Estadísticas

 array:24 [
  "pii" => "S0014256516000515"
  "issn" => "00142565"
  "doi" => "10.1016/j.rce.2016.03.001"
  "estado" => "S300"
  "fechaPublicacion" => "2016-08-01"
  "aid" => "1251"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Rev Clin Esp. 2016;216:293-300"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 78
    "formatos" => array:2 [
      "HTML" => 49
      "PDF" => 29
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S2254887416300121"
      "issn" => "22548874"
      "doi" => "10.1016/j.rceng.2016.04.002"
      "estado" => "S300"
      "fechaPublicacion" => "2016-08-01"
      "aid" => "1251"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Rev Clin Esp. 2016;216:293-300"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 1
        "PDF" => 1
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Chronic myeloid leukaemia in Spain&#58; Its presentation characteristics have changed&#46; Spanish section of the EUTOS population-based registry"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "293"
            "paginaFinal" => "300"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Leucemia mieloide cr&#243;nica en Espa&#241;a&#58; sus caracter&#237;sticas de presentaci&#243;n han cambiado&#46; Secci&#243;n espa&#241;ola del registro poblacional EUTOS"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "S&#46; Osorio, L&#46;F&#46; Casado, P&#46; Giraldo, B&#46; Maestro, M&#46; Andrade, S&#46; Redondo, V&#46; Garc&#237;a-Guti&#233;rrez, R&#46; Ayala, N&#46; Garcia, J&#46;L&#46; Steegmann"
            "autores" => array:10 [
              0 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Osorio"
              ]
              1 => array:2 [
                "nombre" => "L&#46;F&#46;"
                "apellidos" => "Casado"
              ]
              2 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Giraldo"
              ]
              3 => array:2 [
                "nombre" => "B&#46;"
                "apellidos" => "Maestro"
              ]
              4 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Andrade"
              ]
              5 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Redondo"
              ]
              6 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Garc&#237;a-Guti&#233;rrez"
              ]
              7 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Ayala"
              ]
              8 => array:2 [
                "nombre" => "N&#46;"
                "apellidos" => "Garcia"
              ]
              9 => array:2 [
                "nombre" => "J&#46;L&#46;"
                "apellidos" => "Steegmann"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S0014256516000515"
          "doi" => "10.1016/j.rce.2016.03.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256516000515?idApp=WRCEE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887416300121?idApp=WRCEE"
      "url" => "/22548874/0000021600000006/v2_201607300616/S2254887416300121/v2_201607300616/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0014256516300170"
    "issn" => "00142565"
    "doi" => "10.1016/j.rce.2016.03.006"
    "estado" => "S300"
    "fechaPublicacion" => "2016-08-01"
    "aid" => "1256"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Clin Esp. 2016;216:301-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 61
      "formatos" => array:2 [
        "HTML" => 38
        "PDF" => 23
      ]
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "La paradoja del tabaco en el s&#237;ndrome coronario agudo&#46; El abandono previo del h&#225;bito tab&#225;quico como marcador de mejor pron&#243;stico a corto plazo"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "301"
          "paginaFinal" => "307"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "The tobacco paradox in acute coronary syndrome&#46; The prior cessation of smoking as a marker of a better short-term prognosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Bastos-Amador, M&#46; Almendro-Delia, B&#46; Mu&#241;oz-Calero, E&#46; Blanco-Ponce, A&#46; Recio-Mayoral, A&#46; Reina-Toral, J&#46;M&#46; Cruz-Fernandez, A&#46; Garc&#237;a-Alc&#225;ntara, R&#46; Hidalgo-Urbano, J&#46;C&#46; Garc&#237;a-Rubira"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Bastos-Amador"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Almendro-Delia"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Mu&#241;oz-Calero"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Blanco-Ponce"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Recio-Mayoral"
            ]
            5 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Reina-Toral"
            ]
            6 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Cruz-Fernandez"
            ]
            7 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Garc&#237;a-Alc&#225;ntara"
            ]
            8 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Hidalgo-Urbano"
            ]
            9 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Garc&#237;a-Rubira"
            ]
            10 => array:1 [
              "colaborador" => "Grupo SCA plataforma Ariam-Andaluc&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2254887416300182"
        "doi" => "10.1016/j.rceng.2016.03.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887416300182?idApp=WRCEE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256516300170?idApp=WRCEE"
    "url" => "/00142565/0000021600000006/v2_201607300632/S0014256516300170/v2_201607300632/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S0014256516300765"
      "issn" => "00142565"
      "doi" => "10.1016/j.rce.2016.05.003"
      "estado" => "S300"
      "fechaPublicacion" => "2016-08-01"
      "aid" => "1278"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "edi"
      "cita" => "Rev Clin Esp. 2016;216:311-2"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 38
        "formatos" => array:2 [
          "HTML" => 21
          "PDF" => 17
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
        "titulo" => "Epidemiolog&#237;a de la leucemia mieloide cr&#243;nica en Espa&#241;a y sus posibles implicaciones terap&#233;uticas"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "311"
            "paginaFinal" => "312"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Epidemiology of chronic myeloid leukemia in Spain and its possible therapeutic implications"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Garc&#237;a-Su&#225;rez, J&#46;J&#46; Gil-Fern&#225;ndez"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Garc&#237;a-Su&#225;rez"
              ]
              1 => array:2 [
                "nombre" => "J&#46;J&#46;"
                "apellidos" => "Gil-Fern&#225;ndez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256516300765?idApp=WRCEE"
      "url" => "/00142565/0000021600000006/v2_201607300632/S0014256516300765/v2_201607300632/es/main.assets"
    ]
  ]
  "es" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
    "titulo" => "Leucemia mieloide cr&#243;nica en Espa&#241;a&#58; sus caracter&#237;sticas de presentaci&#243;n han cambiado&#46; Secci&#243;n espa&#241;ola del registro poblacional EUTOS"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "293"
        "paginaFinal" => "300"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "S&#46; Osorio, L&#46;F&#46; Casado, P&#46; Giraldo, B&#46; Maestro, M&#46; Andrade, S&#46; Redondo, V&#46; Garc&#237;a-Guti&#233;rrez, R&#46; Ayala, N&#46; Garcia, J&#46;L&#46; Steegmann"
        "autores" => array:10 [
          0 => array:4 [
            "nombre" => "S&#46;"
            "apellidos" => "Osorio"
            "email" => array:2 [
              0 => "sanosorio2000&#64;gmail&#46;com"
              1 => "sanosorio2000&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;F&#46;"
            "apellidos" => "Casado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Giraldo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "B&#46;"
            "apellidos" => "Maestro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Andrade"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Redondo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "V&#46;"
            "apellidos" => "Garc&#237;a-Guti&#233;rrez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Ayala"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "N&#46;"
            "apellidos" => "Garcia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "J&#46;L&#46;"
            "apellidos" => "Steegmann"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:7 [
