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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n del diagn&#243;stico cl&#237;nico de COVID-19&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel A</span>&#46; Diagn&#243;stico diario de COVID-19 &#40;el gr&#225;fico representa para cada fecha la media m&#243;vil de 7 d&#237;as<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>n&#250;mero de diagn&#243;stico diario de la semana anterior&#41; en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel B</span>&#46; Tasa de incidencia acumulada del nuevo diagn&#243;stico cl&#237;nico COVID-19 por regi&#243;n del mundo en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0255" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introducci&#243;n</span><p id="par0040" class="elsevierStylePara elsevierViewall">La pandemia COVID-19 representa un tremendo desaf&#237;o para la humanidad&#44; con dram&#225;ticas consecuencias sanitarias y econ&#243;micas<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; Informes recientes han puesto de relieve el aumento de la mortalidad relacionada con la COVID-19 entre los migrantes y las minor&#237;as &#233;tnicas en diversos pa&#237;ses occidentales<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">4&#8211;10</span></a>&#46; Sin embargo&#44; los resultados cl&#237;nicos &#8212;la mortalidad en particular&#8212; asociados con las minor&#237;as &#233;tnicas est&#225;n inextricablemente relacionados con la situaci&#243;n socioecon&#243;mica&#44; la comorbilidad y el acceso desigual a los servicios m&#233;dicos<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">11&#8211;14</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se han emitido diversos informes en los medios de comunicaci&#243;n y llamadas a la acci&#243;n a este respecto&#44; pero muy pocas publicaciones cient&#237;ficas s&#243;lidas abordan esta cuesti&#243;n&#46; Adem&#225;s&#44; la mayor&#237;a de los estudios publicados provienen de Estados Unidos o el Reino Unido y pr&#225;cticamente ninguno de otros pa&#237;ses europeos<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">15&#8211;18</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En este trabajo describimos la incidencia de COVID-19 en la primera oleada de la enfermedad entre espa&#241;oles y migrantes de diferentes zonas del mundo que viven en Alcorc&#243;n&#44; una ciudad de la periferia de Madrid &#40;Espa&#241;a&#41; con un n&#250;mero considerable de residentes extranjeros&#46; Las diferentes proporciones de migrantes de diversas zonas del mundo pueden proporcionar una oportunidad para evaluar el riesgo de COVID-19 en estas poblaciones&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">M&#233;todos</span><p id="par0055" class="elsevierStylePara elsevierViewall">Estudio de cohorte poblacional realizado en Alcorc&#243;n &#40;Madrid&#41;&#44; que cuenta con una poblaci&#243;n censada total de unos 170&#46;000 habitantes&#46; La poblaci&#243;n en riesgo se defini&#243; como todos los adultos inscritos en el censo municipal del Ayuntamiento de Alcorc&#243;n &#40;&#250;ltima actualizaci&#243;n el 14 de marzo de 2020&#41;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#46; De este censo se obtuvo la distribuci&#243;n de la poblaci&#243;n por nacionalidad y pa&#237;s de origen&#44; estratificada por edad y sexo&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">El caso se defini&#243; como un paciente con un diagn&#243;stico de COVID-19 realizado en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n y confirmado mediante transcripci&#243;n inversa-reacci&#243;n en cadena de la polimerasa &#40;RT-PCR&#41; para SARS-CoV-2 entre adultos residentes en Alcorc&#243;n&#46; Los casos COVID-19 se obtuvieron de la historia cl&#237;nica electr&#243;nica &#40;Selene&#169;&#41;&#46; El diagn&#243;stico cl&#237;nico de COVID-19 fue realizado por los m&#233;dicos del Servicio de Urgencias seg&#250;n los criterios del Centro Europeo para el Control y la Prevenci&#243;n de Enfermedades &#40;ECDCP&#41;-Organizaci&#243;n Mundial de la Salud &#40;OMS&#41;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Para el diagn&#243;stico molecular de la infecci&#243;n por SARS-CoV-2&#44; se procesaron los hisopos nasofar&#237;ngeos de pacientes sintom&#225;ticos mediante extracci&#243;n automatizada con el uso de MagNa Pure LC &#40;Roche Applied Science&#44; Mannheim&#44; Alemania&#41; y RT-PCR en tiempo real &#40;rRT-PCR&#41; utilizando el kit de detecci&#243;n de &#225;cido nucleico VAVA SARS-CoV-2 de VAISURE &#40;CerTest Biotec S&#46;L&#46;&#41;&#44; de acuerdo con las instrucciones del fabricante&#46; Para esta rRT-PCR&#44; se utiliz&#243; Bio-Rad CFX96&#8482; sistema de detecci&#243;n de PCR en tiempo real&#46; Se amplificaron dos regiones virales diferentes&#58; el gen ORF1ab &#40;canal FAM&#41; y el gen N &#40;canal ROX&#41; junto al control interno &#40;canal HEX&#41;&#46; Se consideraron positivos los resultados obtenidos en ciclos de &#61;<span class="elsevierStyleHsp" style=""></span>40&#46; Se incluyeron controles positivos y negativos en cada tanda de ensayos&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Se extrajo un conjunto anonimizado de datos de las historias cl&#237;nicas electr&#243;nicas &#40;del 1 de febrero al 25 de abril&#41; que incluy&#243; los siguientes par&#225;metros&#58; edad&#44; sexo&#44; pa&#237;s de origen&#44; ciudad de residencia&#44; fecha del diagn&#243;stico COVID-19 &#40;cl&#237;nico&#41;&#44; fecha y resultados de la PCR SARS-CoV-2&#44; y evoluci&#243;n cl&#237;nica &#40;ingreso hospitalario&#44; ingreso en unidad de cuidados cr&#237;ticos&#44; alta&#44; duraci&#243;n de la estancia hospitalaria y muerte intrahospitalaria&#41;&#46; Para este estudio&#44; se excluyeron los pacientes con residencia distinta de la ciudad de Alcorc&#243;n&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Se clasific&#243; a los pacientes seg&#250;n su pa&#237;s de origen en uno de los siguientes grupos&#58; a&#41; Espa&#241;a&#44; b&#41; Uni&#243;n Europea &#40;incluyendo Suiza y Noruega&#41;&#44; c&#41; Europa oriental &#40;incluida Rusia&#41;&#44; d&#41; Asia&#44; e&#41; Australia y Nueva Zelanda&#44; f&#41; Norte de &#193;frica&#44; g&#41; &#193;frica subsahariana&#44; h&#41; Am&#233;rica Latina &#40;M&#233;xico y pa&#237;ses continentales de Am&#233;rica Latina&#41;&#44; i&#41; Caribe&#44; y j&#41; Estados Unidos y Canad&#225;&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Estad&#237;stica</span><p id="par0080" class="elsevierStylePara elsevierViewall">Los resultados se muestran como media &#40;&#177; desviaci&#243;n est&#225;ndar&#41;&#44; medianas &#40;rango intercuart&#237;lico &#91;RIC&#93;&#41; o porcentajes&#44; seg&#250;n corresponda&#46; Las variables cuantitativas se compararon utilizando la prueba t de Student&#44; ANOVA o la prueba U de Mann-Whitney&#44; seg&#250;n procediera&#46; Las variables cualitativas se compararon utilizando la prueba de chi-cuadrado o la prueba exacta de Fisher&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Los datos agregados se analizaron seg&#250;n el &#225;rea &#40;o pa&#237;s&#41; de origen mundial&#44; sexo y grupo de edad &#40;&#60;<span class="elsevierStyleHsp" style=""></span>30&#44; 30-39&#44; 40-49&#44; 50-59&#44; 60-69&#44; 70-79&#44; 80-89 y &#61;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41;&#46; Se calcularon las tasas de incidencia y los intervalos de confianza exactos de Poisson del 95&#37;&#46; Se utiliz&#243; un modelo de regresi&#243;n binomial negativa multivariante con varianza robusta para estimar la tasa de incidencia por &#225;rea mundial ajustada por sexo y edad&#46; Estos modelos son apropiados para analizar los datos de recuento con sobredispersi&#243;n<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">21&#44;22</span></a>&#46; Se asumi&#243; la significaci&#243;n estad&#237;stica para los valores p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Todos los an&#225;lisis se realizaron con Stata 14 &#40;StataCorp LLC&#44; Texas&#44; EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46;&#41;&#46; El protocolo fue aprobado por el Comit&#233; &#201;tico de Investigaci&#243;n con medicamentos &#40;CEIm&#41; del centro&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0090" class="elsevierStylePara elsevierViewall">El censo del municipio de Alcorc&#243;n inclu&#237;a 152&#46;018 personas mayores de 17<span class="elsevierStyleHsp" style=""></span>a&#241;os a fecha de 14 de marzo de 2020<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#46; Entre ellos&#44; 20&#46;419 &#40;13&#44;4&#37;&#41; residentes ten&#237;an una nacionalidad distinta de la espa&#241;ola&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se resumen los pa&#237;ses de origen &#40;y las zonas asociadas del mundo&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Se eligieron las diferentes &#225;reas del mundo por razones geogr&#225;ficas&#44; socioecon&#243;micas y de origen &#233;tnico&#44; siempre que hubiera un m&#237;nimo de 500 individuos por &#225;rea&#46; Hab&#237;a menos de 200 migrantes de Estados Unidos&#44; Canad&#225;&#44; Australia y Nueva Zelanda y&#44; por tanto&#44; se excluyeron del an&#225;lisis&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Los migrantes eran sustancialmente m&#225;s j&#243;venes que los espa&#241;oles &#40;mediana de edad 40<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 30-50&#93; frente a 49&#44;5<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 38-67&#93;&#44; respectivamente &#91;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 1</a>&#93;&#41; y hab&#237;a una proporci&#243;n ligeramente mayor de hombres &#40;48&#44;7&#37; vs&#46; 47&#44;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41;&#46; De hecho&#44; las pir&#225;mides de distribuci&#243;n de edad en la poblaci&#243;n de referencia para espa&#241;oles y migrantes fueron notablemente diferentes &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 2</a>&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Entre el 1 de febrero y el 25 de abril de 2020 se diagnosticaron en nuestro hospital un total de 1&#46;691 residentes en Alcorc&#243;n de COVID-19 seg&#250;n criterios cl&#237;nicos ECDCP-OMS<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>A&#41;&#46; El n&#250;mero de casos aument&#243; constantemente hasta finales de marzo y luego comenz&#243; a decaer aproximadamente 2 semanas despu&#233;s del confinamiento decretado por el gobierno espa&#241;ol el 14 de marzo de 2020 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">23</span></a>&#46; Para evitar posibles diagn&#243;sticos err&#243;neos&#44; limitamos nuestro an&#225;lisis a los 1&#46;036 casos con una PCR positiva para SARS-CoV-2 &#40;casos COVID-19-PCR&#43;&#41;&#46; La mediana de edad de los pacientes con COVID-19-PCR&#43; fue de 71<span class="elsevierStyleHsp" style=""></span>a&#241;os &#40;RIC 54-79&#41; y el 57&#44;2&#37; eran varones&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">La incidencia global acumulada de COVID-19-PCR&#43; fue de 6&#44;81 por cada 1&#46;000 habitantes&#46; La incidencia global acumulada de COVID-19-PCR&#43; para espa&#241;oles fue de 6&#44;50 casos por cada 1&#46;000 habitantes&#44; frente a 8&#44;82 por 1&#46;000 para los no espa&#241;oles &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">La edad de los espa&#241;oles COVID-19-PCR&#43; fue sustancialmente mayor que la de los migrantes &#40;mediana de edad 73<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 62-80&#93; vs&#46; 51&#44;5 &#91;RIC 41&#44;7-58&#93;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; con una mayor proporci&#243;n de varones&#44; aunque este hallazgo no fue estad&#237;sticamente significativo &#40;58&#44;6&#37; vs&#46; 