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        "titulo" => "Epidemiological aspects&#44; clinical management and short-term outcomes in elderly patients diagnosed with acute heart failure in the emergency department in Spain&#58; results of the EDEN-34 study"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Flujograma de inclusi&#243;n de pacientes en el estudio EDEN-34</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">SUH&#58; servicio de urgencias hospitalario&#59; ICA&#58; insuficiencia cardiaca aguda&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La insuficiencia cardiaca aguda &#40;ICA&#41; es un s&#237;ndrome que en la gran mayor&#237;a de casos genera una consulta en un servicio de urgencias &#40;SU&#41;&#46; Su incidencia aumenta a medida que avanza la edad de los pacientes y se estima que alcanza el 1&#37; anual en los sujetos mayores de 65 a&#241;os&#44; si bien no hay datos objetivos procedentes de los SU espa&#241;oles<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a>&#46; El Ministerio de Sanidad espa&#241;ol ha reportado que las principales causas de ingreso en los hospitales fueron las enfermedades circulatorias &#40;14&#44;5&#37; del total&#41;&#44; y la ICA es la principal causa dentro de este grupo de enfermedades<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a>&#46; As&#237; mismo&#44; dada la previsi&#243;n de envejecimiento de la poblaci&#243;n espa&#241;ola en las pr&#243;ximas d&#233;cadas&#44; se prev&#233; un aumento progresivo de la prevalencia de insuficiencia cardiaca &#40;IC&#41; en los pr&#243;ximos a&#241;os&#44; que se estima se situar&#225; alrededor del 10&#37; en sujetos mayores de 70 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Por otro lado&#44; existen varios registros en Espa&#241;a que han intentado complementar estos datos administrativos acerca de la ICA&#44; algunos proceden de registros de atenci&#243;n primaria y hospitales de referencia &#40;como el caso del estudio PATHWAYS-HF&#41;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a>&#44; mientras que otros recogen pacientes hospitalizados en determinados servicios asistenciales&#44; esencialmente en medicina interna &#40;registro RICA&#41;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#44; atendidos en consultas espec&#237;ficas de cardiolog&#237;a &#40;registro REDINSCOR&#41;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> o que son diagnosticados durante su consulta en el SU &#40;registro EAHFE&#41;&#46; Los datos procedentes de pacientes atendidos en SU resultan de particular inter&#233;s&#44; pues incluyen no solo pacientes con ICA que requieren hospitalizaci&#243;n&#44; sino tambi&#233;n descompensaciones menos graves que son &#237;ntegramente manejadas en urgencias y dadas de alta a domicilio sin hospitalizaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">7&#44;8</span></a>&#46; En conjunto&#44; estos registros han definido que&#44; en Espa&#241;a&#44; este s&#237;ndrome conlleva una mortalidad intrahospitalaria superior al 5&#37;&#44; una mortalidad a 30 d&#237;as de alrededor del 10&#37;&#44; que alcanza el 30&#37; al cabo de un a&#241;o&#44; y un riesgo de evento adverso &#40;reconsulta en urgencias&#44; hospitalizaci&#243;n o muerte&#41; durante los 30 d&#237;as posteriores al alta tras del episodio de ICA de alrededor del 30&#37;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A pesar de que los pacientes mayores son una poblaci&#243;n especialmente predispuesta a los episodios de ICA&#44; son pocos los estudios que se han centrado espec&#237;ficamente en esta poblaci&#243;n&#44; la cual puede presentar particularidades&#46; No en balde se trata de un segmento infrarrepresentado en los ensayos cl&#237;nicos y que&#44; debido a que suelen ser pacientes pluripatol&#243;gicos o con trastornos neurodegenerativos avanzados&#44; quedan excluidos de los principales registros&#46; El presente estudio profundiza en el conocimiento del manejo de los pacientes mayores que consultan en los SU espa&#241;oles debido a un episodio de ICA mediante el an&#225;lisis del registro EDEN &#40;<span class="elsevierStyleItalic">Emergency Department and Elder Needs</span>&#41;&#44; que incluy&#243; a todos los pacientes de 65 o m&#225;s a&#241;os atendidos en 52 SU espa&#241;oles de 14 comunidades aut&#243;nomas distintas durante una semana<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;10</span></a>&#46; Los objetivos espec&#237;ficos del presente an&#225;lisis fueron estimar la incidencia de diagn&#243;stico de ICA en pacientes mayores atendidos en los SU espa&#241;oles&#44; conocer la necesidad de hospitalizaci&#243;n y la confirmaci&#243;n diagn&#243;stica en aquellos pacientes hospitalizados&#44; definir el flujo habitual de estos pacientes tras su atenci&#243;n en urgencias y cuantificar los eventos adversos a corto plazo&#44; as&#237; como sus factores asociados&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todo</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Dise&#241;o del registro EDEN y del estudio EDEN-34</span><p id="par0020" class="elsevierStylePara elsevierViewall">El registro multiprop&#243;sito EDEN tiene como objetivo primario ampliar el conocimiento acerca de aspectos sociodemogr&#225;ficos&#44; organizativos&#44; de situaci&#243;n basal&#44; cl&#237;nicos&#44; asistenciales y evolutivos de la poblaci&#243;n de 65 o m&#225;s a&#241;os que consulta en los SU espa&#241;oles&#46; Participaron en la creaci&#243;n del registro EDEN 52 SU espa&#241;oles de 14 comunidades aut&#243;nomas&#44; que suponen el 17&#37; de SU hospitalarios p&#250;blicos existentes en Espa&#241;a y que dan cobertura al 25&#37; de su poblaci&#243;n &#40;11&#46;768&#46;548 habitantes&#41;&#46; Los SU participantes incluyeron todos los pacientes de este rango etario atendidos entre el 1 y el 7 de abril de 2019 &#40;siete d&#237;as&#41;&#44; independientemente del motivo de consulta&#46; No existi&#243; ning&#250;n motivo de exclusi&#243;n y se incluyeron todos los pacientes atendidos durante el periodo de estudio&#46; Los detalles del registro EDEN han sido descritos con mayor extensi&#243;n en estudios previos<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;11&#44;12</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El estudio EDEN-34 incluy&#243; a todos los pacientes de la cohorte EDEN en los que se registr&#243; ICA como uno de los diagn&#243;sticos codificados en urgencias&#46; En los informes de urgencias se codificaron hasta un m&#225;ximo de tres diagn&#243;sticos distintos y se acept&#243; el diagn&#243;stico de ICA si este figuraba en cualquiera de ellos &#40;c&#243;digos CIE-10&#58; I50&#46;x&#41;&#46; Adem&#225;s&#44; se recogieron los diagn&#243;sticos registrados al alta de hospitalizaci&#243;n para todos los pacientes de estudio que fueron hospitalizados&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Los objetivos del estudio EDEN-34 fueron cuatro&#46; El primero&#44; conocer la incidencia del diagn&#243;stico de ICA en los SU espa&#241;oles ajustados a la poblaci&#243;n de referencia de dichos SU&#46; El segundo fue analizar el manejo de estos pacientes en los SU&#44; especialmente centrado en la disposici&#243;n de estos tras la atenci&#243;n urgente y tras la hospitalizaci&#243;n&#46; El tercero&#44; analizar la frecuencia y los factores asociados con la hospitalizaci&#243;n y&#44; entre los pacientes hospitalizados&#44; la frecuencia y factores asociados con la confirmaci&#243;n diagn&#243;stica&#46; El cuarto fue explorar la frecuencia de eventos adversos y los factores asociados&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables independientes</span><p id="par0035" class="elsevierStylePara elsevierViewall">Se recogieron 24 variables independientes&#44; que incluyeron dos factores sociodemogr&#225;ficos &#40;edad&#44; sexo&#41;&#44; 11 comorbilidades &#40;hipertensi&#243;n arterial&#44; dislipidemia&#44; diabetes mellitus&#44; neoplasia activa&#44; insuficiencia cardiaca &#40;IC&#41;&#44; cardiopat&#237;a isqu&#233;mica&#44; neumopat&#237;a cr&#243;nica&#44; enfermedad cerebrovascular&#44; enfermedad vascular perif&#233;rica&#44; cirrosis hep&#225;tica&#44; enfermedad renal cr&#243;nica moderada-grave&#59; esta &#250;ltima se defini&#243; siguiendo el criterio de trabajos previos como aquellos pacientes que ten&#237;an una creatinina previa registrada &#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#41;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a>&#44; ocho variables que estimaban el estado basal del paciente teniendo en cuenta una perspectiva geri&#225;trica &#40;&#237;ndice de comorbilidad de Charlson &#8211;ICC&#8211;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a>&#44; &#237;ndice de Barthel &#8211;IB&#8211;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a>&#44; n&#250;mero de f&#225;rmacos cr&#243;nicos&#44; necesidad de ayuda en la deambulaci&#243;n&#44; ca&#237;das durante los seis meses previos&#44; diagn&#243;stico previo de depresi&#243;n&#44; demencia y delirium&#41;&#44; y tres acerca de la situaci&#243;n cl&#237;nica del paciente a su llegada a urgencias &#40;presi&#243;n arterial sist&#243;lica &#8211;PAS&#8211;&#44; frecuencia cardiaca y saturaci&#243;n basal de ox&#237;geno medida por pulsioximetr&#237;a&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; para poder hacer un seguimiento del paciente&#44; se consign&#243; su destino tras el alta&#44; ya fuese desde urgencias o tras hospitalizaci&#243;n&#46; En los pacientes hospitalizados&#44; se consignaron los servicios en los que se ingres&#243; al paciente y la necesidad de ingreso en una unidad de cuidados intensivos &#40;UCI&#41;&#44; ya fuese directamente o tras su estancia previa en una unidad de hospitalizaci&#243;n convencional&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Eventos adversos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Para todos los pacientes diagnosticados de ICA en urgencias&#44; se consign&#243; la mortalidad por cualquier causa intrahospitalaria y a los 30 d&#237;as a partir del evento &#237;ndice &#40;consulta en urgencias&#41;&#44; y en los dados de alta tras el episodio &#237;ndice &#40;se descartaron los fallecidos durante dicho episodio&#41;&#59; se investig&#243; la variable combinada de muerte o necesidad de hospitalizaci&#243;n por cualquier causa durante los 30 d&#237;as de seguimiento posalta&#46; La adjudicaci&#243;n de eventos la realiz&#243; el investigador principal del centro&#44; sin revisi&#243;n externa&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">An&#225;lisis estad&#237;stico</span><p id="par0050" class="elsevierStylePara elsevierViewall">Para la descripci&#243;n de las variables cuantitativas se us&#243; la mediana y rango intercuartil &#40;RIC&#41;&#44; y para las cualitativas&#44; los valores absolutos y porcentajes&#44; y la comparaci&#243;n se realiz&#243; con el test de Mann-Whitney y el test de <span class="elsevierStyleItalic">chi</span> cuadrado&#44; respectivamente&#46; La estimaci&#243;n de la incidencia de diagn&#243;stico de ICA en los SU espa&#241;oles se realiz&#243; por a&#241;o y por cada1&#46;000 habitantes &#40;considerando la poblaci&#243;n de referencia asignada a cada uno de los 52 SU participantes y bajo el supuesto de una incidencia constante a lo largo de todo el a&#241;o&#41; y se calcul&#243; el intervalo de confianza del 95&#37; &#40;IC 95&#37;&#41; de la estimaci&#243;n de incidencia mediante el m&#233;todo binomial exacto de Clopper y Pearson&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Los factores independientes asociados a hospitalizaci&#243;n o a confirmaci&#243;n del diagn&#243;stico se investigaron con un modelo de regresi&#243;n log&#237;stica multivariable&#44; que incluy&#243; las variables que hab&#237;an resultado con un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;10 en el an&#225;lisis univariable&#46; Por otro lado&#44; para analizar la relaci&#243;n entre las caracter&#237;sticas del paciente y la probabilidad de eventos adversos&#44; y dado que se previ&#243; un n&#250;mero bajo de eventos que impedir&#237;a incluir todas las caracter&#237;sticas del paciente&#44; se decidi&#243; incluir en el modelo caracter&#237;sticas definidas <span class="elsevierStyleItalic">a priori</span> como potencialmente relacionadas con dichos eventos adversos y categorizando previamente las variables continuas utilizando puntos de corte con significado cl&#237;nico o de uso habitual&#46; En relaci&#243;n con las comorbilidades&#44; estas se tuvieron en cuenta en el modelo mediante ICC&#44; que contabiliza la carga de comorbilidad&#44; y no de forma individualizada&#46; Al final&#44; las variables incluidas en el modelo multivariable fueron 15&#58; edad avanzada &#40;por unidad de aumento de 10 a&#241;os&#41;&#44; sexo&#44; presencia de deterioro funcional &#40;IB &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&#44; comorbilidad grave &#40;ICC<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&#44; polifarmacia grave &#40;n&#250;mero de f&#225;rmacos cr&#243;nicos<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>10&#41;&#44; necesidad de ayuda para deambular &#40;o no deambulaci&#243;n&#41;&#44; ca&#237;da los seis meses previos&#44; diagn&#243;stico previo de demencia&#44; de depresi&#243;n y de delirium&#44; e hipotensi&#243;n arterial &#40;&#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; hipertensi&#243;n arterial &#40;&#62;<span class="elsevierStyleHsp" style=""></span>160<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41;&#44; taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; e hipoxemia &#40;saturaci&#243;n de ox&#237;geno &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41; a la llegada al SU&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">La magnitud de las asociaciones se estim&#243; con <span class="elsevierStyleItalic">odds</span> ratio &#40;OR&#41; y su IC del 95&#37; y las diferencias se consideraron estad&#237;sticamente significativas si el valor p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 o si el IC 95&#37; de la OR exclu&#237;a el valor 1&#46; El procesamiento estad&#237;stico se realiz&#243; mediante el paquete estad&#237;stico SPSS Statistics V26 &#40;IBM&#44; Armonk&#44; Nueva York&#44; EE&#46; UU&#46;&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Consideraciones &#233;ticas</span><p id="par0065" class="elsevierStylePara elsevierViewall">El proyecto EDEN fue aprobado por el Comit&#233; &#201;tico en Investigaci&#243;n Cl&#237;nica del Hospital Cl&#237;nico San Carlos de Madrid &#40;protocolo HCSC&#47;22&#47;005-E&#41;&#46; La creaci&#243;n de la cohorte EDEN y los trabajos que emanan de ella han seguido en todo momento los principios &#233;ticos de la Declaraci&#243;n de Helsinki&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><p id="par0070" class="elsevierStylePara elsevierViewall">De los 25&#46;557 pacientes incluidos en la cohorte EDEN&#44; 25&#46;538 han sido incluidos en el estudio EDEN-34 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; De ellos&#44; 1&#46;155 &#40;4&#44;5&#37;&#41; fueron diagnosticados de ICA en urgencias&#46; Teniendo en cuenta que el periodo de inclusi&#243;n fue de siete d&#237;as&#44; que los 52 SUH dan cobertura a un total de 11&#46;768&#46;548 habitantes y que en 2019 &#40;a&#241;o del estudio&#41; el porcentaje de poblaci&#243;n espa&#241;ola de 65 o m&#225;s a&#241;os era del 19&#44;3&#37;&#44; la incidencia anual estimada de diagn&#243;sticos de ICA en los SU espa&#241;oles fue de 26&#44;5 por 1&#46;000 habitantes de 65 o m&#225;s a&#241;os &#40;IC 95&#37;&#58; 25&#44;0-28&#44;1&#41;&#46; Los pacientes con ICA ten&#237;an una mediana de edad de 85 a&#241;os&#44; el 45&#37; eran varones&#44; la comorbilidad era frecuente &#40;grave en el 28&#37;&#44; con ICC<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&#44; y la situaci&#243;n funcional basal estaba alterada &#40;IB<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41; en m&#225;s del 50&#37; de los casos&#46; El resto de las caracter&#237;sticas cl&#237;nicas se recoge en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Hubo 774 pacientes &#40;67&#37;&#41; que requirieron hospitalizaci&#243;n&#46; El an&#225;lisis univariable mostr&#243; que los pacientes que precisaban hospitalizaci&#243;n eran m&#225;s frecuentemente hombres&#59; con menor frecuencia ten&#237;an hipertensi&#243;n arterial como comorbilidad&#44; y presentaban mayor deterioro funcional y menor saturaci&#243;n de ox&#237;geno &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; El an&#225;lisis multivariable confirm&#243; estos cuatro factores y mostr&#243; que la hospitalizaci&#243;n se asociaba de forma independiente y directa con sexo masculino &#40;OR ajustada 1&#44;38&#44; 1&#44;05-1&#44;82&#41; y deterioro funcional &#40;1&#44;39&#44; 1&#44;06-1&#44;83&#41;&#44; y de forma inversa con hipertensi&#243;n arterial &#40;0&#44;61&#44; 0&#44;40-0&#44;93&#41; y la saturaci&#243;n de ox&#237;geno &#40;0&#44;90&#44; 0&#44;87-0&#44;93&#41;&#46; En 665 de los pacientes hospitalizados &#40;86&#37;&#41; se confirm&#243; el diagn&#243;stico de ICA en el informe de alta hospitalaria&#44; mientras que en el resto no figuraba dicho diagn&#243;stico entre los codificados&#46; La falta de confirmaci&#243;n diagn&#243;stica fue m&#225;s frecuente en pacientes m&#225;s j&#243;venes&#44; sin diagn&#243;stico previo de cardiopat&#237;a isqu&#233;mica&#44; IC cr&#243;nica y enfermedad renal cr&#243;nica&#44; y que estaban menos taquic&#225;rdicos a la llegada al SU &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; El estudio multivariable confirm&#243; que solo la ausencia de diagn&#243;stico previo de IC se asoci&#243; de forma independiente con falta de confirmaci&#243;n diagn&#243;stica durante la hospitalizaci&#243;n &#40;OR ajustada&#58; 1&#44;66&#44; 1&#44;06-2&#44;62&#41;&#46; Finalmente&#44; hubo 209 diagn&#243;sticos de ICA entre los 5&#46;742 pacientes hospitalizados en los que no constaba el diagn&#243;stico de ICA tras la atenci&#243;n en urgencias&#44; lo cual supone un porcentaje del 3&#44;6&#37;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El manejo de los pacientes con ICA en urgencias se resume en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>&#46; Cuando el paciente precis&#243; hospitalizaci&#243;n&#44; m&#225;s de la mitad de los casos ingresaron en medicina interna&#44; y la mediana de tiempo de hospitalizaci&#243;n fue de 7&#44;2 d&#237;as &#40;RIC&#58; 4&#44;4-10&#44;7&#41;&#46; Hubo 17 &#40;2&#44;2&#37;&#41; que precisaron atenci&#243;n en UCI&#46; En el caso de los pacientes dados de alta de urgencias&#44; la mediana de tiempo de permanencia en urgencias fue de 6&#58;08 horas &#40;RIC&#58; 3&#58;32-12&#58;33&#41;&#46; Los pacientes fueron dados de alta predominantemente a domicilio&#44; tanto si el alta se