          0 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital Virgen de la Salud&#44; Toledo&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n Biom&#233;dica en Red de Enfermedades Raras &#40;CIBERER&#41;&#44; Zaragoza&#44; Espa&#241;a"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Instituto de Investigaci&#243;n Sanitaria del Hospital Universitario de La Princesa &#40;IIS-IP&#41;&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital Miguel Servet&#44; Zaragoza&#44; Espa&#241;a"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital Ram&#243;n y Cajal&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital 12 de Octubre&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Chronic myeloid leukaemia in Spain&#58; Its presentation characteristics have changed&#46; Spanish section of the EUTOS population-based registry"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La leucemia mieloide cr&#243;nica &#40;LMC&#41; es una neoplasia mieloproliferativa cr&#243;nica que se origina de una c&#233;lula pluripotencial hemopoy&#233;tica&#46; Su caracter&#237;stica citogen&#233;tica es la presencia del cromosoma Filadelfia &#40;Ph1&#41;&#44; que se produce por la traslocaci&#243;n de material cromos&#243;mico entre los cromosomas 9 y 22&#44; lo que origina la fusi&#243;n de los genes <span class="elsevierStyleItalic">BCR</span> y <span class="elsevierStyleItalic">ABL1</span>&#46; El gen de fusi&#243;n <span class="elsevierStyleItalic">BCR-ABL1</span> produce una tirosina cinasa BCR-ABL&#44; responsable de la proliferaci&#243;n mieloide caracter&#237;stica de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a>&#46; Cl&#237;nicamente se caracteriza por la presencia de leucocitosis marcada y esplenomegalia&#44; y por la tendencia a evolucionar desde una fase cr&#243;nica prolongada a fases m&#225;s avanzadas &#40;fase acelerada&#44; crisis bl&#225;stica&#41; de comportamiento agresivo y alta mortalidad<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a>&#46; Los datos epidemiol&#243;gicos sobre la enfermedad en Espa&#241;a y en Europa son escasos&#44; y se basan en estudios mayormente retrospectivos y metodol&#243;gicamente limitados<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#8211;12</span></a>&#44; por lo que la incidencia real no es conocida&#46; Adem&#225;s&#44; las caracter&#237;sticas de presentaci&#243;n parecen haber ido cambiando desde las descripciones cl&#225;sicas a las series m&#225;s recientes<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">13&#8211;15</span></a>&#46; Por estos motivos es de gran inter&#233;s disponer de un estudio que aporte informaci&#243;n fiable sobre la incidencia actual de la enfermedad y sus caracter&#237;sticas de presentaci&#243;n&#46; Estas razones justificaron la realizaci&#243;n de un gran estudio epidemiol&#243;gico sobre la LMC en Europa &#40;registro poblacional del proyecto <span class="elsevierStyleItalic">European Treatment and Outcome Study for Chronic Myeloid Leukemia</span> &#91;EUTOS&#93;&#41;&#44; en el que participaron 20 pa&#237;ses incluyendo Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a>&#46; En este art&#237;culo presentamos un an&#225;lisis detallado de la secci&#243;n espa&#241;ola&#44; que aporta datos epidemiol&#243;gicos de la enfermedad m&#225;s representativos y fiables que los actualmente disponibles en nuestro pa&#237;s&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Pacientes y m&#233;todos</span><p id="par0010" class="elsevierStylePara elsevierViewall">El proyecto EUTOS se enmarca dentro de las actividades de la red europea de investigaci&#243;n en leucemia&#58; <span class="elsevierStyleItalic">European LeukemiaNet</span>&#46; Incluye un registro poblacional de casos nuevos de LMC&#44; incluyendo 22 &#225;reas en 20 pa&#237;ses europeos&#44; con un m&#225;ximo de 10 millones de habitantes por &#225;rea&#46; En cada una de estas &#225;reas se deb&#237;an incluir consecutivamente todos los casos nuevos de LMC en pacientes<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&#46; El diagn&#243;stico se bas&#243; en la detecci&#243;n de <span class="elsevierStyleItalic">BCR-ABL</span> o del cromosoma Ph1&#46; La secci&#243;n espa&#241;ola incluy&#243; las comunidades aut&#243;nomas &#40;CC&#46; AA&#46;&#41; de Madrid&#44; Castilla-La Mancha y Arag&#243;n en un plazo de selecci&#243;n de 35 meses &#40;del 1-2-2010 al 31-12-2012&#41;&#46; Para detectar los casos se realiz&#243; un listado exhaustivo de todos los centros p&#250;blicos y privados con potencial para diagnosticarlos o tratarlos&#44; utilizando la informaci&#243;n disponible en las p&#225;ginas web de los servicios de salud de dichas comunidades y los listados de centros privados&#46; Se contact&#243; con todos los centros y se incluyeron en el estudio aquellos que confirmaron su capacidad de diagnosticar o tratar casos&#46; Adem&#225;s&#44; se incluyeron los laboratorios centrales p&#250;blicos y privados capaces de diagnosticar casos por incluir en su cartera de servicios la realizaci&#243;n de citogen&#233;tica convencional y&#47;o <span class="elsevierStyleItalic">BCR-ABL</span>&#46; Todos los centros seleccionados accedieron a participar&#46; Finalmente&#44; el n&#250;mero de hospitales y laboratorios centrales incluidos&#44; respectivamente&#44; fue&#58; Madrid 39 y 6&#44; Castilla-La Mancha 14 y 3&#44; Arag&#243;n 9 y 3&#46; El tama&#241;o de los centros incluidos fue muy variable&#44; con una dotaci&#243;n m&#237;nima de camas de 69 &#40;Hospital Sur IDC Salud&#44; Madrid&#41;&#44; hasta un m&#225;ximo de 1&#46;671 &#40;Hospital Gregorio Mara&#241;&#243;n&#44; Madrid&#41;&#46; Un listado completo de los centros colaboradores&#44; con el n&#250;mero de camas y de casos incluidos por centro&#44; se aporta en el <a class="elsevierStyleCrossRef" href="#sec0060">anexo 1</a>&#46; Se establecieron colaboradores en cada centro&#44; que fueron comunicando los casos prospectivamente&#46; Peri&#243;dicamente se contact&#243; con dichos investigadores para evitar casos sin notificar&#46; Las unidades que mostraron un alto grado de colaboraci&#243;n recogieron y enviaron sus propios datos&#44; mientras que el resto contaron con la colaboraci&#243;n de un administrador de datos <span class="elsevierStyleItalic">&#40;data manager&#41;</span>&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">An&#225;lisis estad&#237;stico</span><p id="par0015" class="elsevierStylePara elsevierViewall">Se analizaron las caracter&#237;sticas del conjunto de casos registrados&#46; Las variables num&#233;ricas como la edad y las cifras hematol&#243;gicas al diagn&#243;stico se caracterizaron mediante medidas de dispersi&#243;n sencillas&#44; como media&#44; mediana y percentil 75 o rango&#46; Las variables categ&#243;ricas se expresaron como frecuencias absolutas y porcentajes&#46; Con el n&#250;mero de casos registrados y las cifras poblacionales se calcularon las incidencias&#44; expresadas como n&#250;mero de casos por 100&#46;000 habitantes&#46; Las cifras poblacionales se obtuvieron del Instituto Nacional de Estad&#237;stica &#40;<a id="intr0005" class="elsevierStyleInterRef" href="http://www.ine.es/">www&#46;ine&#46;es</a>&#41;&#46; Al incluirse solo pacientes<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&#44; para el c&#225;lculo de incidencias se utiliz&#243; en el denominador las poblaciones de m&#225;s de 18 a&#241;os &#40;en concreto&#44; las cifras poblacionales de habitantes entre 20 y 99 a&#241;os&#41;&#46; Para calcular la incidencia anual del a&#241;o 2010&#44; dado que el periodo de selecci&#243;n ese a&#241;o fue de 11 meses&#44; se realiz&#243; una extrapolaci&#243;n estad&#237;stica sum&#225;ndose al n&#250;mero de casos observados la media mensual de casos en dicho a&#241;o&#46; Adicionalmente a las incidencias brutas&#44; se calcul&#243; la incidencia estandarizada por edad&#44; usando la poblaci&#243;n estandarizada escandinava de Doll y Cook aceptada por la WHO como patr&#243;n de poblaci&#243;n estandarizada europea&#46; Este ajuste de tasas se realiz&#243; por el m&#233;todo directo utilizando el programa EPIDAT 4&#46;1 &#40;<a id="intr0010" class="elsevierStyleInterRef" href="http://www.sergas.es/Saude-publica/EPIDAT">http&#58;&#47;&#47;www&#46;sergas&#46;es&#47;Saude-publica&#47;EPIDAT</a>&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El estudio se desarroll&#243; seg&#250;n las directrices centrales de la <span class="elsevierStyleItalic">European LeukemiaNet</span>&#44; respetando los principios &#233;ticos de la Declaraci&#243;n de Helsinki y tras la aprobaci&#243;n por el Comit&#233; &#201;tico del Hospital de La Princesa de Madrid&#46;</p></span></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0025" class="elsevierStylePara elsevierViewall">Se registraron 250 casos en 35 meses&#44; con la siguiente distribuci&#243;n geogr&#225;fica&#58; Madrid 174&#44; Castilla-La Mancha 40 y Arag&#243;n 36&#46; Se incluyeron 146 hombres &#40;H&#41; &#40;58&#37;&#41; y 104 mujeres &#40;M&#41; &#40;42&#37;&#41; &#40;relaci&#243;n H&#47;M de 1&#44;40&#41;&#44; con una edad mediana de 54 a&#241;os &#40;rango&#58; 21-99&#44; percentil 75&#58; 71 a&#241;os&#41;&#44; similar en las 3 CC&#46; AA&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Incidencias</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se calcularon las incidencias por 100&#46;000 habitantes-a&#241;o&#44; global&#44; por sexo&#44; edad&#44; comunidad aut&#243;noma y a&#241;o&#46; La incidencia global&#44; incluyendo las 3 CC&#46; AA&#46; y los 3 a&#241;os del estudio&#44; fue de 1&#44;08 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 1</a>&#41;&#46; La incidencia estandarizada por edad &#40;IEE&#41; fue parecida &#40;1&#44;04&#41;&#46; La incidencia fue inferior en Castilla-La Mancha &#40;0&#44;82&#41;&#44; y muy similar en Madrid &#40;1&#44;16&#41; y Arag&#243;n &#40;1&#44;12&#41;&#46; Las IEE para las 3 CC&#46; AA&#46; fueron 0&#44;78 &#40;Castilla-La Mancha&#41;&#44; 1&#44;10 &#40;Madrid&#41; y 1&#44;11 &#40;Arag&#243;n&#41;&#46; Dada la menor incidencia encontrada en Castilla-La Mancha&#44; se realiz&#243; una nueva revisi&#243;n que descart&#243; que existiesen casos no comunicados&#46; Se produjo una tendencia a la disminuci&#243;n de la incidencia en los a&#241;os 2011 y 2012 respecto a 2010&#44; muy similar en las 3 CC&#46; AA&#46; Respecto al sexo&#44; la incidencia fue superior en varones&#58; 1&#44;31 vs&#46; 0&#44;87 &#40;IEE 1&#44;31 y 0&#44;81&#41;&#46; En este aspecto&#44; hubo importantes diferencias entre CC&#46; AA&#46;&#44; observ&#225;ndose un predominio masculino en