52&#44;5&#37;&#59; p &#61; 0&#44;15&#41; &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 3</a>&#41;&#46; La incidencia acumulada global aument&#243; dr&#225;sticamente con la edad tanto en espa&#241;oles como en migrantes &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 3A</a>&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A continuaci&#243;n&#44; evaluamos la incidencia acumulada de COVID-19-PCR&#43; para nativos de diferentes regiones del mundo en comparaci&#243;n con la de los espa&#241;oles &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;&#46; Las tasas de incidencia no ajustadas para individuos de Europa&#44; Asia y el norte de &#193;frica fueron m&#225;s bajas que la media&#44; mientras que las tasas para las personas procedentes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina fueron m&#225;s elevadas&#46; Las tasas de incidencia acumuladas para la mayor&#237;a de los pa&#237;ses representativos se muestran en la <a class="elsevierStyleCrossRef" href="#sec0050">tabla suplementaria 1</a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Con el fin de comprender mejor los riesgos para los espa&#241;oles y los migrantes de diferentes regiones del mundo&#44; realizamos un an&#225;lisis de regresi&#243;n binomial negativa multivariante<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">21&#44;22</span></a> ajustado para edad y sexo&#44; ya que estos factores son determinantes del riesgo de COVID-19 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; Los riesgos relativos ajustados para COVID-19-PCR&#43; entre los migrantes de Asia&#44; la Uni&#243;n Europea y Europa del Este no fueron significativamente distintos a los de los espa&#241;oles &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Por el contrario&#44; el riesgo relativo para los migrantes de Am&#233;rica Latina fue aproximadamente 7 veces mayor que el de los espa&#241;oles &#40;RR 6&#44;92&#59; IC 95&#37; 4&#44;49-10&#44;67&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Adem&#225;s&#44; el riesgo ajustado tambi&#233;n fue mayor en los migrantes procedentes del &#193;frica subsahariana &#40;RR 3&#44;66&#59; IC 95&#37; 1&#44;42-9&#44;41&#59; p &#61; 0&#44;007&#41; as&#237; como los del Caribe &#40;RR 6&#44;35&#59; IC 95&#37; 3&#44;83-10&#44;55&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; de modo altamente significativo&#44; cl&#237;nica y estad&#237;sticamente&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Realizamos un an&#225;lisis de sensibilidad &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#44; repitiendo la estimaci&#243;n de riesgo&#58; estimaci&#243;n con criterios m&#225;s amplios &#40;diagn&#243;stico cl&#237;nico independientemente de los resultados de la PCR&#59; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;691&#41; y criterios m&#225;s estrictos &#40;pacientes que requirieron ingreso hospitalario debido a COVID-19 moderada-grave&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>877&#41;&#46; En ambos casos&#44; los resultados se mantuvieron esencialmente inalterados&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Los riesgos de COVID-19 ajustados para los migrantes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina fueron aproximadamente 3&#44; 6 y 7 veces superiores a los de los espa&#241;oles en todos los escenarios cl&#237;nicos &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; De modo exploratorio&#44; realizamos un an&#225;lisis similar para los pa&#237;ses que ten&#237;an al menos 800 residentes en Alcorc&#243;n &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Los ciudadanos de Rumania&#44; Ucrania&#44; China y Marruecos no presentaron un aumento del riesgo de COVID-19 &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 4</a>&#41;&#46; En coherencia con su zona mundial&#44; los migrantes de todos los pa&#237;ses de Am&#233;rica Latina mostraron un aumento definido del riesgo de COVID-19&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">La COVID-19 grave&#44; definida como muerte&#44; ingreso en la unidad de cuidados intensivos o estancia hospitalaria de m&#225;s de 7 d&#237;as&#44; se produjo en el 63&#37; de los espa&#241;oles en comparaci&#243;n con el 33&#37; de los migrantes&#46; Del mismo modo&#44; la mortalidad no ajustada fue mayor para los espa&#241;oles &#40;25&#37; de los ingresos&#41; que para los migrantes &#40;6&#37;&#41;&#46; Este hallazgo refleja probablemente la edad avanzada de los pacientes con enfermedad grave &#40;mediana de edad 76<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 69-82&#93;&#41; o que fallecieron &#40;mediana de 79<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 74-85&#93;&#41;&#44; dado que este rango de edad est&#225; pr&#225;cticamente ausente en los migrantes &#40;<a class="elsevierStyleCrossRef" href="#sec0050">figs&#46; suplementarias 1 y 2</a>&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Nuestros datos no respaldan la idea de que los migrantes residentes en Espa&#241;a tienen una forma m&#225;s grave de COVID-19 que los espa&#241;oles&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discusi&#243;n</span><p id="par0155" class="elsevierStylePara elsevierViewall">Con una aproximaci&#243;n de base poblacional&#44; nuestros datos muestran que la incidencia de COVID-19 var&#237;a entre los migrantes de diferentes zonas del mundo y la poblaci&#243;n de referencia espa&#241;ola&#46; Un hallazgo relevante de nuestro trabajo es un aparente mayor riesgo para COVID-19 en los sujetos procedentes del &#193;frica subsahariana&#44; el Caribe o Am&#233;rica Latina en comparaci&#243;n con los migrantes de Europa&#44; Asia o el norte de &#193;frica&#44; o con los espa&#241;oles&#46; Los datos preliminares descritos en otros municipios de Madrid son coherentes con nuestros resultados<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a>&#46; Se detecta constantemente un riesgo m&#225;s elevado cuando la estimaci&#243;n se realiza ya sea globalmente para las regiones de origen mencionadas&#44; ya sea para determinados pa&#237;ses&#46; Este incremento de riesgo crudo aumenta claramente cuando se realizan ajustes por edad y sexo&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Tambi&#233;n encontramos un menor riesgo relativo no ajustado para COVID-19 para otros ciudadanos de la Uni&#243;n Europea en comparaci&#243;n con los espa&#241;oles&#46; Sin embargo&#44; los migrantes representan una poblaci&#243;n m&#225;s joven que la espa&#241;ola<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;25</span></a>&#44; como es el caso tambi&#233;n en nuestro entorno&#46; De hecho&#44; cuando se ajusta por edad y sexo&#44; el riesgo relativo para COVID-19 para los migrantes de Europa &#40;tanto de la Uni&#243;n Europea como de Europa del Este&#41; no difer&#237;a del de los espa&#241;oles&#46; An&#225;logamente&#44; la tasa de incidencia ajustada de COVID-19 en migrantes del norte de &#193;frica no difer&#237;a de la poblaci&#243;n de referencia espa&#241;ola&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Las razones que subyacen a este aparente aumento del riesgo de COVID-19 entre los migrantes de diferentes zonas del mundo no est&#225;n claras&#46; En primer lugar&#44; todos los migrantes tienen el mismo acceso a la cobertura sanitaria pr&#225;cticamente universal de que disponen tambi&#233;n los espa&#241;oles&#46; En segundo lugar&#44; la mayor&#237;a de los migrantes tienen empleos y estatus socioecon&#243;mico m&#225;s bajo que la poblaci&#243;n espa&#241;ola<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#44;27</span></a>&#44; lo que tambi&#233;n es cierto para los migrantes &#171;europeos&#187;&#44; ya que este grupo incluye principalmente a individuos de Ruman&#237;a y Ucrania en nuestra ciudad&#46; Una mayor prevalencia de hipertensi&#243;n u obesidad puede subyacer a un mayor riesgo para los migrantes del &#193;frica subsahariana o Am&#233;rica Latina&#44; tal como se ha descrito en negros o hispanos en Estados Unidos<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#46; Sin embargo&#44; en nuestro entorno&#44; los migrantes de estas &#225;reas no parecen tener una mayor prevalencia de obesidad&#44; hipertensi&#243;n&#44; diabetes o enfermedades cardiovasculares&#46; Esto puede estar relacionado con su edad m&#225;s joven y el llamado &#171;efecto migrante saludable&#187;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;25&#44;29&#44;30</span></a>&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene varias fortalezas&#46; La primera es su aproximaci&#243;n de base poblacional&#58; utilizamos el mejor registro actualizado disponible de las personas que viven en el &#225;rea de referencia &#40;censo municipal actualizado&#41;&#46; Es probable que la mayor&#237;a de los migrantes residentes en la zona est&#233;n incluidos en este registro&#44; ya que varios servicios sociales dependen del lugar de residencia actual<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">En segundo lugar&#44; nuestra estimaci&#243;n de la incidencia de COVID-19 en toda la poblaci&#243;n es razonable dado que la poblaci&#243;n a la que se asiste principalmente en nuestro hospital es precisamente la ciudad de Alcorc&#243;n y no hay otro hospital p&#250;blico en la ciudad<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">31</span></a>&#46; En una emergencia de salud p&#250;blica como la COVID-19 es probable que los residentes dependan a&#250;n m&#225;s de sus instalaciones sanitarias de proximidad&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">En cualquier caso&#44; es casi seguro que un n&#250;mero reducido de residentes de Alcorc&#243;n buscara atenci&#243;n por COVID-19 en hospitales diferentes al nuestro y&#44; por lo tanto&#44; nuestros datos son probablemente una subestimaci&#243;n de la incidencia real&#46; El 16&#37; de los casos COVID-19 atendidos en nuestro hospital no residentes en Alcorc&#243;n se excluyeron del an&#225;lisis&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Los datos oficiales del observatorio de resultados de la Comunidad de Madrid indican que nuestro hospital recibe un n&#250;mero ligeramente mayor de pacientes de otras zonas sanitarias que viceversa<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">31</span></a>&#46; En consecuencia&#44; nuestra subestimaci&#243;n de la incidencia de COVID-19 en Alcorc&#243;n puede estar entre el 10 y el 15&#37;&#46; No creemos que estos datos modifiquen sustancialmente la incidencia relativa de los migrantes&#44; dado que la proporci&#243;n de casos COVID-19 en los migrantes que fueron excluidos de nuestro estudio porque su residencia estaba fuera de Alcorc&#243;n fue esencialmente id&#233;ntica a la de los espa&#241;oles &#40;17&#37; vs&#46; 16&#37;&#44; respectivamente&#41;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Otra cuesti&#243;n cr&#237;tica es el acceso de los migrantes a la atenci&#243;n m&#233;dica&#46; Desde julio de 2018 todos los residentes en Espa&#241;a tienen acceso a atenci&#243;n m&#233;dica gratuita en condiciones pr&#225;cticamente id&#233;nticas a las de los espa&#241;oles<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">32</span></a>&#46; Se puede argumentar que algunos migrantes pueden depender menos de los m&#233;dicos de atenci&#243;n primaria&#44; lo que conduce a un uso desproporcionado de los servicios hospitalarios<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">25&#44;33</span></a>&#46; Sin embargo&#44; nuestro an&#225;lisis de sensibilidad&#44; que se limit&#243; a casos COVID-19 m&#225;s graves que requieren ingreso hospitalario&#44; no apoya este uso excesivo te&#243;rico de los recursos hospitalarios&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Nuestro estudio presenta tambi&#233;n algunas limitaciones&#46; En