produc&#237;a desde urgencias o tras hospitalizaci&#243;n&#44; en tanto que a residencia se remiti&#243; el 7&#44;3&#37; y el 11&#44;2&#37; de pacientes&#44; respectivamente&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">La mortalidad intrahospitalaria fue del 7&#44;9&#37; y la mortalidad global a 30 d&#237;as fue del 10&#44;7&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; En ambos casos&#44; el principal factor asociado independientemente a estos eventos fue la hipotensi&#243;n arterial &#40;presi&#243;n arterial sist&#243;lica &#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg&#59; OR ajustada&#58; 74&#44;0&#44; IC 95&#37;&#58; 5&#44;39-1&#46;015&#59; y 42&#44;6&#44; 3&#44;74-485&#44; respectivamente&#41; y la hipoxemia &#40;saturaci&#243;n &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#59; 2&#44;14&#44; 1&#44;27-3&#44;61&#59; y 1&#44;87&#44; 1&#44;19-2&#44;93&#41; a la llegada a urgencias y precisar ayuda en la deambulaci&#243;n &#40;2&#44;24&#44; 1&#44;04-4&#44;83&#59; y 2&#44;48&#44; 1&#44;27-4&#44;86&#41; y la edad &#40;por cada incremento de 10 a&#241;os&#59; 1&#44;54&#44; 1&#44;04-2&#44;29&#44; y 1&#44;60&#44; 1&#44;13-2&#44;28&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; El evento adverso combinado a los 30 d&#237;as posalta se produjo en el 15&#44;6&#37; de los pacientes&#44; y no se asoci&#243; a ninguna caracter&#237;stica&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discusi&#243;n</span><p id="par0090" class="elsevierStylePara elsevierViewall">El estudio EDEN-34 aporta cuatro hallazgos relevantes&#46; Primero&#44; la frecuencia del diagn&#243;stico de ICA en los pacientes mayores en los SU espa&#241;oles es elevada&#58; supone el 4&#44;4&#37; de todas las consultas y una incidencia anual de 26&#44;5 episodios por 1&#46;000 personas en este segmento de poblaci&#243;n&#46; Segunda&#44; mientras que se identifican varios factores asociados con necesidad de hospitalizaci&#243;n&#44; solo la ausencia de diagn&#243;stico previo de IC cr&#243;nica se asoci&#243; con falta de confirmaci&#243;n del diagn&#243;stico de ICA durante la hospitalizaci&#243;n&#46; Tercero&#44; los eventos adversos a corto plazo son considerables&#44; y la edad y la limitaci&#243;n a la deambulaci&#243;n entre las caracter&#237;sticas del paciente&#44; y la hipotensi&#243;n y la hipoxemia a la llegada a urgencias&#44; se asocian espec&#237;ficamente con la mortalidad&#46; Finalmente&#44; el estudio muestra de forma global cu&#225;l es el perfil basal y el manejo que se produce en la ICA en los SU en pacientes mayores&#44; donde dos de cada tres pacientes son hospitalizados&#44; m&#225;s de la mitad de ellos en servicios de medicina interna&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En cuanto a la incidencia encontrada en la poblaci&#243;n estudiada&#44; los datos son congruentes con el estudio de morbilidad hospitalaria del Instituto Nacional de Estad&#237;stica&#44; donde las enfermedades del aparato circulatorio son el diagn&#243;stico principal tanto de ingresos como de las altas hospitalarias &#40;tasas de morbilidad de 1&#46;416 por 100&#46;000 hombres&#44; y 1&#46;053 por 100&#46;000 mujeres&#41;&#44; y en el que se muestra que el 64&#44;1&#37; de las altas hospitalarias ingresaron con car&#225;cter urgente<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a>&#46; Por ello&#44; dado que la ICA es la principal etiolog&#237;a de las enfermedades del aparato circulatorio&#44; es de suponer que exista un alto porcentaje de consultas por ICA en los SU espa&#241;oles&#46; Sin embargo&#44; en Espa&#241;a tan s&#243;lo disponemos de un estudio sobre incidencia anual de ICA&#44; que la estim&#243; en 2&#44;96 casos por 1&#46;000 personas-a&#241;o en 2000 y en 3&#44;90 casos por 1&#46;000 personas-a&#241;o en 2007<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a>&#46; Por ello&#44; los datos que aqu&#237; se presentan proporcionan una estimaci&#243;n actualizada de la incidencia de ICA en la poblaci&#243;n mayor&#46; En estudios europeos m&#225;s recientes<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#44;18</span></a>&#44; se ha descrito una incidencia de ICA creciente con la edad&#44; de 1&#44;4 cada 1&#46;000 personas-a&#241;o a los 50-59 a&#241;os&#44; 3&#44;1 a los 60-64 a&#241;os&#44; 5&#44;4 a los 65-69 a&#241;os&#44; 11&#44;7 a los 70-74 a&#241;os y superior a 17&#44;0 a los 75 y m&#225;s a&#241;os&#44; lo cual ir&#237;a en consonancia con los datos obtenidos en el estudio EDEN-34&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">En el presente estudio&#44; la ICA en pacientes mayores de 65 a&#241;os gener&#243; el 4&#44;4&#37; del total de consultas en el SU&#46; Tampoco exist&#237;an estudios al respecto en Espa&#241;a hasta la fecha&#46; Congruentes con nuestros resultados fueron los resultados de un estudio europeo realizado en Finlandia<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a>&#46; Se analizaron 6&#46;944 pacientes mayores de 80 a&#241;os &#40;85 a&#241;os de edad media&#44; rango 80-104 a&#241;os&#41; atendidos de forma consecutiva durante dos a&#241;os en un SU&#44; y evidenciaron que las consultas por ICA en urgencias fueron un 4&#44;3&#37; del total&#44; con una incidencia anual de 35 episodios por 1&#46;000 personas en este segmento poblaci&#243;n&#46; Por el contrario&#44; Storrow et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> en un estudio retrospectivo realizado en Estados Unidos desde 2006 hasta 2010&#44; donde hubo 958&#46;167 visitas promedio anuales ponderadas al SU&#44; las consultas por ICA representaban el 0&#44;77&#37; de todas las visitas al SU&#44; cifras muy inferiores a las del estudio EDEN-34&#46; Sin embargo&#44; en el estudio estadounidense se incluyeron pacientes mayores de 18 a&#241;os&#59; con lo que creemos que si se hubiera acotado la franja de edad a mayores de 65 a&#241;os&#44; los porcentajes de consultas ser&#237;an superiores y m&#225;s pr&#243;ximos a los que aqu&#237; se presentan&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En un 14&#37; de los pacientes hospitalizados no se confirm&#243; el diagn&#243;stico de ICA en el informe de alta hospitalaria&#46; La ausencia de confirmaci&#243;n diagn&#243;stica result&#243; m&#225;s frecuente en pacientes sin un diagn&#243;stico previo de IC cr&#243;nica&#46; A pesar de la alta prevalencia de la ICA en urgencias&#44; su diagn&#243;stico en pacientes con disnea puede ser dif&#237;cil&#44; sobre todo en pacientes de edad avanzada y con comorbilidad asociada como los del presente estudio<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a>&#46; Un diagn&#243;stico de ICA en urgencias basado en los antecedentes&#44; exploraci&#243;n f&#237;sica&#44; radiograf&#237;a de t&#243;rax y electrocardiograma se califica de &#171;incierto&#187; en el 44&#37; de los casos y es discordante con el diagn&#243;stico final al alta en casi uno de cada cuatro casos&#46; La capacidad del antecedente de IC cr&#243;nica para predecir el diagn&#243;stico de ICA como causa de disnea en pacientes adultos en urgencias ha sido evaluada en m&#250;ltiples estudios&#46; Una revisi&#243;n reciente&#44; que evalu&#243; 22 estudios y que incluy&#243; un total de 8&#46;493 pacientes&#44; evidenci&#243; que el antecedente de IC cr&#243;nica ten&#237;a una sensibilidad del 55&#44;5&#37; &#40;IC 95&#37; 53&#44;9&#8211;57&#44;1&#41;&#44; una especificidad del 80&#44;2&#37; &#40;IC 95&#37; 79&#44;0&#8211;81&#44;3&#41; y con una raz&#243;n de verosimilitud negativa de 0&#44;58 &#40;IC 95&#37; 0&#44;49&#8211;0&#44;68&#41; para el diagn&#243;stico de ICA&#46; En la actualidad&#44; la ecograf&#237;a pulmonar a pie de cama&#44; la ecocardiograf&#237;a y los p&#233;ptidos natriur&#233;ticos proporcionan informaci&#243;n fiable para confirmar o excluir el diagn&#243;stico de ICA en los SU&#44; con lo que los porcentajes de pacientes ingresados con diagn&#243;sticos de disnea de origen &#171;incierto&#187; o ausencia de confirmaci&#243;n final&#44; son cada vez menores<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a>&#46; Con todo&#44; creemos que este potencial error en el 14&#37; de los diagn&#243;sticos de ICA realizados en urgencias es susceptible de mejora&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">La situaci&#243;n basal del paciente es un aspecto determinante del pron&#243;stico&#46; De forma general&#44; hemos comprobado que la limitaci&#243;n en la deambulaci&#243;n se relaciona con el pron&#243;stico a corto plazo durante un episodio de ICA&#46; Este es un par&#225;metro ya asentado como factor pron&#243;stico&#44; y aunque es ampliamente reconocido&#44; su implantaci&#243;n y la recogida sistem&#225;tica en hospitales de agudos y en pacientes con enfermedades m&#233;dicas agudas no est&#225;n totalmente establecidas&#46; Una mala situaci&#243;n funcional al ingreso de pacientes de edad avanzada y con enfermedad aguda predice una mayor mortalidad intrahospitalaria y a los seis meses&#44; una estancia m&#225;s prolongada y una mayor institucionalizaci&#243;n al alta&#46; Incluso el deterioro de la situaci&#243;n funcional causado por la propia enfermedad aguda aumenta el riesgo de mortalidad tras el alta &#40;al mes e incluso a&#241;os despu&#233;s&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a>&#46; As&#237;&#44; los resultados del estudio EDEN-34 est&#225;n en relaci&#243;n con estudios previos sobre el deterioro funcional en los ancianos con ICA en los SU&#44; su aumento progresivo seg&#250;n avanza la edad y su asociaci&#243;n con el pron&#243;stico a corto plazo<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#44;25</span></a>&#46; El estudio&#44; adem&#225;s&#44; ha detectado que las cifras de PAS y de saturaci&#243;n de ox&#237;geno a la llegada al SU&#44; se asocian a mal pron&#243;stico&#44; aspectos ya definidos en diferentes estudios previos<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a>&#46; En un estudio realizado en diferentes SU espa&#241;oles&#44; y en consonancia con estos resultados&#44; la presencia de hipotensi&#243;n arterial se defin&#237;a como un factor independiente de mal pron&#243;stico a corto plazo &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#44;8&#59; IC 95&#37; 1&#44;6-14&#44;5&#41;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">El estudio EDEN-34 identifica la necesidad de ingreso hospitalario en dos de cada tres pacientes valorados en urgencias y dicho ingreso se realiza en m&#225;s de la mitad de pacientes &#40;55&#37;&#41; en servicios de medicina interna&#46; De hecho&#44; el perfil del paciente con ICA encontrado en este estudio es similar al encontrado en el registro espa&#241;ol EAHFE<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a>&#44; que incluye&#44; de forma intermitente desde el 2007&#44; a pacientes con ICA atendidos en SU&#46; En dicho registro se evidencia que el 75&#44;1&#37; de pacientes con ICA precisa hospitalizaci&#243;n&#44; de los que el 43&#37; lo hace en servicios de medicina interna&#46; Teniendo en cuenta que el registro EAHFE incluye pacientes mayores a 18 a&#241;os&#44; es posible que este porcentaje de pacientes ingresados en medicina interna fuese m&#225;s parecido al encontrado en el estudio EDEN-34 si la franja de edad se acotara a pacientes mayores de 65 a&#241;os&#46; Es de destacar que las caracter&#237;sticas cl&#237;nicas de los pacientes del estudio EDEN-34 se superponen en gran medida a las de los pacientes de los registros EAHFE cuando se analiza este segmento poblacional&#44; as&#237; como tambi&#233;n con los del registro RICA<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#44; que incluye pacientes mayores de 65 a&#241;os hospitalizados en servicios de medicina interna espa&#241;oles &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; Por tanto&#44; creemos que el estudio EDEN-34&#44; en conjunci&#243;n con los datos aportados por estos otros dos registros&#44; contribuye a definir el manejo del paciente con ICA en Espa&#241;a&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Limitaciones</span><p id="par0120" class="elsevierStylePara elsevierViewall">Primera&#44; los 52 SUH que han aportado pacientes al registro EDEN no fueron escogidos al azar&#44; sino que mostraron su disponibilidad a participar&#59; sin embargo&#44; la amplia representaci&#243;n territorial &#40;14 de las 17 comunidades aut&#243;nomas estaban representadas&#41; y de tipolog&#237;a &#40;hospitales universitarios&#44; de alta tecnolog&#237;a y comarcales&#41; hace que el sesgo en este sentido sea probablemente escaso&#46; Segunda&#44; el an&#225;lisis se realiza de forma general&#44; sin separar la ICA en las diferentes categor&#237;as fenot&#237;picas seg&#250;n la fracci&#243;n de eyecci&#243;n del ventr&#237;culo izquierdo o la forma cl&#237;nica de presentaci&#243;n&#46; Con todo&#44; creemos que con esta aproximaci&#243;n&#44; el estudio EDEN-34 aporta una visi&#243;n global de la pr&#225;ctica cl&#237;nica habitual en los SU espa&#241;oles&#44; al incluir a todos los pacientes y analizarlos de forma global&#46; Tercera&#44; se trata de un an&#225;lisis secundario de una cohorte multiprop&#243;sito&#44; por lo que las asociaciones que se presentan pueden estar influidas por factores no contemplados en el dise&#241;o de la cohorte&#59; por lo tanto&#44; los hallazgos deben considerarse generadores de hip&#243;tesis que deber&#225;n confirmarse con estudios espec&#237;ficamente dise&#241;ados a tal fin&#46; Cuarta&#44; los resultados del estudio EDEN-34 pueden haberse visto afectados por las din&#225;micas individuales de cada hospital &#40;especialmente por lo que se refiere al ingreso o alta de pacientes&#41; y pueden haber estado influidos tambi&#233;n por la &#233;poca del a&#241;o en la que se realiz&#243; el estudio &#40;primera semana de abril&#41;&#46; La ICA tiene cierto patr&#243;n estacional y la &#233;poca del a&#241;o analizada en este estudio a&#250;n se encuentra bajo las condiciones que imponen las pandemias gripales y v&#237;ricas habituales del invierno e inicio de primavera&#46; Por tanto&#44; podr&#237;a haber variaciones&#44; especialmente en la incidencia al analizar otros periodos de a&#241;o&#46; Quinta&#44; la inclusi&#243;n de pacientes en la cohorte EDEN se ha realizado por episodios en vez de por pacientes&#44; por lo que es posible que alg&#250;n episodio pueda corresponder al mismo paciente&#46; No obstante&#44; dado que el periodo de inclusi&#243;n fue muy corto &#40;siete d&#237;as&#41;&#44; las posibilidades de repetici&#243;n de consulta para un paciente concreto cabe considerarse escasa&#46; Finalmente&#44; aunque en el presente estudio de pacientes mayores se consideraron espec&#237;ficamente la dependencia y la comorbilidad&#44; la fragilidad fue solo evaluada de forma tangencial a trav&#233;s de la existencia de ca&#237;das durante los seis meses previos y es bien conocido que la fragilidad es un elemento con un importante impacto en esta poblaci&#243;n&#44; que no es suficientemente estimada&#44; especialmente en los SU<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#8211;30</span></a>&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusi&#243;n</span><p id="par0125" class="elsevierStylePara elsevierViewall">La ICA es un diagn&#243;stico frecuente en los pacientes mayores que consultan en SU&#46; Su situaci&#243;n basal&#44; especialmente el deterioro funcional y la edad&#44; y la hipotensi&#243;n e hipoxemia a la llegada a urgencias son los factores que m&#225;s se asocian a eventos adversos&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Financiaci&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Esta investigaci&#243;n no recibi&#243; financiaci&#243;n de entidades p&#250;blicas&#44; comerciales ni sin &#225;nimo de lucro&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Autor&#237;a</span><p id="par0135" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Concepci&#243;n y dise&#241;o del manuscrito&#58; &#210;scar Mir&#243;&#44; Pere Llorens y Juan Gonz&#225;lez del Castillo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Recogida de datos&#58; Sira Aguil&#243;&#44; Aitor Alqu&#233;zar-Arb&#233;&#44; Ces&#225;reo Fern&#225;ndez&#44; Guillermo Burillo-Putze&#44; Naila Canadell Marcos&#44; Anette Arce Mara&#241;&#243;n&#44; Gemma S&#225;nchez Oms y los investigadores de la red SIESTA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">An&#225;lisis e interpretaci&#243;n de los datos&#58; &#210;scar Mir&#243; y Juan Gonz&#225;lez del Castillo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Redacci&#243;n&#44; revisi&#243;n&#44; aprobaci&#243;n del manuscrito remitido&#58; &#210;scar Mir&#243;&#44; Pere Llorens&#44; Sira Aguil&#243;&#44; Aitor Alqu&#233;zar-Arb&#233;&#44; Ces&#225;reo Fern&#225;ndez&#44; Guillermo Burillo-Putze&#44; Naila Canadell Marcos&#44; Anette Arce Mara&#241;&#243;n&#44; Gemma S&#225;nchez Oms y Juan Gonz&#225;lez del Castillo&#46;</p></li></ul></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicto de intereses</span><p id="par0160" class="elsevierStylePara elsevierViewall">Todos los autores declaran no tener conflicto de intereses&#46;</p></span></span>"
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          "titulo" => "Referencias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2024-02-08"
    "fechaAceptado" => "2024-02-11"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1807198"
          "palabras" => array:6 [
            0 => "Insuficiencia cardiaca aguda"
            1 => "Geriatr&#237;a"
            2 => "Gravedad"
            3 => "Mortalidad"
            4 => "Hospitalizaci&#243;n"
            5 => "Urgencias"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1807197"
          "palabras" => array:6 [
            0 => "Acute heart failure"
            1 => "Geriatrics"
            2 => "Severity"
            3 => "Mortality"
            4 => "Hospitalization"