Arag&#243;n &#40;1&#44;90 vs&#46; 0&#44;37&#41;&#44; algo menos marcado en Madrid &#40;1&#44;4 vs&#46; 0&#44;95&#41;&#44; y un predominio femenino en Castilla-La Mancha &#40;0&#44;69 vs&#46; 0&#44;94&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 1</a>&#41;&#46; En cuanto a la distribuci&#243;n por edad&#44; aunque la mediana de presentaci&#243;n fue de 54 a&#241;os&#44; la incidencia aument&#243; con ella&#44; siendo mayor a partir de 65 a&#241;os&#46; Aun as&#237;&#44; el porcentaje de j&#243;venes fue apreciable&#58; 31&#44;7&#37; de casos entre 20 y 44 a&#241;os &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Presentaci&#243;n cl&#237;nica</span><p id="par0035" class="elsevierStylePara elsevierViewall">En 245 enfermos se dispuso de datos sobre la fase de la enfermedad&#59; de ellos&#44; 235 &#40;96&#37;&#41; se diagnosticaron en fase cr&#243;nica&#44; 6 &#40;2&#44;4&#37;&#41; en fase acelerada y 3 &#40;1&#44;6&#37;&#41; en crisis bl&#225;stica&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se obtuvo informaci&#243;n cl&#237;nica en 240 pacientes&#46; Solo el 44&#37; &#40;105&#41; estaban sintom&#225;ticos&#44; siendo los s&#237;ntomas m&#225;s frecuentes&#58; astenia &#40;21&#37;&#41;&#44; s&#237;ndrome constitucional &#40;14&#37;&#41;&#44; molestias abdominales &#40;9&#44;6&#37;&#41; y fiebre &#40;6&#37;&#41;&#46; El 38&#37; ten&#237;an esplenomegalia &#40;media desde el reborde costal de 4&#44;5<span class="elsevierStyleHsp" style=""></span>cm&#44; rango 1-22<span class="elsevierStyleHsp" style=""></span>cm&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Valores hematol&#243;gicos iniciales y distribuci&#243;n por sistemas de puntuaci&#243;n pron&#243;sticos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los par&#225;metros hematol&#243;gicos iniciales y la distribuci&#243;n seg&#250;n los sistemas de puntuaci&#243;n pron&#243;sticos de Sokal y Hasford se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 2</a>&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Caracter&#237;sticas citogen&#233;ticas y moleculares</span><p id="par0050" class="elsevierStylePara elsevierViewall">El 4&#37; de los casos no presentaron cromosoma Ph1&#44; el 92&#44;5&#37; mostraron la traslocaci&#243;n t&#40;9&#59;22&#41;&#40;q34&#59;q11&#41; convencional&#44; el 3&#44;5&#37; traslocaciones variantes&#44; y el 6&#44;5&#37; alteraciones citogen&#233;ticas adicionales&#46; Un 49&#37; de los pacientes presentaron el tr&#225;nscrito b2a2 &#40;e13a2&#41;&#44; el 42&#37; el b3a2 &#40;e14a2&#41;&#44; y el 8&#37;&#44; transcritos at&#237;picos&#46; El 66&#37; de los pacientes ten&#237;an ratios de <span class="elsevierStyleItalic">BCR-ABL</span> medidos en escala internacional&#46; La media de ratio de <span class="elsevierStyleItalic">BCR-ABL</span> al diagn&#243;stico fue del 83&#37; &#40;0&#44;05-423&#37;&#41;&#46; Si incluimos solo casos con resultados en la escala internacional la media fue del 79&#37; &#40;0&#44;28-401&#37;&#41;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discusi&#243;n</span><p id="par0055" class="elsevierStylePara elsevierViewall">Este estudio aporta posiblemente la informaci&#243;n epidemiol&#243;gica m&#225;s completa y fiable de la LMC en Espa&#241;a disponible hasta la fecha&#46; Disponemos de diversos estudios epidemiol&#243;gicos nacionales<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#8211;7</span></a>&#44; europeos<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#8211;12&#44;16</span></a> y americanos<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">17&#8211;19</span></a> con los que hemos comparado nuestros datos &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabla 3</a>&#41;&#46; En este estudio la incidencia global de LMC fue de 1&#44;08 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o&#46; En Espa&#241;a las incidencias globales brutas y estandarizadas de los estudios publicados oscilan entre los 0&#44;35 y 1&#44;9 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#8211;7</span></a>&#46; Existen diferencias entre ellos que dificultan realizar comparaciones directas&#58; los resultados se expresan de forma variable con incidencias brutas&#44; estandarizadas o acumuladas&#44; y algunos incluyen enfermos solo en fase cr&#243;nica<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a>&#46; Adem&#225;s&#44; la mayor&#237;a incluyen casos y poblaciones de todas las edades&#44; cuya informaci&#243;n se obtuvo de forma retrospectiva&#44; mientras que el estudio EUTOS se llev&#243; a cabo de forma prospectiva y solo incluy&#243; enfermos<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os y poblaci&#243;n con edad<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>20 a&#241;os&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">En el &#225;mbito internacional la informaci&#243;n epidemiol&#243;gica m&#225;s relevante procede del registro de tumores del programa <span class="elsevierStyleItalic">National Cancer Institute&#39;s Surveillance&#44; Epidemiology&#44; and End Results</span>&#44; que incluy&#243; al 28&#37; de la poblaci&#243;n de Estados Unidos&#44; de edades comprendidas entre los 25 y los 84 a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">17&#8211;19</span></a>&#46; La IEE de LMC en el per&#237;odo 1992-2009 fue de 2&#44;93 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o en hombres y de 1&#44;69 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o en mujeres<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a>&#46; Esta incidencia claramente aument&#243; con la edad&#44; siendo unas 10 veces mayor a los 80 a&#241;os que a los 30&#46; Comparativamente con las nuestras&#44; las incidencias de dicho estudio son altas&#44; posiblemente debido a criterios diagn&#243;sticos m&#225;s imprecisos&#44; con inclusi&#243;n de casos sin confirmaci&#243;n molecular o citogen&#233;tica y de otras enfermedades&#44; como la leucemia mielomonoc&#237;tica cr&#243;nica&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En Europa los 2 estudios m&#225;s importantes son el registro nacional sueco<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> y el estudio EUTOS&#44; del que forma parte el presente trabajo<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a>&#46; El primero objetiv&#243; una incidencia bruta de 0&#44;9 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o&#44; mientras que la del estudio global EUTOS fue de 0&#44;99 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o &#40;variando desde 0&#44;69 en Polonia a 1&#44;38 en Italia&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">La edad de presentaci&#243;n en nuestro estudio &#40;media 55 a&#241;os&#44; mediana 54 a&#241;os&#41; coincide con la registrada en otros &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabla 3</a>&#41;&#46; Sin embargo&#44; en estudios m&#225;s antiguos &#40;a&#241;os 1910 a 1948&#41; se describen presentaciones m&#225;s tempranas&#44; entre los 39 y los 43 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">20</span></a>&#46; Adem&#225;s&#44; hemos observado un marcado aumento de la incidencia con la edad&#44; con cifras que oscilan desde los 0&#44;7 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o entre los 20 y los 44 a&#241;os hasta 1&#44;81 en mayores de 65 a&#241;os&#44; de manera similar a lo descrito en la literatura&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En cuanto al sexo&#44; nuestro estudio muestra un predominio masculino &#40;relaci&#243;n hombre&#47;mujer de 1&#44;40&#41;&#44; lo que coincide con estudios previos &#40;predominio masculino entre 1&#44;17 y 1&#44;44&#41;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#44;5&#44;6&#44;8&#8211;10&#44;12&#44;16</span></a>&#46; Son notables las diferencias regionales en relaci&#243;n con el sexo&#44; para lo que no tenemos una explicaci&#243;n adecuada&#46; En el global del estudio EUTOS-Europa tambi&#233;n existen diferencias regionales con proporciones de varones que oscilan entre un m&#225;ximo de 74&#44;2&#37; en Estonia y un m&#237;nimo de 38&#44;8&#37; en Francia<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a>&#46; Respecto a las caracter&#237;sticas de la presentaci&#243;n cl&#237;nica&#44; a diferencia de las descripciones cl&#225;sicas<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">13&#44;21</span></a>&#44; nuestro estudio pone de manifiesto que actualmente la LMC se diagnostica de forma mucho m&#225;s precoz debido a la realizaci&#243;n de anal&#237;ticas rutinarias en individuos asintom&#225;ticos&#46; Otras series m&#225;s recientes ya apuntaban esta tendencia<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">14&#44;15</span></a>&#46; Asimismo&#44; la cifra de leucocitos en el momento del diagn&#243;stico en nuestro estudio fue muy inferior a la observada en trabajos previos&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">En relaci&#243;n con la distribuci&#243;n por grupos de clasificaci&#243;n pron&#243;stica&#44; destaca la incidencia menor de casos con <span class="elsevierStyleItalic">scores</span> de alto riesgo en nuestra serie&#44; respecto al global del registro EUTOS-Europa<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> y a otras<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;14&#44;22</span></a>&#46; En cuanto al porcentaje de enfermos que se presentan en las distintas fases de la enfermedad&#44; nuestras cifras coinciden con las de estudios europeos recientes<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;16</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Las conclusiones