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seg&#250;n datos del estudio Di&#64;bet&#46;es<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a>&#44; se sit&#250;a entre el 25&#37; y el 35&#37;&#44; dependiendo de los grupos etarios&#46; En mayores de 76 a&#241;os la prevalencia de DM2 es del 20&#44;7&#37; en varones y del 23&#44;2&#37; en mujeres&#46; En pacientes entre 61 y 75 a&#241;os afecta al 24&#44;8&#37; de los varones y al 18&#44;7&#37; de las mujeres&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los datos analizados por la RedGDPS en el a&#241;o 2007 mostraban que la edad media de los pacientes con DM2 en Espa&#241;a era 68&#44;2 a&#241;os&#44; siendo el 63&#37; mayor de 65 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46; Datos publicados en Alemania y Estados Unidos se&#241;alan una situaci&#243;n epidemiol&#243;gica similar<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11&#44;12</span></a>&#46; En Estados Unidos&#44; en 2014&#44; entre los residentes de 65 o m&#225;s a&#241;os la prevalencia de prediabetes fue del 51&#37; y la de DM2 del 25&#44;9&#37;&#44; lo que representa para esta &#250;ltima una poblaci&#243;n de 11&#44;2 millones de personas<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a>&#46; Respecto al abordaje terap&#233;utico de la DM2 en los pacientes<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#44; los <span class="elsevierStyleItalic">Standards of Medical Care in Diabetes</span> publicados recientemente por la <span class="elsevierStyleItalic">American Diabetes Association</span> &#40;ADA&#41; consideran prioritario individualizar el tratamiento para cumplir con los objetivos de control de la hemoglobina glucosilada &#40;HbA1c&#41; y proponen 3 niveles de control &#40;&#60;<span class="elsevierStyleHsp" style=""></span>7&#44;5&#37;&#44; &#60;<span class="elsevierStyleHsp" style=""></span>8&#37; y &#60;<span class="elsevierStyleHsp" style=""></span>8&#44;5&#37;&#41; en funci&#243;n de los diferentes grados de discapacidad&#44; comorbilidad y deterioro cognitivo<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Por otra parte&#44; se ha objetivado que los pacientes ancianos con DM2 tienen una elevada prevalencia de discapacidad y de comorbilidades asociadas&#44; como la hipertensi&#243;n arterial&#44; enfermedad coronaria&#44; enfermedad cerebrovascular&#44; e incluso un porcentaje elevado de s&#237;ndromes geri&#225;tricos como deterioro cognitivo&#44; ca&#237;das&#44; dolor cr&#243;nico y polifarmacia<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a>&#46; Hasta la fecha desconocemos la verdadera situaci&#243;n de los pacientes ancianos con DM2 en Espa&#241;a&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleItalic">Estudio de las caracter&#237;sticas de los pacientes ancianos con diabetes en Espa&#241;a</span> &#40;ESCADIANE&#41;&#44; cuyos resultados se presentan en este art&#237;culo&#44; fue dise&#241;ado por el Grupo de Atenci&#243;n Primaria de la Sociedad Espa&#241;ola de Diabetes&#44; con el fin de conocer las caracter&#237;sticas de los pacientes ancianos con DM2 en nuestro pa&#237;s y poder as&#237; mejorar las estrategias de atenci&#243;n sociosanitaria en este grupo de poblaci&#243;n&#46; El objetivo principal de este estudio fue conocer el estado del control gluc&#233;mico de los pacientes ancianos con DM2 en Espa&#241;a y su relaci&#243;n con la capacidad funcional y la comorbilidad&#46; Los objetivos secundarios fueron conocer la prevalencia de los factores de riesgo cardiovascular y el grado de control de los mismos&#44; la prevalencia de complicaciones macro y microvasculares&#44; describir los tratamientos empleados para el control gluc&#233;mico&#44; analizar el porcentaje de pacientes con hipoglucemias registradas en la historia cl&#237;nica y describir las caracter&#237;sticas de las mismas durante el a&#241;o previo al estudio&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Material y m&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se trata de un estudio epidemiol&#243;gico&#44; observacional&#44; transversal&#44; multic&#233;ntrico&#44; de &#225;mbito nacional&#44; que se desarroll&#243; entre octubre de 2014 y abril de 2015&#46; Participaron 82 investigadores&#44; m&#233;dicos de atenci&#243;n primaria de las diferentes comunidades aut&#243;nomas&#44; cuya distribuci&#243;n fue proporcional a la poblaci&#243;n de cada comunidad aut&#243;noma de Espa&#241;a&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La poblaci&#243;n de estudio comprendi&#243; todos los pacientes &#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os con DM2 conocida o de nuevo diagn&#243;stico seg&#250;n criterios de la ADA 2011<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> &#40;s&#237;ntomas cardinales de diabetes y glucemia al azar &#8805;<span class="elsevierStyleHsp" style=""></span>200<span class="elsevierStyleHsp" style=""></span>mg&#47;dl en una sola ocasi&#243;n&#59; glucemia en ayunas &#8805;<span class="elsevierStyleHsp" style=""></span>126<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; HbA1c<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>6&#44;5&#37; o glucemia &#8805;<span class="elsevierStyleHsp" style=""></span>200<span class="elsevierStyleHsp" style=""></span>mg&#47;dl a las 2<span class="elsevierStyleHsp" style=""></span>horas de una sobrecarga oral con 75<span class="elsevierStyleHsp" style=""></span>g de glucosa&#41;&#46; Si no exist&#237;a hiperglucemia inequ&#237;voca los resultados se deb&#237;an confirmar repitiendo los an&#225;lisis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Los pacientes deb&#237;an firmar el consentimiento informado &#40;ellos o su representante legal&#41; y no ten&#237;an que estar participando en ning&#250;n otro tipo de estudio epidemiol&#243;gico&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se excluyeron personas &#60;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os que no cumpl&#237;an los criterios diagn&#243;sticos de DM2 de la ADA 2011&#44; pacientes en situaci&#243;n terminal y aquellos cuya historia cl&#237;nica no aportaba los datos necesarios y suficientes para el estudio&#44; a juicio del comit&#233; evaluador&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A cada m&#233;dico investigador se le propuso seleccionar 12 pacientes con DM2 que cumplieran los criterios de inclusi&#243;n&#46; Para ello se proporcion&#243; una secuencia de n&#250;meros aleatorios mediante la que se deb&#237;an elegir dichos pacientes de un listado en el que figuraban todos los DM2<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os de la consulta del m&#233;dico investigador&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Variables del estudio</span><p id="par0060" class="elsevierStylePara elsevierViewall">Se estudiaron las siguientes variables demogr&#225;ficas y antropom&#233;tricas&#58; edad&#44; sexo&#44; peso&#44; talla&#44; &#237;ndice de masa corporal&#44; per&#237;metro abdominal&#44; h&#225;bito tab&#225;quico &#40;fumador&#44; ex-fumador&#44; no fumador&#41;&#44; consumo de alcohol &#40;bebedor&#44; ex-bebedor&#44; no bebedor&#41;&#44; presi&#243;n arterial sist&#243;lica y diast&#243;lica&#44; a&#241;os de evoluci&#243;n y fecha de diagn&#243;stico de la diabetes mellitus&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Se recogieron los antecedentes de enfermedades y la aparici&#243;n de complicaciones macro y microvasculares de la DM2 con un diagn&#243;stico confirmado y datado en la historia cl&#237;nica&#44; como cardiopat&#237;a isqu&#233;mica &#40;<span class="elsevierStyleItalic">angor pectoris</span> o infarto de miocardio&#41;&#44; insuficiencia cardiaca&#44; enfermedad vascular cerebral&#44; arteriopat&#237;a perif&#233;rica sintom&#225;tica&#44; enfermedad renal &#40;filtrado glomerular