            5 => "Emergency department"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estimar la incidencia de diagn&#243;stico de insuficiencia cardiaca aguda &#40;ICA&#41; en pacientes mayores en los servicios de urgencias &#40;SU&#41;&#44; la confirmaci&#243;n diagn&#243;stica de la ICA en pacientes hospitalizados y los eventos adversos a corto plazo&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron a todos los pacientes de &#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os atendidos en 52 SU espa&#241;oles durante una semana y se seleccionaron los diagnosticados de ICA&#46; En los hospitalizados se recogieron los diagnosticados de ICA al alta&#46; Como eventos adversos&#44; se recogi&#243; la mortalidad intrahospitalaria y a 30 d&#237;as&#44; y evento adverso combinado &#40;muerte u hospitalizaci&#243;n&#41; a 30 d&#237;as posalta&#46; Se calcularon las <span class="elsevierStyleItalic">odds</span> ratio &#40;OR&#41; ajustadas de las caracter&#237;sticas demogr&#225;ficas&#44; de estado basal y a la llegada al SU asociadas con mortalidad y evento adverso posalta a 30 d&#237;as&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 1&#46;155 pacientes con ICA &#40;incidencia anual&#58; 26&#44;5 por 1&#46;000 habitantes &#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#44; IC95&#37;&#58; 25&#44;0-28&#44;1&#41;&#46; En el 86&#37;&#44; el diagn&#243;stico de ICA constaba al alta&#46; La mortalidad global a 30 d&#237;as fue del 10&#44;7&#37;&#44; la intrahospitalaria del 7&#44;9&#37; y el evento combinado posalta del 15&#44;6&#37;&#46; La mortalidad intrahospitalaria y a 30 d&#237;as se asoci&#243; con hipotensi&#243;n arterial &#40;OR ajustada&#58; 74&#44;0&#44; IC95&#37;&#58; 5&#44;39-1&#46;015&#46;&#59; y 42&#44;6&#44; 3&#44;74-485&#44; respectivamente&#41; e hipoxemia &#40;2&#44;14&#44; 1&#44;27-3&#44;61&#59; y 1&#44;87&#44; 1&#44;19-2&#44;93&#41; a la llegada a urgencias y con precisar ayuda en la deambulaci&#243;n &#40;2&#44;24&#44; 1&#44;04-4&#44;83&#59; y 2&#44;48&#44; 1&#44;27-4&#44;86&#41; y la edad &#40;por cada incremento de 10 a&#241;os&#59; 1&#44;54&#44; 1&#44;04-2&#44;29&#44; y 1&#44;60&#44; 1&#44;13-2&#44;28&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La ICA es un diagn&#243;stico frecuente en los pacientes mayores que consultan en los SU&#46; El deterioro funcional&#44; la edad&#44; la hipotensi&#243;n e hipoxemia son los factores que m&#225;s se asocian a mortalidad&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "M&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To estimate the incidence of acute heart failure &#40;AHF&#41; diagnosis in elderly patients in emergency departments &#40;ED&#41;&#44; diagnostic confirmation in hospitalized patients&#44; and short-term adverse events&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">All patients aged &#8805;<span class="elsevierStyleHsp" style=""></span>65 years attended in 52 Spanish EDs during 1 week were included and those diagnosed with AHF were selected&#46; In hospitalized patients&#44; those diagnosed with AHF at discharge were collected&#46; As adverse events&#44; in-hospital and 30-day mortality&#44; and combined adverse event &#40;death or hospitalization&#41; at 30 days post-discharge were collected&#46; Adjusted odds ratios &#40;OR&#41; for association of demographic variables&#44; baseline status and constants at ED arrival with mortality and 30-day post-discharge adverse event were calculated&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We included 1&#44;155 patients with AHF &#40;annual incidence&#58; 26&#46;5 per 1000 inhabitants &#8805;<span class="elsevierStyleHsp" style=""></span>65 years&#44; 95&#37;<span class="elsevierStyleSmallCaps">C</span>I&#58; 25&#46;0-28&#46;1&#41;&#46; In 86&#37; the diagnosis of AHF was known at discharge&#46; Overall 30-day mortality was 10&#46;7&#37; and in-hospital mortality was 7&#46;9&#37;&#44; and the combined event in 15&#46;6&#37;&#46; In-hospital and 30-day mortality was associated with arterial hypotension &#40;adjusted OR&#58; 74&#46;0&#44; 95&#37;CI&#58; 5&#46;39-1015&#46; and 42&#46;6&#44; 3&#46;74-485&#44; respectively and hypoxemia &#40;2&#46;14&#44; 1&#46;27-3&#46;61&#59; and 1&#46;87&#44; 1&#46;19-2&#46;93&#41; on arrival at the ED and requiring assistance with ambulation &#40;2&#46;24&#44; 1&#46;04-4&#46;83&#59; and 2&#46;48&#44; 1&#46;27-4&#46;86&#41; and age &#40;per 10-year increment&#59; 1&#46;54&#44; 1&#46;04-2&#46;29&#59; and 1&#46;60&#44; 1&#46;13-2&#46;28&#41;&#46; The combined post-discharge adverse event was not associated with any characteristic&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">AHF is a frequent diagnosis in elderly patients consulting in the ED&#46; The functional impairment&#44; age&#44; hypotension and hypoxemia are the factors most associated with mortality&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
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      0 => array:3 [
        "etiqueta" => "&#9674;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">En el <a class="elsevierStyleCrossRef" href="#sec0075">Anexo A</a> se recogen los nombres de los autores del Equipo Espa&#241;ol de Investigadores en Situaciones de Emergencia &#40;SIESTA&#41;&#46;</p>"
        "identificador" => "fn0005"
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    "apendice" => array:1 [
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            "apendice" => "<p id="par0165" class="elsevierStylePara elsevierViewall">Hospital Cl&#237;nico San Carlos&#44; Madrid&#58; Juan Gonz&#225;lez del Castillo&#44; Ces&#225;reo Fern&#225;ndez Alonso&#44; Jorge Garc&#237;a Lamberechts&#44; Paula Queiz&#225;n Garc&#237;a&#44; Andrea B&#46; Bravo Periago&#44; Blanca Andrea Gallardo S&#225;nchez&#44; Alejandro Melcon Villalibre&#44; Sara Vargas Lob&#233;&#44; Laura Fern&#225;ndez Garc&#237;a&#44; Beatriz Escudero Bl&#225;zquez&#44; Estrella Serrano Molina&#44; Julia Barrado Cuchillo&#44; Leire Paramas L&#243;pez&#44; Ana Chac&#243;n Garc&#237;a&#46;</p> <p id="par0170" class="elsevierStylePara elsevierViewall">Hospital Universitario Infanta Cristina&#44; Parla&#58; &#193;ngel Iv&#225;n Diaz Salado&#44; Beatriz Honrado Gal&#225;n&#44; Sandra Moreno Ru&#237;z&#46;</p> <p id="par0175" class="elsevierStylePara elsevierViewall">Hospital Santa Tecla&#44; Tarragona&#58; Enrique Mart&#237;n Mojarro&#44; Lidia Cuevas Jim&#233;nez&#46;</p> <p id="par0180" class="elsevierStylePara elsevierViewall">Hospital Universitario de Canarias&#44; Tenerife&#58; Guillermo Burillo Putze&#44; Aarati Vaswani-Bulchand&#44; Patricia Eiroa-Hern&#225;ndez&#46;</p> <p id="par0185" class="elsevierStylePara elsevierViewall">Hospital Norte Tenerife&#58; Patricia Parra-Esquivel&#44; Montserrat Rodr&#237;guez-Cabrera&#46;</p> <p id="par0190" class="elsevierStylePara elsevierViewall">Hospital General Universitario Reina Sof&#237;a&#44; Murcia&#58; Pascual Pi&#241;era Salmer&#243;n&#44; Jos&#233; Andr&#233;s S&#225;nchez Nicol&#225;s&#44; Yurena Reverte Pag&#225;n&#44; Lorena Bernab&#233; Vera&#44; Juan Jos&#233; L&#243;pez P&#233;rez&#46;</p> <p id="par0195" class="elsevierStylePara elsevierViewall">Hospital Universitario del Henares&#44; Madrid&#58; Mart&#237;n Ruiz Grinspan&#44; Crist&#243;bal Rodr&#237;guez Leal&#44; Roc&#237;o Mart&#237;nez Avil&#233;s&#44; Mar&#237;a Luisa P&#233;rez D&#237;az-Guerra&#46;</p> <p id="par0200" class="elsevierStylePara elsevierViewall">Hospital Cl&#237;nic&#44; Barcelona&#58; &#210;scar Mir&#44; S&#242;nia Jim&#233;nez&#44; Sira Aguil&#243; Mir&#44; Francesc Xavier Alemany Gonz&#225;lez&#44; Mar&#237;a Florencia Poblete Palacios&#44; Claudia Lorena Amarilla Molinas&#44; Ivet Gina Osorio Quispe&#44; Sandra Cuerpo Carde&#241;osa&#46;</p> <p id="par0205" class="elsevierStylePara elsevierViewall">Hospital Universitario y Polit&#233;cnico La Fe&#44; Valencia&#58; Leticia Serrano L&#225;zaro&#44; Javier Mill&#225;n Soria&#44; J&#233;sica Mansilla Collado&#44; Mar&#237;a B&#243;veda Garc&#237;a&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall">Hospital Universitario Dr&#46; Balmis&#44; Alicante&#58; Pere Llorens Soriano&#44; Adriana Gil Rodrigo&#44; Bego&#241;a Espinosa Fern&#225;ndez&#44; M&#243;nica Veguillas Benito&#44; Sergio Guzm&#225;n Mart&#237;nez&#44; Gema Jara Torres&#44; Mar&#237;a Caballero Mart&#237;nez&#46;</p> <p id="par0215" class="elsevierStylePara elsevierViewall">Hospital Universitario de Bellvitge&#44; L&#8217;Hospitalet de Llobregat&#44; Barcelona&#58; Javier Jacob Rodr&#237;guez&#44; Ferran Llopis&#44; Elena Fuentes&#44; Lidia Fuentes&#44; Francisco Chamorro&#44; Lara Guillen&#44; Nieves L&#243;pez&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall">Hospital de Axiarquia&#44; M&#225;laga&#58; Coral Suero M&#233;ndez&#44; Luc&#237;a Zambrano Serrano&#44; Roc&#237;o Lorenzo &#193;lvarez&#46;</p> <p id="par0225" class="elsevierStylePara elsevierViewall">Hospital Regional Universitario de M&#225;laga&#58; Manuel Salido Mota&#44; Valle Toro Gallardo&#44; Antonio Real L&#243;pez&#44; Luc&#237;a Oca&#241;a Mart&#237;nez&#44; Esther Mu&#241;oz Soler&#44; Mario Lozano S&#225;nchez&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall">Hospital Santa Barbara&#44; Soria&#58; Fahd Beddar Chaib&#44; Rodrigo Javier Gil Hern&#225;ndez&#46;</p> <p id="par0235" class="elsevierStylePara elsevierViewall">Hospital Valle de los Pedroches&#44; Pozoblanco&#44; C&#243;rdoba&#58; Jorge Pedraza Garc&#237;a&#44; Paula Pedraza Ram&#237;rez&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall">Hospital Universitario Reina Sof&#237;a&#44; C&#243;rdoba&#58; F&#46; Javier Montero-P&#233;rez&#44; Carmen Lucena Aguilera&#44; F&#46; de Borja Quero Espinosa&#44; &#193;ngela Cobos Requena&#44; Esperanza Mu&#241;oz Triano&#44; Inmaculada Bajo Fern&#225;ndez&#44; Mar&#237;a Calder&#243;n Caro&#44; Sierra Bretones Baena&#46;</p> <p id="par0245" class="elsevierStylePara elsevierViewall">Hospital Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#58; Esther Gargallo Garc&#237;a&#44; Leonor Andr&#233;s Beri&#225;n&#44; Mar&#237;a Esther Mart&#237;nez Larrull&#44; Susana Gordo Remart&#237;nez&#44; Ana Isabel Castuera Gil&#44; Laura Mart&#237;n Gonz&#225;lez&#44; Melisa San Juli&#225;n Romero&#44; Montserrat Jim&#233;nez Lucena&#44; Mar&#237;a Dolores Pulfer&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall">Hospital Universitario de Burgos&#58; Pilar L&#243;pez Diez&#44; M&#243;nica de Diego Arnaiz&#44; Ver&#243;nica Castro Jim&#233;nez&#44; Luc&#237;a Gonz&#225;lez Ferreira&#44; Roc&#237;o Hernando Gonz&#225;lez&#44; Mar&#237;a Eugenia Rodr&#237;guez Palma&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall">Complejo Asistencial Universitario de Le&#243;n&#58; Marta Iglesias Vela&#44; Rudiger Carlos Ch&#225;vez Flores&#44; Alberto &#193;lvarez Madrigal&#44; Albert Carb&#243; Jord&#225;&#44; Enrique Gonz&#225;lez Revuelta&#44; H&#233;ctor Lago Gancedo&#44; Miguel Moreno Mart&#237;n&#44; M&#46; Isabel Fern&#225;ndez Gonz&#225;lez&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall">Hospital Universitario Morales Meseguer&#44; Murcia&#58; Rafael Antonio P&#233;rez-Costa&#44; Mar&#237;a Rodr&#237;guez Romero&#44; Esperanza Mar&#237;n Arranz&#44; Sara Barnes Parra&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall">Hospital Francesc de Borja de Gand&#237;a&#44; Valencia&#58; Mar&#237;a Jos&#233; Fortuny Bayarri&#44; Elena Quesada Rodr&#237;guez&#44; Lorena Hern&#225;ndez Taboas&#44; Alicia Sara Knabe&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall">Hospital Universitario Severo Ochoa&#44; Legan&#233;s&#44; Madrid&#58; Beatriz Valle Borrego&#44; Julia Mart&#237;nez-Ibarreta Zorita&#44; Irene Cabrera Rodrigo&#44; Beatriz Ma&#241;ero Criado&#44; Raquel Torres G&#225;rate&#44; Rebeca Gonz&#225;lez Gonz&#225;lez&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall">Hospital Cl&#237;nico Universitario Virgen Arrixaca&#44; Murcia&#58; Eva Quero Motto&#44; Nuria Tomas Garc&#237;a&#44; Lilia Amer Al Arud&#44; Miguel Parra Morata&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall">Hospital Universitario Lorenzo Guirao&#44; Cieza&#44; Murcia&#58; Carmen Escudero S&#225;nchez&#44; Bel&#233;n Morales Franco&#44; Jos&#233; Joaqu&#237;n Gim&#233;nez Bell&#243;&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall">Hospital Universitario Dr&#46; Josep Trueta&#44; Girona&#58; Mar&#237;a Adroher Mu&#241;oz&#44; Ester Soy Ferrer&#44; Eduard Anton Poch Ferrer&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall">Hospital de Mendaro&#44; Guipuzkoa&#58; Jeong-Uh Hong Cho&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall">Hospital Universitario Miguel Servet&#44; Zaragoza&#58; Rafael Marr&#243;n&#44; Cristina Mart&#237;n Dur&#225;n&#44; Fernando L&#243;pez L&#243;pez&#44; Alberto Guillen Bove&#44; Violeta Gonz&#225;lez Guill&#233;n&#44; Mar&#237;a Diamanti&#44; Beatriz Casado Ram&#243;n&#44; Ana Herrer Castej&#243;n&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall">Hospital Comarcal El Escorial&#44; Madrid&#58; Sara Gayoso Mart&#237;n&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall">Hospital Do Salnes&#44; Villagarcia de Arosa&#44; Pontevedra&#58; Mar&#237;a Goretti S&#225;nchez Sind&#237;n&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall">Hospital de Barbanza&#44; Ribeira&#44; A Coru&#241;a&#58; Azucena Prieto Zapico&#44; Mar&#237;a Esther Fern&#225;ndez &#193;lvarez&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall">Hospital del Mar&#44; Barcelona&#58; Isabel Cirera&#44; B&#225;rbara G&#243;mez y G&#243;mez&#44; Carmen Petrus Rivas&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall">Hospital Santa Creu y Sant Pau&#44; Barcelona&#58; Aitor Alquezar Arb&#233;&#44; Miguel Rizzi&#44; Marta Bl&#225;zquez Andion&#44; Carlos Romero Carret&#44; Sergio P&#233;rez Baena&#44; Laura Lozano Polo&#44; Roser Arenos Sambro&#44; Jos&#233; Mar&#237;a Guardiola Tey&#44; Carme Beltr&#225;n Vilagrasa&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall">Hospital de Vic&#44; Barcelona&#58; Llu&#237;s Llauger&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall">Hospital Valle del Nal&#243;n&#44; Langreo&#44; Asturias&#58; Ana Murcia Olag&#252;enaga&#44; Celia Rodr&#237;guez Valles&#44; Ver&#243;nica V&#225;zquez Rey&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall">Hospital Altagracia&#44; Manzanares&#44; Cuidad Real&#58; Elena Carrasco Fern&#225;ndez&#44; Sara Calle Fern&#225;ndez&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall">Hospital Nuestra Se&#241;ora del Prado de Talavera de la Reina&#44; Toledo&#58; Ricardo Ju&#225;rez Gonz&#225;lez&#44; Mar Sousa&#44; Laura Molina&#44; M&#243;nica Ca&#241;ete&#46;</p> <p id="par0345" class="elsevierStylePara elsevierViewall">Hospital Universitario Vinalop&#243;&#44; Elche&#44; Alicante&#58; Esther Ruescas&#44; Mar&#237;a Mart&#237;nez Juan&#44; Pedro Ruiz Asensio&#44; Mar&#237;a Jos&#233; Blanco Hoffman&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall">Hospital de M&#243;stoles&#44; Madrid&#58; F&#225;tima Fern&#225;ndez Salgado&#44; Eva de las Nieves Rodr&#237;guez&#44; Gema G&#243;mez Garc&#237;a&#44; Beatriz Paderne D&#237;az&#46;</p>"
            "etiqueta" => "Anexo A"
            "titulo" => "Miembros de la red SIESTA"
            "identificador" => "sec0075"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Manejo de los pacientes diagnosticados de insuficiencia cardiaca aguda en urgencias y frecuencia de los eventos adversos &#40;cajas azules&#41; considerados en el estudio EDEN-34</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">&#42;24 de los 28 pacientes proced&#237;an de residencia &#40;85&#44;7&#37;&#41; y los 4 restantes &#40;14&#44;3&#37;&#41; de su domicilio&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;Los hospitales a los que se trasladaron los pacientes fueron hospitales de apoyo en 31 casos &#40;47&#44;7&#37;&#41;&#44; hospitales de media estancia o paliativos en 13 casos &#40;20&#44;0&#37;&#41;&#44; traslado por sectorizaci&#243;n en 12 casos &#40;18&#44;5&#37;&#41;&#44; traslado a hospitales con los que el paciente estaba vinculado por otro proceso en 7 casos &#40;10&#44;8&#37;&#41;&#44; y por necesidad de incremento de cuidados en 2 casos &#40;3&#44;1&#37;&#41; &#40;en un caso&#44; no consta el motivo de traslado&#41;&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;&#42;66 de los 87 pacientes &#40;75&#46;9&#37;&#41; proced&#237;an de residencia&#59; los 21 restantes &#40;24&#44;1&#37;&#41; proced&#237;an de domicilio&#46;</p> <p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;&#42;&#42;Los datos no se recogieron o no consta un seguimiento de los pacientes de al menos 30 d&#237;as&#46;</p>"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Los valores en negrita denotan significaci&#243;n estad&#237;stica &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">ICC&#58; &#237;ndice de comorbilidad de Charlson&#46; RI&#58; rango intercuartil&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alta desde urgenciasN<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>381n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">85 &#40;79-89&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">84 &#40;78-89&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">85 &#40;79-89&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">85 &#40;79-89&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">84 &#40;78-89&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;047&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">510 &#40;45&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">148 &#40;39&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">362 &#40;47&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">305 &#40;47&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">57 &#40;53&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="8" align="left" valign="\n