de nuestro estudio son muy superponibles al global de la serie europea&#46; La incidencia &#40;1&#44;08 vs&#46; 0&#44;99&#41;&#44; la mediana de edad &#40;54 vs&#46; 56 a&#241;os&#41;&#44; la distribuci&#243;n por sexo &#40;58&#37; de varones vs&#46; 53&#37;&#41;&#44; y la tendencia al incremento de la incidencia con la edad son similares&#44; al igual que las caracter&#237;sticas de presentaci&#243;n &#40;fase cr&#243;nica 96 vs&#46; 94&#37;&#44; pacientes asintom&#225;ticos 56 vs&#46; 57&#37;&#44; y enfermos con esplenomegalia 38 vs&#46; 46&#44;5&#37;&#41;&#46; El &#250;nico punto donde se aprecia una diferencia importante es en la distribuci&#243;n por <span class="elsevierStyleItalic">scores</span> pron&#243;sticos&#44; siendo menor la cifra de enfermos de alto riesgo en nuestra serie &#40;11 vs&#46; 24&#44;7&#37;&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">La principal limitaci&#243;n de este estudio es la posibilidad de que haya casos de LMC no comunicados&#44; ya que&#44; por una parte&#44; la participaci&#243;n fue voluntaria&#44; y por otra&#44; algunos pacientes de edad avanzada y con comorbilidades pueden haber sido atendidos por otras especialidades como Medicina Interna o en el &#225;mbito de la atenci&#243;n primaria&#46; No obstante&#44; consideramos que estos casos &#171;perdidos&#187; ser&#237;an escasos&#46; El hecho de que las cifras obtenidas sean muy parecidas a las del global del estudio europeo<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> y a las del registro sueco<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a>&#44; donde la comunicaci&#243;n de casos es obligatoria por ley&#44; avala nuestros datos&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; la secci&#243;n espa&#241;ola del estudio EUTOS aporta la informaci&#243;n epidemiol&#243;gica m&#225;s fiable de la LMC en Espa&#241;a&#44; con cifras de incidencia generalmente superiores a las previamente descritas y un mayor n&#250;mero de casos diagnosticados en estadios evolutivos m&#225;s precoces de la enfermedad&#46; No obstante&#44; conviene rese&#241;ar que sigue existiendo un 4&#37; de enfermos que se presentan en fases avanzadas&#44; un 11&#37; con un &#237;ndice Sokal de alto riesgo y un 6&#44;5&#37; con alteraciones citogen&#233;ticas adicionales&#44; lo que constituir&#237;a una situaci&#243;n de alarma seg&#250;n los criterios de la <span class="elsevierStyleItalic">European LeukemiaNet</span><a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">23</span></a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Financiaci&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">El proyecto EUTOS a nivel europeo ha contado con financiaci&#243;n de la compa&#241;&#237;a farmac&#233;utica Novartis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicto de intereses</span><p id="par0105" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres708034"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Material y m&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec717656"
          "titulo" => "Palabras clave"
        ]
        2 => array:3 [
          "identificador" => "xres708033"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Material and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec717655"
          "titulo" => "Keywords"
        ]
        4 => array:3 [
          "identificador" => "sec0005"
          "titulo" => "Pacientes y m&#233;todos"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0010"
              "titulo" => "An&#225;lisis estad&#237;stico"
            ]
          ]
        ]
        5 => array:3 [
          "identificador" => "sec0015"
          "titulo" => "Resultados"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Incidencias"
            ]
            1 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Presentaci&#243;n cl&#237;nica"
            ]
            2 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Valores hematol&#243;gicos iniciales y distribuci&#243;n por sistemas de puntuaci&#243;n pron&#243;sticos"
            ]
            3 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Caracter&#237;sticas citogen&#233;ticas y moleculares"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Discusi&#243;n"
        ]
        7 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Financiaci&#243;n"
        ]
        8 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflicto de intereses"
        ]
        9 => array:2 [
          "identificador" => "xack236604"
          "titulo" => "Agradecimientos"
        ]
        10 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-11-15"
    "fechaAceptado" => "2016-03-02"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec717656"
          "palabras" => array:3 [
            0 => "Leucemia mieloide cr&#243;nica"
            1 => "Epidemiolog&#237;a"
            2 => "Espa&#241;a"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec717655"
          "palabras" => array:3 [
            0 => "Chronic myeloid leukaemia"
            1 => "Epidemiology"
            2 => "Spain"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pretendemos aportar datos m&#225;s fiables sobre la epidemiolog&#237;a de la leucemia mieloide cr&#243;nica &#40;LMC&#41; en Espa&#241;a que los disponibles hasta la fecha&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El registro poblacional EUTOS&#44; de la <span class="elsevierStyleItalic">European LeukemiaNet</span>&#44; es un registro de casos nuevos de LMC en pacientes<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>de 18 a&#241;os de 22 &#225;reas europeas&#46; La secci&#243;n espa&#241;ola incluy&#243; las comunidades aut&#243;nomas de Madrid&#44; Castilla-La Mancha y Arag&#243;n&#44; en el periodo comprendido entre el 1-2-2010 y el 31-12-2012&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se registraron 250 casos en 35 meses&#46; La incidencia global fue de 1&#44;08 casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o&#44; con predominio masculino &#40;58&#37; de varones&#41; y claras diferencias entre comunidades aut&#243;nomas&#46; La incidencia estandarizada por edad fue similar &#40;global 1&#44;04&#44; varones 1&#44;31&#44; mujeres 0&#44;81&#41;&#46; La mediana de edad fue de 54 a&#241;os&#46; La incidencia aument&#243; con la edad&#44; siendo m&#225;xima en<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#44; aunque un 31&#44;7&#37; de los casos aparecieron entre los 20 y los 44 a&#241;os&#46; Un 4&#37; se diagnosticaron en fases avanzadas &#40;2&#44;4&#37; en fase acelerada&#44; 1&#44;6&#37; en crisis bl&#225;stica&#41;&#44; el 56&#37; estaban asintom&#225;ticos&#44; el 38&#37; ten&#237;an esplenomegalia&#44; y el <span class="elsevierStyleItalic">score</span> Sokal era alto en el 11&#37; &#40;inferior a lo previamente reflejado en la literatura&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La incidencia actual de LMC en Espa&#241;a es superior a la previamente descrita y similar a la de los estudios europeos&#46; A diferencia de las descripciones cl&#225;sicas&#44; la LMC se presenta mayoritariamente de forma asintom&#225;tica&#44; sin esplenomegalia&#44; con menor leucocitosis y en estadios con mejor pron&#243;stico&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To provide more reliable data on the epidemiology of chronic myeloid leukaemia &#40;CML&#41; in Spain than are currently available&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The EUTOS population-based project of European LeukemiaNet is a population registry of new CML cases in patients 18 years of age or older from 22 European areas&#46; The Spanish section included the autonomous communities of Madrid&#44; Castilla-La Mancha and Aragon&#44; from 1-2-2010 to 31-12-2012&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 250 cases were recorded in 35 months&#46; The overall incidence was 1&#46;08 cases&#47;10<span class="elsevierStyleSup">5</span> inhabitants-year&#44; with a predominance of men &#40;58&#37;&#41; and clear differences among the communities&#46; The incidence standardised by age was similar &#40;overall&#44; 1&#46;04&#59; men&#44; 1&#46;31&#59; women&#44; 0&#46;81&#41;&#46; The median age was 54 years&#46; The incidence increased with age&#44; reaching a peak at<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>65 years&#44; although 31&#46;7&#37; of cases appeared between the ages of 20 and 44 years&#46; Four percent of cases were diagnosed in advanced stages &#40;2&#46;4&#37; in accelerated phase&#44; 1&#46;6&#37; in blast crisis&#41;&#44; 56&#37; were asymptomatic&#44; 38&#37; had splenomegaly&#44; and the Sokal score was high in 11&#37; &#40;lower than what was previously reflected in the literature&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The current incidence of CML in Spain is higher than previously reported and similar to that of the European studies&#46; Unlike the classical descriptions&#44; CML presented mostly in asymptomatic form&#44; with no splenomegaly&#44; less leucocytosis and in stages with better prognosis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0130" class="elsevierStylePara elsevierViewall">Madrid<elsevierMultimedia ident="tbl0005"></elsevierMultimedia></p> <p id="par0135" class="elsevierStylePara elsevierViewall">Arag&#243;n<elsevierMultimedia ident="tbl0010"></elsevierMultimedia></p> <p id="par0140" class="elsevierStylePara elsevierViewall">Castilla-La Mancha<elsevierMultimedia ident="tbl0015"></elsevierMultimedia></p>"
            "etiqueta" => "Anexo 1"
            "titulo" => "Listado de hospitales colaboradores"
