencias (varones 82,9%, p<0,001). La cocaína estaba presente en el 70% de los casos, seguida del cannabis (35,7%) y las anfetaminas y derivados (21,4%). La clínica inicial más frecuente fue: palpitaciones (45,5%, p<0,001), ansiedad (42,5%, p<0,001), hipertensión (13,6%, p<0,001) y arritmias (5,9%, p<0,001). Recibieron más tratamiento los pacientes con DT (81,9% vs. 74,1%; p<0,001), aunque ingresaron menos (7,6%, p=0,0), sin diferencias en cuanto a maniobras de reanimación cardiopulmonar, sedación, intubación, o ingreso en cuidados intensivos (1,9%).

Conclusiones

En el DT tras una intoxicación aguda por drogas predomina el uso de la cocaína, aunque aumentan los casos por consumo de cannabis.

Palabras clave:
Dolor torácico
Drogas ilegales
Cocaína
Cannabis
Urgencias hospitalarias
Abstract
Objective

To determine the characteristics of patients with chest pain (CP) associated with recent drug use.

Methods

Study of cases from the REUrHE registry attended in the emergency department of 11 Spanish hospitals for CP following recreational drug use.

Results

CP accounted for 8.97% of attendances (males 82.9%, P<.001). Cocaine was present in 70% of cases, followed by cannabis (35.7%) and amphetamines and derivatives (21.4%). The most frequent initial symptoms were: palpitations (45.5%, P<.001), anxiety (42.5%, P<.001), hypertension (13.6%, P<.001) and arrhythmias (5.9%, P<.001). Patients with TD received more treatment (81.9% vs. 74.1%; P<.001), although they were admitted less (7.6%, P=.0), with no differences in terms of CPR manoeuvres, sedation, intubation, or admission to intensive care (1.9%).

Conclusions

In CP following acute drug intoxication, cocaine use predominates, although cases of cannabis use are increasing.

Keywords:
Chest pain
Illicit drugs
Cocaine
Cannabis
Emergency department

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