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                  \t\t\t\t  " colspan="8" align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#205;ndice de comorbilidad de Charlson &#40;ICC&#44; puntos&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;156&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;001 &#40;86&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">342 &#40;89&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">659 &#40;85&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">569 &#40;85&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">89 &#40;82&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insuficiencia cardiaca cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">715 &#40;61&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">235 &#40;61&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">480 &#40;62&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;912&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">432 &#40;65&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 &#40;44&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">644 &#40;56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200 &#40;52&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">444 &#40;57&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;117&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">377 &#40;56&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;61&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;297&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">459 &#40;39&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">144 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">315 &#40;40&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;343&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">273 &#40;41&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;38&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">375 &#40;32&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;31&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">254 &#40;32&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;718&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">228 &#40;34&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;23&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neumopat&#237;a cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">361 &#40;31&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106 &#40;27&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">255 &#40;32&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;077&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">214 &#40;32&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;37&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad renal cr&#243;nica &#40;creatinina &#8805;<span class="elsevierStyleHsp" style=""></span>2 mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">299 &#40;25&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;23&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">208 &#40;26&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;276&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;28&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;18&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad cerebrovascular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">201 &#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132 &#40;17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;656&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112 &#40;16&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;18&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;698&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad vascular perif&#233;rica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">199 &#40;17&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;14&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">145 &#40;18&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;19&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;365&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neoplasia activa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">193 &#40;16&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;16&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;823&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107 &#40;16&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;19&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;408&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cirrosis hepatica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;586&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Situaci&#243;n basal</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#250;mero de f&#225;rmacos cr&#243;nicos &#40;mediana&#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;838&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">68 &#40;62&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para la deambulaci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62 &#40;56&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;461&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de demencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">148 &#40;19&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;060&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">97 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">86 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;10&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;406&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ca&#237;das los seis meses previos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">70 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">45 &#40;5&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">39 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;882&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de delirium&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46 &#40;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32 &#40;4&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;707&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;438&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Constantes vitales a la llegada a urgencias</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica &#40;mmHg&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">137 &#40;120-154&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">138 &#40;121-157&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">136 &#40;120-153&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">136 &#40;120-153&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">138 &#40;121-157&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;368&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia cardiaca &#40;lpm&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">82 &#40;70-100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;70-98&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">83 &#40;71-100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;313&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">83 &#40;71-100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;70-98&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Saturaci&#243;n de ox&#237;geno &#40;&#37;&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94 &#40;91-97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95 &#40;93-97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">94 &#40;90-97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">94 &#40;90-97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95 &#40;93-97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;150&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">L&#237;mite inferior&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">L&#237;mite superior&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Mortalidad intrahospitalaria &#40;todos los pacientes&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipotensi&#243;n arterial &#40;PAS &#60;<span class="elsevierStyleHsp" style=""></span>80 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44;976&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;393&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para deambular o no deambula&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;244&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;833&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoxemia &#40;saturaci&#243;n basal de ox&#237;geno de la hemoglobina &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;144&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;272&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;613&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de deterioro cognitivo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;605&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;904&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbilidad grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;544&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;628&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;por cada incremento de 10 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;294&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;284&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;550&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;728&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;399&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;938&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;056&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;634&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;759&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Caidas seis meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;403&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;512&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Depresion basal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;876&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;845&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipotensi&#243;n arterial &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;696&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;343&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polifarmacia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;625&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;352&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100 lpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;575&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mortalidad a 30 d&#237;as &#40;todos los pacientes&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiptotensi&#243;n arterial &#40;PAS &#60;<span class="elsevierStyleHsp" style=""></span>80 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#44;605&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;739&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">485&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para deambular o no deambula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;481&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;266&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;861&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoxemia &#40;saturaci&#243;n basal de ox&#237;geno de la hemoglobina &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;870&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;194&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;927&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de deterioro cognitivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;653&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;992&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;757&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;por cada incremento de 10 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;602&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;127&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;276&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbilidad grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;572&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;515&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;385&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;574&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;337&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;619&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;520&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100 lpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;222&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;443&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;752&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;835&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;681&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;893&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de ca&#237;das los seis meses previos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;856&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;363&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polifarmacia grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>10 f&#225;rmacos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;683&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;501&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;070&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crisis hipertensiva &#40;PAS &#62;<span class="elsevierStyleHsp" style=""></span>160 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;708&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;383&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Evento combinado a los 30 d&#237;as posalta &#40;pacientes dados de alta&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100 lpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;647&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoxemia &#40;saturaci&#243;n basal de ox&#237;geno de la hemoglobina &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;404&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;950&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;074&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para deambular o no deambula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;403&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;810&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;432&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;830&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;057&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polifarmacia grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>10 f&#225;rmacos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;805&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;por cada incremento de 10 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;843&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;522&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbilidad grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;699&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;734&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;051&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;696&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;585&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;968&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;532&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;763&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de deterioro cognitivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;889&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;517&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;530&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de ca&#237;das los seis meses previos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;678&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;278&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;658&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiptotensi&#243;n arterial &#40;PAS &#60;<span class="elsevierStyleHsp" style=""></span>80 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;576&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;327&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;425&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;095&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crisis hipertensiva &#40;PAS &#62;<span class="elsevierStyleHsp" style=""></span>160 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;c&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">44&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">45&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">41&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">38&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">28&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neumopat&#237;a cr&#243;nica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">23&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad renal cr&#243;nica &#40;creatinina &#8805;<span class="elsevierStyleHsp" style=""></span>2 mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">25&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad cerebrovascular&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad vascular perif&#233;rica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neoplasia activa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cirrosis hep&#225;tica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Situaci&#243;n basal</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Clase NYHA III-IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">37&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>FEVI &#60;<span class="elsevierStyleHsp" style=""></span>50&#37; &#40;media&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">50<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;35-60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#205;ndice de comorbilidad de Charlson &#40;ICC&#44; puntos&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">59&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">67&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;75-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#250;mero de f&#225;rmacos cr&#243;nicos &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de demencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Constantes vitales a la llegada a urgencias</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica &#40;mmHg&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">139&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">138&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia cardiaca &#40;lpm&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Saturaci&#243;n de ox&#237;geno &#40;&#37;&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">94&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Eventos adversos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mortalidad intrahospitalaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mortalidad a 30 d&#237;as&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">10&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">9&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Muerte u hospitalizaci&#243;n a 30 d&#237;as posalta&nbsp;\t\t\t\t\t\t\n
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                  "referenciaCompleta" => "Encuesta de morbilidad hospitalaria 2021&#46; Instituto Nacional de Estad&#237;stica&#46; &#91;consultado 7 Ene 2024&#93;&#46; Disponible en&#58; <a target="_blank" href="https://www.ine.es/dyngs/INEbase/es/operacion.htm?c=Estadistica_C%26cid=1254736176778%26menu=ultiDatos%26idp=1254735573175">https&#58;&#47;&#47;www&#46;ine&#46;es&#47;dyngs&#47;INEbase&#47;es&#47;operacion&#46;htm&#63;c&#61;Estadistica&#95;C&#38;cid&#61;1254736176778&#38;menu&#61;ultiDatos&#38;idp&#61;1254735573175</a>&#46;"
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                      "titulo" => "Impacto pron&#243;stico de la especialidad en el paciente ambulatorio con insuficiencia cardiaca&#58; un an&#225;lisis emparejado de los registros REDINSCOR y RICA"
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                      "titulo" => "Estudio EDEN-16&#58; sodio plasm&#225;tico determinado a la llegada a urgencias como indicador de gravedad en pacientes ancianos"
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Aspectos epidemiológicos, manejo clínico y resultados a corto plazo en pacientes mayores diagnosticados de insuficiencia cardiaca aguda en urgencias en España: resultados del estudio EDEN-34
Epidemiological aspects, clinical management and short-term outcomes in elderly patients diagnosed with acute heart failure in the emergency department in Spain: results of the EDEN-34 study
Ò. Miróa, P. Llorensb,
Autor para correspondencia
llorens_ped@gva.es

Autor para correspondencia.