estimado<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> y&#47;o presencia de albuminuria &#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h y&#47;o &#237;ndice alb&#250;mina&#47;creatinina en muestra aislada de orina &#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mg&#47;g&#41;&#44; neuropat&#237;a&#44; retinopat&#237;a&#44; dislipidemia&#44; hipertensi&#243;n arterial&#44; hipertrofia ventricular izquierda y arritmia card&#237;aca&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Se registr&#243; el tratamiento farmacol&#243;gico utilizado de forma habitual por los pacientes &#40;antidiab&#233;ticos&#44; antihipertensivos&#44; hipolipidemiantes&#44; antiagregantes o anticoagulantes&#41; y se investigaron los antecedentes de hipoglucemias que aparec&#237;an en la historia cl&#237;nica y si precisaron de ayuda externa&#44; es decir&#44; de otra persona para su recuperaci&#243;n&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Entre las variables anal&#237;ticas se recogieron la HbA1c &#40;&#37;&#41;&#44; glucemia basal &#40;mg&#47;dl&#41;&#44; perfil lip&#237;dico &#40;colesterol total&#44; colesterol HDL&#44; colesterol LDL&#44; triglic&#233;ridos&#41;&#44; perfil hep&#225;tico&#44; creatinina plasm&#225;tica&#44; filtrado glomerular estimado seg&#250;n la f&#243;rmula <span class="elsevierStyleItalic">Modification of diet in renal disease</span> &#40;ml&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41; e &#237;ndice de alb&#250;mina&#47;creatinina en orina&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Para estudiar el nivel de dependencia se emple&#243; el &#237;ndice de Barthel<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a> y se clasific&#243; a los pacientes seg&#250;n su puntuaci&#243;n en&#58; independientes &#40;100 puntos&#41;&#44; o con dependencia leve &#40;91-99 puntos&#41;&#44; moderada &#40;61-90 puntos&#41;&#44; grave &#40;21-60 puntos&#41; o total &#40;0-20 puntos&#41;&#46; La comorbilidad&#44; basada en el &#237;ndice de Charlson<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a>&#44; permiti&#243; clasificar a los pacientes en&#58; comorbilidad baja &#40;0 puntos&#41;&#44; media &#40;1-2 puntos&#41;&#44; alta &#40;3-4 puntos&#41; y muy alta &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>5 puntos&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">El estudio fue calificado como un &#171;Estudio post-autorizaci&#243;n observacional-otros dise&#241;os&#187; por la Agencia Espa&#241;ola del Medicamento &#40;c&#243;digo FJS-DIA-2013-01&#41; y aprobado por el Comit&#233; &#201;tico de Investigaci&#243;n Cl&#237;nica de Arag&#243;n&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0095" class="elsevierStylePara elsevierViewall">Para un nivel de confianza del 95&#37; se calcul&#243; que con una muestra de 939 pacientes se conseguir&#237;a una precisi&#243;n del 2-3&#37;&#46; Se realiz&#243; un an&#225;lisis descriptivo de las variables demogr&#225;ficas&#44; sociales&#44; antropom&#233;tricas&#44; anal&#237;ticas y de las comorbilidades&#46; Las variables continuas se han descrito mediante medidas de tendencia central &#40;media o mediana&#41;&#44; no central &#40;cuartiles&#41; o de dispersi&#243;n &#40;desviaci&#243;n est&#225;ndar&#41; y las variables cualitativas mediante distribuciones de frecuencias absolutas y relativas &#40;porcentajes&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Para la comparaci&#243;n entre variables cuantitativas y cualitativas se comprob&#243;&#44; mediante prueba de Kolmogorov-Smirnov&#44; si las primeras segu&#237;an una distribuci&#243;n normal&#46; Se utilizaron pruebas param&#233;tricas &#40;&#171;t&#187; de Student o ANOVA&#41; o no param&#233;tricas &#40;U de Mann Whitney o Kruskal Wallis&#41; seg&#250;n se cumpliera o no la normalidad&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Las diferencias entre proporciones se calcularon mediante prueba la prueba de Chi-cuadrado&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Cuando se ha precisado se ha utilizado la correcci&#243;n de Yates&#46; En caso de realizar comparaciones m&#250;ltiples se aplic&#243; el m&#233;todo de Bonferroni&#46; Se tom&#243; como nivel de significaci&#243;n p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 y se realiz&#243; el estudio mediante el Sofware IBM SPSS Statistics v&#46;23&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0115" class="elsevierStylePara elsevierViewall">Se incluyeron 939 pacientes&#44; cuya edad media fue de 76&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;7 a&#241;os&#46; Los valores de las variables antropom&#233;tricas&#44; capacidad funcional y comorbilidad distribuidos por grupos etarios se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Los resultados del grado de control gluc&#233;mico&#44; glucemia basal en ayunas y el porcentaje de hipoglucemias seg&#250;n el grado de dependencia y comorbilidad se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; El nivel de HbA1c present&#243; diferencias estad&#237;sticamente significativas seg&#250;n el grado de discapacidad entre los ancianos con DM2 y dependencia grave y los que eran independientes &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; o ten&#237;an dependencia leve &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; Los pacientes con dependencia grave ten&#237;an la HbA1c m&#225;s elevada &#40;7&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;1&#37;&#41;&#46; Tambi&#233;n fue significativa la diferencia entre la media de HbA1c de los ancianos diab&#233;ticos con dependencia moderada&#44; frente a los independientes &#40;7&#44;43&#37; vs&#46; 7&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;047&#41;&#46; Un porcentaje elevado de los pacientes con dependencia total &#40;62&#44;5&#37;&#41; recib&#237;an tratamiento con insulina&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Seg&#250;n el &#237;ndice de Charlson el 57&#44;2&#37; de los ancianos con DM2 ten&#237;an un grado de comorbilidad media &#40;puntuaci&#243;n 1-2&#41;&#44; el 28&#44;4&#37; de comorbilidad alta &#40;3-4&#41; y el 14&#44;4&#37; de comorbilidad muy alta &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>5&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">A medida que la comorbilidad era mayor&#44; tambi&#233;n lo era el nivel de HbA1c&#44; con diferencias estad&#237;sticamente significativas entre las cifras de HbA1c de los DM2 ancianos con comorbilidad media frente a los de comorbilidad muy alta &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;012&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Conforme aumentaba la comorbilidad&#44; tambi&#233;n lo hac&#237;a el porcentaje de pacientes tratados con insulina sola o asociada a secretagogos&#44; y disminu&#237;a el porcentaje de pacientes tratados con antidiab&#233;ticos orales&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se muestran los datos de control gluc&#233;mico y la prevalencia de los factores de riesgo cardiovascular&#46; El 40&#37; de los pacientes ten&#237;a un &#237;ndice de masa corporal<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30&#44; el 43&#44;7&#37; presentaban cifras de presi&#243;n arterial sist&#243;lica<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>140<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg y&#47;o de diast&#243;lica &#62;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Solo el 3&#44;2&#37; ten&#237;a cifras de colesterol total<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>250<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; En el 84&#44;3&#37; de los pacientes sin enfermedad cardiovascular el colesterol LDL fue<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>130<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; y en un 69&#44;1&#37; de los que ten&#237;a enfermedad cardiovascular previa se