            "identificador" => "sec0060"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">IB&#58; incidencia bruta&#59; IE&#58; incidencia estandarizada&#46;</p>"
          "tablatextoimagen" => array:2 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="char" valign="top" scope="col">Incidencias globales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="char" valign="top" scope="col">2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="char" valign="top" scope="col">2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="char" valign="top" scope="col">2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total 3 a&#241;os</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="char" valign="top" scope="col" style="border-bottom: 2px solid black">IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="char" valign="top" scope="col" style="border-bottom: 2px solid black">IE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Arag&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Castilla-La Mancha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">En las 3 regiones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167983.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Incidencias por edad y sexo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Madrid</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Castilla-La Mancha</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Arag&#243;n</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hombre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mujere&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20-44 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">45-65 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#62;<span class="elsevierStyleHsp" style=""></span>65 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167982.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Incidencias anuales de leucemia mieloide cr&#243;nica &#40;&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o&#41;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Rango</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="2" align="left" valign="top">6&#44;3-18<span class="elsevierStyleHsp" style=""></span>g&#47;dl</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leucocitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85&#46;400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="2" align="left" valign="top">2&#46;800-791&#46;000<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;l</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plaquetas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">458&#46;000<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="2" align="left" valign="top">19&#46;000-2&#46;068&#46;000<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Porcentaje de blastos en sangre perif&#233;rica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="2" align="left" valign="top">0-41</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sokal &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>240&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alto 11&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intermedio 41&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bajo 48&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hasford &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>221&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alto 5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intermedio 34&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bajo 61&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167980.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Valores hematol&#243;gicos al diagn&#243;stico y distribuci&#243;n por escalas pron&#243;sticas</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">H&#58; hombres&#59; IB&#58; incidencia bruta&#59; IE&#58; incidencia estandarizada&#59; M&#58; mujeres&#59; ND&#58; no disponible&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#193;rea geogr&#225;fica&#44; n&#250;mero de pacientes&#44; periodo de estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Incidencia en casos&#47;10<span class="elsevierStyleSup">5</span> habitantes-a&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Edad de presentaci&#243;n&#44; a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Relaci&#243;n H&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Fuente de datos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gerona<br>N&#58; 102<br>1994-2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB global&#58; 1&#44;15<br>IE global&#58; 0&#44;96<br>H&#58; 1&#44;13&#44; M&#58; 0&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>H&#58; 64&#44; M&#58; 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro poblacional de c&#225;ncer de Gerona<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Espa&#241;a<br>N&#58; 226<br>2002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">H&#58; 0&#44;9&#44; M&#58; 0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Media 55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registros poblacionales de c&#225;ncer en Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tarragona<br>N&#58; 122<br>1980-1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IE&#58; 1&#44;3 a 1&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Media 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Predominio masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro poblacional de c&#225;ncer en Tarragona<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Asturias<br>N&#58; 108<br>1972-1986&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB global&#58; 0&#44;64<br>H&#58; 0&#44;8&#44; M&#58; 0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana 51 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Predominio masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro retrospectivo en Servicio de Hematolog&#237;a<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;35 a 0&#44;98 seg&#250;n regiones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">EUTOS espa&#241;ol &#40;presente estudio&#41;<br>N&#58; 250<br>2010-2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB global&#58; 1&#44;08 &#40;H&#58; 1&#44;31&#44; M&#58; 0&#44;87&#41;&#46;<br>IE global&#58; 1&#44;04 &#40;H&#58; 1&#44;31&#44; M&#58; 0&#44;81&#41; en<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana&#58; 54<br>H&#58; 52&#44; M&#58; 57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro poblacional prospectivo&#44; hospitales y laboratorios centrales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Suecia<br>N&#58; 779<br>2002-2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB&#58; 0&#44;9 &#40;&#62;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro poblacional de c&#225;ncer sueco<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">EUTOS Europa&#44; N&#58; 2&#46;957<br>2008-2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB&#58; 0&#44;99 &#40;H&#58; 1&#44;12&#44; M&#58; 0&#44;88&#41;<br>IE&#58; 0&#44;96<br>&#62;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana 55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro poblacional prospectivo&#44; hospitales y laboratorios centrales<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dinamarca<br>N&#58; ND<br>1973-1976&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB&#58; 1&#44;5 &#40;todas las edades&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Media 66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro dan&#233;s de c&#225;ncer<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Reino Unido<br>N&#58; ND<br>1987-2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB&#58; 0&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Predominio masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Base de datos de medicina general<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Escocia<br>N&#58; 64<br>1999-2000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB&#58; 0&#44;64 &#40;todas las edades&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro escoc&#233;s de leucemias<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alemania<br>N&#58; 218<br>1998-2000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IB&#58; 0&#44;72 &#40;todas las edades&#41;<br>H&#58; 0&#44;79&#44; M&#58; 0&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Media 56&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registro prospectivo en centros sanitarios<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167981.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estudios epidemiol&#243;gicos sobre leucemia mileoide cr&#243;nica espa&#241;oles y europeos</p>"
        ]
      ]
      3 => array:5 [