, S. Aguilóa, A. Alquézar-Arbéc, C. Fernándezd, G. Burillo-Putzee, N. Canadell Marcosa, A. Arce Marañóna, G. Sánchez Omsa, J. González del Castillod, en representación de los investigadores de la red SIESTA (Spanish Investigators in Emergency Situations TeAm) ◊
a Área de Urgencias, Hospital Clínico, IDIBAPS, Universidad de Barcelona, Barcelona, España
b Servicio de Urgencias, Corta Estancia y Hospitalización a Domicilio, Hospital General Dr. Balmis, Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Universidad Miguel Hernández, Alicante, España
c Servicio de Urgencias, Hospital de la Santa Creu i Sant Pau, Barcelona, España
d Servicio de Urgencias, Hospital Clínico San Carlos, IDISSC, Universidad Complutense, Madrid, España
e Servicio de Urgencias, Hospital Universitario de Canarias, Tenerife, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La insuficiencia cardiaca aguda &#40;ICA&#41; es un s&#237;ndrome que en la gran mayor&#237;a de casos genera una consulta en un servicio de urgencias &#40;SU&#41;&#46; Su incidencia aumenta a medida que avanza la edad de los pacientes y se estima que alcanza el 1&#37; anual en los sujetos mayores de 65 a&#241;os&#44; si bien no hay datos objetivos procedentes de los SU espa&#241;oles<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a>&#46; El Ministerio de Sanidad espa&#241;ol ha reportado que las principales causas de ingreso en los hospitales fueron las enfermedades circulatorias &#40;14&#44;5&#37; del total&#41;&#44; y la ICA es la principal causa dentro de este grupo de enfermedades<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a>&#46; As&#237; mismo&#44; dada la previsi&#243;n de envejecimiento de la poblaci&#243;n espa&#241;ola en las pr&#243;ximas d&#233;cadas&#44; se prev&#233; un aumento progresivo de la prevalencia de insuficiencia cardiaca &#40;IC&#41; en los pr&#243;ximos a&#241;os&#44; que se estima se situar&#225; alrededor del 10&#37; en sujetos mayores de 70 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Por otro lado&#44; existen varios registros en Espa&#241;a que han intentado complementar estos datos administrativos acerca de la ICA&#44; algunos proceden de registros de atenci&#243;n primaria y hospitales de referencia &#40;como el caso del estudio PATHWAYS-HF&#41;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a>&#44; mientras que otros recogen pacientes hospitalizados en determinados servicios asistenciales&#44; esencialmente en medicina interna &#40;registro RICA&#41;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#44; atendidos en consultas espec&#237;ficas de cardiolog&#237;a &#40;registro REDINSCOR&#41;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> o que son diagnosticados durante su consulta en el SU &#40;registro EAHFE&#41;&#46; Los datos procedentes de pacientes atendidos en SU resultan de particular inter&#233;s&#44; pues incluyen no solo pacientes con ICA que requieren hospitalizaci&#243;n&#44; sino tambi&#233;n descompensaciones menos graves que son &#237;ntegramente manejadas en urgencias y dadas de alta a domicilio sin hospitalizaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">7&#44;8</span></a>&#46; En conjunto&#44; estos registros han definido que&#44; en Espa&#241;a&#44; este s&#237;ndrome conlleva una mortalidad intrahospitalaria superior al 5&#37;&#44; una mortalidad a 30 d&#237;as de alrededor del 10&#37;&#44; que alcanza el 30&#37; al cabo de un a&#241;o&#44; y un riesgo de evento adverso &#40;reconsulta en urgencias&#44; hospitalizaci&#243;n o muerte&#41; durante los 30 d&#237;as posteriores al alta tras del episodio de ICA de alrededor del 30&#37;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A pesar de que los pacientes mayores son una poblaci&#243;n especialmente predispuesta a los episodios de ICA&#44; son pocos los estudios que se han centrado espec&#237;ficamente en esta poblaci&#243;n&#44; la cual puede presentar particularidades&#46; No en balde se trata de un segmento infrarrepresentado en los ensayos cl&#237;nicos y que&#44; debido a que suelen ser pacientes pluripatol&#243;gicos o con trastornos neurodegenerativos avanzados&#44; quedan excluidos de los principales registros&#46; El presente estudio profundiza en el conocimiento del manejo de los pacientes mayores que consultan en los SU espa&#241;oles debido a un episodio de ICA mediante el an&#225;lisis del registro EDEN &#40;<span class="elsevierStyleItalic">Emergency Department and Elder Needs</span>&#41;&#44; que incluy&#243; a todos los pacientes de 65 o m&#225;s a&#241;os atendidos en 52 SU espa&#241;oles de 14 comunidades aut&#243;nomas distintas durante una semana<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;10</span></a>&#46; Los objetivos espec&#237;ficos del presente an&#225;lisis fueron estimar la incidencia de diagn&#243;stico de ICA en pacientes mayores atendidos en los SU espa&#241;oles&#44; conocer la necesidad de hospitalizaci&#243;n y la confirmaci&#243;n diagn&#243;stica en aquellos pacientes hospitalizados&#44; definir el flujo habitual de estos pacientes tras su atenci&#243;n en urgencias y cuantificar los eventos adversos a corto plazo&#44; as&#237; como sus factores asociados&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todo</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Dise&#241;o del registro EDEN y del estudio EDEN-34</span><p id="par0020" class="elsevierStylePara elsevierViewall">El registro multiprop&#243;sito EDEN tiene como objetivo primario ampliar el conocimiento acerca de aspectos sociodemogr&#225;ficos&#44; organizativos&#44; de situaci&#243;n basal&#44; cl&#237;nicos&#44; asistenciales y evolutivos de la poblaci&#243;n de 65 o m&#225;s a&#241;os que consulta en los SU espa&#241;oles&#46; Participaron en la creaci&#243;n del registro EDEN 52 SU espa&#241;oles de 14 comunidades aut&#243;nomas&#44; que suponen el 17&#37; de SU hospitalarios p&#250;blicos existentes en Espa&#241;a y que dan cobertura al 25&#37; de su poblaci&#243;n &#40;11&#46;768&#46;548 habitantes&#41;&#46; Los SU participantes incluyeron todos los pacientes de este rango etario atendidos entre el 1 y el 7 de abril de 2019 &#40;siete d&#237;as&#41;&#44; independientemente del motivo de consulta&#46; No existi&#243; ning&#250;n motivo de exclusi&#243;n y se incluyeron todos los pacientes atendidos durante el periodo de estudio&#46; Los detalles del registro EDEN han sido descritos con mayor extensi&#243;n en estudios previos<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;11&#44;12</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El estudio EDEN-34 incluy&#243; a todos los pacientes de la cohorte EDEN en los que se registr&#243; ICA como uno de los diagn&#243;sticos codificados en urgencias&#46; En los informes de urgencias se codificaron hasta un m&#225;ximo de tres diagn&#243;sticos distintos y se acept&#243; el diagn&#243;stico de ICA si este figuraba en cualquiera de ellos &#40;c&#243;digos CIE-10&#58; I50&#46;x&#41;&#46; Adem&#225;s&#44; se recogieron los diagn&#243;sticos registrados al alta de hospitalizaci&#243;n para todos los pacientes de estudio que fueron hospitalizados&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Los objetivos del estudio EDEN-34 fueron cuatro&#46; El primero&#44; conocer la incidencia del diagn&#243;stico de ICA en los SU espa&#241;oles ajustados a la poblaci&#243;n de referencia de dichos SU&#46; El segundo fue analizar el manejo de estos pacientes en los SU&#44; especialmente centrado en la disposici&#243;n de estos tras la atenci&#243;n urgente y tras la hospitalizaci&#243;n&#46; El tercero&#44; analizar la frecuencia y los factores asociados con la hospitalizaci&#243;n y&#44; entre los pacientes hospitalizados&#44; la frecuencia y factores asociados con la confirmaci&#243;n diagn&#243;stica&#46; El cuarto fue explorar la frecuencia de eventos adversos y los factores asociados&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables independientes</span><p id="par0035" class="elsevierStylePara elsevierViewall">Se recogieron 24 variables independientes&#44; que incluyeron dos factores sociodemogr&#225;ficos &#40;edad&#44; sexo&#41;&#44; 11 comorbilidades &#40;hipertensi&#243;n arterial&#44; dislipidemia&#44; diabetes mellitus&#44; neoplasia activa&#44; insuficiencia cardiaca &#40;IC&#41;&#44; cardiopat&#237;a isqu&#233;mica&#44; neumopat&#237;a cr&#243;nica&#44; enfermedad cerebrovascular&#44; enfermedad vascular perif&#233;rica&#44; cirrosis hep&#225;tica&#44; enfermedad renal cr&#243;nica moderada-grave&#59; esta &#250;ltima se defini&#243; siguiendo el criterio de trabajos previos como aquellos pacientes que ten&#237;an una creatinina previa registrada &#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#41;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a>&#44; ocho variables que estimaban el estado basal del paciente teniendo en cuenta una perspectiva geri&#225;trica &#40;&#237;ndice de comorbilidad de Charlson &#8211;ICC&#8211;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a>&#44; &#237;ndice de Barthel &#8211;IB&#8211;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a>&#44; n&#250;mero de f&#225;rmacos cr&#243;nicos&#44; necesidad de ayuda en la deambulaci&#243;n&#44; ca&#237;das durante los seis meses previos&#44; diagn&#243;stico previo de depresi&#243;n&#44; demencia y delirium&#41;&#44; y tres acerca de la situaci&#243;n cl&#237;nica del paciente a su llegada a urgencias &#40;presi&#243;n arterial sist&#243;lica &#8211;PAS&#8211;&#44; frecuencia cardiaca y saturaci&#243;n basal de ox&#237;geno medida por pulsioximetr&#237;a&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; para poder hacer un seguimiento del paciente&#44; se consign&#243; su destino tras el alta&#44; ya fuese desde urgencias o tras hospitalizaci&#243;n&#46; En los pacientes hospitalizados&#44; se consignaron los servicios en los que se ingres&#243; al paciente y la necesidad de ingreso en una unidad de cuidados intensivos &#40;UCI&#41;&#44; ya fuese directamente o tras su estancia previa en una unidad de hospitalizaci&#243;n convencional&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Eventos adversos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Para todos los pacientes diagnosticados de ICA en urgencias&#44; se consign&#243; la mortalidad por cualquier causa intrahospitalaria y a los 30 d&#237;as a partir del evento &#237;ndice &#40;consulta en urgencias&#41;&#44; y en los dados de alta tras el episodio &#237;ndice &#40;se descartaron los fallecidos durante dicho episodio&#41;&#59; se investig&#243; la variable combinada de muerte o necesidad de hospitalizaci&#243;n por cualquier causa durante los 30 d&#237;as de seguimiento posalta&#46; La adjudicaci&#243;n de eventos la realiz&#243; el investigador principal del centro&#44; sin revisi&#243;n externa&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">An&#225;lisis estad&#237;stico</span><p id="par0050" class="elsevierStylePara elsevierViewall">Para la descripci&#243;n de las variables cuantitativas se us&#243; la mediana y rango intercuartil &#40;RIC&#41;&#44; y para las cualitativas&#44; los valores absolutos y porcentajes&#44; y la comparaci&#243;n se realiz&#243; con el test de Mann-Whitney y el test de <span class="elsevierStyleItalic">chi</span> cuadrado&#44; respectivamente&#46; La estimaci&#243;n de la incidencia de diagn&#243;stico de ICA en los SU espa&#241;oles se realiz&#243; por a&#241;o y por cada1&#46;000 habitantes &#40;considerando la poblaci&#243;n de referencia asignada a cada uno de los 52 SU participantes y bajo el supuesto de una incidencia constante a lo largo de todo el a&#241;o&#41; y se calcul&#243; el intervalo de confianza del 95&#37; &#40;IC 95&#37;&#41; de la estimaci&#243;n de incidencia mediante el m&#233;todo binomial exacto de Clopper y Pearson&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Los factores independientes asociados a hospitalizaci&#243;n o a confirmaci&#243;n del diagn&#243;stico se investigaron con un modelo de regresi&#243;n log&#237;stica multivariable&#44; que incluy&#243; las variables que hab&#237;an resultado con un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;10 en el an&#225;lisis univariable&#46; Por otro lado&#44; para analizar la relaci&#243;n entre las caracter&#237;sticas del paciente y la probabilidad de eventos adversos&#44; y dado que se previ&#243; un n&#250;mero bajo de eventos que impedir&#237;a incluir todas las caracter&#237;sticas del paciente&#44; se decidi&#243; incluir en el modelo caracter&#237;sticas definidas <span class="elsevierStyleItalic">a priori</span> como potencialmente relacionadas con dichos eventos adversos y categorizando previamente las variables continuas utilizando puntos de corte con significado cl&#237;nico o de uso habitual&#46; En relaci&#243;n con las comorbilidades&#44; estas se tuvieron en cuenta en el modelo mediante ICC&#44; que contabiliza la carga de comorbilidad&#44; y no de forma individualizada&#46; Al final&#44; las variables incluidas en el modelo multivariable fueron 15&#58; edad avanzada &#40;por unidad de aumento de 10 a&#241;os&#41;&#44; sexo&#44; presencia de deterioro funcional &#40;IB &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&#44; comorbilidad grave &#40;ICC<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&#44; polifarmacia grave &#40;n&#250;mero de f&#225;rmacos cr&#243;nicos<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>10&#41;&#44; necesidad de ayuda para deambular &#40;o no deambulaci&#243;n&#41;&#44; ca&#237;da los seis meses previos&#44; diagn&#243;stico previo de demencia&#44; de depresi&#243;n y de delirium&#44; e hipotensi&#243;n arterial &#40;&#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; hipertensi&#243;n arterial &#40;&#62;<span class="elsevierStyleHsp" style=""></span>160<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41;&#44; taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; e hipoxemia &#40;saturaci&#243;n de ox&#237;geno &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41; a la llegada al SU&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">La magnitud de las asociaciones se estim&#243; con <span class="elsevierStyleItalic">odds</span> ratio &#40;OR&#41; y su IC del 95&#37; y las diferencias se consideraron estad&#237;sticamente significativas si el valor p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 o si el IC 95&#37; de la OR exclu&#237;a el valor 1&#46; El procesamiento estad&#237;stico se realiz&#243; mediante el paquete estad&#237;stico SPSS Statistics V26 &#40;IBM&#44; Armonk&#44; Nueva York&#44; EE&#46; UU&#46;&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Consideraciones &#233;ticas</span><p id="par0065" class="elsevierStylePara elsevierViewall">El proyecto EDEN fue aprobado por el Comit&#233; &#201;tico en Investigaci&#243;n Cl&#237;nica del Hospital Cl&#237;nico San Carlos de Madrid &#40;protocolo HCSC&#47;22&#47;005-E&#41;&#46; La creaci&#243;n de la cohorte EDEN y los trabajos que emanan de ella han seguido en todo momento los principios &#233;ticos de la Declaraci&#243;n de Helsinki&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><p id="par0070" class="elsevierStylePara elsevierViewall">De los 25&#46;557 pacientes incluidos en la cohorte EDEN&#44; 25&#46;538 han sido incluidos en el estudio EDEN-34 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; De ellos&#44; 1&#46;155 &#40;4&#44;5&#37;&#41; fueron diagnosticados de ICA en urgencias&#46; Teniendo en cuenta que el periodo de inclusi&#243;n fue de siete d&#237;as&#44; que los 52 SUH dan cobertura a un total de 11&#46;768&#46;548 habitantes y que en 2019 &#40;a&#241;o del estudio&#41; el porcentaje de poblaci&#243;n espa&#241;ola de 65 o m&#225;s a&#241;os era del 19&#44;3&#37;&#44; la incidencia anual estimada de diagn&#243;sticos de ICA en los SU espa&#241;oles fue de 26&#44;5 por 1&#46;000 habitantes de 65 o m&#225;s a&#241;os &#40;IC 95&#37;&#58; 25&#44;0-28&#44;1&#41;&#46; Los pacientes con ICA ten&#237;an una mediana de edad de 85 a&#241;os&#44; el 45&#37; eran varones&#44; la comorbilidad era frecuente &#40;grave en el 28&#37;&#44; con ICC<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&#44; y la situaci&#243;n funcional basal estaba alterada &#40;IB<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41; en m&#225;s del 50&#37; de los casos&#46; El resto de las caracter&#237;sticas cl&#237;nicas se recoge en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Hubo 774 pacientes &#40;67&#37;&#41; que requirieron hospitalizaci&#243;n&#46; El an&#225;lisis univariable mostr&#243; que los pacientes que precisaban hospitalizaci&#243;n eran m&#225;s frecuentemente hombres&#59; con menor frecuencia ten&#237;an hipertensi&#243;n arterial como comorbilidad&#44; y presentaban mayor deterioro funcional y menor saturaci&#243;n de ox&#237;geno &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; El an&#225;lisis multivariable confirm&#243; estos cuatro factores y mostr&#243; que la hospitalizaci&#243;n se asociaba de forma independiente y directa con sexo masculino &#40;OR ajustada 1&#44;38&#44; 1&#44;05-1&#44;82&#41; y deterioro funcional &#40;1&#44;39&#44; 1&#44;06-1&#44;83&#41;&#44; y de forma inversa con hipertensi&#243;n arterial &#40;0&#44;61&#44; 0&#44;40-0&#44;93&#41; y la saturaci&#243;n de ox&#237;geno &#40;0&#44;90&#44; 0&#44;87-0&#44;93&#41;&#46; En 665 de los pacientes hospitalizados &#40;86&#37;&#41; se confirm&#243; el diagn&#243;stico de ICA en el informe de alta hospitalaria&#44; mientras que en el resto no figuraba dicho diagn&#243;stico entre los codificados&#46; La falta de confirmaci&#243;n diagn&#243;stica fue m&#225;s frecuente en pacientes m&#225;s j&#243;venes&#44; sin diagn&#243;stico previo de cardiopat&#237;a isqu&#233;mica&#44; IC cr&#243;nica y enfermedad renal cr&#243;nica&#44; y que estaban menos taquic&#225;rdicos a la llegada al SU &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; El estudio multivariable confirm&#243; que solo la ausencia de diagn&#243;stico previo de IC se asoci&#243; de forma independiente con falta de confirmaci&#243;n diagn&#243;stica durante la hospitalizaci&#243;n &#40;OR ajustada&#58; 1&#44;66&#44; 1&#44;06-2&#44;62&#41;&#46; Finalmente&#44; hubo 209 diagn&#243;sticos de ICA entre los 5&#46;742 pacientes hospitalizados en los que no constaba el diagn&#243;stico de ICA tras la atenci&#243;n en urgencias&#44; lo cual supone un porcentaje del 3&#44;6&#37;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El manejo de los pacientes con ICA en urgencias se resume en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>&#46; Cuando el paciente precis&#243; hospitalizaci&#243;n&#44; m&#225;s de la mitad de los casos ingresaron en medicina