primer lugar&#44; no disponemos de datos locales sobre la situaci&#243;n socioecon&#243;mica&#44; el nivel educativo u otras condiciones de salud de los migrantes&#46; Sin embargo&#44; en conjunto&#44; los migrantes de Ruman&#237;a&#44; Ucrania y Marruecos que residen en Espa&#241;a pertenecen a una clase socioecon&#243;mica relativamente baja<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">27</span></a>&#44; al igual que los migrantes procedentes del &#193;frica subsahariana o Am&#233;rica Latina&#46; No obstante&#44; no se ha constatado que los primeros tengan un mayor riesgo de COVID-19&#44; mientras que los segundos s&#237; lo presentan&#44; lo que sugiere que la situaci&#243;n socioecon&#243;mica puede no ser una de las principales razones de las diferencias en la incidencia de COVID-19 entre los distintos grupos de migrantes&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Dado que los factores mencionados no parecen explicar adecuadamente este aumento de incidencia&#44; se debe prestar atenci&#243;n al origen &#233;tnico de las poblaciones&#46; Es interesante destacar que un informe reciente de una gran base de datos del Departamento de Veteranos de EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46; sugiere que las personas negras e hispanas en ese pa&#237;s tienen una carga excesiva de COVID-19 no explicada completamente por las condiciones m&#233;dicas subyacentes<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#44; lo que est&#225; de acuerdo con nuestros resultados&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Informes recientes de EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46; sugieren que el mayor riesgo descrito para la poblaci&#243;n negra no es extensible a la poblaci&#243;n de origen asi&#225;tico&#44; lo que tambi&#233;n concuerda con nuestros datos<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">34</span></a>&#46; Estos hallazgos apuntan a un papel del origen &#233;tnico en el aumento del riesgo de COVID-19 para determinadas poblaciones&#44; sin perjuicio de la importancia de otras razones socioecon&#243;micas&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Hay escasos datos sobre diferentes susceptibilidades a los virus respiratorios en personas de diferentes or&#237;genes &#233;tnicos&#46; Algunos estudios han sugerido que las minor&#237;as raciales tienen una mayor susceptibilidad a la gripe<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">35</span></a>&#46; Sin embargo&#44; muchos trabajos no han logrado disociar los resultados cl&#237;nicos de las cuestiones socioecon&#243;micas&#44; en particular el acceso desigual a la atenci&#243;n de la salud&#46; De hecho&#44; se est&#225;n empezando a explorar diferentes susceptibilidades a la COVID-19 basadas en antecedentes gen&#233;ticos que tienen una distribuci&#243;n desigual<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">36&#8211;38</span></a>&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Por &#250;ltimo&#44; nuestros datos no sugieren un mayor riesgo de mortalidad para los migrantes&#46; Cabe destacar que las personas negras e hispanas atendidas por el Departamento de Veteranos &#40;y&#44; por tanto&#44; con igual acceso a atenci&#243;n sanitaria&#41; no mostraron un aumento de la mortalidad<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#44; a diferencia de otros resultados descritos en otro contexto de atenci&#243;n sanitaria en Estados Unidos<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">6</span></a>&#46; Estos datos sugieren que el acceso a la atenci&#243;n sanitaria&#44; m&#225;s que la etnia&#44; puede ser el principal determinante de la supervivencia en COVID-19&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusiones</span><p id="par0225" class="elsevierStylePara elsevierViewall">Nuestro trabajo muestra un aumento selectivo del riesgo de COVID-19 entre ciertas poblaciones migrantes en Espa&#241;a&#44; incluidas las procedentes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina&#44; que no est&#225; relacionada con un acceso desigual a la atenci&#243;n sanitaria&#46; Estos grupos pueden merecer una atenci&#243;n especial&#44; sobre todo cuando nuestro pa&#237;s y otros est&#225;n experimentando un aumento de la incidencia de COVID-19 tras la desescalada de medidas de distanciamiento social extremas al final de la primera oleada COVID-19&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; nuestros datos sugieren una diferente susceptibilidad gen&#233;tica a la COVID-19 entre individuos de diferentes or&#237;genes &#233;tnicos&#44; un hallazgo que merece ser investigado con m&#225;s detalle&#46; Independientemente de las razones que subyacen al riesgo diferencial de COVID-19 en diferentes poblaciones migrantes&#44; nuestros datos sirven para ayudar a identificar individuos o grupos de riesgo particularmente elevado que pueden merecer una atenci&#243;n especial por razones cl&#237;nicas y epidemiol&#243;gicas&#46;</p></span><span id="sec1040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect1100">Financiaci&#243;n</span><p id="par1235" class="elsevierStylePara elsevierViewall">Financiado en parte con el Proyecto de Investigaci&#243;n del Instituto de Salud Carlos III&#58; COV20&#47;00644&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0235" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span><span id="sec3040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect3100">Agradecimientos</span><p id="par3235" class="elsevierStylePara elsevierViewall">Los autores agradecen al Dr&#46; Fernando Rodr&#237;guez Artalejo la revisi&#243;n cr&#237;tica del manuscrito&#46;</p></span></span>"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios sobre el potencial papel de los or&#237;genes raciales&#47;&#233;tnicos en el riesgo de infecci&#243;n de COVID-19&#44; particularmente en Europa&#46; Evaluamos el riesgo de COVID-19 entre los migrantes de diferentes zonas del mundo en un contexto de acceso universal gratuito a la atenci&#243;n m&#233;dica&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizamos un an&#225;lisis de cohortes poblacional de la incidencia acumulada de COVID-19 confirmada mediante PCR entre los residentes adultos en Alcorc&#243;n &#40;Espa&#241;a&#41; en la primera oleada de la enfermedad hasta el 25 de abril de 2020&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La incidencia acumulada bruta entre los migrantes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#46;419&#41; fue mayor que entre los espa&#241;oles &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>131&#46;599&#41;&#58; 8&#44;81 y 6&#44;51 por cada 1&#46;000 habitantes&#44; respectivamente &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; pero difer&#237;a seg&#250;n la regi&#243;n de origen mundial&#46; Mediante regresi&#243;n binomial negativa&#44; ajustada por edad y sexo&#44; los riesgos relativos &#40;RR&#41; para COVID-19 no fueron significativamente diferentes de los espa&#241;oles para los individuos provenientes de Europa&#44; Asia o el norte de &#193;frica&#46; Por el contrario&#44; hubo un marcado aumento del riesgo para los del &#193;frica subsahariana &#40;RR 3&#44;66&#44; intervalo de confianza del 95&#37; &#91;IC&#93; 1&#44;42-9&#44;41&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;007&#41;&#44; el Caribe &#40;RR 6&#44;35&#44; IC 95&#37; 3&#44;83-10&#44;55&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y Am&#233;rica Latina &#40;RR 6&#44;92&#44; IC 95&#37; 4&#44;49-10&#44;67&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los migrantes procedentes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina&#44; a diferencia de los espa&#241;oles o migrantes procedentes de Europa&#44; el norte de &#193;frica o Asia&#44; presentaron un mayor riesgo de COVID-19&#46; Nuestros datos sugieren un papel para el origen &#233;tnico en el riesgo de COVID-19&#46; Los migrantes de algunas zonas del mundo pueden merecer una atenci&#243;n m&#225;s cercana tanto por razones cl&#237;nicas como epidemiol&#243;gicas&#46;</p></span>"
        "secciones" => array:4 [
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Little is known regarding the relevance of racial&#47;ethnic background to the risk for COVID-19 infection&#44; particularly in Europe&#46; We evaluated the risk of COVID-19 among migrants from different areas of the world within the context of universal free access to medical care&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We conducted a population-based cohort analysis of the cumulative incidence of PCR-confirmed COVID-19 among adult residents of Alcorcon &#40;Spain&#41; in the first wave of the disease up to April 25&#44; 2020&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The crude cumulative incidence among migrants &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#44;419&#41; was higher than among Spaniards &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>131&#44;599&#41;&#58; 8&#46;81 and 6&#46;51 and per 1&#44;000 inhabitants&#44; respectively &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; but differed by region of origin&#46; As per a negative binomial regression adjusted for age and sex&#44; relative risk &#40;RR&#41; for COVID-19 for individuals from Europe&#44; Asia&#44; or North Africa was not significantly different from Spaniards&#46; In contrast&#44; a markedly increased risk was found for people from Sub-Saharan Africa &#40;RR 3&#46;66&#44; 95&#37; confidence interval &#40;CI&#41; 1&#46;42-9&#46;41&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;007&#41;&#44; the Caribbean &#40;RR 6&#46;35&#44; 95&#37; CI 3&#46;83-10&#46;55&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; and Latin America &#40;RR 6&#46;92&#44; 95&#37; CI 4&#46;49-10&#46;67&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Migrants from Sub-Saharan Africa&#44; the Caribbean&#44; and Latin America exhibited increased risk for COVID-19 as compared to Spaniards or migrants from Europe&#44; North Africa&#44; or Asia&#46; Our data suggest that the ethnic background may play a role in risk for COVID-19&#46; Migrants from some areas of the world may merit closer attention for both clinical and epidemiological reasons&#46;</p></span>"
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            "apendice" => "<p id="par0240" class="elsevierStylePara elsevierViewall">Alejandro Algora&#44; Juan Carlos Alonso-Punter&#44; Gregorio Bonilla Zafra&#44; Mercedes Bueno-Campa&#241;a&#44; Virgilio Castilla&#44; Ana Isabel D&#237;az-Cuasante&#44; Aurora Fabero&#44; Rosa Mar&#237;a Fari&#241;a&#44; Isabel M&#46; Gal&#225;n&#44; Isabel Gonz&#225;lez-Anglada&#44; M&#46; Mercedes Izquierdo&#44; Susana Lorenzo&#44; Juan Emilio Losa&#44; Margarita Mosquera&#44; Carmen Noguera&#44; Montserrat P&#233;rez-Encinas&#44; Gil Rodr&#237;guez-Caravaca&#44; Jos&#233; Francisco Valverde&#46;</p>"
            "etiqueta" => "Anexo"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n del diagn&#243;stico cl&#237;nico de COVID-19&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel A</span>&#46; Diagn&#243;stico diario de COVID-19 &#40;el gr&#225;fico representa para cada fecha la media m&#243;vil de 7 d&#237;as<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>n&#250;mero de diagn&#243;stico diario de la semana anterior&#41; en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel B</span>&#46; Tasa de incidencia acumulada del nuevo diagn&#243;stico cl&#237;nico COVID-19 por regi&#243;n del mundo en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p>"
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      1 => array:7 [