situ&#243; por debajo de 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Las concentraciones de colesterol HDL fueron adecuadas en el 60&#44;7&#37; &#40;HDL<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>mg&#47;dl en mujeres y &#62;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mg&#47;dl en hombres&#41; y el 66&#44;6&#37; de los pacientes manten&#237;a unos triglic&#233;ridos por debajo de 150<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; El colesterol LDL fue inferior a 70<span class="elsevierStyleHsp" style=""></span>mg&#47;dl en el 34&#37; de los pacientes con enfermedad macrovascular y en el 24&#44;1&#37; de los pacientes con insuficiencia renal avanzada&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">El 58&#44;4&#37; de la poblaci&#243;n tuvo complicaciones macrovasculares y&#47;o microvasculares &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">El 28&#44;6&#37; padec&#237;a al menos una enfermedad macrovascular y el 45&#44;7&#37; alguna complicaci&#243;n microvascular&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">El 91&#37; de los pacientes segu&#237;a tratamiento farmacol&#243;gico&#58; el 25&#44;5&#37; insulina y el 82&#37; tratamiento no insul&#237;nico&#46; El 17&#37; utilizaba insulina junto a antidiab&#233;ticos orales&#46; El 16&#37; de los pacientes tomaban sulfonilureas &#40;SU&#41;&#44; siendo la m&#225;s usada la gliclazida &#40;54&#37; de las SU&#41;&#46; El 28&#37; recib&#237;a inhibidores de la enzima dipeptidil peptidasa 4 &#40;iDPP-4&#41;&#46; Dentro de este grupo destacaban la sitagliptina &#40;46&#44;5&#37;&#41;&#44; la vildagliptina &#40;30&#37;&#41; y la linagliptina &#40;19&#37;&#41;&#46; Los antidiab&#233;ticos orales &#40;o combinaciones&#41; m&#225;s utilizados fueron&#58; metformina &#40;47&#37;&#41;&#44; metformina<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>IDPP4 &#40;19&#37;&#41;&#44; metformina<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>sulfonilureas &#40;9&#37;&#41;&#44; IDPP4 &#40;6&#37;&#41; e IDPP4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>metformina<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>sulfonilureas &#40;5&#37;&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El 12&#44;5&#37; de los pacientes ten&#237;a registrados episodios de hipoglucemia en la historia cl&#237;nica&#46; El 18&#37; de estos episodios fueron considerados graves&#44; ya que precisaron la asistencia de otra persona&#46; El 86&#37; de las hipoglucemias graves ocurrieron en pacientes tratados con insulina&#44; frente al 14&#37; ocurrido en sujetos tratados con secretagogos &#40;sulfonilureas o repaglinida&#41;&#46; La utilizaci&#243;n de insulina y secretagogos fue porcentualmente mayor en los pacientes que ten&#237;an una mayor comorbilidad y dependencia y&#44; adem&#225;s&#44; estos f&#225;rmacos fueron m&#225;s empleados en los pacientes con peor control metab&#243;lico &#40;un 67&#37; de los pacientes con una HbA1c<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>7&#37; estaban siendo tratados con insulina y&#47;o secretagogos&#44; frente al 25&#37;</p><p id="par0155" class="elsevierStylePara elsevierViewall">de los pacientes con una HbA1c<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0160" class="elsevierStylePara elsevierViewall">El manejo de los pacientes con DM2 precisa de una adecuada valoraci&#243;n individual con el fin de establecer los objetivos de control y la mejor estrategia terap&#233;utica&#46; La edad&#44; la esperanza de vida&#44; la capacidad funcional&#44; la comorbilidad&#44; los a&#241;os de evoluci&#243;n de la enfermedad y la colaboraci&#243;n del paciente son los pilares sobre los que se deben basar las decisiones cl&#237;nicas y establecer los objetivos de control gluc&#233;mico<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">En el caso de los pacientes ancianos con DM2 es de especial importancia evitar los episodios hipogluc&#233;micos y los efectos adversos farmacol&#243;gicos&#44; que pueden empeorar su calidad de vida y provocar ca&#237;das&#44; accidentes o deterioro cognitivo&#46; El control estricto de los par&#225;metros metab&#243;licos en estos pacientes es menos probable que aporte beneficios a largo plazo<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6&#44;8</span></a>&#44; especialmente en los m&#225;s ancianos&#46; En nuestro estudio llama la atenci&#243;n la baja concentraci&#243;n de HbA1c de los ancianos con DM2&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">La media de HbA1c fue del 7&#37;&#44; a pesar de que eran pacientes con un tiempo medio de evoluci&#243;n de la enfermedad de m&#225;s de 10 a&#241;os &#40;11&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;9&#41;&#46; Un 75&#37; de los pacientes ten&#237;a una HbA1c<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7&#44;5&#37;&#46; Estas cifras son orientativas de la intensidad terap&#233;utica y podr&#237;an explicar el porqu&#233; de las hipoglucemias registradas en la historia cl&#237;nica &#40;uno de cada 8 pacientes experiment&#243; al menos un episodio de hipoglucemia&#41;&#46; De estas&#44; el 18&#37; precisaron de ayuda externa para la recuperaci&#243;n del paciente&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Los datos de control gluc&#233;mico de este estudio son similares a los de otros realizados en nuestro entorno<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">20&#8211;22</span></a> u otros pa&#237;ses&#46; En concreto&#44; un an&#225;lisis de 1&#46;288 pacientes mayores de 65 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> de una encuesta de salud de Estados Unidos &#40;NHANES&#41;&#44; apunt&#243; hacia el posible sobretratamiento de los pacientes ancianos&#44; ya que el 61&#44;5&#37; de la muestra estudiada ten&#237;a una HbA1c<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7&#37; y un 41&#44;9&#37; menor al 6&#44;5&#37;&#46; En otra encuesta de salud llevada a cabo en Alemania&#44; el 65&#37; de los diab&#233;ticos ten&#237;a una HbA1c<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7&#37;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a>&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Los resultados mostraron un peor control gluc&#233;mico cuando el anciano diab&#233;tico ten&#237;a un mayor grado de comorbilidad&#44; aunque la diferencia de HbA1c entre los grupos con mayor y menor comorbilidad fue solamente de 0&#44;36&#37;&#44; diferencia de escasa relevancia cl&#237;nica&#46; Tambi&#233;n se observ&#243; un peor control gluc&#233;mico conforme aumentaba el grado de dependencia&#44; excepto en el caso de los ancianos con dependencia total&#44; que presentaron niveles medios similares a los ancianos sin ning&#250;n grado de dependencia&#46; Este control gluc&#233;mico estricto en ancianos diab&#233;ticos totalmente dependientes podr&#237;a estar asociado a la intensificaci&#243;n del tratamiento con insulina&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">En Francia<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a> se realiz&#243; un estudio en pacientes diab&#233;ticos mayores de 70 a&#241;os para investigar la relaci&#243;n entre el control metab&#243;lico y la morbimortalidad&#46; Se investigaron 3 cohortes seg&#250;n el tratamiento empleado&#58; solo insulina&#44; insulina m&#225;s antidiab&#233;ticos orales y solo antidiab&#233;ticos orales y&#47;o an&#225;logos de <span class="elsevierStyleItalic">glucagon like peptide-1</span>&#46; Se observ&#243; un alto porcentaje de hipoglucemias &#40;53&#37;&#41; en el primer grupo&#44; siendo&#44; adem&#225;s&#44; su control gluc&#233;mico peor y mayor la proporci&#243;n de retinopat&#237;a&#44; enfermedad renal&#44; afectaci&#243;n cardiovascular y complicaciones geri&#225;tricas&#46; Los pacientes tratados exclusivamente con antidiab&#233;ticos orales o an&#225;logos