array:22 [
  "pii" => "S001425651600028X"
  "issn" => "00142565"
  "doi" => "10.1016/j.rce.2016.02.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-06-01"
  "aid" => "1243"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Rev Clin Esp. 2016;216:292"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 13
    "formatos" => array:2 [
      "HTML" => 9
      "PDF" => 4
    ]
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0014256516000291"
    "issn" => "00142565"
    "doi" => "10.1016/j.rce.2016.02.003"
    "estado" => "S300"
    "fechaPublicacion" => "2016-06-01"
    "aid" => "1244"
    "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Rev Clin Esp. 2016;216:290-1"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 24
      "formatos" => array:2 [
        "HTML" => 18
        "PDF" => 6
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Correspondencia</span>"
      "titulo" => "Meningitis linfocitarias causadas por el virus herpes simple tipo 2"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "290"
          "paginaFinal" => "291"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Lymphocytic meningitis caused by herpes simplex virus type 2"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Reina, M&#46; Leyes, C&#46; Taboada"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Reina"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Leyes"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Taboada"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256516000291?idApp=WRCEE"
    "url" => "/00142565/0000021600000005/v1_201606010023/S0014256516000291/v1_201606010023/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Correspondencia</span>"
    "titulo" => "El aumento de la incidencia del c&#225;ncer diferenciado de tiroides no se relaciona con un incremento en la detecci&#243;n de microcarcinomas incidentales"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Sr&#46; Director&#58;</span>"
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "292"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46; Ruiz, F&#46; Carral, R&#46; Tinoco, C&#46; Ayala"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "G&#46;"
            "apellidos" => "Ruiz"
            "email" => array:2 [
              0 => "ruizgemam&#64;gmail&#46;com"
              1 => "ruizvillenag&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Carral"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Tinoco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Ayala"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Medicina Interna&#44; Hospital Universitario de Puerto Real&#44; Puerto Real&#44; C&#225;diz&#44; Espa&#241;a"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Endocrinolog&#237;a y Nutrici&#243;n&#44; Hospital Universitario de Puerto Real&#44; Puerto Real&#44; C&#225;diz&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Rise in differentiated thyroid cancer incidence in our hospital is not related with an increased incidental microcarcinoma detection"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">El carcinoma de tiroides &#40;CT&#41; es una neoplasia rara&#44; que comprende menos del 2&#44;5&#37; de los c&#225;nceres en humanos&#46; El c&#225;ncer diferenciado de tiroides &#40;CDT&#41; incluye al carcinoma papilar &#40;CP&#41; y al folicular &#40;CF&#41;&#44; y constituye m&#225;s del 90&#37; de todos los CT<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En el Hospital Universitario de Puerto Real&#44; C&#225;diz&#44; se ha llevado a cabo un estudio observacional descriptivo de cohortes hist&#243;ricas incluyendo a todos los pacientes intervenidos mediante tiroidectom&#237;a entre 2000-2014&#44; con el objetivo de evaluar los cambios en la incidencia del CDT en nuestra &#225;rea&#46; Se analizaron un total de 1&#46;605 informes de anatom&#237;a patol&#243;gica y se detectaron 224 casos de CDT&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Se observ&#243; un aumento significativo de las tasas de incidencia de CDT&#44; pasando de 3&#44;7 &#40;2000-2004&#41; a 4&#44;8 &#40;2005-2009&#41; y 6&#44;8 &#40;2009-2014&#41; casos por 100&#46;000 habitantes&#47;a&#241;o&#46; Este incremento fue documentado en ambos sexos &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; correspondi&#233;ndose con un incremento medio del 5&#44;2&#37; en el conjunto de la poblaci&#243;n estudiada&#44; del 2&#44;07&#37; entre los varones y del 8&#44;26&#37; entre las mujeres&#46; No existieron diferencias significativas en la edad al diagn&#243;stico&#44; sexo&#44; tama&#241;o del tumor&#44; tiroiditis en la pieza&#44; extensi&#243;n linf&#225;tica o extratiroidea del tumor&#44; ni estadio tumoral entre los per&#237;odos estudiados&#46; El 29&#44;5&#37; de todos los casos detectados fueron microcarcinomas &#40;97&#37; papilares y 3&#37; foliculares&#41;&#44; observ&#225;ndose un incremento de este tipo de tumores en los 2 &#250;ltimos per&#237;odos&#44; si bien las diferencias no fueron estad&#237;sticamente significativas&#46; El 73&#37; de los microcarcinomas hallados fueron incidentales&#44; detectados en tiroidectom&#237;as indicadas por tama&#241;o de n&#243;dulos tiroideos &#62;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>cm o s&#237;ntomas compresivos locales&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">En las &#250;ltimas d&#233;cadas&#44; la incidencia anual de CT ha aumentado notablemente en todo el mundo&#44; con incrementos anuales que oscilan entre el 7&#37; en EE&#46;UU&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a>&#44; el 16&#37; en Italia<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> y el 1&#44;6-8&#44;37&#37; en nuestro pa&#237;s<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4&#8211;6</span></a>&#46; Algunos autores consideran que este incremento es debido&#44; fundamentalmente&#44; al mayor diagn&#243;stico incidental de microcarcinomas papilares &#40;MCP&#41;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">7&#44;8</span></a>&#46; Sin embargo&#44; en