        "identificador" => "tbl0005"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Poblaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">N&#46;<span class="elsevierStyleSup">o</span> de camas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casos incluidos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Fundaci&#243;n Alcorc&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alcorc&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">409&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Cl&#237;nico San Carlos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">964&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Central de la Cruz Roja&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">156&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario 12 de Octubre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;314&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; El Escorial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">El Escorial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario de Fuenlabrada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fuenlabrada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">406&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fundaci&#243;n Jim&#233;nez D&#237;az&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">665&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario de Getafe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Getafe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">589&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Central de la Defensa G&#243;mez Ulla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">498&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; General Universitario Gregorio Mara&#241;&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;671&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario del Henares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Coslada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">210&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Infanta Cristina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Parla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">188&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Infanta Elena&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valdemoro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Infanta Leonor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">269&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Infanta Sof&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">San Sebasti&#225;n de los Reyes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">283&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hospital Universitario la Paz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;308&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Madrid Montepr&#237;ncipe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">183&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Madrid Norte San Chinarro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Madrid Torrelodones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Torrelodones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Sur IDC Salud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; MD Anderson Cancer Center Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Moncloa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">230&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Sanitas La Moraleja&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hospital Universitario de M&#243;stoles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#243;stoles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Vithas Nuestra Se&#241;ora de Am&#233;rica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario de La Princesa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">564&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Pr&#237;ncipe de Asturias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alcal&#225; de Henares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">594&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Puerta de Hierro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Majadahonda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">613&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Quir&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pozuelo de Alarc&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">190&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Ram&#243;n y Cajal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">947&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Rey Juan Carlos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#243;stoles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hospital Ruber Internacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#237;nica Ruber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Severo Ochoa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Legan&#233;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario del Sureste&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Arganda del Rey&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario del Tajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Aranjuez&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario de Torrej&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Torrej&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">250&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Sanitas La Zarzuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Aravaca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167985.png"
              ]
            ]
          ]
        ]
      ]
      4 => array:5 [
        "identificador" => "tbl0010"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Poblaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">N&#46;<span class="elsevierStyleSup">o</span> de camas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casos incluidos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; de Alca&#241;iz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alca&#241;iz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; de Barbastro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Barbastro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; de Calatayud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Calatayud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HUC Lozano Blesa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Zaragoza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">802&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Militar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Zaragoza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Obispo Polanco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Teruel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">215&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Royo Villanova&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Zaragoza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">235&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; General San Jorge&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Huesca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">312&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario Miguel Servet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Zaragoza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167984.png"
              ]
            ]
          ]
        ]
      ]
      5 => array:5 [
        "identificador" => "tbl0015"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Poblaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">N&#46;<span class="elsevierStyleSup">o</span> de camas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casos incluidos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Guti&#233;rrez Ortega&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valdepe&#241;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; de Hell&#237;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hell&#237;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">136&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Gral&#46; de Almansa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Almansa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Gral&#46; de Villarrobledo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Villarrobledo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Virgen de Altagracia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Manzanares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Gral&#46; de Albacete&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Albacete&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">488&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Santa B&#225;rbara&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Puertollano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">173&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Gral&#46; de Tomelloso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tomelloso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Nuestra Se&#241;ora del Prado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Talavera de la Reina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">338&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Gral&#46; de Ciudad Real&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Ciudad Real&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">564&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Gral&#46; La Mancha Centro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alcazar de San Juan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">339&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Virgen de la Luz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cuenca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">411&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Universitario de Guadalajara&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Guadalajara&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">414&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#46; Virgen de la Salud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Toledo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">635&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1167979.png"
              ]
            ]