de <span class="elsevierStyleItalic">glucagon like peptide-1</span>tuvieron una evoluci&#243;n de su enfermedad y unas caracter&#237;sticas y comorbilidades muy parecidas a las de nuestra muestra y presentaron niveles de HbA1c media semejantes &#40;7&#44;1&#37;&#41;&#44; con un 75&#37; de pacientes con HbA1c<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7&#44;5&#37;&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">En los ancianos de nuestra muestra&#44; como era de esperar&#44; los factores de riesgo cardiovascular y las complicaciones vasculares fueron elevadas&#46; La hipertensi&#243;n arterial&#44; presente en un 78&#37; de pacientes&#44; sigue siendo el factor m&#225;s dif&#237;cil de controlar&#46; Aproximadamente un tercio de los ancianos con DM2 padec&#237;a enfermedad macrovascular y&#44; de manera semejante a otros estudios espa&#241;oles<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">20&#44;21&#44;26</span></a>&#44; la principal complicaci&#243;n fue la cardiopat&#237;a isqu&#233;mica &#40;13&#44;9&#37;&#41;&#44; seguida de la enfermedad cerebro-vascular &#40;11&#44;9&#37;&#41; y de la enfermedad arterial perif&#233;rica &#40;9&#37;&#41;&#46; Sin embargo&#44; la prevalencia de enfermedad macrovascular fue muy inferior en comparaci&#243;n con la de otros pa&#237;ses occidentales como Estados Unidos<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">23&#44;27</span></a>&#44; Alemania<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#44;29</span></a>&#44; Escocia<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> o Francia<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a>&#44; incluso en cohortes con edades m&#225;s j&#243;venes&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Las complicaciones microvasculares afectaron al 45&#44;7&#37; de los pacientes&#44; siendo la m&#225;s prevalente la enfermedad renal cr&#243;nica&#46; La alta prevalencia de la enfermedad renal cr&#243;nica deber&#237;a tener influencia en los tratamientos farmacol&#243;gicos empleados y ser objetivo de m&#225;s estudios&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">En referencia al tratamiento farmacol&#243;gico la metformina fue el f&#225;rmaco m&#225;s frecuentemente utilizado&#44; seguida de los IDPP-4&#46; La utilizaci&#243;n de insulina no fue residual&#44; ya que se emple&#243; en un 25&#37; de los casos&#44; por lo que el conocimiento de su manejo es importante&#46; Insulina y secretagogos fueron los f&#225;rmacos con una relaci&#243;n m&#225;s intensa con las hipoglucemias&#44; y su uso era m&#225;s frecuente en los pacientes con peor control metab&#243;lico&#46; Tambi&#233;n resulta llamativo que la glibenclamida supusiera todav&#237;a el 7&#37; de las SU empleadas&#44; a pesar de su vida media prolongada y de la capacidad para provocar hipoglucemias&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">El presente trabajo tiene las limitaciones propias de los estudios transversales&#46; Los datos fueron extra&#237;dos de la historia cl&#237;nica y probablemente algunos resultados&#44; como la prevalencia de las hipoglucemias o de los s&#237;ndromes geri&#225;tricos&#44; est&#233;n infraestimados&#46; Sin embargo&#44; el tama&#241;o de la muestra estudiada y el m&#233;todo de elecci&#243;n de la misma&#44; con investigadores distribuidos por toda Espa&#241;a y con el empleo de series de n&#250;meros aleatorios para la selecci&#243;n de los pacientes&#44; nos hacen pensar que los resultados obtenidos son representativos de la situaci&#243;n actual en nuestro pa&#237;s&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusi&#243;n</span><p id="par0210" class="elsevierStylePara elsevierViewall">Los valores medios de HbA1c en los pacientes ancianos con DM2 analizados en Espa&#241;a son inferiores a los recomendados por las principales gu&#237;as de pr&#225;ctica cl&#237;nica&#46; Estos valores resultaron m&#225;s elevados en los pacientes con un nivel m&#225;s alto de comorbilidad y se vieron influidos por el grado de discapacidad del paciente&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financiaci&#243;n</span><p id="par0215" class="elsevierStylePara elsevierViewall">Este trabajo ha sido desarrollado gracias al soporte financiero de Boehringer-Ingelgeim&#46; Las fuentes financieras no han tenido ning&#250;n papel en el dise&#241;o del estudio&#44; recogida de datos o interpretaci&#243;n de los mismos&#46; Tampoco han participado en la preparaci&#243;n&#44; revisi&#243;n o aprobaci&#243;n del manuscrito&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0225" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer el estado del control gluc&#233;mico de los pacientes ancianos con diabetes mellitus tipo 2 en Espa&#241;a y su relaci&#243;n con la capacidad funcional y la comorbilidad&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal&#44; observacional&#44; multic&#233;ntrico&#44; de &#225;mbito nacional&#44; en pacientes con diabetes mellitus<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#46; Se estudiaron variables sociodemogr&#225;ficas&#44; antropom&#233;tricas&#44; factores de riesgo cardiovascular&#44; datos de exploraci&#243;n cl&#237;nica y anal&#237;ticos&#44; comorbilidad asociada y tratamientos utilizados&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se analiz&#243; la capacidad funcional mediante el &#237;ndice de Barthel y la comorbilidad con el de Charlson&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 939 pacientes&#46; La edad media fue 76&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;7 a&#241;os&#46; La hemoglobina glucosilada &#40;HbA1c&#41; media fue 7&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;2&#37; y la glucemia basal media 137<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#44;6<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; El nivel de HbA1c present&#243; diferencias estad&#237;sticamente significativas seg&#250;n el grado de discapacidad&#46; En los pacientes con dependencia total&#44; grave&#44; moderada&#44; leve o independientes las concentraciones de HbA1c media fueron de 7&#44;0&#37;&#44; 7&#44;9&#37;&#44; 7&#44;4&#37; y 7&#44;0&#37; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;028&#41; respectivamente&#46; Los niveles de HbA1c fueron de 7&#44;3&#37;&#44; 7&#44;1&#37; y 6&#44;9&#37; en los pacientes con comorbilidad muy alta&#44; alta y media&#44; respectivamente &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los valores medios de HbA1c en los pacientes ancianos con diabetes tipo 2 analizados en Espa&#241;a son inferiores a los recomendados por las principales gu&#237;as de pr&#225;ctica cl&#237;nica&#46; Son m&#225;s elevados en los pacientes que presentan mayor grado de discapacidad funcional y un nivel m&#225;s alto de comorbilidad&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objectives</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">To understand the state of glycaemic control of elderly patients with type 2 diabetes mellitus in Spain and its relationship with functional capacity and comorbidity&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional&#44; observational&#44; multicentre national study on patients with diabetes mellitus aged 65 years or older&#46; The study analysed demographic and anthropometric variables&#44; cardiovascular risk factors&#44; clinical and laboratory data&#44; associated comorbidity and treatments&#46;</p><p id="spar0155" class="elsevierStyleSimplePara elsevierViewall">We analysed the functional capacity using the Barthel index and the comorbidity with Charlson index&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The study included 939 patients with a mean age of 76&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;7 years&#46; The mean glycated haemoglobin &#40;HbA1c&#41; level was 