nuestra poblaci&#243;n&#44; el incremento observado de casos de MCP no alcanz&#243; diferencias significativas&#44; ni se relacion&#243; con un mayor intervencionismo tiroideo&#46; Ser&#237;a recomendable la puesta en marcha de estudios epidemiol&#243;gicos orientados a evaluar los cambios en la incidencia de CT en distintas poblaciones de nuestro pa&#237;s&#44; as&#237; como investigaciones dise&#241;adas para detectar los posibles factores responsables de su mayor incidencia&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Per&#237;odo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2000-2004 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2005-2009 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2010-2014 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;69 &#40;3&#44;67-3&#44;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;84 &#40;4&#44;82-4&#44;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;82 &#40;6&#44;81-6&#44;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#44;20 &#40;5&#44;19-5&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Varones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;07 &#40;1&#44;05-1&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;67 &#40;1&#44;65-1&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;32 &#40;3&#44;30-3&#44;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;07 &#40;2&#44;06-2&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mujeres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;35 &#40;6&#44;33-6&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;90 &#40;7&#44;88-7&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;17 &#40;10&#44;14-10&#44;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#44;26 &#40;8&#44;25-8&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1095884.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Casos de CDT por 100&#46;000 habitantes y a&#241;o&#44; entre par&#233;ntesis el intervalo de confianza del 95&#37;&#46;</p> <p class="elsevierStyleNotepara" id="npar0010">CDT&#58; c&#225;ncer diferenciado de tiroides&#59; PCA&#58; porcentaje de cambio anual&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Incidencia de CDT y porcentaje de cambio anual por per&#237;odo y sexo</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer statistics&#44; 2009"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Jemal"
                            1 => "R&#46; Siegel"
                            2 => "E&#46; Ward"
                            3 => "Y&#46; Hao"
                            4 => "J&#46; Xu"
                            5 => "M&#46;J&#46; Thun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3322/caac.20006"
                      "Revista" => array:6 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "225"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19474385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gender is an age-specific effect modifier for papillary cancers of the thyroid gland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;A&#46; Kilfoy"
                            1 => "S&#46;S&#46; Devesa"
                            2 => "M&#46;H&#46; Ward"
                            3 => "Y&#46; Zhang"
                            4 => "P&#46;S&#46; Rosenberg"
                            5 => "T&#46;R&#46; Holford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1055-9965.EPI-08-0976"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "1092"
                        "paginaFinal" => "1100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19293311"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased incidence of thyroid cancer in Latina&#44; Italy&#58; A possible role of detection of subclinical disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Busco"
                            1 => "P&#46; Giorgi"
                            2 => "I&#46; Sperduti"
                            3 => "P&#46; Pezzotti"
                            4 => "C&#46; Buzzoni"
                            5 => "F&#46; Pannozzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.canep.2013.02.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol"
                        "fecha" => "2013"
                        "volumen" => "37"
                        "paginaInicial" => "262"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23518150"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time trends of cancer incidence and mortality in Catalonia during 1993-2007"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Cleries"
                            1 => "L&#46; Esteban"
                            2 => "J&#46; Borras"
                            3 => "R&#46; Marcos"
                            4 => "A&#46; Freitas"
                            5 => "M&#46; Carulla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12094-013-1060-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transl Oncol"
                        "fecha" => "2014"
                        "volumen" => "16"
                        "paginaInicial" => "18"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23740137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patr&#243;n evolutivo de la incidencia de c&#225;ncer de tiroides en la Regi&#243;n de Murcia de 1984 a 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;D&#46; Chirlaque"
                            1 => "F&#46; Moldenhauer"
                            2 => "D&#46; Salmer&#243;n"
                            3 => "C&#46; Navarro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.gaceta.2014.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "2014"
                        "volumen" => "28"
                        "paginaInicial" => "397"
                        "paginaFinal" => "400"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24946694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolution of diferentiatted thyroid cancer&#58; A decade of thyroidectomies in a single institution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Zaf&#243;n"