interna&#44; y la mediana de tiempo de hospitalizaci&#243;n fue de 7&#44;2 d&#237;as &#40;RIC&#58; 4&#44;4-10&#44;7&#41;&#46; Hubo 17 &#40;2&#44;2&#37;&#41; que precisaron atenci&#243;n en UCI&#46; En el caso de los pacientes dados de alta de urgencias&#44; la mediana de tiempo de permanencia en urgencias fue de 6&#58;08 horas &#40;RIC&#58; 3&#58;32-12&#58;33&#41;&#46; Los pacientes fueron dados de alta predominantemente a domicilio&#44; tanto si el alta se produc&#237;a desde urgencias o tras hospitalizaci&#243;n&#44; en tanto que a residencia se remiti&#243; el 7&#44;3&#37; y el 11&#44;2&#37; de pacientes&#44; respectivamente&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">La mortalidad intrahospitalaria fue del 7&#44;9&#37; y la mortalidad global a 30 d&#237;as fue del 10&#44;7&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; En ambos casos&#44; el principal factor asociado independientemente a estos eventos fue la hipotensi&#243;n arterial &#40;presi&#243;n arterial sist&#243;lica &#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg&#59; OR ajustada&#58; 74&#44;0&#44; IC 95&#37;&#58; 5&#44;39-1&#46;015&#59; y 42&#44;6&#44; 3&#44;74-485&#44; respectivamente&#41; y la hipoxemia &#40;saturaci&#243;n &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#59; 2&#44;14&#44; 1&#44;27-3&#44;61&#59; y 1&#44;87&#44; 1&#44;19-2&#44;93&#41; a la llegada a urgencias y precisar ayuda en la deambulaci&#243;n &#40;2&#44;24&#44; 1&#44;04-4&#44;83&#59; y 2&#44;48&#44; 1&#44;27-4&#44;86&#41; y la edad &#40;por cada incremento de 10 a&#241;os&#59; 1&#44;54&#44; 1&#44;04-2&#44;29&#44; y 1&#44;60&#44; 1&#44;13-2&#44;28&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; El evento adverso combinado a los 30 d&#237;as posalta se produjo en el 15&#44;6&#37; de los pacientes&#44; y no se asoci&#243; a ninguna caracter&#237;stica&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discusi&#243;n</span><p id="par0090" class="elsevierStylePara elsevierViewall">El estudio EDEN-34 aporta cuatro hallazgos relevantes&#46; Primero&#44; la frecuencia del diagn&#243;stico de ICA en los pacientes mayores en los SU espa&#241;oles es elevada&#58; supone el 4&#44;4&#37; de todas las consultas y una incidencia anual de 26&#44;5 episodios por 1&#46;000 personas en este segmento de poblaci&#243;n&#46; Segunda&#44; mientras que se identifican varios factores asociados con necesidad de hospitalizaci&#243;n&#44; solo la ausencia de diagn&#243;stico previo de IC cr&#243;nica se asoci&#243; con falta de confirmaci&#243;n del diagn&#243;stico de ICA durante la hospitalizaci&#243;n&#46; Tercero&#44; los eventos adversos a corto plazo son considerables&#44; y la edad y la limitaci&#243;n a la deambulaci&#243;n entre las caracter&#237;sticas del paciente&#44; y la hipotensi&#243;n y la hipoxemia a la llegada a urgencias&#44; se asocian espec&#237;ficamente con la mortalidad&#46; Finalmente&#44; el estudio muestra de forma global cu&#225;l es el perfil basal y el manejo que se produce en la ICA en los SU en pacientes mayores&#44; donde dos de cada tres pacientes son hospitalizados&#44; m&#225;s de la mitad de ellos en servicios de medicina interna&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En cuanto a la incidencia encontrada en la poblaci&#243;n estudiada&#44; los datos son congruentes con el estudio de morbilidad hospitalaria del Instituto Nacional de Estad&#237;stica&#44; donde las enfermedades del aparato circulatorio son el diagn&#243;stico principal tanto de ingresos como de las altas hospitalarias &#40;tasas de morbilidad de 1&#46;416 por 100&#46;000 hombres&#44; y 1&#46;053 por 100&#46;000 mujeres&#41;&#44; y en el que se muestra que el 64&#44;1&#37; de las altas hospitalarias ingresaron con car&#225;cter urgente<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a>&#46; Por ello&#44; dado que la ICA es la principal etiolog&#237;a de las enfermedades del aparato circulatorio&#44; es de suponer que exista un alto porcentaje de consultas por ICA en los SU espa&#241;oles&#46; Sin embargo&#44; en Espa&#241;a tan s&#243;lo disponemos de un estudio sobre incidencia anual de ICA&#44; que la estim&#243; en 2&#44;96 casos por 1&#46;000 personas-a&#241;o en 2000 y en 3&#44;90 casos por 1&#46;000 personas-a&#241;o en 2007<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a>&#46; Por ello&#44; los datos que aqu&#237; se presentan proporcionan una estimaci&#243;n actualizada de la incidencia de ICA en la poblaci&#243;n mayor&#46; En estudios europeos m&#225;s recientes<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#44;18</span></a>&#44; se ha descrito una incidencia de ICA creciente con la edad&#44; de 1&#44;4 cada 1&#46;000 personas-a&#241;o a los 50-59 a&#241;os&#44; 3&#44;1 a los 60-64 a&#241;os&#44; 5&#44;4 a los 65-69 a&#241;os&#44; 11&#44;7 a los 70-74 a&#241;os y superior a 17&#44;0 a los 75 y m&#225;s a&#241;os&#44; lo cual ir&#237;a en consonancia con los datos obtenidos en el estudio EDEN-34&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">En el presente estudio&#44; la ICA en pacientes mayores de 65 a&#241;os gener&#243; el 4&#44;4&#37; del total de consultas en el SU&#46; Tampoco exist&#237;an estudios al respecto en Espa&#241;a hasta la fecha&#46; Congruentes con nuestros resultados fueron los resultados de un estudio europeo realizado en Finlandia<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a>&#46; Se analizaron 6&#46;944 pacientes mayores de 80 a&#241;os &#40;85 a&#241;os de edad media&#44; rango 80-104 a&#241;os&#41; atendidos de forma consecutiva durante dos a&#241;os en un SU&#44; y evidenciaron que las consultas por ICA en urgencias fueron un 4&#44;3&#37; del total&#44; con una incidencia anual de 35 episodios por 1&#46;000 personas en este segmento poblaci&#243;n&#46; Por el contrario&#44; Storrow et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> en un estudio retrospectivo realizado en Estados Unidos desde 2006 hasta 2010&#44; donde hubo 958&#46;167 visitas promedio anuales ponderadas al SU&#44; las consultas por ICA representaban el 0&#44;77&#37; de todas las visitas al SU&#44; cifras muy inferiores a las del estudio EDEN-34&#46; Sin embargo&#44; en el estudio estadounidense se incluyeron pacientes mayores de 18 a&#241;os&#59; con lo que creemos que si se hubiera acotado la franja de edad a mayores de 65 a&#241;os&#44; los porcentajes de consultas ser&#237;an superiores y m&#225;s pr&#243;ximos a los que aqu&#237; se presentan&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En un 14&#37; de los pacientes hospitalizados no se confirm&#243; el diagn&#243;stico de ICA en el informe de alta hospitalaria&#46; La ausencia de confirmaci&#243;n diagn&#243;stica result&#243; m&#225;s frecuente en pacientes sin un diagn&#243;stico previo de IC cr&#243;nica&#46; A pesar de la alta prevalencia de la ICA en urgencias&#44; su diagn&#243;stico en pacientes con disnea puede ser dif&#237;cil&#44; sobre todo en pacientes de edad avanzada y con comorbilidad asociada como los del presente estudio<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a>&#46; Un diagn&#243;stico de ICA en urgencias basado en los antecedentes&#44; exploraci&#243;n f&#237;sica&#44; radiograf&#237;a de t&#243;rax y electrocardiograma se califica de &#171;incierto&#187; en el 44&#37; de los casos y es discordante con el diagn&#243;stico final al alta en casi uno de cada cuatro casos&#46; La capacidad del antecedente de IC cr&#243;nica para predecir el diagn&#243;stico de ICA como causa de disnea en pacientes adultos en urgencias ha sido evaluada en m&#250;ltiples estudios&#46; Una revisi&#243;n reciente&#44; que evalu&#243; 22 estudios y que incluy&#243; un total de 8&#46;493 pacientes&#44; evidenci&#243; que el antecedente de IC cr&#243;nica ten&#237;a una sensibilidad del 55&#44;5&#37; &#40;IC 95&#37; 53&#44;9&#8211;57&#44;1&#41;&#44; una especificidad del 80&#44;2&#37; &#40;IC 95&#37; 79&#44;0&#8211;81&#44;3&#41; y con una raz&#243;n de verosimilitud negativa de 0&#44;58 &#40;IC 95&#37; 0&#44;49&#8211;0&#44;68&#41; para el diagn&#243;stico de ICA&#46; En la actualidad&#44; la ecograf&#237;a pulmonar a pie de cama&#44; la ecocardiograf&#237;a y los p&#233;ptidos natriur&#233;ticos proporcionan informaci&#243;n fiable para confirmar o excluir el diagn&#243;stico de ICA en los SU&#44; con lo que los porcentajes de pacientes ingresados con diagn&#243;sticos de disnea de origen &#171;incierto&#187; o ausencia de confirmaci&#243;n final&#44; son cada vez menores<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a>&#46; Con todo&#44; creemos que este potencial error en el 14&#37; de los diagn&#243;sticos de ICA realizados en urgencias es susceptible de mejora&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">La situaci&#243;n basal del paciente es un aspecto determinante del pron&#243;stico&#46; De forma general&#44; hemos comprobado que la limitaci&#243;n en la deambulaci&#243;n se relaciona con el pron&#243;stico a corto plazo durante un episodio de ICA&#46; Este es un par&#225;metro ya asentado como factor pron&#243;stico&#44; y aunque es ampliamente reconocido&#44; su implantaci&#243;n y la recogida sistem&#225;tica en hospitales de agudos y en pacientes con enfermedades m&#233;dicas agudas no est&#225;n totalmente establecidas&#46; Una mala situaci&#243;n funcional al ingreso de pacientes de edad avanzada y con enfermedad aguda predice una mayor mortalidad intrahospitalaria y a los seis meses&#44; una estancia m&#225;s prolongada y una mayor institucionalizaci&#243;n al alta&#46; Incluso el deterioro de la situaci&#243;n funcional causado por la propia enfermedad aguda aumenta el riesgo de mortalidad tras el alta &#40;al mes e incluso a&#241;os despu&#233;s&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a>&#46; As&#237;&#44; los resultados del estudio EDEN-34 est&#225;n en relaci&#243;n con estudios previos sobre el deterioro funcional en los ancianos con ICA en los SU&#44; su aumento progresivo seg&#250;n avanza la edad y su asociaci&#243;n con el pron&#243;stico a corto plazo<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#44;25</span></a>&#46; El estudio&#44; adem&#225;s&#44; ha detectado que las cifras de PAS y de saturaci&#243;n de ox&#237;geno a la llegada al SU&#44; se asocian a mal pron&#243;stico&#44; aspectos ya definidos en diferentes estudios previos<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a>&#46; En un estudio realizado en diferentes SU espa&#241;oles&#44; y en consonancia con estos resultados&#44; la presencia de hipotensi&#243;n arterial se defin&#237;a como un factor independiente de mal pron&#243;stico a corto plazo &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#44;8&#59; IC 95&#37; 1&#44;6-14&#44;5&#41;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">El estudio EDEN-34 identifica la necesidad de ingreso hospitalario en dos de cada tres pacientes valorados en urgencias y dicho ingreso se realiza en m&#225;s de la mitad de pacientes &#40;55&#37;&#41; en servicios de medicina interna&#46; De hecho&#44; el perfil del paciente con ICA encontrado en este estudio es similar al encontrado en el registro espa&#241;ol EAHFE<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a>&#44; que incluye&#44; de forma intermitente desde el 2007&#44; a pacientes con ICA atendidos en SU&#46; En dicho registro se evidencia que el 75&#44;1&#37; de pacientes con ICA precisa hospitalizaci&#243;n&#44; de los que el 43&#37; lo hace en servicios de medicina interna&#46; Teniendo en cuenta que el registro EAHFE incluye pacientes mayores a 18 a&#241;os&#44; es posible que este porcentaje de pacientes ingresados en medicina interna fuese m&#225;s parecido al encontrado en el estudio EDEN-34 si la franja de edad se acotara a pacientes mayores de 65 a&#241;os&#46; Es de destacar que las caracter&#237;sticas cl&#237;nicas de los pacientes del estudio EDEN-34 se superponen en gran medida a las de los pacientes de los registros EAHFE cuando se analiza este segmento poblacional&#44; as&#237; como tambi&#233;n con los del registro RICA<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#44; que incluye pacientes mayores de 65 a&#241;os hospitalizados en servicios de medicina interna espa&#241;oles &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; Por tanto&#44; creemos que el estudio EDEN-34&#44; en conjunci&#243;n con los datos aportados por estos otros dos registros&#44; contribuye a definir el manejo del paciente con ICA en Espa&#241;a&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Limitaciones</span><p id="par0120" class="elsevierStylePara elsevierViewall">Primera&#44; los 52 SUH que han aportado pacientes al registro EDEN no fueron escogidos al azar&#44; sino que mostraron su disponibilidad a participar&#59; sin embargo&#44; la amplia representaci&#243;n territorial &#40;14 de las 17 comunidades aut&#243;nomas estaban representadas&#41; y de tipolog&#237;a &#40;hospitales universitarios&#44; de alta tecnolog&#237;a y comarcales&#41; hace que el sesgo en este sentido sea probablemente escaso&#46; Segunda&#44; el an&#225;lisis se realiza de forma general&#44; sin separar la ICA en las diferentes categor&#237;as fenot&#237;picas seg&#250;n la fracci&#243;n de eyecci&#243;n del ventr&#237;culo izquierdo o la forma cl&#237;nica de presentaci&#243;n&#46; Con todo&#44; creemos que con esta aproximaci&#243;n&#44; el estudio EDEN-34 aporta una visi&#243;n global de la pr&#225;ctica cl&#237;nica habitual en los SU espa&#241;oles&#44; al incluir a todos los pacientes y analizarlos de forma global&#46; Tercera&#44; se trata de un an&#225;lisis secundario de una cohorte multiprop&#243;sito&#44; por lo que las asociaciones que se presentan pueden estar influidas por factores no contemplados en el dise&#241;o de la cohorte&#59; por lo tanto&#44; los hallazgos deben considerarse generadores de hip&#243;tesis que deber&#225;n confirmarse con estudios espec&#237;ficamente dise&#241;ados a tal fin&#46; Cuarta&#44; los resultados del estudio EDEN-34 pueden haberse visto afectados por las din&#225;micas individuales de cada hospital &#40;especialmente por lo que se refiere al ingreso o alta de pacientes&#41; y pueden haber estado influidos tambi&#233;n por la &#233;poca del a&#241;o en la que se realiz&#243; el estudio &#40;primera semana de abril&#41;&#46; La ICA tiene cierto patr&#243;n estacional y la &#233;poca del a&#241;o analizada en este estudio a&#250;n se encuentra bajo las condiciones que imponen las pandemias gripales y v&#237;ricas habituales del invierno e inicio de primavera&#46; Por tanto&#44; podr&#237;a haber variaciones&#44; especialmente en la incidencia al analizar otros periodos de a&#241;o&#46; Quinta&#44; la inclusi&#243;n de pacientes en la cohorte EDEN se ha realizado por episodios en vez de por pacientes&#44; por lo que es posible que alg&#250;n episodio pueda corresponder al mismo paciente&#46; No obstante&#44; dado que el periodo de inclusi&#243;n fue muy corto &#40;siete d&#237;as&#41;&#44; las posibilidades de repetici&#243;n de consulta para un paciente concreto cabe considerarse escasa&#46; Finalmente&#44; aunque en el presente estudio de pacientes mayores se consideraron espec&#237;ficamente la dependencia y la comorbilidad&#44; la fragilidad fue solo evaluada de forma tangencial a trav&#233;s de la existencia de ca&#237;das durante los seis meses previos y es bien conocido que la fragilidad es un elemento con un importante impacto en esta poblaci&#243;n&#44; que no es suficientemente estimada&#44; especialmente en los SU<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#8211;30</span></a>&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusi&#243;n</span><p id="par0125" class="elsevierStylePara elsevierViewall">La ICA es un diagn&#243;stico frecuente en los pacientes mayores que consultan en SU&#46; Su situaci&#243;n basal&#44; especialmente el deterioro funcional y la edad&#44; y la hipotensi&#243;n e hipoxemia a la llegada a urgencias son los factores que m&#225;s se asocian a eventos adversos&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Financiaci&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Esta investigaci&#243;n no recibi&#243; financiaci&#243;n de entidades p&#250;blicas&#44; comerciales ni sin &#225;nimo de lucro&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Autor&#237;a</span><p id="par0135" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Concepci&#243;n y dise&#241;o del manuscrito&#58; &#210;scar Mir&#243;&#44; Pere Llorens y Juan Gonz&#225;lez del Castillo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Recogida de datos&#58; Sira Aguil&#243;&#44; Aitor Alqu&#233;zar-Arb&#233;&#44; Ces&#225;reo Fern&#225;ndez&#44; Guillermo Burillo-Putze&#44; Naila Canadell Marcos&#44; Anette Arce Mara&#241;&#243;n&#44; Gemma S&#225;nchez Oms y los investigadores de la red SIESTA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">An&#225;lisis e interpretaci&#243;n de los datos&#58; &#210;scar Mir&#243; y Juan Gonz&#225;lez del Castillo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Redacci&#243;n&#44; revisi&#243;n&#44; aprobaci&#243;n del manuscrito remitido&#58; &#210;scar Mir&#243;&#44; Pere Llorens&#44; Sira Aguil&#243;&#44; Aitor Alqu&#233;zar-Arb&#233;&#44; Ces&#225;reo Fern&#225;ndez&#44; Guillermo Burillo-Putze&#44; Naila Canadell Marcos&#44; Anette Arce Mara&#241;&#243;n&#44; Gemma S&#225;nchez Oms y Juan Gonz&#225;lez del Castillo&#46;</p></li></ul></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicto de intereses</span><p id="par0160" class="elsevierStylePara elsevierViewall">Todos los autores declaran no tener conflicto de intereses&#46;</p></span></span>"
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            0 => "Insuficiencia cardiaca aguda"
            1 => "Geriatr&#237;a"
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            0 => "Acute heart failure"
            1 => "Geriatrics"