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO classification of tumours of haematopoietic and lymphoid tissues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Swerdlow"
                            1 => "E&#46; Campo"
                            2 => "N&#46;L&#46; Harris"
                            3 => "E&#46;S&#46; Jaffe"
                            4 => "S&#46;A&#46; Pileri"
                            5 => "H&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "4th ed&#46;"
                        "fecha" => "2008"
                        "editorial" => "Internacional Agency for Research on Cancer"
                        "editorialLocalizacion" => "Lyon"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic myeloid leukemia&#58; 2014 update on diagnosis&#44; monitoring&#44; and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Jabbour"
                            1 => "H&#46; Kantarjian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajh.23691"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hematol&#46;"
                        "fecha" => "2014"
                        "volumen" => "89"
                        "paginaInicial" => "547"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24729196"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population-based incidence of myeloid malignancies&#58; Fifteen years of epidemiological data in the province of Girona&#44; Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Osca-Gelis"
                            1 => "M&#46; Puig-Vives"
                            2 => "M&#46; Saez"
                            3 => "D&#46; Gallardo"
                            4 => "N&#46; Lloveras"
                            5 => "R&#46; Marcos-Gragera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3324/haematol.2013.084061"
                      "Revista" => array:6 [
                        "tituloSerie" => "Haematologica&#46;"
                        "fecha" => "2013"
                        "volumen" => "98"
                        "paginaInicial" => "e95"
                        "paginaFinal" => "e97"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23812933"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Grupo Cooperativo del Registro Espa&#241;ol de Leucemia&#46; Registro espa&#241;ol de leucemias&#46; Madrid&#58; Fundaci&#243;n Leucemia y Linfoma Nova Sidonia&#59; 2003&#46; ISBN 84-7885-336-7&#46;"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and survival of leukemias according to the different histologic subsets&#44; in Tarragona&#44; Spain&#44; between 1980-1994"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Gonz&#225;lez"
                            1 => "V&#46; Moreno"
                            2 => "J&#46;M&#46; Borr&#224;s"
                            3 => "J&#46; Borr&#224;s"
                            4 => "J&#46; Galceran"
                            5 => "A&#46; Gra&#241;ena"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2001"
                        "volumen" => "116"
                        "paginaInicial" => "174"
                        "paginaFinal" => "178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11222173"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiological data on chronic myeloid leukemia in Asturias&#44; 1972-1986"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Jonte"
                            1 => "C&#46; Ray&#243;n"
                            2 => "J&#46; Medina"
                            3 => "J&#46; Garc&#237;a Gala"
                            4 => "A&#46; Garc&#237;a Jal&#243;n"
                            5 => "E&#46; Fanjul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sangre &#40;Barc&#41;&#46;"
                        "fecha" => "1993"
                        "volumen" => "38"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8470030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Datos epidemiol&#243;gicos de la leucemia mieloide cr&#243;nica en Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;N&#46; Fernandez"
                            1 => "S&#46; Lamas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sangre &#40;Barc&#41;&#46;"
                        "fecha" => "1982"
                        "volumen" => "27"
                        "paginaInicial" => "96"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tyrosine kinase inhibitor usage&#44; treatment outcome&#44; and prognostic scores in CML&#58; Report from the population-based Swedish CML registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; H&#246;glund"
                            1 => "F&#46; Sandin"
                            2 => "K&#46; Hellstr&#246;m"
                            3 => "M&#46; Bj&#246;reman"
                            4 => "M&#46; Bj&#246;rkholm"
                            5 => "M&#46; Brune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2013-04-495598"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood&#46;"
                        "fecha" => "2013"
                        "volumen" => "122"
                        "paginaInicial" => "1284"
                        "paginaFinal" => "1292"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23843494"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population-based age- and sex-specific incidence rates in the 4 main types of leukaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Brincker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Haematol&#46;"
                        "fecha" => "1982"
                        "volumen" => "29"
                        "paginaInicial" => "241"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6959254"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The incidence of and mortality from leukaemias in the UK&#58; A general population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Bhayat"
                            1 => "E&#46; Das-Gupta"
                            2 => "C&#46; Smith"
                            3 => "T&#46; McKeever"
                            4 => "R&#46; Hubbard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2407-9-252"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Cancer&#46;"
                        "fecha" => "2009"
                        "volumen" => "9"
                        "paginaInicial" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19630999"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Scotland Leukaemia Registry audit of incidence&#44; diagnosis and clinical management of new patients with chronic myeloid leukaemia in 1999 and 2000"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Harrison"
                            1 => "P&#46;R&#46; Johnson"
                            2 => "T&#46;L&#46; Holyoake"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scott Med J&#46;"
                        "fecha" => "2004"
                        "volumen" => "49"
                        "paginaInicial" => "87"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15462221"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical trials underestimate the age of chronic myeloid leukemia &#40;CML&#41; patients&#46; Incidence and median age of Ph&#47;BCR-ABL-positive CML and other chronic myeloproliferative disorders in a representative area in Germany"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rohrbacher"
                            1 => "U&#46; Berger"
                            2 => "A&#46; Hochhaus"
                            3 => "G&#46; Metzgeroth"
                            4 => "K&#46; Adam"
                            5 => "T&#46; Lahaye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/leu.2008.245"
                      "Revista" => array:6 [
                        "tituloSerie" => "Leukemia&#46;"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "602"
                        "paginaFinal" => "604"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18784744"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical features of chronic granulocytic leukaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;S&#46; Spiers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Haematol&#46;"
                        "fecha" => "1977"
                        "volumen" => "6"
                        "paginaInicial" => "77"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/269763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The changing profile of Ph-positive chronic myeloid leukemia at presentation&#58; Possible impact of earlier diagnosis on survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Cervantes"
                            1 => "J&#46;C&#46; Hern&#225;ndez-Boluda"
                            2 => "A&#46; Ferrer"
                            3 => "J&#46; Cid"
                            4 => "E&#46; Montserrat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Haematologica&#46;"
                        "fecha" => "1999"
                        "volumen" => "84"
                        "paginaInicial" => "324"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10190946"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history and staging of chronic myelogenous leukaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Cortes"
                            1 => "H&#46;M&#46; Kantarjian"
                            2 => "S&#46; Giralt"
                            3 => "M&#46; Talpaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Baillieres Clin Haematol&#46;"
                        "fecha" => "1997"
                        "volumen" => "10"
                        "paginaInicial" => "277"