7&#46;0&#37;<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2&#37;&#44; and the mean basal blood glucose level was 137<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; The HbA1c level showed statistically significant differences depending on the degree of disability&#46; In the patients who were totally&#44; severely&#44; moderately or slightly dependent or who were independent&#44; the mean HbA1c levels were 7&#46;0&#37;&#44; 7&#46;9&#37;&#44; 7&#46;4&#37; and 7&#46;0&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;028&#41;&#46; HbA1c levels were 7&#46;3&#37;&#44; 7&#46;1&#37; and 6&#46;9&#37; in the patients with very high&#44; high and medium comorbidity&#44; respectively &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Mean HbA1c levels in elderly patients with type 2 diabetes analysed in Spain are below those recommended by the main clinical practice guidelines&#46; The levels are higher in patients who have more functional disability and a higher level of comorbidity&#46;</p></span>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Los datos se expresan como media &#40;DE&#41;&#44; mediana &#40;RI&#41; o n&#250;mero &#40;&#37;&#41; seg&#250;n corresponda&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Para variables cualitativas &#40;n &#91;&#37;&#93;&#41;&#58; p-valor test Chi cuadrado&#46; Para variables cuantitativas&#58; test param&#233;trico &#40;&#171;t&#187; de Student o ANOVA 1 factor&#41; si siguen distribuci&#243;n normal&#44; test no param&#233;trico &#40;U-Mann Whitney&#44; K Kruskal Wallis&#41; si no siguen distribuci&#243;n normal&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; IMC&#58; &#237;ndice de masa corporal&#59; ns&#58; no significativo&#59; RI&#58; rango intercuart&#237;lico&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">a&#44;b&#44;c</span> Las letras en super&#237;ndice denotan un subconjunto de grupos de edad&#59; categor&#237;as cuyas proporciones de columna no difieren de forma significativa entre s&#237; en el nivel 0&#44;05&#46;</p>"
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Poblaci&#243;n total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">65-74 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">75-84 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#8805;<span class="elsevierStyleHsp" style=""></span>85 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hombre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">442 &#40;47&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">196 &#40;49&#44;6&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">203 &#40;49&#44;8&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;31&#44;6&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Mujer</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">497 &#40;52&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">199 &#40;50&#44;4&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">205 &#40;50&#44;2&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93 &#40;68&#44;4&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Edad&#44; a&#241;os</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70 &#40;5&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78 &#40;4&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87 &#40;3&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Peso&#44; kg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44;5 &#40;18&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#44;0 &#40;17&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#44;6 &#40;17&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#44;0 &#40;17&#44;5&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Talla&#44; cm</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">160&#44;0 &#40;13&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&#44;0 &#40;12&#44;5&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">159&#44;0&#40;13&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">156&#44;0 &#40;11&#44;0&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Per&#237;metro cintura&#44; cm</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hombres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104&#44;1 &#40;11&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104&#44;6 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104&#44;2 &#40;11&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100&#44;6 &#40;11&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mujeres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">98&#44;7 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">99&#44;8 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">98&#44;2 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">97&#44;4 &#40;14&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">RA&#47;E&#44; relaci&#243;n per&#237;metro abdomen&#47;estatura</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hombres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;625 &#40;0&#44;070&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;622&#40;0&#44;066&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;630 &#40;0&#44;070&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;614 &#40;0&#44;080&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mujeres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;641 &#40;0&#44;086&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;641 &#40;0&#44;082&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;641 &#40;0&#44;085&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;639 &#40;0&#44;101&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">IMC&#44; kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;9 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;4 &#40;6&#44;5&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;7 &#40;5&#44;7&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;0 &#40;5&#44;9&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">&#205;ndice de Barthel</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Independientes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">671 &#40;71&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">348 &#40;88&#44;1&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">276 &#40;67&#44;6&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47 &#40;34&#44;6&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="5" align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dependencia leve&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">204 &#40;21&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;9&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104 &#40;25&#44;5&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;44&#44;9<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dependencia moderada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;1&#44;3&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;4&#44;2&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;14&#44;0<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dependencia grave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;0&#44;5&#41;<span class="elsevierStyleSup">a&#44;b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0&#44;2&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;2&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dependencia total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0&#44;3&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;2&#44;5&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;3&#44;7&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Institucionalizados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;2&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;0&#44;5&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;2&#44;2&#41;<span class="elsevierStyleSup">a&#44;b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;5&#44;9&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">&#205;ndice