            2 => "Severity"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estimar la incidencia de diagn&#243;stico de insuficiencia cardiaca aguda &#40;ICA&#41; en pacientes mayores en los servicios de urgencias &#40;SU&#41;&#44; la confirmaci&#243;n diagn&#243;stica de la ICA en pacientes hospitalizados y los eventos adversos a corto plazo&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron a todos los pacientes de &#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os atendidos en 52 SU espa&#241;oles durante una semana y se seleccionaron los diagnosticados de ICA&#46; En los hospitalizados se recogieron los diagnosticados de ICA al alta&#46; Como eventos adversos&#44; se recogi&#243; la mortalidad intrahospitalaria y a 30 d&#237;as&#44; y evento adverso combinado &#40;muerte u hospitalizaci&#243;n&#41; a 30 d&#237;as posalta&#46; Se calcularon las <span class="elsevierStyleItalic">odds</span> ratio &#40;OR&#41; ajustadas de las caracter&#237;sticas demogr&#225;ficas&#44; de estado basal y a la llegada al SU asociadas con mortalidad y evento adverso posalta a 30 d&#237;as&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 1&#46;155 pacientes con ICA &#40;incidencia anual&#58; 26&#44;5 por 1&#46;000 habitantes &#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#44; IC95&#37;&#58; 25&#44;0-28&#44;1&#41;&#46; En el 86&#37;&#44; el diagn&#243;stico de ICA constaba al alta&#46; La mortalidad global a 30 d&#237;as fue del 10&#44;7&#37;&#44; la intrahospitalaria del 7&#44;9&#37; y el evento combinado posalta del 15&#44;6&#37;&#46; La mortalidad intrahospitalaria y a 30 d&#237;as se asoci&#243; con hipotensi&#243;n arterial &#40;OR ajustada&#58; 74&#44;0&#44; IC95&#37;&#58; 5&#44;39-1&#46;015&#46;&#59; y 42&#44;6&#44; 3&#44;74-485&#44; respectivamente&#41; e hipoxemia &#40;2&#44;14&#44; 1&#44;27-3&#44;61&#59; y 1&#44;87&#44; 1&#44;19-2&#44;93&#41; a la llegada a urgencias y con precisar ayuda en la deambulaci&#243;n &#40;2&#44;24&#44; 1&#44;04-4&#44;83&#59; y 2&#44;48&#44; 1&#44;27-4&#44;86&#41; y la edad &#40;por cada incremento de 10 a&#241;os&#59; 1&#44;54&#44; 1&#44;04-2&#44;29&#44; y 1&#44;60&#44; 1&#44;13-2&#44;28&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La ICA es un diagn&#243;stico frecuente en los pacientes mayores que consultan en los SU&#46; El deterioro funcional&#44; la edad&#44; la hipotensi&#243;n e hipoxemia son los factores que m&#225;s se asocian a mortalidad&#46;</p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To estimate the incidence of acute heart failure &#40;AHF&#41; diagnosis in elderly patients in emergency departments &#40;ED&#41;&#44; diagnostic confirmation in hospitalized patients&#44; and short-term adverse events&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">All patients aged &#8805;<span class="elsevierStyleHsp" style=""></span>65 years attended in 52 Spanish EDs during 1 week were included and those diagnosed with AHF were selected&#46; In hospitalized patients&#44; those diagnosed with AHF at discharge were collected&#46; As adverse events&#44; in-hospital and 30-day mortality&#44; and combined adverse event &#40;death or hospitalization&#41; at 30 days post-discharge were collected&#46; Adjusted odds ratios &#40;OR&#41; for association of demographic variables&#44; baseline status and constants at ED arrival with mortality and 30-day post-discharge adverse event were calculated&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We included 1&#44;155 patients with AHF &#40;annual incidence&#58; 26&#46;5 per 1000 inhabitants &#8805;<span class="elsevierStyleHsp" style=""></span>65 years&#44; 95&#37;<span class="elsevierStyleSmallCaps">C</span>I&#58; 25&#46;0-28&#46;1&#41;&#46; In 86&#37; the diagnosis of AHF was known at discharge&#46; Overall 30-day mortality was 10&#46;7&#37; and in-hospital mortality was 7&#46;9&#37;&#44; and the combined event in 15&#46;6&#37;&#46; In-hospital and 30-day mortality was associated with arterial hypotension &#40;adjusted OR&#58; 74&#46;0&#44; 95&#37;CI&#58; 5&#46;39-1015&#46; and 42&#46;6&#44; 3&#46;74-485&#44; respectively and hypoxemia &#40;2&#46;14&#44; 1&#46;27-3&#46;61&#59; and 1&#46;87&#44; 1&#46;19-2&#46;93&#41; on arrival at the ED and requiring assistance with ambulation &#40;2&#46;24&#44; 1&#46;04-4&#46;83&#59; and 2&#46;48&#44; 1&#46;27-4&#46;86&#41; and age &#40;per 10-year increment&#59; 1&#46;54&#44; 1&#46;04-2&#46;29&#59; and 1&#46;60&#44; 1&#46;13-2&#46;28&#41;&#46; The combined post-discharge adverse event was not associated with any characteristic&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">AHF is a frequent diagnosis in elderly patients consulting in the ED&#46; The functional impairment&#44; age&#44; hypotension and hypoxemia are the factors most associated with mortality&#46;</p></span>"
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            "apendice" => "<p id="par0165" class="elsevierStylePara elsevierViewall">Hospital Cl&#237;nico San Carlos&#44; Madrid&#58; Juan Gonz&#225;lez del Castillo&#44; Ces&#225;reo Fern&#225;ndez Alonso&#44; Jorge Garc&#237;a Lamberechts&#44; Paula Queiz&#225;n Garc&#237;a&#44; Andrea B&#46; Bravo Periago&#44; Blanca Andrea Gallardo S&#225;nchez&#44; Alejandro Melcon Villalibre&#44; Sara Vargas Lob&#233;&#44; Laura Fern&#225;ndez Garc&#237;a&#44; Beatriz Escudero Bl&#225;zquez&#44; Estrella Serrano Molina&#44; Julia Barrado Cuchillo&#44; Leire Paramas L&#243;pez&#44; Ana Chac&#243;n Garc&#237;a&#46;</p> <p id="par0170" class="elsevierStylePara elsevierViewall">Hospital Universitario Infanta Cristina&#44; Parla&#58; &#193;ngel Iv&#225;n Diaz Salado&#44; Beatriz Honrado Gal&#225;n&#44; Sandra Moreno Ru&#237;z&#46;</p> <p id="par0175" class="elsevierStylePara elsevierViewall">Hospital Santa Tecla&#44; Tarragona&#58; Enrique Mart&#237;n Mojarro&#44; Lidia Cuevas Jim&#233;nez&#46;</p> <p id="par0180" class="elsevierStylePara elsevierViewall">Hospital Universitario de Canarias&#44; Tenerife&#58; Guillermo Burillo Putze&#44; Aarati Vaswani-Bulchand&#44; Patricia Eiroa-Hern&#225;ndez&#46;</p> <p id="par0185" class="elsevierStylePara elsevierViewall">Hospital Norte Tenerife&#58; Patricia Parra-Esquivel&#44; Montserrat Rodr&#237;guez-Cabrera&#46;</p> <p id="par0190" class="elsevierStylePara elsevierViewall">Hospital General Universitario Reina Sof&#237;a&#44; Murcia&#58; Pascual Pi&#241;era Salmer&#243;n&#44; Jos&#233; Andr&#233;s S&#225;nchez Nicol&#225;s&#44; Yurena Reverte Pag&#225;n&#44; Lorena Bernab&#233; Vera&#44; Juan Jos&#233; L&#243;pez P&#233;rez&#46;</p> <p id="par0195" class="elsevierStylePara elsevierViewall">Hospital Universitario del Henares&#44; Madrid&#58; Mart&#237;n Ruiz Grinspan&#44; Crist&#243;bal Rodr&#237;guez Leal&#44; Roc&#237;o Mart&#237;nez Avil&#233;s&#44; Mar&#237;a Luisa P&#233;rez D&#237;az-Guerra&#46;</p> <p id="par0200" class="elsevierStylePara elsevierViewall">Hospital Cl&#237;nic&#44; Barcelona&#58; &#210;scar Mir&#44; S&#242;nia Jim&#233;nez&#44; Sira Aguil&#243; Mir&#44; Francesc Xavier Alemany Gonz&#225;lez&#44; Mar&#237;a Florencia Poblete Palacios&#44; Claudia Lorena Amarilla Molinas&#44; Ivet Gina Osorio Quispe&#44; Sandra Cuerpo Carde&#241;osa&#46;</p> <p id="par0205" class="elsevierStylePara elsevierViewall">Hospital Universitario y Polit&#233;cnico La Fe&#44; Valencia&#58; Leticia Serrano L&#225;zaro&#44; Javier Mill&#225;n Soria&#44; J&#233;sica Mansilla Collado&#44; Mar&#237;a B&#243;veda Garc&#237;a&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall">Hospital Universitario Dr&#46; Balmis&#44; Alicante&#58; Pere Llorens Soriano&#44; Adriana Gil Rodrigo&#44; Bego&#241;a Espinosa Fern&#225;ndez&#44; M&#243;nica Veguillas Benito&#44; Sergio Guzm&#225;n Mart&#237;nez&#44; Gema Jara Torres&#44; Mar&#237;a Caballero Mart&#237;nez&#46;</p> <p id="par0215" class="elsevierStylePara elsevierViewall">Hospital Universitario de Bellvitge&#44; L&#8217;Hospitalet de Llobregat&#44; Barcelona&#58; Javier Jacob Rodr&#237;guez&#44; Ferran Llopis&#44; Elena Fuentes&#44; Lidia Fuentes&#44; Francisco Chamorro&#44; Lara Guillen&#44; Nieves L&#243;pez&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall">Hospital de Axiarquia&#44; M&#225;laga&#58; Coral Suero M&#233;ndez&#44; Luc&#237;a Zambrano Serrano&#44; Roc&#237;o Lorenzo &#193;lvarez&#46;</p> <p id="par0225" class="elsevierStylePara elsevierViewall">Hospital Regional Universitario de M&#225;laga&#58; Manuel Salido Mota&#44; Valle Toro Gallardo&#44; Antonio Real L&#243;pez&#44; Luc&#237;a Oca&#241;a Mart&#237;nez&#44; Esther Mu&#241;oz Soler&#44; Mario Lozano S&#225;nchez&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall">Hospital Santa Barbara&#44; Soria&#58; Fahd Beddar Chaib&#44; Rodrigo Javier Gil Hern&#225;ndez&#46;</p> <p id="par0235" class="elsevierStylePara elsevierViewall">Hospital Valle de los Pedroches&#44; Pozoblanco&#44; C&#243;rdoba&#58; Jorge Pedraza Garc&#237;a&#44; Paula Pedraza Ram&#237;rez&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall">Hospital Universitario Reina Sof&#237;a&#44; C&#243;rdoba&#58; F&#46; Javier Montero-P&#233;rez&#44; Carmen Lucena Aguilera&#44; F&#46; de Borja Quero Espinosa&#44; &#193;ngela Cobos Requena&#44; Esperanza Mu&#241;oz Triano&#44; Inmaculada Bajo Fern&#225;ndez&#44; Mar&#237;a Calder&#243;n Caro&#44; Sierra Bretones Baena&#46;</p> <p id="par0245" class="elsevierStylePara elsevierViewall">Hospital Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#58; Esther Gargallo Garc&#237;a&#44; Leonor Andr&#233;s Beri&#225;n&#44; Mar&#237;a Esther Mart&#237;nez Larrull&#44; Susana Gordo Remart&#237;nez&#44; Ana Isabel Castuera Gil&#44; Laura Mart&#237;n Gonz&#225;lez&#44; Melisa San Juli&#225;n Romero&#44; Montserrat Jim&#233;nez Lucena&#44; Mar&#237;a Dolores Pulfer&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall">Hospital Universitario de Burgos&#58; Pilar L&#243;pez Diez&#44; M&#243;nica de Diego Arnaiz&#44; Ver&#243;nica Castro Jim&#233;nez&#44; Luc&#237;a Gonz&#225;lez Ferreira&#44; Roc&#237;o Hernando Gonz&#225;lez&#44; Mar&#237;a Eugenia Rodr&#237;guez Palma&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall">Complejo Asistencial Universitario de Le&#243;n&#58; Marta Iglesias Vela&#44; Rudiger Carlos Ch&#225;vez Flores&#44; Alberto &#193;lvarez Madrigal&#44; Albert Carb&#243; Jord&#225;&#44; Enrique Gonz&#225;lez Revuelta&#44; H&#233;ctor Lago Gancedo&#44; Miguel Moreno Mart&#237;n&#44; M&#46; Isabel Fern&#225;ndez Gonz&#225;lez&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall">Hospital Universitario Morales Meseguer&#44; Murcia&#58; Rafael Antonio P&#233;rez-Costa&#44; Mar&#237;a Rodr&#237;guez Romero&#44; Esperanza Mar&#237;n Arranz&#44; Sara Barnes Parra&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall">Hospital Francesc de Borja de Gand&#237;a&#44; Valencia&#58; Mar&#237;a Jos&#233; Fortuny Bayarri&#44; Elena Quesada Rodr&#237;guez&#44; Lorena Hern&#225;ndez Taboas&#44; Alicia Sara Knabe&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall">Hospital Universitario Severo Ochoa&#44; Legan&#233;s&#44; Madrid&#58; Beatriz Valle Borrego&#44; Julia Mart&#237;nez-Ibarreta Zorita&#44; Irene Cabrera Rodrigo&#44; Beatriz Ma&#241;ero Criado&#44; Raquel Torres G&#225;rate&#44; Rebeca Gonz&#225;lez Gonz&#225;lez&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall">Hospital Cl&#237;nico Universitario Virgen Arrixaca&#44; Murcia&#58; Eva Quero Motto&#44; Nuria Tomas Garc&#237;a&#44; Lilia Amer Al Arud&#44; Miguel Parra Morata&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall">Hospital Universitario Lorenzo Guirao&#44; Cieza&#44; Murcia&#58; Carmen Escudero S&#225;nchez&#44; Bel&#233;n Morales Franco&#44; Jos&#233; Joaqu&#237;n Gim&#233;nez Bell&#243;&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall">Hospital Universitario Dr&#46; Josep Trueta&#44; Girona&#58; Mar&#237;a Adroher Mu&#241;oz&#44; Ester Soy Ferrer&#44; Eduard Anton Poch Ferrer&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall">Hospital de Mendaro&#44; Guipuzkoa&#58; Jeong-Uh Hong Cho&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall">Hospital Universitario Miguel Servet&#44; Zaragoza&#58; Rafael Marr&#243;n&#44; Cristina Mart&#237;n Dur&#225;n&#44; Fernando L&#243;pez L&#243;pez&#44; Alberto Guillen Bove&#44; Violeta Gonz&#225;lez Guill&#233;n&#44; Mar&#237;a Diamanti&#44; Beatriz Casado Ram&#243;n&#44; Ana Herrer Castej&#243;n&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall">Hospital Comarcal El Escorial&#44; Madrid&#58; Sara Gayoso Mart&#237;n&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall">Hospital Do Salnes&#44; Villagarcia de Arosa&#44; Pontevedra&#58; Mar&#237;a Goretti S&#225;nchez Sind&#237;n&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall">Hospital de Barbanza&#44; Ribeira&#44; A Coru&#241;a&#58; Azucena Prieto Zapico&#44; Mar&#237;a Esther Fern&#225;ndez &#193;lvarez&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall">Hospital del Mar&#44; Barcelona&#58; Isabel Cirera&#44; B&#225;rbara G&#243;mez y G&#243;mez&#44; Carmen Petrus Rivas&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall">Hospital Santa Creu y Sant Pau&#44; Barcelona&#58; Aitor Alquezar Arb&#233;&#44; Miguel Rizzi&#44; Marta Bl&#225;zquez Andion&#44; Carlos Romero Carret&#44; Sergio P&#233;rez Baena&#44; Laura Lozano Polo&#44; Roser Arenos Sambro&#44; Jos&#233; Mar&#237;a Guardiola Tey&#44; Carme Beltr&#225;n Vilagrasa&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall">Hospital de Vic&#44; Barcelona&#58; Llu&#237;s Llauger&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall">Hospital Valle del Nal&#243;n&#44; Langreo&#44; Asturias&#58; Ana Murcia Olag&#252;enaga&#44; Celia Rodr&#237;guez Valles&#44; Ver&#243;nica V&#225;zquez Rey&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall">Hospital Altagracia&#44; Manzanares&#44; Cuidad Real&#58; Elena Carrasco Fern&#225;ndez&#44; Sara Calle Fern&#225;ndez&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall">Hospital Nuestra Se&#241;ora del Prado de Talavera de la Reina&#44; Toledo&#58; Ricardo Ju&#225;rez Gonz&#225;lez&#44; Mar Sousa&#44; Laura Molina&#44; M&#243;nica Ca&#241;ete&#46;</p> <p id="par0345" class="elsevierStylePara elsevierViewall">Hospital Universitario Vinalop&#243;&#44; Elche&#44; Alicante&#58; Esther Ruescas&#44; Mar&#237;a Mart&#237;nez Juan&#44; Pedro Ruiz Asensio&#44; Mar&#237;a Jos&#233; Blanco Hoffman&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall">Hospital de M&#243;stoles&#44; Madrid&#58; F&#225;tima Fern&#225;ndez Salgado&#44; Eva de las Nieves Rodr&#237;guez&#44; Gema G&#243;mez Garc&#237;a&#44; Beatriz Paderne D&#237;az&#46;</p>"
            "etiqueta" => "Anexo A"
            "titulo" => "Miembros de la red SIESTA"
            "identificador" => "sec0075"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Los valores en negrita denotan significaci&#243;n estad&#237;stica &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">ICC&#58; &#237;ndice de comorbilidad de Charlson&#46; RI&#58; rango intercuartil&#46;</p>"
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                  \t\t\t\t">0&#44;234&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#205;ndice de comorbilidad de Charlson &#40;ICC&#44; puntos&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">659 &#40;85&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">569 &#40;85&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;82&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insuficiencia cardiaca cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">715 &#40;61&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">235 &#40;61&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">480 &#40;62&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;912&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">432 &#40;65&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">48 &#40;44&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">644 &#40;56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200 &#40;52&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">444 &#40;57&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">377 &#40;56&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;61&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;297&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">459 &#40;39&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">144 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">315 &#40;40&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;343&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">273 &#40;41&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">42 &#40;38&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">375 &#40;32&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;31&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">254 &#40;32&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;718&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">228 &#40;34&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;23&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neumopat&#237;a cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">361 &#40;31&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106 &#40;27&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">255 &#40;32&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;077&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">214 &#40;32&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;37&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad renal cr&#243;nica &#40;creatinina &#8805;<span class="elsevierStyleHsp" style=""></span>2 mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">299 &#40;25&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;23&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">208 &#40;26&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;276&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;28&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">20 &#40;18&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad cerebrovascular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">201 &#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132 &#40;17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;656&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112 &#40;16&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;18&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;698&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad vascular perif&#233;rica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">199 &#40;17&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;14&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">145 &#40;18&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;19&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;365&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neoplasia activa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">193 &#40;16&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;16&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;823&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107 &#40;16&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;19&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;408&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cirrosis hepatica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;586&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Situaci&#243;n basal</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#250;mero de f&#225;rmacos cr&#243;nicos &#40;mediana&#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;6-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;838&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">682 &#40;59&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207 &#40;54&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">475 &#40;61&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">407 &#40;61&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;62&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;814&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para la deambulaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">604 &#40;52&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">189 &#40;49&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">415 &#40;53&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;199&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">353 &#40;53&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;56&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;461&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de demencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">214 &#40;18&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;17&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">148 &#40;19&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;459&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120 &#40;18&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;25&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;060&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;10&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;406&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ca&#237;das los seis meses previos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;5&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;617&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;882&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica &#40;mmHg&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">137 &#40;120-154&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia cardiaca &#40;lpm&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">82 &#40;70-100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;70-98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;71-100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;313&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">83 &#40;71-100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;70-98&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;044&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Saturaci&#243;n de ox&#237;geno &#40;&#37;&#41; &#40;mediana &#91;RIC&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95 &#40;93-97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94 &#40;90-97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94 &#40;90-97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95 &#40;93-97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">73&#44;976&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para deambular o no deambula&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;244&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;042&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4&#44;833&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoxemia &#40;saturaci&#243;n basal de ox&#237;geno de la hemoglobina &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;144&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#44;272&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">3&#44;613&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de deterioro cognitivo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;605&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;904&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#44;849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbilidad grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;544&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;628&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;por cada incremento de 10 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;294&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;284&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;550&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;728&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;399&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;938&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;056&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;634&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;759&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Caidas seis meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;403&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;512&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Depresion basal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;876&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;845&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipotensi&#243;n arterial &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;696&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;343&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polifarmacia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;625&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;352&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100 lpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;575&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mortalidad a 30 d&#237;as &#40;todos los pacientes&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiptotensi&#243;n arterial &#40;PAS &#60;<span class="elsevierStyleHsp" style=""></span>80 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#44;605&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;739&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">485&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para deambular o no deambula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;481&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;266&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;861&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoxemia &#40;saturaci&#243;n basal de ox&#237;geno de la hemoglobina &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;870&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;194&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;927&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de deterioro cognitivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;653&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;992&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;757&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;por cada incremento de 10 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;602&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;127&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;276&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbilidad grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;572&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;515&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;385&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;574&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;337&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;619&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;520&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100 lpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;222&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;443&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;752&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;835&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;681&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;893&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de ca&#237;das los seis meses previos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;856&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;363&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polifarmacia grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>10 f&#225;rmacos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;683&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;501&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;070&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crisis hipertensiva &#40;PAS &#62;<span class="elsevierStyleHsp" style=""></span>160 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;708&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;383&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Evento combinado a los 30 d&#237;as posalta &#40;pacientes dados de alta&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bradicardia &#40;&#60;<span class="elsevierStyleHsp" style=""></span>50 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100 lpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;647&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoxemia &#40;saturaci&#243;n basal de ox&#237;geno de la hemoglobina &#60;<span class="elsevierStyleHsp" style=""></span>95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;404&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;950&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;074&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Precisa ayuda para deambular o no deambula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;403&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;810&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;432&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>100 lpm&#41; &#40;comparado con frecuencia cardiaca entre 50 y 100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;830&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;057&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polifarmacia grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>10 f&#225;rmacos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;805&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;por cada incremento de 10 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;843&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;522&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbilidad grave &#40;&#62;<span class="elsevierStyleHsp" style=""></span>4 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;699&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;734&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;051&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;696&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;585&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;968&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;532&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;763&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de deterioro cognitivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;889&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;517&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;530&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes de ca&#237;das los seis meses previos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;678&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;278&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;658&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiptotensi&#243;n arterial &#40;PAS &#60;<span class="elsevierStyleHsp" style=""></span>80 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;576&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;327&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;425&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;095&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crisis hipertensiva &#40;PAS &#62;<span class="elsevierStyleHsp" style=""></span>160 mmHg&#41; &#40;comparado con PAS entre 80 y 160 mmHg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;c&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A&#241;o de inclusi&#243;n de los pacientes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2019&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2007-2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#250;mero de pacientes inclu&#237;dos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18&#46;283&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#46;480&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;638&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad de inclusi&#243;n de los pacientes analizados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad &#40;a&#241;os&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidad</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insuficiencia cardiaca cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">61&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">63&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">71&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">56&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">44&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">45&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">39&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">41&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">38&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">32&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">28&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neumopat&#237;a cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">23&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">23&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad renal cr&#243;nica &#40;creatinina &#8805;<span class="elsevierStyleHsp" style=""></span>2 mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad cerebrovascular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">11&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad vascular perif&#233;rica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">8&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neoplasia activa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">13&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cirrosis hep&#225;tica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Situaci&#243;n basal</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Clase NYHA III-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">37&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>FEVI &#60;<span class="elsevierStyleHsp" style=""></span>50&#37; &#40;media&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">30&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">50<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;35-60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#205;ndice de comorbilidad de Charlson &#40;ICC&#44; puntos&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro funcional &#40;&#237;ndice de Barthel &#60;<span class="elsevierStyleHsp" style=""></span>100 puntos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">59&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;75-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#250;mero de f&#225;rmacos cr&#243;nicos &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagn&#243;stico previo de demencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">5&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Constantes vitales a la llegada a urgencias</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica &#40;mmHg&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">138&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia cardiaca &#40;lpm&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Saturaci&#243;n de ox&#237;geno &#40;&#37;&#41; &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Eventos adversos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mortalidad intrahospitalaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mortalidad a 30 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Muerte u hospitalizaci&#243;n a 30 d&#237;as posalta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;7<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Mortalidad calculada al a&#241;o posalta&#46;</p>"
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          "es" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Comparaci&#243;n entre hallazgos en EDEN-34&#44; registro EAHFE y registro RICA para algunas variables de los pacientes con insuficiencia cardiaca aguda</p>"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a de la insuficiencia card&#237;aca"
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                          "etal" => false
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                            0 => "F&#46; Rodr&#237;guez-Artalejo"
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                  "referenciaCompleta" => "Encuesta de morbilidad hospitalaria 2021&#46; Instituto Nacional de Estad&#237;stica&#46; &#91;consultado 7 Ene 2024&#93;&#46; Disponible en&#58; <a target="_blank" href="https://www.ine.es/dyngs/INEbase/es/operacion.htm?c=Estadistica_C%26cid=1254736176778%26menu=ultiDatos%26idp=1254735573175">https&#58;&#47;&#47;www&#46;ine&#46;es&#47;dyngs&#47;INEbase&#47;es&#47;operacion&#46;htm&#63;c&#61;Estadistica&#95;C&#38;cid&#61;1254736176778&#38;menu&#61;ultiDatos&#38;idp&#61;1254735573175</a>&#46;"
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                      "titulo" => "Prevalence of heart failure in Asturias &#40;a region in the North of Spain&#41;"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Cortina"
                            1 => "J&#46; Reguero"
                            2 => "E&#46; Segovia"
                            3 => "J&#46;L&#46; Rodr&#237;guez Lambert"
                            4 => "R&#46; Cortina"
                            5 => "J&#46;C&#46; Arias"
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                      "doi" => "10.1016/s0002-9149(01)01568-5"
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                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a y tratamiento de la insuficiencia cardiaca en Espa&#241;a&#58; estudio PATHWAYS-HF"
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                          "etal" => false
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                            0 => "A&#46; Sicras-Mainar"
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                            2 => "B&#46; Palacios"
                            3 => "L&#46; Varela"
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                      "doi" => "10.1016/j.rec.2020.09.033"
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Información del artículo
ISSN: 00142565
Idioma original: Español
DOI:10.1016/j.rce.2024.02.003
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