                            1 => "J&#46;A&#46; Baena"
                            2 => "J&#46; Castellv&#237;"
                            3 => "G&#46; Obiols"
                            4 => "O&#46; Gonz&#225;lez"
                            5 => "J&#46;M&#46; Fort"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000365416"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Thyroid J"
                        "fecha" => "2014"
                        "volumen" => "3"
                        "paginaInicial" => "197"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25538902"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A time trend analysis of papillary and follicular cancers as a function of tumour size&#58; A study of data from six cancer registries in France &#40;1983-2000&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Colonna"
                            1 => "A&#46;V&#46; Guizard"
                            2 => "C&#46; Schvartz"
                            3 => "M&#46; Velten"
                            4 => "N&#46; Raverdy"
                            5 => "F&#46; Molinie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2006.11.024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2007"
                        "volumen" => "43"
                        "paginaInicial" => "891"
                        "paginaFinal" => "900"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Korea&#39;s thyroid-cancer &#171;epidemic&#187;&#46; Screening and over diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Sik"
                            1 => "H&#46; Jung"
                            2 => "H&#46; Gilbert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMp1409841"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2014"
                        "volumen" => "371"
                        "paginaInicial" => "1765"
                        "paginaFinal" => "1767"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25372084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00142565/0000021600000005/v1_201606010023/S001425651600028X/v1_201606010023/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "992"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Correspondencia"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00142565/0000021600000005/v1_201606010023/S001425651600028X/v1_201606010023/es/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S001425651600028X?idApp=WRCEE"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Correspondencia
El aumento de la incidencia del cáncer diferenciado de tiroides no se relaciona con un incremento en la detección de microcarcinomas incidentales
Rise in differentiated thyroid cancer incidence in our hospital is not related with an increased incidental microcarcinoma detection
G. Ruiza,
Autor para correspondencia
, F. Carralb, R. Tinocoa, C. Ayalab
a Unidad de Gestión Clínica de Medicina Interna, Hospital Universitario de Puerto Real, Puerto Real, Cádiz, España
b Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario de Puerto Real, Puerto Real, Cádiz, España
Leído
29
Veces
se ha leído el artículo
8
Total PDF
21
Total HTML
Compartir estadísticas
 array:22 [
  "pii" => "S001425651600028X"
  "issn" => "00142565"
  "doi" => "10.1016/j.rce.2016.02.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-06-01"
  "aid" => "1243"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Rev Clin Esp. 2016;216:292"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 13
    "formatos" => array:2 [
      "HTML" => 9
      "PDF" => 4
    ]
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0014256516000291"
    "issn" => "00142565"
    "doi" => "10.1016/j.rce.2016.02.003"
    "estado" => "S300"
    "fechaPublicacion" => "2016-06-01"
    "aid" => "1244"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Rev Clin Esp. 2016;216:290-1"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 24
      "formatos" => array:2 [
        "HTML" => 18
        "PDF" => 6
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Correspondencia</span>"
      "titulo" => "Meningitis linfocitarias causadas por el virus herpes simple tipo 2"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "290"
          "paginaFinal" => "291"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Lymphocytic meningitis caused by herpes simplex virus type 2"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Reina, M&#46; Leyes, C&#46; Taboada"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Reina"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Leyes"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Taboada"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256516000291?idApp=WRCEE"
    "url" => "/00142565/0000021600000005/v1_201606010023/S0014256516000291/v1_201606010023/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Correspondencia</span>"
    "titulo" => "El aumento de la incidencia del c&#225;ncer diferenciado de tiroides no se relaciona con un incremento en la detecci&#243;n de microcarcinomas incidentales"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Sr&#46; Director&#58;</span>"
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "292"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46; Ruiz, F&#46; Carral, R&#46; Tinoco, C&#46; Ayala"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "G&#46;"
            "apellidos" => "Ruiz"
            "email" => array:2 [
              0 => "ruizgemam&#64;gmail&#46;com"