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Riesgos relativos para COVID-19&#46; An&#225;lisis de regresi&#243;n binomial negativa&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel A</span>&#46; Riesgo de COVID-19 seg&#250;n intervalos de edad &#40;edad de referencia &#60;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41; y sexo&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel B</span>&#46; Riesgo de COVID-19 seg&#250;n &#225;reas del mundo de origen &#40;referencia Espa&#241;a&#41;&#46;</p>"
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                  \t\t\t\t">Espa&#241;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">69&#46;011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Uni&#243;n Europea<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;819&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;749&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Ruman&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Polonia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">407&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Bulgaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">305&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">299&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">260&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">590&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Portugal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">359&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">314&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rusia y Europa del Este&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">921&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;137&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ucrania&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">1&#46;865&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">71&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#46;439&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">China&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">869&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;174&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">778&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;952&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Marruecos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">755&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;884&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guinea Ecuatorial&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nigeria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">111&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;496&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;826&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">537&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">641&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;178&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Per&#250;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">484&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">595&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ecuador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">357&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">304&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">661&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Honduras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">380&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">528&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">840&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caribe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">319&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">338&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rep&#250;blica Dominicana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">247&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">473&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuba&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">178&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miscel&#225;nea<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estados Unidos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total general&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;539&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">79&#46;479&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">152&#46;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Estados Unidos&#44; Canad&#225;&#44; Australia y Nueva Zelanda se fusionaron debido a su bajo n&#250;mero&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Europa del Este y Rusia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Asia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caribe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Casos &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">1&#46;036&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Edad &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">71&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">73&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">57&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rango intercuart&#237;lico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54-79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62-79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">45&#44;75-64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">45&#44;5-61&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42-49&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34-76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">49&#44;5-66&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;25-57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39-55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Hombres &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">52&#44;3&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4&#44;49-10&#44;67&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">B&#46; Diagn&#243;stico cl&#237;nico &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;691&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;Referencia&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Uni&#243;n Europea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Europa del Este&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;51-1&#44;88&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;964&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;11-6&#44;57&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caribe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;37-8&#44;09&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5&#44;11-8&#44;27&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#46; Casos confirmados con PCR e ingreso hospitalario &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>877&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Espa&#241;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;Referencia&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;57&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#44;20-1&#44;66&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;311&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uni&#243;n Europea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;64&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#44;33-1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;188&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europa del Este&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;95&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#44;35-2&#44;54&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;921&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;46&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;50-4&#44;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;480&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Modelos de regresi&#243;n binomial negativa para la incidencia COVID-19 por regi&#243;n de origen mundial &#40;A&#41; y an&#225;lisis de sensibilidad &#40;B y C&#41;&#46; Alcorc&#243;n &#40;Espa&#241;a&#41;&#44; febrero-abril 2020</p>"
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Aspectos destacados</span><p id="par0010" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Diversos estudios sugieren un aumento de la carga de COVID-19 para los migrantes o las minor&#237;as &#233;tnicas en Estados Unidos o el Reino Unido&#44; pero hay escasos datos para otros pa&#237;ses europeos&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0020" class="elsevierStylePara elsevierViewall">El aumento de riesgo para COVID-19 podr&#237;a agravarse por un acceso desigual a la atenci&#243;n m&#233;dica&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Nuestros datos muestran un aumento del riesgo de COVID-19 entre los migrantes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina residentes en Espa&#241;a&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0030" class="elsevierStylePara elsevierViewall">No hubo un mayor riesgo de COVID-19 entre los migrantes de Europa&#44; Asia o el norte de &#193;frica residentes en Espa&#241;a&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nuestros datos sugieren un papel del origen &#233;tnico en el riesgo de COVID-19&#44; concurrente con el atribuible a condiciones socioecon&#243;micas&#46;</p></li></ul></p></span></span>"
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                      "titulo" => "Factors associated with COVID-19-related death using OpenSAFELY"
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                      "titulo" => "COVID-19 en pacientes espa&#241;oles e inmigrantes en un &#225;rea sanitaria de Madrid"
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                          "etal" => false
                          "autores" => array:4 [
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                      "titulo" => "Potential association between COVID-19 mortality and health-care resource availability"
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                          "etal" => false
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                            0 => "Y&#46; Ji"
                            1 => "Z&#46; Ma"
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                            3 => "Q&#46; Pan"
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                      "titulo" => "SARS-CoV-2 Positivity Rate for Latinos in the Baltimore-Washington&#44; DC Region"
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                          "etal" => true
                          "autores" => array:6 [
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                            3 => "N&#46;A&#46; Irvin"
                            4 => "M&#46; Saheed"
                            5 => "K&#46;R&#46; Page"
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                      "titulo" => "Revealing the unequal burden of COVID-19 by income&#44; race&#47;ethnicity&#44; and household crowding&#58; US county vs ZIP code analyses"
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                          "etal" => false
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                      "titulo" => "Racial health disparities and Covid-19 - Caution and context"
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Riesgo de COVID-19 en españoles y migrantes de distintas zonas del mundo residentes en España en la primera oleada de la enfermedad
Differential risk for COVID-19 in the first wave of the disease among Spaniards and migrants from different areas of the world living in Spain
C. Guijarroa,c,h,?
Autor para correspondencia
cguijarro@fhalcorcon.es

Autor para correspondencia.
, E. Pérez-Fernándezc, B. González-Piñeirod, V. Meléndezi, M.J. Goyanese, M.E. Renillaf, M.L. Casasg, I. Sastred, M. Velascoa,b,c,h, e investigadores COVID Alcorcón ?