                        "paginaFinal" => "290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9376664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The EUTOS population-based registry&#58; Incidence and clinical characteristics of 2904 CML patients in 20 European countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46;S&#46; Hoffmann"
                            1 => "M&#46; Baccarani"
                            2 => "J&#46; Hasford"
                            3 => "D&#46; Lindoerfer"
                            4 => "S&#46; Burgstaller"
                            5 => "D&#46; Sertic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/leu.2015.73"
                      "Revista" => array:6 [
                        "tituloSerie" => "Leukemia&#46;"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "1336"
                        "paginaFinal" => "1343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25783795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in leukemia incidence and survival in the United States &#40;1973-1998&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Xie"
                            1 => "S&#46;M&#46; Davies"
                            2 => "Y&#46; Xiang"
                            3 => "L&#46;L&#46; Robison"
                            4 => "J&#46;A&#46; Ross"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.11316"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer&#46;"
                        "fecha" => "2003"
                        "volumen" => "97"
                        "paginaInicial" => "2229"
                        "paginaFinal" => "2235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12712476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in all-cause mortality among patients with chronic myeloid leukemia&#58; A surveillance&#44; epidemiology&#44; and end results database analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Brunner"
                            1 => "F&#46; Campigotto"
                            2 => "H&#46; Sadrzadeh"
                            3 => "B&#46;J&#46; Drapkin"
                            4 => "Y&#46;B&#46; Chen"
                            5 => "D&#46;S&#46; Neuberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.28106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer&#46;"
                        "fecha" => "2013"
                        "volumen" => "119"
                        "paginaInicial" => "2620"
                        "paginaFinal" => "2629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23625575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are incidence rates of adult leukemia in the United States significantly associated with birth cohort&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;S&#46; Rosenberg"
                            1 => "K&#46;L&#46; Wilson"
                            2 => "W&#46;F&#46; Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1055-9965.EPI-12-0910"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev&#46;"
                        "fecha" => "2012"
                        "volumen" => "21"
                        "paginaInicial" => "2159"
                        "paginaFinal" => "2166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23064005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history of chronic granulocytic leukaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;C&#46; Moloney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Haematol&#46;"
                        "fecha" => "1977"
                        "volumen" => "6"
                        "paginaInicial" => "41"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/334416"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;G&#46; Savage"
                            1 => "R&#46;M&#46; Szydlo"
                            2 => "J&#46;M&#46; Goldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Haematol&#46;"
                        "fecha" => "1997"
                        "volumen" => "96"
                        "paginaInicial" => "111"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9012696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Saglio"
                            1 => "D&#46;W&#46; Kim"
                            2 => "S&#46; Issaragrisil"
                            3 => "P&#46; Le Coutre"
                            4 => "G&#46; Etienne"
                            5 => "C&#46; Lobo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0912614"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2010"
                        "volumen" => "362"
                        "paginaInicial" => "2251"
                        "paginaFinal" => "2259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20525993"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "European LeukemiaNet recommendations for the management of chronic myeloid leukemia&#58; 2013"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Baccarani"
                            1 => "M&#46;W&#46; Deininger"
                            2 => "G&#46; Rosti"
                            3 => "A&#46; Hochhaus"
                            4 => "S&#46; Soverini"
                            5 => "J&#46;F&#46; Apperley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2013-05-501569"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood&#46;"
                        "fecha" => "2013"
                        "volumen" => "122"
                        "paginaInicial" => "872"
                        "paginaFinal" => "884"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23803709"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack236604"
        "titulo" => "Agradecimientos"
        "texto" => "<p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">A los siguientes</span> data managers <span class="elsevierStyleItalic">que han recogido datos&#58;</span> C&#46; Mba &#40;Instituto de Investigaci&#243;n del Hospital de La Princesa&#44; Madrid&#41;&#44; F&#46; Carretero &#40;Hospital Gregorio Mara&#241;&#243;n&#44; Madrid&#41;&#46;</p> <p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">A los siguientes investigadores que han incluido casos</span>&#58; R&#46; de Paz &#40;Hospital de La Paz&#44; Madrid&#41;&#44; J&#46; P&#233;rez de Oteiza &#40;Hospital Madrid San Chinarro&#44; Madrid&#41;&#44; J&#46; L&#46; L&#243;pez &#40;Fundaci&#243;n Jim&#233;nez D&#237;az&#44; Madrid&#41;&#44; A&#46; Pe&#241;a &#40;Hospital Cl&#237;nico San Carlos&#44; Madrid&#41;&#44; L&#46; Benito &#40;Hospital Universitario de Getafe&#44; Madrid&#41;&#44; C&#46; Alaez &#40;Hospital Moncloa&#44; Madrid&#41;&#44; M&#46; J&#46; Requena &#40;Hospital Severo Ochoa&#44; Legan&#233;s&#44; Madrid&#41;&#44; J&#46; A&#46; Hern&#225;ndez Rivas &#40;Hospital Infanta Leonor&#44; Madrid&#41;&#44; D&#46; Monteagudo &#40;Hospital General de M&#243;stoles&#44; Madrid&#41;&#44; I<span class="elsevierStyleSmallCaps">&#46;</span> San Rom&#225;n &#40;Hospital Universitario de Guadalajara&#41;&#44; I&#46; Cano &#40;Hospital de Alc&#225;zar de San Juan&#44; Ciudad Real&#41;&#44; L&#46; Villal&#243;n &#40;Hospital de Alcorc&#243;n&#44; Madrid&#41;&#44; A&#46; Coza &#40;Hospital de El Escorial&#41;&#44; D&#46; Garc&#237;a &#40;Hospital La Zarzuela&#41;&#44; R&#46; Flores &#40;Hospital de Fuenlabrada&#41;&#44; J&#46; F&#46; del Campo&#40;Hospital del Henares&#44; Coslada&#44; Madrid&#41;&#44; R&#46; C&#243;rdoba &#40;Hospital Infanta Sof&#237;a&#44; San Sebasti&#225;n de los Reyes&#44; Madrid&#41;&#44; E&#46; G&#243;ngora &#40;Hospital Nuestra Se&#241;ora de Am&#233;rica&#44; Madrid&#41;&#44; C&#46; Burgaleta &#40;Hospital Pr&#237;ncipe de Asturias&#44; Alcal&#225; de Henares&#44; Madrid&#41;&#44; E&#46; G&#243;mez &#40;Hospital del Sureste&#44; Arganda del Rey&#44; Madrid&#41;&#44; E&#46; Ruiz &#40;Hospital del Tajo&#44; Aranjuez&#44; Madrid&#41;&#44; J&#46; D&#237;az Mediavilla &#40;Hospital Ruber Internacional&#44; Madrid&#41;&#44; M&#46; G&#46; Salvatierra &#40;Hospital Rey Juan Carlos&#44; M&#243;stoles&#44; Madrid&#41;&#44; G&#46; Bautista &#40;Hospital Puerta de Hierro&#44; Madrid&#41;&#44; J&#46; Mart&#237;nez L&#243;pez &#40;Hospital 12 de Octubre&#44; Madrid&#41;&#44; M&#46; Jarilla &#40;Hospital Santa B&#225;rbara&#44; Puertollano&#41;&#44; C&#46; Calle &#40;Hospital General de Ciudad Real&#41;&#44; J&#46; S&#46; Berm&#243;n &#40;Complejo Hospitalario de Albacete&#41;&#44; C&#46; Cervero &#40;Hospital Virgen de la Luz&#44; Cuenca&#41;&#44; F&#46; Solano &#40;Hospital Nuestra Se&#241;ora del Prado&#44; Talavera&#44; Toledo&#41;&#44; L&#46; L&#243;pez G&#243;mez &#40;Hospital Royo-Villanova&#44; Zaragoza&#41;&#44; A&#46; Asensio &#40;Hospital San Jorge&#44; Huesca&#41;&#44; M&#46; Perella &#40;Hospital de Barbastro&#44; Huesca&#41;&#44; N&#46; Gonzalez &#40;Hospital Obispo Polanco&#44; Teruel&#41; y L&#46; Palomera &#40;Hospital Cl&#237;nico&#44; Zaragoza&#41;&#46;</p> <p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">A los miembros de la</span> European LeukemiaNet <span class="elsevierStyleItalic">implicados en el registro europeo&#44; y en concreto a&#58;</span> M&#46; Baccarani&#44; D&#46; Lindoerfer y V&#46; Hoffmann por su colaboraci&#243;n en el manejo e interpretaci&#243;n de los datos&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00142565/0000021600000006/v2_201607300632/S0014256516000515/v2_201607300632/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "1062"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00142565/0000021600000006/v2_201607300632/S0014256516000515/v2_201607300632/es/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256516000515?idApp=WRCEE"
]