              1 => "ruizvillenag&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Carral"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Tinoco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Ayala"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Medicina Interna&#44; Hospital Universitario de Puerto Real&#44; Puerto Real&#44; C&#225;diz&#44; Espa&#241;a"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Endocrinolog&#237;a y Nutrici&#243;n&#44; Hospital Universitario de Puerto Real&#44; Puerto Real&#44; C&#225;diz&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Rise in differentiated thyroid cancer incidence in our hospital is not related with an increased incidental microcarcinoma detection"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">El carcinoma de tiroides &#40;CT&#41; es una neoplasia rara&#44; que comprende menos del 2&#44;5&#37; de los c&#225;nceres en humanos&#46; El c&#225;ncer diferenciado de tiroides &#40;CDT&#41; incluye al carcinoma papilar &#40;CP&#41; y al folicular &#40;CF&#41;&#44; y constituye m&#225;s del 90&#37; de todos los CT<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En el Hospital Universitario de Puerto Real&#44; C&#225;diz&#44; se ha llevado a cabo un estudio observacional descriptivo de cohortes hist&#243;ricas incluyendo a todos los pacientes intervenidos mediante tiroidectom&#237;a entre 2000-2014&#44; con el objetivo de evaluar los cambios en la incidencia del CDT en nuestra &#225;rea&#46; Se analizaron un total de 1&#46;605 informes de anatom&#237;a patol&#243;gica y se detectaron 224 casos de CDT&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Se observ&#243; un aumento significativo de las tasas de incidencia de CDT&#44; pasando de 3&#44;7 &#40;2000-2004&#41; a 4&#44;8 &#40;2005-2009&#41; y 6&#44;8 &#40;2009-2014&#41; casos por 100&#46;000 habitantes&#47;a&#241;o&#46; Este incremento fue documentado en ambos sexos &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; correspondi&#233;ndose con un incremento medio del 5&#44;2&#37; en el conjunto de la poblaci&#243;n estudiada&#44; del 2&#44;07&#37; entre los varones y del 8&#44;26&#37; entre las mujeres&#46; No existieron diferencias significativas en la edad al diagn&#243;stico&#44; sexo&#44; tama&#241;o del tumor&#44; tiroiditis en la pieza&#44; extensi&#243;n linf&#225;tica o extratiroidea del tumor&#44; ni estadio tumoral entre los per&#237;odos estudiados&#46; El 29&#44;5&#37; de todos los casos detectados fueron microcarcinomas &#40;97&#37; papilares y 3&#37; foliculares&#41;&#44; observ&#225;ndose un incremento de este tipo de tumores en los 2 &#250;ltimos per&#237;odos&#44; si bien las diferencias no fueron estad&#237;sticamente significativas&#46; El 73&#37; de los microcarcinomas hallados fueron incidentales&#44; detectados en tiroidectom&#237;as indicadas por tama&#241;o de n&#243;dulos tiroideos &#62;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>cm o s&#237;ntomas compresivos locales&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">En las &#250;ltimas d&#233;cadas&#44; la incidencia anual de CT ha aumentado notablemente en todo el mundo&#44; con incrementos anuales que oscilan entre el 7&#37; en EE&#46;UU&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a>&#44; el 16&#37; en Italia<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> y el 1&#44;6-8&#44;37&#37; en nuestro pa&#237;s<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4&#8211;6</span></a>&#46; Algunos autores consideran que este incremento es debido&#44; fundamentalmente&#44; al mayor diagn&#243;stico incidental de microcarcinomas papilares &#40;MCP&#41;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">7&#44;8</span></a>&#46; Sin embargo&#44; en nuestra poblaci&#243;n&#44; el incremento observado de casos de MCP no alcanz&#243; diferencias significativas&#44; ni se relacion&#243; con un mayor intervencionismo tiroideo&#46; Ser&#237;a recomendable la puesta en marcha de estudios epidemiol&#243;gicos orientados a evaluar los cambios en la incidencia de CT en distintas poblaciones de nuestro pa&#237;s&#44; as&#237; como investigaciones dise&#241;adas para detectar los posibles factores responsables de su mayor incidencia&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Per&#237;odo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2000-2004 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2005-2009 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2010-2014 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;69 &#40;3&#44;67-3&#44;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;84 &#40;4&#44;82-4&#44;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;82 &#40;6&#44;81-6&#44;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#44;20 &#40;5&#44;19-5&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Varones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;07 &#40;1&#44;05-1&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;67 &#40;1&#44;65-1&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;32 &#40;3&#44;30-3&#44;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;07 &#40;2&#44;06-2&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mujeres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;35 &#40;6&#44;33-6&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;90 &#40;7&#44;88-7&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;17 &#40;10&#44;14-10&#44;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#44;26 &#40;8&#44;25-8&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1095884.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Casos de CDT por 100&#46;000 habitantes y a&#241;o&#44; entre par&#233;ntesis el intervalo de confianza del 95&#37;&#46;</p> <p class="elsevierStyleNotepara" id="npar0010">CDT&#58; c&#225;ncer diferenciado de tiroides&#59; PCA&#58; porcentaje de cambio anual&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Incidencia de CDT y porcentaje de cambio anual por per&#237;odo y sexo</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer statistics&#44; 2009"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Jemal"
                            1 => "R&#46; Siegel"
                            2 => "E&#46; Ward"
                            3 => "Y&#46; Hao"
                            4 => "J&#46; Xu"
                            5 => "M&#46;J&#46; Thun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3322/caac.20006"