a Unidad de Medicina Interna, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
b Unidad de Medicina Interna, Sección Infecciosas, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
c Unidad de Investigación, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
d Sistemas de Información y Tecnología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
e Unidad de Microbiología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
f Unidad de Urgencias, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
g Unidad de Laboratorio, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
h Departamento de Especialidades Médicas y Salud Pública, Universidad Rey Juan Carlos, Alcorcón, Madrid, España
i Concejalía de Asuntos sociales, Mayores y Salud Pública, Ayuntamiento de Alcorcón, Alcorcón, Madrid, España
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n del diagn&#243;stico cl&#237;nico de COVID-19&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel A</span>&#46; Diagn&#243;stico diario de COVID-19 &#40;el gr&#225;fico representa para cada fecha la media m&#243;vil de 7 d&#237;as<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>n&#250;mero de diagn&#243;stico diario de la semana anterior&#41; en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel B</span>&#46; Tasa de incidencia acumulada del nuevo diagn&#243;stico cl&#237;nico COVID-19 por regi&#243;n del mundo en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0255" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introducci&#243;n</span><p id="par0040" class="elsevierStylePara elsevierViewall">La pandemia COVID-19 representa un tremendo desaf&#237;o para la humanidad&#44; con dram&#225;ticas consecuencias sanitarias y econ&#243;micas<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; Informes recientes han puesto de relieve el aumento de la mortalidad relacionada con la COVID-19 entre los migrantes y las minor&#237;as &#233;tnicas en diversos pa&#237;ses occidentales<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">4&#8211;10</span></a>&#46; Sin embargo&#44; los resultados cl&#237;nicos &#8212;la mortalidad en particular&#8212; asociados con las minor&#237;as &#233;tnicas est&#225;n inextricablemente relacionados con la situaci&#243;n socioecon&#243;mica&#44; la comorbilidad y el acceso desigual a los servicios m&#233;dicos<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">11&#8211;14</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se han emitido diversos informes en los medios de comunicaci&#243;n y llamadas a la acci&#243;n a este respecto&#44; pero muy pocas publicaciones cient&#237;ficas s&#243;lidas abordan esta cuesti&#243;n&#46; Adem&#225;s&#44; la mayor&#237;a de los estudios publicados provienen de Estados Unidos o el Reino Unido y pr&#225;cticamente ninguno de otros pa&#237;ses europeos<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">15&#8211;18</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En este trabajo describimos la incidencia de COVID-19 en la primera oleada de la enfermedad entre espa&#241;oles y migrantes de diferentes zonas del mundo que viven en Alcorc&#243;n&#44; una ciudad de la periferia de Madrid &#40;Espa&#241;a&#41; con un n&#250;mero considerable de residentes extranjeros&#46; Las diferentes proporciones de migrantes de diversas zonas del mundo pueden proporcionar una oportunidad para evaluar el riesgo de COVID-19 en estas poblaciones&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">M&#233;todos</span><p id="par0055" class="elsevierStylePara elsevierViewall">Estudio de cohorte poblacional realizado en Alcorc&#243;n &#40;Madrid&#41;&#44; que cuenta con una poblaci&#243;n censada total de unos 170&#46;000 habitantes&#46; La poblaci&#243;n en riesgo se defini&#243; como todos los adultos inscritos en el censo municipal del Ayuntamiento de Alcorc&#243;n &#40;&#250;ltima actualizaci&#243;n el 14 de marzo de 2020&#41;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#46; De este censo se obtuvo la distribuci&#243;n de la poblaci&#243;n por nacionalidad y pa&#237;s de origen&#44; estratificada por edad y sexo&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">El caso se defini&#243; como un paciente con un diagn&#243;stico de COVID-19 realizado en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n y confirmado mediante transcripci&#243;n inversa-reacci&#243;n en cadena de la polimerasa &#40;RT-PCR&#41; para SARS-CoV-2 entre adultos residentes en Alcorc&#243;n&#46; Los casos COVID-19 se obtuvieron de la historia cl&#237;nica electr&#243;nica &#40;Selene&#169;&#41;&#46; El diagn&#243;stico cl&#237;nico de COVID-19 fue realizado por los m&#233;dicos del Servicio de Urgencias seg&#250;n los criterios del Centro Europeo para el Control y la Prevenci&#243;n de Enfermedades &#40;ECDCP&#41;-Organizaci&#243;n Mundial de la Salud &#40;OMS&#41;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Para el diagn&#243;stico molecular de la infecci&#243;n por SARS-CoV-2&#44; se procesaron los hisopos nasofar&#237;ngeos de pacientes sintom&#225;ticos mediante extracci&#243;n automatizada con el uso de MagNa Pure LC &#40;Roche Applied Science&#44; Mannheim&#44; Alemania&#41; y RT-PCR en tiempo real &#40;rRT-PCR&#41; utilizando el kit de detecci&#243;n de &#225;cido nucleico VAVA SARS-CoV-2 de VAISURE &#40;CerTest Biotec S&#46;L&#46;&#41;&#44; de acuerdo con las instrucciones del fabricante&#46; Para esta rRT-PCR&#44; se utiliz&#243; Bio-Rad CFX96&#8482; sistema de detecci&#243;n de PCR en tiempo real&#46; Se amplificaron dos regiones virales diferentes&#58; el gen ORF1ab &#40;canal FAM&#41; y el gen N &#40;canal ROX&#41; junto al control interno &#40;canal HEX&#41;&#46; Se consideraron positivos los resultados obtenidos en ciclos de &#61;<span class="elsevierStyleHsp" style=""></span>40&#46; Se incluyeron controles positivos y negativos en cada tanda de ensayos&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Se extrajo un conjunto anonimizado de datos de las historias cl&#237;nicas electr&#243;nicas &#40;del 1 de febrero al 25 de abril&#41; que incluy&#243; los siguientes par&#225;metros&#58; edad&#44; sexo&#44; pa&#237;s de origen&#44; ciudad de residencia&#44; fecha del diagn&#243;stico COVID-19 &#40;cl&#237;nico&#41;&#44; fecha y resultados de la PCR SARS-CoV-2&#44; y evoluci&#243;n cl&#237;nica &#40;ingreso hospitalario&#44; ingreso en unidad de cuidados cr&#237;ticos&#44; alta&#44; duraci&#243;n de la estancia hospitalaria y muerte intrahospitalaria&#41;&#46; Para este estudio&#44; se excluyeron los pacientes con residencia distinta de la ciudad de Alcorc&#243;n&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Se clasific&#243; a los pacientes seg&#250;n su pa&#237;s de origen en uno de los siguientes grupos&#58; a&#41; Espa&#241;a&#44; b&#41; Uni&#243;n Europea &#40;incluyendo Suiza y Noruega&#41;&#44; c&#41; Europa oriental &#40;incluida Rusia&#41;&#44; d&#41; Asia&#44; e&#41; Australia y Nueva Zelanda&#44; f&#41; Norte de &#193;frica&#44; g&#41; &#193;frica subsahariana&#44; h&#41; Am&#233;rica Latina &#40;M&#233;xico y pa&#237;ses continentales de Am&#233;rica Latina&#41;&#44; i&#41; Caribe&#44; y j&#41; Estados Unidos y Canad&#225;&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Estad&#237;stica</span><p id="par0080" class="elsevierStylePara elsevierViewall">Los resultados se muestran como media &#40;&#177; desviaci&#243;n est&#225;ndar&#41;&#44; medianas &#40;rango intercuart&#237;lico &#91;RIC&#93;&#41; o porcentajes&#44; seg&#250;n corresponda&#46; Las variables cuantitativas se compararon utilizando la prueba t de Student&#44; ANOVA o la prueba U de Mann-Whitney&#44; seg&#250;n procediera&#46; Las variables cualitativas se compararon utilizando la prueba de chi-cuadrado o la prueba exacta de Fisher&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Los datos agregados se analizaron seg&#250;n el &#225;rea &#40;o pa&#237;s&#41; de origen mundial&#44; sexo y grupo de edad &#40;&#60;<span class="elsevierStyleHsp" style=""></span>30&#44; 30-39&#44; 40-49&#44; 50-59&#44; 60-69&#44; 70-79&#44; 80-89 y &#61;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41;&#46; Se calcularon las tasas de incidencia y los intervalos de confianza exactos de Poisson del 95&#37;&#46; Se utiliz&#243; un modelo de regresi&#243;n binomial negativa multivariante con varianza robusta para estimar la tasa de incidencia por &#225;rea mundial ajustada por sexo y edad&#46; Estos modelos son apropiados para analizar los datos de recuento con sobredispersi&#243;n<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">21&#44;22</span></a>&#46; Se asumi&#243; la significaci&#243;n estad&#237;stica para los valores p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Todos los an&#225;lisis se realizaron con Stata 14 &#40;StataCorp LLC&#44; Texas&#44; EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46;&#41;&#46; El protocolo fue aprobado por el Comit&#233; &#201;tico de Investigaci&#243;n con medicamentos &#40;CEIm&#41; del centro&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0090" class="elsevierStylePara elsevierViewall">El censo del municipio de Alcorc&#243;n inclu&#237;a 152&#46;018 personas mayores de 17<span class="elsevierStyleHsp" style=""></span>a&#241;os a fecha de 14 de marzo de 2020<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#46; Entre ellos&#44; 20&#46;419 &#40;13&#44;4&#37;&#41; residentes ten&#237;an una nacionalidad distinta de la espa&#241;ola&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se resumen los pa&#237;ses de origen &#40;y las zonas asociadas del mundo&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Se eligieron las diferentes &#225;reas del mundo por razones geogr&#225;ficas&#44; socioecon&#243;micas y de origen &#233;tnico&#44; siempre que hubiera un m&#237;nimo de 500 individuos por &#225;rea&#46; Hab&#237;a menos de 200 migrantes de Estados Unidos&#44; Canad&#225;&#44; Australia y Nueva Zelanda y&#44; por tanto&#44; se excluyeron del an&#225;lisis&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Los migrantes eran sustancialmente m&#225;s j&#243;venes que los espa&#241;oles &#40;mediana de edad 40<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 30-50&#93; frente a 49&#44;5<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 38-67&#93;&#44; respectivamente &#91;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 1</a>&#93;&#41; y hab&#237;a una proporci&#243;n ligeramente mayor de hombres &#40;48&#44;7&#37; vs&#46; 47&#44;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41;&#46; De hecho&#44; las pir&#225;mides de distribuci&#243;n de edad en la poblaci&#243;n de referencia para espa&#241;oles y migrantes fueron notablemente diferentes &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 2</a>&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Entre el 1 de febrero y el 25 de abril de 2020 se diagnosticaron en nuestro hospital un total de 1&#46;691 residentes en Alcorc&#243;n de COVID-19 seg&#250;n criterios cl&#237;nicos ECDCP-OMS<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>A&#41;&#46; El n&#250;mero de casos aument&#243; constantemente hasta finales de marzo y luego comenz&#243; a decaer aproximadamente 2 semanas despu&#233;s del confinamiento decretado por el gobierno espa&#241;ol el 14 de marzo de 2020 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">23</span></a>&#46; Para evitar posibles diagn&#243;sticos err&#243;neos&#44; limitamos nuestro an&#225;lisis a los 1&#46;036 casos con una PCR positiva para SARS-CoV-2 &#40;casos COVID-19-PCR&#43;&#41;&#46; La mediana de edad de los pacientes con COVID-19-PCR&#43; fue de 71<span class="elsevierStyleHsp" style=""></span>a&#241;os &#40;RIC 54-79&#41; y el 57&#44;2&#37; eran varones&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">La incidencia global acumulada de COVID-19-PCR&#43; fue de 6&#44;81 por cada 1&#46;000 habitantes&#46; La incidencia global acumulada de COVID-19-PCR&#43; para espa&#241;oles fue de 6&#44;50 casos por cada 1&#46;000 habitantes&#44; frente a 8&#44;82 por 1&#46;000 para los no espa&#241;oles &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">La edad de los espa&#241;oles COVID-19-PCR&#43; fue sustancialmente mayor que la de los migrantes &#40;mediana de edad 73<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 62-80&#93; vs&#46; 51&#44;5 &#91;RIC 41&#44;7-58&#93;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; con una mayor proporci&#243;n de varones&#44; aunque este hallazgo no fue estad&#237;sticamente significativo &#40;58&#44;6&#37; vs&#46; 52&#44;5&#37;&#59; p &#61; 0&#44;15&#41; &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 3</a>&#41;&#46; La incidencia acumulada global aument&#243; dr&#225;sticamente con la edad tanto en espa&#241;oles como en migrantes &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 3A</a>&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A continuaci&#243;n&#44; evaluamos la incidencia acumulada de COVID-19-PCR&#43; para nativos de diferentes regiones del mundo en comparaci&#243;n con la de los espa&#241;oles &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;&#46; Las tasas de incidencia no ajustadas para individuos de Europa&#44; Asia y el norte de &#193;frica fueron m&#225;s bajas que la media&#44; mientras que las tasas para las personas procedentes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina fueron m&#225;s elevadas&#46; Las tasas de incidencia acumuladas para la mayor&#237;a de los pa&#237;ses representativos se muestran en la <a class="elsevierStyleCrossRef" href="#sec0050">tabla suplementaria 1</a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Con el fin de comprender mejor los riesgos para los espa&#241;oles y los migrantes de diferentes regiones del mundo&#44; realizamos un an&#225;lisis de regresi&#243;n binomial negativa multivariante<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">21&#44;22</span></a> ajustado para edad y sexo&#44; ya que estos factores son determinantes del riesgo de COVID-19 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; Los riesgos relativos ajustados para COVID-19-PCR&#43; entre los migrantes de Asia&#44; la Uni&#243;n Europea y Europa del Este no fueron significativamente distintos a los de los espa&#241;oles &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Por el contrario&#44; el riesgo relativo para los migrantes de Am&#233;rica Latina fue aproximadamente 7 veces mayor que el de los espa&#241;oles &#40;RR 6&#44;92&#59; IC 95&#37; 4&#44;49-10&#44;67&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Adem&#225;s&#44; el riesgo ajustado tambi&#233;n fue mayor en los migrantes procedentes del &#193;frica subsahariana &#40;RR 3&#44;66&#59; IC 95&#37; 1&#44;42-9&#44;41&#59; p &#61; 0&#44;007&#41; as&#237; como los del Caribe &#40;RR 6&#44;35&#59; IC 95&#37; 3&#44;83-10&#44;55&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; de modo altamente significativo&#44; cl&#237;nica y estad&#237;sticamente&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Realizamos un an&#225;lisis de sensibilidad &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#44; repitiendo la estimaci&#243;n de riesgo&#58; estimaci&#243;n con criterios m&#225;s amplios &#40;diagn&#243;stico cl&#237;nico independientemente de los resultados de la PCR&#59; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;691&#41; y criterios m&#225;s estrictos &#40;pacientes que requirieron ingreso hospitalario debido a COVID-19 moderada-grave&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>877&#41;&#46; En ambos casos&#44; los resultados se mantuvieron esencialmente inalterados&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Los riesgos de COVID-19 ajustados para los migrantes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina fueron aproximadamente 3&#44; 6 y 7 veces superiores a los de los espa&#241;oles en todos los escenarios cl&#237;nicos &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; De modo exploratorio&#44; realizamos un an&#225;lisis similar para los pa&#237;ses que ten&#237;an al menos 800 residentes en Alcorc&#243;n &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Los ciudadanos de Rumania&#44; Ucrania&#44; China y Marruecos no presentaron un aumento del riesgo de COVID-19 &#40;<a class="elsevierStyleCrossRef" href="#sec0050">fig&#46; suplementaria 4</a>&#41;&#46; En coherencia con su zona mundial&#44; los migrantes de todos los pa&#237;ses de Am&#233;rica Latina mostraron un aumento definido del riesgo de COVID-19&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">La COVID-19 grave&#44; definida como muerte&#44; ingreso en la unidad de cuidados intensivos o estancia hospitalaria de m&#225;s de 7 d&#237;as&#44; se produjo en el 63&#37; de los espa&#241;oles en comparaci&#243;n con el 33&#37; de los migrantes&#46; Del mismo modo&#44; la mortalidad no ajustada fue mayor para los espa&#241;oles &#40;25&#37; de los ingresos&#41; que para los migrantes &#40;6&#37;&#41;&#46; Este hallazgo refleja probablemente la edad avanzada de los pacientes con enfermedad grave &#40;mediana de edad 76<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 69-82&#93;&#41; o que fallecieron &#40;mediana de 79<span class="elsevierStyleHsp" style=""></span>a&#241;os &#91;RIC 74-85&#93;&#41;&#44; dado que este rango de edad est&#225; pr&#225;cticamente ausente en los migrantes &#40;<a class="elsevierStyleCrossRef" href="#sec0050">figs&#46; suplementarias 1 y 2</a>&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Nuestros datos no respaldan la idea de que los migrantes residentes en Espa&#241;a tienen una forma m&#225;s grave de COVID-19 que los espa&#241;oles&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discusi&#243;n</span><p id="par0155" class="elsevierStylePara elsevierViewall">Con una aproximaci&#243;n de base poblacional&#44; nuestros datos muestran que la incidencia de COVID-19 var&#237;a entre los migrantes de diferentes zonas del mundo y la poblaci&#243;n de referencia espa&#241;ola&#46; Un hallazgo relevante de nuestro trabajo es un aparente mayor riesgo para COVID-19 en los sujetos procedentes del &#193;frica subsahariana&#44; el Caribe o Am&#233;rica Latina en comparaci&#243;n con los migrantes de Europa&#44; Asia o el norte de &#193;frica&#44; o con los espa&#241;oles&#46; Los datos preliminares descritos en otros municipios de Madrid son coherentes con nuestros resultados<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a>&#46; Se detecta constantemente un riesgo m&#225;s elevado cuando la estimaci&#243;n se realiza ya sea globalmente para las regiones de origen mencionadas&#44; ya sea para determinados pa&#237;ses&#46; Este incremento de riesgo crudo aumenta claramente cuando se realizan ajustes por edad y sexo&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Tambi&#233;n encontramos un menor riesgo relativo no ajustado para COVID-19 para otros ciudadanos de la Uni&#243;n Europea en comparaci&#243;n con los espa&#241;oles&#46; Sin embargo&#44; los migrantes representan una poblaci&#243;n m&#225;s joven que la espa&#241;ola<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;25</span></a>&#44; como es el caso tambi&#233;n en nuestro entorno&#46; De hecho&#44; cuando se ajusta por edad y sexo&#44; el riesgo relativo para COVID-19 para los migrantes de Europa &#40;tanto de la Uni&#243;n Europea como de Europa del Este&#41; no difer&#237;a del de los espa&#241;oles&#46; An&#225;logamente&#44; la tasa de incidencia ajustada de COVID-19 en migrantes del norte de &#193;frica no difer&#237;a de la poblaci&#243;n de referencia espa&#241;ola&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Las razones que subyacen a este aparente aumento del riesgo de COVID-19 entre los migrantes de diferentes zonas del mundo no est&#225;n claras&#46; En primer lugar&#44; todos los migrantes tienen el mismo acceso a la cobertura sanitaria pr&#225;cticamente universal de que disponen tambi&#233;n los espa&#241;oles&#46; En segundo lugar&#44; la mayor&#237;a de los migrantes tienen empleos y estatus socioecon&#243;mico m&#225;s bajo que la poblaci&#243;n espa&#241;ola<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#44;27</span></a>&#44; lo que tambi&#233;n es cierto para los migrantes &#171;europeos&#187;&#44; ya que este grupo incluye principalmente a individuos de Ruman&#237;a y Ucrania en nuestra ciudad&#46; Una mayor prevalencia de hipertensi&#243;n u obesidad puede subyacer a un mayor riesgo para los migrantes del &#193;frica subsahariana o Am&#233;rica Latina&#44; tal como se ha descrito en negros o hispanos en Estados Unidos<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#46; Sin embargo&#44; en nuestro entorno&#44; los migrantes de estas &#225;reas no parecen tener una mayor prevalencia de obesidad&#44; hipertensi&#243;n&#44; diabetes o enfermedades cardiovasculares&#46; Esto puede estar relacionado con su edad m&#225;s joven y el llamado &#171;efecto migrante saludable&#187;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;25&#44;29&#44;30</span></a>&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene varias fortalezas&#46; La primera es su aproximaci&#243;n de base poblacional&#58; utilizamos el mejor registro actualizado disponible de las personas que viven en el &#225;rea de referencia &#40;censo municipal actualizado&#41;&#46; Es probable que la mayor&#237;a de los migrantes residentes en la zona est&#233;n incluidos en este registro&#44; ya que varios servicios sociales dependen del lugar de residencia actual<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">En segundo lugar&#44; nuestra estimaci&#243;n de la incidencia de COVID-19 en toda la poblaci&#243;n es razonable dado que la poblaci&#243;n a la que se asiste principalmente en nuestro hospital es precisamente la ciudad de Alcorc&#243;n y no hay otro hospital p&#250;blico en la ciudad<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">31</span></a>&#46; En una emergencia de salud p&#250;blica como la COVID-19 es probable que los residentes dependan a&#250;n m&#225;s de sus instalaciones sanitarias de proximidad&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">En cualquier caso&#44; es casi seguro que un n&#250;mero reducido de residentes de Alcorc&#243;n buscara atenci&#243;n por COVID-19 en hospitales diferentes al nuestro y&#44; por lo tanto&#44; nuestros datos son probablemente una subestimaci&#243;n de la incidencia real&#46; El 16&#37; de los casos COVID-19 atendidos en nuestro hospital no residentes en Alcorc&#243;n se excluyeron del an&#225;lisis&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Los datos oficiales del observatorio de resultados de la Comunidad de Madrid indican que nuestro hospital recibe un n&#250;mero ligeramente mayor de pacientes de otras zonas sanitarias que viceversa<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">31</span></a>&#46; En consecuencia&#44; nuestra subestimaci&#243;n de la incidencia de COVID-19 en Alcorc&#243;n puede estar entre el 10 y el 15&#37;&#46; No creemos que estos datos modifiquen sustancialmente la incidencia relativa de los migrantes&#44; dado que la proporci&#243;n de casos COVID-19 en los migrantes que fueron excluidos de nuestro estudio porque su residencia estaba fuera de Alcorc&#243;n fue esencialmente id&#233;ntica a la de los espa&#241;oles &#40;17&#37; vs&#46; 16&#37;&#44; respectivamente&#41;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Otra cuesti&#243;n cr&#237;tica es el acceso de los migrantes a la atenci&#243;n m&#233;dica&#46; Desde julio de 2018 todos los residentes en Espa&#241;a tienen acceso a atenci&#243;n m&#233;dica gratuita en condiciones pr&#225;cticamente id&#233;nticas a las de los espa&#241;oles<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">32</span></a>&#46; Se puede argumentar que algunos migrantes pueden depender menos de los m&#233;dicos de atenci&#243;n primaria&#44; lo que conduce a un uso desproporcionado de los servicios hospitalarios<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">25&#44;33</span></a>&#46; Sin embargo&#44; nuestro an&#225;lisis de sensibilidad&#44; que se limit&#243; a casos COVID-19 m&#225;s graves que requieren ingreso hospitalario&#44; no apoya este uso excesivo te&#243;rico de los recursos hospitalarios&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Nuestro estudio presenta tambi&#233;n algunas limitaciones&#46; En primer lugar&#44; no disponemos de datos locales sobre la situaci&#243;n socioecon&#243;mica&#44; el nivel educativo u otras condiciones de salud de los migrantes&#46; Sin embargo&#44; en conjunto&#44; los migrantes de Ruman&#237;a&#44; Ucrania y Marruecos que residen en Espa&#241;a pertenecen a una clase socioecon&#243;mica relativamente baja<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">27</span></a>&#44; al igual que los migrantes procedentes del &#193;frica subsahariana o Am&#233;rica Latina&#46; No obstante&#44; no se ha constatado que los primeros tengan un mayor riesgo de COVID-19&#44; mientras que los segundos s&#237; lo presentan&#44; lo que sugiere que la situaci&#243;n socioecon&#243;mica puede no ser una de las principales razones de las diferencias en la incidencia de COVID-19 entre los distintos grupos de migrantes&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Dado que los factores mencionados no parecen explicar adecuadamente este aumento de incidencia&#44; se debe prestar atenci&#243;n al origen &#233;tnico de las poblaciones&#46; Es interesante destacar que un informe reciente de una gran base de datos del Departamento de Veteranos de EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46; sugiere que las personas negras e hispanas en ese pa&#237;s tienen una carga excesiva de COVID-19 no explicada completamente por las condiciones m&#233;dicas subyacentes<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#44; lo que est&#225; de acuerdo con nuestros resultados&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Informes recientes de EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46; sugieren que el mayor riesgo descrito para la poblaci&#243;n negra no es extensible a la poblaci&#243;n de origen asi&#225;tico&#44; lo que tambi&#233;n concuerda con nuestros datos<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">34</span></a>&#46; Estos hallazgos apuntan a un papel del origen &#233;tnico en el aumento del riesgo de COVID-19 para determinadas poblaciones&#44; sin perjuicio de la importancia de otras razones socioecon&#243;micas&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Hay escasos datos sobre diferentes susceptibilidades a los virus respiratorios en personas de diferentes or&#237;genes &#233;tnicos&#46; Algunos estudios han sugerido que las minor&#237;as raciales tienen