de Charlson</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Comorbilidad baja &#40;1-2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">532 &#40;57&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">247 &#40;63&#44;0&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">217 &#40;53&#44;7&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;51&#44;1&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">0&#44;003</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Comorbilidad media &#40;3-4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">263 &#40;28&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">97 &#40;24&#44;7&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">131 &#40;32&#44;4&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;26&#44;3&#41;<span class="elsevierStyleSup">a&#44;b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Comorbilidad alta<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;12&#44;2&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;13&#44;9&#41;<span class="elsevierStyleSup">a&#44;b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;22&#44;6&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Medidas antropom&#233;tricas&#46; Capacidad funcional y comorbilidad de la poblaci&#243;n estudiada</p>"
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        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">ADO&#58; antidiab&#233;ticos orales&#59; DE&#58; desviaci&#243;n est&#225;ndar&#59; SU&#58; sulfonilureas&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">a&#44;b</span> Cada letra en super&#237;ndice denota un subconjunto de grupos de edad&#59; categor&#237;as cuyas proporciones de columna no difieren de forma significativa entre s&#237; en el nivel 0&#44;05&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Discapacidad &#205;ndice de Barthel</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HbA1C&#44; &#37; Media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Glucemia&#44; mg&#47;dl Media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hipoglucemias n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiento insulina n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiento con ADO n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiento ADO<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>insulina n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tatamiento insulina y&#47;o secretagogos &#40;SU o repaglinida&#41; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dependencia total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;99 &#40;1&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134&#44;9 &#40;52&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;25&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;62&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;43&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;18&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;68&#44;85&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dependencia grave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;93 &#40;1&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125&#44;3 &#40;47&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;42&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;57&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;14&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;71&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dependencia moderada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;43 &#40;1&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">135&#44;9 &#40;41&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;48&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;80&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;34&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;61&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dependencia leve&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">202 &#40;21&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;05 &#40;1&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">135&#44;5 &#40;42&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;16&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 &#40;32&#44;3&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152 &#40;75&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36 &#40;17&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96 &#40;47&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Independiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">672 &#40;71&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;00 &#40;1&#44;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">137&#44;8 &#40;35&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66 &#40;9&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141 &#40;21&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">576 &#40;85&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">107 &#40;15&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">263 &#40;39&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            1 => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Comorbilidad &#205;ndice de Charlson</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HbA1c&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Glucemia&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hipoglucemias n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiento Insulina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiento ADO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiento ADO<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Insulina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tratamiemto insulina y&#47;osecretagogos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Comorbilidad media&#58; 1-2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">535 &#40;57&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;95 &#40;1&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#44;34 &#40;36&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;41&#44;0&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88 &#40;16&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">473 &#40;88&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70 &#40;13&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">194 &#40;36&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Comorbilidad alta&#58; 3-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">265 &#40;28&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;06 &#40;1&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#44;90 &#40;40&#44;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;27&#44;4&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83 &#40;31&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">210 &#40;79&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;23&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">120 &#40;45&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Comorbilidad muy alta<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;31 &#40;1&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">140&#44;99 &#40;48&#44;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37 &#40;31&#44;6&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;50&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87 &#40;64&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;22&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85 &#40;63&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;5 &#40;8&#44;6&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;2 &#40;8&#44;4&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;6 &#40;9&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="4" align="left" valign="top">0&#44;003</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">168 &#40;17&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;17&#44;3&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77 &#40;18&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;16&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>5-10 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">159 &#40;40&#44;4&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124 &#40;30&#44;4&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;25&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>10 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453 &#40;48&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">167 &#40;42&#44;4&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">207 &#40;50&#44;7&#41;<span class="elsevierStyleSup">a&#44;b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79 &#40;58&#44;1&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">171&#44;5 &#40;49&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">171&#44;0 &#40;52&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#44;0 &#40;19&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#44;0 &#40;18&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#44;0 &#40;16&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#44;6 &#40;43&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#44;6 &#40;40&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44;4 &#40;30&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#44;1 &#40;30&#44;6&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&#44;8 &#40;32&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#44;4 &#40;29&#44;8&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">261 &#40;29&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;18&#44;8&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">121 &#40;31&#44;4&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72 &#40;55&#44;4&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fumador</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fumador habitual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;8&#44;1&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;5&#44;7&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#44;2&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ex fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">214 &#40;23&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;28&#44;2&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88 &#40;21&#44;7&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;11&#44;2&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">656 &#40;70&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">250 &#40;63&#44;6&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">294 &#40;72&#44;6&#41; <span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">112 &#40;83&#44;6&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hipertensi&#243;n arterial</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">731 &#40;78&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">303 &#40;77&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">320 &#40;79&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">108 &#40;80&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hipercolesterolemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">545 &#40;58&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">254 &#40;64&#44;6&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">229 &#40;56&#44;5&#41;<span class="elsevierStyleSup">a&#44;b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62 &#40;46&#44;3&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hipertrigliceridemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">224 &#40;24&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">122 &#40;31&#44;0&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77 &#40;19&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;18&#44;7&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Control gluc&#233;mico y factores de riesgo cardiovascular en la poblaci&#243;n de estudio</p>"
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          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Los datos se expresan como n&#250;mero &#40;&#37;&#41;&#46; Para variables cualitativas&#58; c&#225;lculo del valor p mediante el test Chi cuadrado&#46; Para variables cuantitativas&#58; test param&#233;trico &#40;&#171;t&#187; de Student o ANOVA un factor&#41; si siguen distribuci&#243;n normal&#44; test no param&#233;trico &#40;U-Mann Whitney&#44; K Kruskal Wallis&#41; si no siguen distribuci&#243;n normal&#46;</p><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">ACVA&#58; accidente cerebrovascular agudo&#59; ns&#58; no significativo&#46;</p><p id="spar0130" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">a&#44;b&#44;c</span> Cada letra en super&#237;ndice denota un subconjunto de grupos de edad&#59; categor&#237;as cuyas proporciones de columna no difieren de forma significativa entre s&#237; en el nivel 0&#44;05&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Poblaci&#243;n total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">75-84 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#8805;<span class="elsevierStyleHsp" style=""></span>85 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Complicaciones macrovasculares</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">267 &#40;28&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">108 &#40;27&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">119 &#40;29&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;29&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">130 &#40;13&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 &#40;12&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;13&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ACVA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111 &#40;11&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#40;11&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46 &#40;11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;15&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Enfermedad arterial perif&#233;rica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">84 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42 &#40;10&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;7&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Complicaciones microvasculares</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">422 &#40;45&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">143 &#40;36&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">197 &#40;49&#44;0&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82 &#40;61&#44;7&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Enfermedad renal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">339 &#40;36&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101 &#40;25&#44;9&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161 &#40;39&#44;9&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77 &#40;57&#44;5&#41;<span class="elsevierStyleSup">c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neuropat&#237;a diab&#233;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Retinopat&#237;a<br>&#40;retinopat&#237;a diab&#233;tica no proliferativa y&#47;o proliferativa&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111 &#40;11&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;13&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;7&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Complicaciones microvasculares y&#47;o macrovasculares</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">541 &#40;58&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">194 &#40;50&#44;0&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">251 &#40;62&#44;4&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">94 &#40;70&#44;7&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">Tratamientos utilizados y control metab&#243;lico en la poblaci&#243;n total y en los diferentes grupos etarios</p>"