                      "Revista" => array:6 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "225"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19474385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gender is an age-specific effect modifier for papillary cancers of the thyroid gland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;A&#46; Kilfoy"
                            1 => "S&#46;S&#46; Devesa"
                            2 => "M&#46;H&#46; Ward"
                            3 => "Y&#46; Zhang"
                            4 => "P&#46;S&#46; Rosenberg"
                            5 => "T&#46;R&#46; Holford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1055-9965.EPI-08-0976"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "1092"
                        "paginaFinal" => "1100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19293311"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased incidence of thyroid cancer in Latina&#44; Italy&#58; A possible role of detection of subclinical disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Busco"
                            1 => "P&#46; Giorgi"
                            2 => "I&#46; Sperduti"
                            3 => "P&#46; Pezzotti"
                            4 => "C&#46; Buzzoni"
                            5 => "F&#46; Pannozzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.canep.2013.02.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol"
                        "fecha" => "2013"
                        "volumen" => "37"
                        "paginaInicial" => "262"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23518150"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time trends of cancer incidence and mortality in Catalonia during 1993-2007"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Cleries"
                            1 => "L&#46; Esteban"
                            2 => "J&#46; Borras"
                            3 => "R&#46; Marcos"
                            4 => "A&#46; Freitas"
                            5 => "M&#46; Carulla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12094-013-1060-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transl Oncol"
                        "fecha" => "2014"
                        "volumen" => "16"
                        "paginaInicial" => "18"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23740137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patr&#243;n evolutivo de la incidencia de c&#225;ncer de tiroides en la Regi&#243;n de Murcia de 1984 a 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;D&#46; Chirlaque"
                            1 => "F&#46; Moldenhauer"
                            2 => "D&#46; Salmer&#243;n"
                            3 => "C&#46; Navarro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.gaceta.2014.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "2014"
                        "volumen" => "28"
                        "paginaInicial" => "397"
                        "paginaFinal" => "400"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24946694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolution of diferentiatted thyroid cancer&#58; A decade of thyroidectomies in a single institution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Zaf&#243;n"
                            1 => "J&#46;A&#46; Baena"
                            2 => "J&#46; Castellv&#237;"
                            3 => "G&#46; Obiols"
                            4 => "O&#46; Gonz&#225;lez"
                            5 => "J&#46;M&#46; Fort"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000365416"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Thyroid J"
                        "fecha" => "2014"
                        "volumen" => "3"
                        "paginaInicial" => "197"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25538902"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A time trend analysis of papillary and follicular cancers as a function of tumour size&#58; A study of data from six cancer registries in France &#40;1983-2000&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Colonna"
                            1 => "A&#46;V&#46; Guizard"
                            2 => "C&#46; Schvartz"
                            3 => "M&#46; Velten"
                            4 => "N&#46; Raverdy"
                            5 => "F&#46; Molinie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2006.11.024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2007"
                        "volumen" => "43"
                        "paginaInicial" => "891"
                        "paginaFinal" => "900"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Korea&#39;s thyroid-cancer &#171;epidemic&#187;&#46; Screening and over diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Sik"
                            1 => "H&#46; Jung"
                            2 => "H&#46; Gilbert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMp1409841"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2014"
                        "volumen" => "371"
                        "paginaInicial" => "1765"
                        "paginaFinal" => "1767"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25372084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00142565/0000021600000005/v1_201606010023/S001425651600028X/v1_201606010023/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "992"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Correspondencia"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00142565/0000021600000005/v1_201606010023/S001425651600028X/v1_201606010023/es/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S001425651600028X?idApp=WRCEE"
]
Información del artículo
ISSN: 00142565
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2023 Marzo 11 4 15
2022 Enero 1 0 1
2017 Febrero 1 0 1
2017 Enero 1 1 2
2016 Noviembre 2 0 2
2016 Septiembre 2 1 3
2016 Julio 3 2 5

Siga este enlace para acceder al texto completo del artículo

Idiomas
Revista Clínica Española
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?