una mayor susceptibilidad a la gripe<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">35</span></a>&#46; Sin embargo&#44; muchos trabajos no han logrado disociar los resultados cl&#237;nicos de las cuestiones socioecon&#243;micas&#44; en particular el acceso desigual a la atenci&#243;n de la salud&#46; De hecho&#44; se est&#225;n empezando a explorar diferentes susceptibilidades a la COVID-19 basadas en antecedentes gen&#233;ticos que tienen una distribuci&#243;n desigual<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">36&#8211;38</span></a>&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Por &#250;ltimo&#44; nuestros datos no sugieren un mayor riesgo de mortalidad para los migrantes&#46; Cabe destacar que las personas negras e hispanas atendidas por el Departamento de Veteranos &#40;y&#44; por tanto&#44; con igual acceso a atenci&#243;n sanitaria&#41; no mostraron un aumento de la mortalidad<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#44; a diferencia de otros resultados descritos en otro contexto de atenci&#243;n sanitaria en Estados Unidos<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">6</span></a>&#46; Estos datos sugieren que el acceso a la atenci&#243;n sanitaria&#44; m&#225;s que la etnia&#44; puede ser el principal determinante de la supervivencia en COVID-19&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusiones</span><p id="par0225" class="elsevierStylePara elsevierViewall">Nuestro trabajo muestra un aumento selectivo del riesgo de COVID-19 entre ciertas poblaciones migrantes en Espa&#241;a&#44; incluidas las procedentes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina&#44; que no est&#225; relacionada con un acceso desigual a la atenci&#243;n sanitaria&#46; Estos grupos pueden merecer una atenci&#243;n especial&#44; sobre todo cuando nuestro pa&#237;s y otros est&#225;n experimentando un aumento de la incidencia de COVID-19 tras la desescalada de medidas de distanciamiento social extremas al final de la primera oleada COVID-19&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; nuestros datos sugieren una diferente susceptibilidad gen&#233;tica a la COVID-19 entre individuos de diferentes or&#237;genes &#233;tnicos&#44; un hallazgo que merece ser investigado con m&#225;s detalle&#46; Independientemente de las razones que subyacen al riesgo diferencial de COVID-19 en diferentes poblaciones migrantes&#44; nuestros datos sirven para ayudar a identificar individuos o grupos de riesgo particularmente elevado que pueden merecer una atenci&#243;n especial por razones cl&#237;nicas y epidemiol&#243;gicas&#46;</p></span><span id="sec1040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect1100">Financiaci&#243;n</span><p id="par1235" class="elsevierStylePara elsevierViewall">Financiado en parte con el Proyecto de Investigaci&#243;n del Instituto de Salud Carlos III&#58; COV20&#47;00644&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0235" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span><span id="sec3040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect3100">Agradecimientos</span><p id="par3235" class="elsevierStylePara elsevierViewall">Los autores agradecen al Dr&#46; Fernando Rodr&#237;guez Artalejo la revisi&#243;n cr&#237;tica del manuscrito&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios sobre el potencial papel de los or&#237;genes raciales&#47;&#233;tnicos en el riesgo de infecci&#243;n de COVID-19&#44; particularmente en Europa&#46; Evaluamos el riesgo de COVID-19 entre los migrantes de diferentes zonas del mundo en un contexto de acceso universal gratuito a la atenci&#243;n m&#233;dica&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizamos un an&#225;lisis de cohortes poblacional de la incidencia acumulada de COVID-19 confirmada mediante PCR entre los residentes adultos en Alcorc&#243;n &#40;Espa&#241;a&#41; en la primera oleada de la enfermedad hasta el 25 de abril de 2020&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La incidencia acumulada bruta entre los migrantes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#46;419&#41; fue mayor que entre los espa&#241;oles &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>131&#46;599&#41;&#58; 8&#44;81 y 6&#44;51 por cada 1&#46;000 habitantes&#44; respectivamente &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; pero difer&#237;a seg&#250;n la regi&#243;n de origen mundial&#46; Mediante regresi&#243;n binomial negativa&#44; ajustada por edad y sexo&#44; los riesgos relativos &#40;RR&#41; para COVID-19 no fueron significativamente diferentes de los espa&#241;oles para los individuos provenientes de Europa&#44; Asia o el norte de &#193;frica&#46; Por el contrario&#44; hubo un marcado aumento del riesgo para los del &#193;frica subsahariana &#40;RR 3&#44;66&#44; intervalo de confianza del 95&#37; &#91;IC&#93; 1&#44;42-9&#44;41&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;007&#41;&#44; el Caribe &#40;RR 6&#44;35&#44; IC 95&#37; 3&#44;83-10&#44;55&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y Am&#233;rica Latina &#40;RR 6&#44;92&#44; IC 95&#37; 4&#44;49-10&#44;67&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los migrantes procedentes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina&#44; a diferencia de los espa&#241;oles o migrantes procedentes de Europa&#44; el norte de &#193;frica o Asia&#44; presentaron un mayor riesgo de COVID-19&#46; Nuestros datos sugieren un papel para el origen &#233;tnico en el riesgo de COVID-19&#46; Los migrantes de algunas zonas del mundo pueden merecer una atenci&#243;n m&#225;s cercana tanto por razones cl&#237;nicas como epidemiol&#243;gicas&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introducci&#243;n y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Little is known regarding the relevance of racial&#47;ethnic background to the risk for COVID-19 infection&#44; particularly in Europe&#46; We evaluated the risk of COVID-19 among migrants from different areas of the world within the context of universal free access to medical care&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We conducted a population-based cohort analysis of the cumulative incidence of PCR-confirmed COVID-19 among adult residents of Alcorcon &#40;Spain&#41; in the first wave of the disease up to April 25&#44; 2020&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The crude cumulative incidence among migrants &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#44;419&#41; was higher than among Spaniards &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>131&#44;599&#41;&#58; 8&#46;81 and 6&#46;51 and per 1&#44;000 inhabitants&#44; respectively &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; but differed by region of origin&#46; As per a negative binomial regression adjusted for age and sex&#44; relative risk &#40;RR&#41; for COVID-19 for individuals from Europe&#44; Asia&#44; or North Africa was not significantly different from Spaniards&#46; In contrast&#44; a markedly increased risk was found for people from Sub-Saharan Africa &#40;RR 3&#46;66&#44; 95&#37; confidence interval &#40;CI&#41; 1&#46;42-9&#46;41&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;007&#41;&#44; the Caribbean &#40;RR 6&#46;35&#44; 95&#37; CI 3&#46;83-10&#46;55&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; and Latin America &#40;RR 6&#46;92&#44; 95&#37; CI 4&#46;49-10&#46;67&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Migrants from Sub-Saharan Africa&#44; the Caribbean&#44; and Latin America exhibited increased risk for COVID-19 as compared to Spaniards or migrants from Europe&#44; North Africa&#44; or Asia&#46; Our data suggest that the ethnic background may play a role in risk for COVID-19&#46; Migrants from some areas of the world may merit closer attention for both clinical and epidemiological reasons&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introduction and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
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        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:3 [
        "etiqueta" => "&#63;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">El resto de los componentes del grupo investigadores COVID Alcorc&#243;n est&#225;n relacionados en el <a class="elsevierStyleCrossRef" href="#sec0045">anexo</a>&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:2 [
          0 => array:4 [
            "apendice" => "<p id="par0240" class="elsevierStylePara elsevierViewall">Alejandro Algora&#44; Juan Carlos Alonso-Punter&#44; Gregorio Bonilla Zafra&#44; Mercedes Bueno-Campa&#241;a&#44; Virgilio Castilla&#44; Ana Isabel D&#237;az-Cuasante&#44; Aurora Fabero&#44; Rosa Mar&#237;a Fari&#241;a&#44; Isabel M&#46; Gal&#225;n&#44; Isabel Gonz&#225;lez-Anglada&#44; M&#46; Mercedes Izquierdo&#44; Susana Lorenzo&#44; Juan Emilio Losa&#44; Margarita Mosquera&#44; Carmen Noguera&#44; Montserrat P&#233;rez-Encinas&#44; Gil Rodr&#237;guez-Caravaca&#44; Jos&#233; Francisco Valverde&#46;</p>"
            "etiqueta" => "Anexo"
            "titulo" => "Investigadores COVID Alcorc&#243;n &#40;colaboradores&#41;"
            "identificador" => "sec0045"
          ]
          1 => array:4 [
            "apendice" => "<p id="par0250" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Anexo A"
            "titulo" => "Material adicional"
            "identificador" => "sec0055"
          ]
        ]
      ]
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2546
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            "Tamanyo" => 365558
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        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n del diagn&#243;stico cl&#237;nico de COVID-19&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel A</span>&#46; Diagn&#243;stico diario de COVID-19 &#40;el gr&#225;fico representa para cada fecha la media m&#243;vil de 7 d&#237;as<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>n&#250;mero de diagn&#243;stico diario de la semana anterior&#41; en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel B</span>&#46; Tasa de incidencia acumulada del nuevo diagn&#243;stico cl&#237;nico COVID-19 por regi&#243;n del mundo en el Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Riesgos relativos para COVID-19&#46; An&#225;lisis de regresi&#243;n binomial negativa&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel A</span>&#46; Riesgo de COVID-19 seg&#250;n intervalos de edad &#40;edad de referencia &#60;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41; y sexo&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Panel B</span>&#46; Riesgo de COVID-19 seg&#250;n &#225;reas del mundo de origen &#40;referencia Espa&#241;a&#41;&#46;</p>"
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        "detalles" => array:1 [
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            "identificador" => "at1"
            "detalle" => "Tabla "
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujeres&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ambos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Uni&#243;n Europea<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Polonia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bulgaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">305&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">299&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">590&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Portugal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">177&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">359&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">314&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">290&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rusia y Europa del Este&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">921&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ucrania&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">850&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;865&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">758&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">681&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;439&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">China&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">418&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">451&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">869&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">230&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;952&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Marruecos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">755&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;884&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">409&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">801&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guinea