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          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:30 [
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              "identificador" => "bib0155"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "World Health Organization&#46; Dept&#46; of Noncommunicable Disease Surveillance&#46; Definition&#44; diagnosis&#46;and classification of diabetes mellitus and its complications&#58; Report of WHO consultation&#46; Part 1&#46; Diagnosis and classification of diabetes mellitus&#46; 1999&#46; Ed&#46; Geneva&#58; World Health Organization&#59; p&#46; 60&#46;"
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            1 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Estrategia en diabetes del Sistema Nacional de Salud&#46; Prevalencia e incidencia de la DM y sus complicaciones&#46; Madrid&#58; Ministerio de Sanidad y Consumo&#59; 2007&#46; p&#46; 85&#46;"
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            2 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ministerio de Sanidad y Pol&#237;tica Social&#46; Encuesta Nacional de Salud &#91;consultado 23 May 2016&#93;&#46; Disponible en&#58; <a href="http://pestadistico.msc.es/PEMSC25/ArbolNodos.aspx">http&#58;&#47;&#47;pestadistico&#46;msc&#46;es&#47;PEMSC25&#47;ArbolNodos&#46;aspx</a>"
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            3 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Centers for Disease Control and Prevention&#46; National diabetes fact sheet&#58; National estimates and general information on diabetes and prediabetes in the United States&#59; 2011&#46; Atlanta&#44; GA&#58; U&#46;S&#46; Department of Health and Human Services&#44; Centers for Disease Control and Prevention&#44; 2011 &#91;consultado 23 May 2016&#93; 13 pp&#46; Disponible en&#58; <a href="http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf">http&#58;&#47;&#47;www&#46;cdc&#46;gov&#47;diabetes&#47;pubs&#47;pdf&#47;ndfs&#95;2011&#46;pdf</a>"
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              "identificador" => "bib0175"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetes mellitus in older people"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Position statement on behalf of the International Association of Gerontology and Geriatrics &#40;IAGG&#41;&#44; the European Diabetes Working Party for Older People &#40;EDWPOP&#41;&#44; and the International Task Force of Experts in Diabetes"
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                          "autores" => array:6 [
                            0 => "A&#46; Sinclair"
                            1 => "J&#46; Morley"
                            2 => "L&#46; Rodriguez-Ma&#241;as"
                            3 => "G&#46; Paolisso"
                            4 => "T&#46; Bayer"
                            5 => "A&#46; Zeyfang"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jamda.2012.04.012"
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                        "tituloSerie" => "J Am Med Dir Assoc"
                        "fecha" => "2012"
                        "volumen" => "13"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22748719"
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              "identificador" => "bib0180"
              "etiqueta" => "6"
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                  "referenciaCompleta" => "Sinclair A&#44; Dunning T&#44; Colagiuri S&#46; IDF Global guideline for managing older people with type 2 diabetes&#46; 2013 &#91;consultado 21 May 2016&#93;&#46; p&#46; 94&#46; Disponible en&#58; hppt&#46;&#47;&#47;www&#46;idf&#46;org&#47;sites&#47;default&#47;files7IDFGuideline- for-older-people-T2D&#46;pdf"
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                      "titulo" => "Clinical practice guidelines diabetes in the elderly Canadian Diabetes Association clinical practice guidelines expert committee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;S&#46; Meneilly"
                            1 => "A&#46; Knip"
                            2 => "D&#46; Daniel Tessier"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcjd.2013.01.045"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Diabetes"
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                        "volumen" => "37"
                        "paginaInicial" => "S184"
                        "paginaFinal" => "S190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24070944"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conferencia de consenso&#58; tratamiento de la diabetes tipo 2 en el paciente anciano"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; G&#243;mez Huelgas"
                            1 => "J&#46; D&#237;ez-Espino"
                            2 => "F&#46; Formiga"
                            3 => "J&#46; Lafita"
                            4 => "L&#46; Rodr&#237;guez- Ma&#241;as"
                            5 => "E&#46; Gonz&#225;lez-Sarmiento"
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                        ]
                      ]
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                  ]
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                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
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              "identificador" => "bib0195"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of diabetes mellitus and impaired glucose regulation in Spain&#58; The Di&#64;bet&#46;es Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Soriguer"
                            1 => "A&#46; Goday"
                            2 => "A&#46; Bosch-Comas"
                            3 => "E&#46; Bordi&#250;"
                            4 => "A&#46; Calle"
                            5 => "R&#46; Carmena"
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                      ]
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                  ]
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                    0 => array:2 [
                      "doi" => "10.1007/s00125-011-2336-9"
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                        "tituloSerie" => "Diabetologia"
                        "fecha" => "2012"
                        "volumen" => "55"
                        "paginaInicial" => "88"
                        "paginaFinal" => "93"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21987347"
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              "identificador" => "bib0200"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "en representaci&#243;n de la Red de Grupos de Estudio de la Diabetes en Atenci&#243;n Primaria de la Salud&#46; Evoluci&#243;n de los indicadores de calidad asistencial al diab&#233;tico tipo 2 en atenci&#243;n primaria &#40;1996-2007&#41;&#46; Programa de mejora continua de calidad de la Red de Grupos de Estudio de la Diabetes en Atenci&#243;n Primaria de la Salud"
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                          "etal" => false
                          "autores" => array:4 [
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                            1 => "S&#46; Artola"
                            2 => "J&#46; Diez-Espino"
                            3 => "M&#46; Mata"
                          ]
                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
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                        "volumen" => "135"
                        "paginaInicial" => "600"
                        "paginaFinal" => "607"
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