Ecuatorial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">212&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">313&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nigeria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">172&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">111&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;496&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;826&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">537&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">641&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;178&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Per&#250;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">484&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">595&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ecuador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">357&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">304&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">661&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Honduras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">380&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">528&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">840&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caribe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">319&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">338&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rep&#250;blica Dominicana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">226&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">473&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">178&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">Miscel&#225;nea<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Estados Unidos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total general&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">72&#46;539&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">152&#46;018&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Asia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">1&#46;036&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Edad &#40;mediana&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">71&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">73&#44;0&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">A&#46; Casos confirmados con PCR &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;036&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;Referencia&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Europa del Este&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Caribe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;83-10&#44;55&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4&#44;49-10&#44;67&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">B&#46; Diagn&#243;stico cl&#237;nico &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;691&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Espa&#241;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;Referencia&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;44-1&#44;34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uni&#243;n Europea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;40-0&#44;78&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europa del Este&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;63-2&#44;57&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;99&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;51-1&#44;88&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;964&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">3&#44;73</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">2&#44;11-6&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caribe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">5&#44;22</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">3&#44;37-8&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">6&#44;50</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">5&#44;11-8&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#46; Casos confirmados con PCR e ingreso hospitalario &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>877&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Espa&#241;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;Referencia&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;20-1&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uni&#243;n Europea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;33-1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;188&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Europa del Este&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;35-2&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;921&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;frica del Norte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;50-4&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;frica subsahariana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">3&#44;32</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;29-8&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caribe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">6&#44;39</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;79-10&#44;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Am&#233;rica Latina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">7&#44;65</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;99-11&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Modelos de regresi&#243;n binomial negativa para la incidencia COVID-19 por regi&#243;n de origen mundial &#40;A&#41; y an&#225;lisis de sensibilidad &#40;B y C&#41;&#46; Alcorc&#243;n &#40;Espa&#241;a&#41;&#44; febrero-abril 2020</p>"
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        "tipo" => "MULTIMEDIATEXTO"
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Aspectos destacados</span><p id="par0010" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Diversos estudios sugieren un aumento de la carga de COVID-19 para los migrantes o las minor&#237;as &#233;tnicas en Estados Unidos o el Reino Unido&#44; pero hay escasos datos para otros pa&#237;ses europeos&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0020" class="elsevierStylePara elsevierViewall">El aumento de riesgo para COVID-19 podr&#237;a agravarse por un acceso desigual a la atenci&#243;n m&#233;dica&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Nuestros datos muestran un aumento del riesgo de COVID-19 entre los migrantes del &#193;frica subsahariana&#44; el Caribe y Am&#233;rica Latina residentes en Espa&#241;a&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0030" class="elsevierStylePara elsevierViewall">No hubo un mayor riesgo de COVID-19 entre los migrantes de Europa&#44; Asia o el norte de &#193;frica residentes en Espa&#241;a&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nuestros datos sugieren un papel del origen &#233;tnico en el riesgo de COVID-19&#44; concurrente con el atribuible a condiciones socioecon&#243;micas&#46;</p></li></ul></p></span></span>"
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      "titulo" => "Bibliograf&#237;a"
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          "identificador" => "bibs0015"
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              "identificador" => "bib0195"
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                  "referenciaCompleta" => "Coronavirus Disease &#40;COVID-19&#41;&#46; Situation Reports &#91;consultado 31 Sep 2020&#93;&#46; Disponible en&#58; <a target="_blank" href="https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports">https&#58;&#47;&#47;www&#46;who&#46;int&#47;emergencies&#47;diseases&#47;novel-coronavirus-2019&#47;situation-reports</a>"
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "COVID-19&#44; a worldwide public health emergency"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Palacios Cruz"
                            1 => "E&#46; Santos"
                            2 => "M&#46;A&#46; Vel&#225;zquez Cervantes"
                            3 => "M&#46; Le&#243;n Ju&#225;rez"
                          ]
                        ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.rce.2020.03.001"
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Clin Esp&#46;"
                        "fecha" => "2021"
                        "volumen" => "221"
                        "paginaInicial" => "55"
                        "paginaFinal" => "61"
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              "identificador" => "bib0205"
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                  "referenciaCompleta" => "World Economic Outlook Update&#44; June 2020&#58; A crisis like no other&#44; an uncertain recovery&#46; IMF &#91;consultado 24 Jun 2020&#93;&#46; Disponible en&#58; <a target="_blank" href="https://www.imf.org/en/Publications/WEO/Issues/2020/06/24/WEOUpdateJune2020">https&#58;&#47;&#47;www&#46;imf&#46;org&#47;en&#47;Publications&#47;WEO&#47;Issues&#47;2020&#47;06&#47;24&#47;WEOUpdateJune2020</a>"
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              "identificador" => "bib0210"
              "etiqueta" => "4"
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                0 => array:1 [
                  "referenciaCompleta" => "CDC&#46; Coronavirus Disease 2019 &#40;COVID-19&#41; in Racial and Ethnic Minority Groups&#46; Centers for Disease Control and Prevention &#91;consultado 31 Sep 2020&#93;&#46; Disponible en&#58; <a target="_blank" href="https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/racial-ethnic-minorities.html">https&#58;&#47;&#47;www&#46;cdc&#46;gov&#47;coronavirus&#47;2019-ncov&#47;need-extra-precautions&#47;racial-ethnic-minorities&#46;html</a>"
                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Black&#44; Asian and minority ethnic groups in England are at increased risk of death from COVID-19&#58; indirect standardisation of NHS mortality data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;W&#46; Aldridge"
                            1 => "D&#46; Lewer"
                            2 => "S&#46;V&#46; Katikireddi"
                            3 => "R&#46; Mathur"
                            4 => "N&#46; Pathak"
                            5 => "R&#46; Burns"
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                    0 => array:2 [
                      "doi" => "10.12688/wellcomeopenres.15922.2"
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                        "tituloSerie" => "Wellcome Open Res&#46;"
                        "fecha" => "2020"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hospitalization and mortality among black patients and white patients with Covid-19"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;G&#46; Price-Haywood"
                            1 => "J&#46; Burton"
                            2 => "D&#46; Fort"
                            3 => "L&#46; Seoane"
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                      "doi" => "10.1056/NEJMsa2011686"
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                        "tituloSerie" => "N Engl J Med&#46;"
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                        "volumen" => "382"
                        "paginaInicial" => "2534"
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                    0 => array:2 [
                      "titulo" => "Assessing racial and ethnic disparities using a COVID-19 outcomes continuum for New York State"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;R&#46; Holtgrave"
                            1 => "M&#46;A&#46; Barranco"
                            2 => "J&#46;M&#46; Tesoriero"
                            3 => "D&#46;S&#46; Blog"
                            4 => "E&#46;S&#46; Rosenberg"
                          ]
                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.annepidem.2020.06.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Epidemiol&#46;"
                        "fecha" => "2020"
                        "volumen" => "48"
                        "paginaInicial" => "9"
                        "paginaFinal" => "14"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32723697"
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                          "pii" => "S1695403320300977"
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                          "issn" => "16954033"
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              "etiqueta" => "8"
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                  "referenciaCompleta" => "The COVID Racial Data Tracker&#46; The COVID Tracking Project &#91;consultado 31 Sep 2020&#93;&#46; Disponible en&#58; <a target="_blank" href="https://covidtracking.com/race">https&#58;&#47;&#47;covidtracking&#46;com&#47;race</a>"
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            8 => array:3 [
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              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors associated with COVID-19-related death using OpenSAFELY"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;J&#46; Williamson"
                            1 => "A&#46;J&#46; Walker"
                            2 => "K&#46; Bhaskaran"
                            3 => "S&#46; Bacon"
                            4 => "C&#46; Bates"
                            5 => "C&#46;E&#46; Morton"
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                      ]
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Información del artículo
ISSN: 00142565
Idioma original: Español
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