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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La insuficiencia cardiaca &#40;IC&#41; constituye un problema asistencial de primera magnitud por su elevada prevalencia y morbimortalidad&#44; siendo la primera causa de hospitalizaci&#243;n de pacientes mayores de 65 a&#241;os en los pa&#237;ses occidentales<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a>&#46; Con el envejecimiento de la poblaci&#243;n el impacto de la IC est&#225; aumentando&#44; existiendo en este rango de edad una mayor proporci&#243;n de mujeres&#46; De hecho las mujeres constituyen aproximadamente la mitad de los pacientes hospitalizados por IC<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#8211;6</span></a>&#44; o incluso un porcentaje superior si consideramos &#250;nicamente los servicios de Medicina Interna<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; Sin embargo&#44; han permanecido escasamente representadas en la mayor&#237;a de los ensayos cl&#237;nicos en IC<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a>&#44; con un porcentaje inferior al 25&#37;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a> en la mayor&#237;a de estos&#46; La IC en la mujer ha mostrado una serie de diferencias en cuanto a su epidemiolog&#237;a&#44; etiolog&#237;a&#44; fisiopatolog&#237;a y cl&#237;nica<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;8&#8211;11</span></a>&#46; Otros aspectos de la IC en la mujer como el manejo terap&#233;utico y pron&#243;stico han sido menos estudiados<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#44;12</span></a>&#46; Por todo ello&#44; el objetivo del estudio fue analizar las caracter&#237;sticas cl&#237;nicas diferenciales de las mujeres hospitalizadas por IC en relaci&#243;n a los varones en cuanto a etiolog&#237;a&#44; comorbilidad&#44; desencadenantes&#44; tratamiento farmacol&#243;gico&#44; estancia hospitalaria y mortalidad global al a&#241;o&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes y m&#233;todo</span><p id="par0010" class="elsevierStylePara elsevierViewall">Los pacientes se han recogido del Registro Nacional de Insuficiencia Cardiaca &#40;RICA&#41; creado por el Grupo de Trabajo de Insuficiencia Cardiaca de la Sociedad Espa&#241;ola de Medicina Interna<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; El Registro RICA es un estudio de cohortes multic&#233;ntrico&#44; que incluye de forma prospectiva pacientes procedentes de 52 hospitales p&#250;blicos y privados de Espa&#241;a&#46; En este estudio se incluyen pacientes mayores de 50 a&#241;os hospitalizados por IC descompensada en servicios de Medicina Interna&#44; dados de alta y seguidos al menos durante un a&#241;o&#46; Las caracter&#237;sticas del registro se han descrito previamente<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a>&#46; El registro fue aprobado por el Comit&#233; de &#201;tica del Hospital Universitario Reina Sof&#237;a de C&#243;rdoba&#46; Los datos se cumplimentaron a trav&#233;s de la p&#225;gina web <a href="http://www.registrorica.org/">http&#58;&#47;&#47;www&#46;registrorica&#46;org</a>&#44; de forma an&#243;nima&#44; garantizando la confidencialidad del paciente&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">En el momento de la inclusi&#243;n de los pacientes se registraron las siguientes variables&#58; caracter&#237;sticas sociodemogr&#225;ficas&#44; antecedentes cl&#237;nicos&#44; incluyendo hipertensi&#243;n arterial&#44; diabetes mellitus&#44; infarto de miocardio&#44; fibrilaci&#243;n auricular &#40;FA&#41;&#44; hiperlipidemia&#44; enfermedad pulmonar obstructiva cr&#243;nica&#44; neoplasia&#44; enfermedad arterial perif&#233;rica e ictus&#59; &#237;ndice de comorbilidad de Charlson<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a>&#44; grado de capacidad funcional previo evaluado mediante el &#237;ndice de Barthel<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a>&#44; estado mental evaluado mediante el test de Pfeiffer<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a>&#44; &#237;ndice de masa corporal&#46; En relaci&#243;n a la IC se incluyeron&#58; etiolog&#237;a de la cardiopat&#237;a&#44; factor desencadenante&#44; clase funcional de la New York Heart Association &#40;NYHA&#41;&#44; clasificaci&#243;n de la IC como de debut o cr&#243;nica descompensada&#44; fracci&#243;n de eyecci&#243;n del ventr&#237;culo izquierdo &#40;FEVI&#41; evaluada mediante ecocardiograf&#237;a&#44; ritmo cardiaco en el electrocardiograma&#44; antecedente previo de FA&#44; valores de presi&#243;n arterial y frecuencia cardiaca&#46; Tambi&#233;n se recogieron los valores de hemoglobina y creatinina&#46; Se estim&#243; el filtrado glomerular mediante la f&#243;rmula MDRD-4<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a>&#46; Se consider&#243; la presencia de insuficiencia renal cuando el filtrado glomerular estimado mediante dicha f&#243;rmula era inferior a 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73m<span class="elsevierStyleSup">2</span>&#46; Se defini&#243; la presencia de anemia siguiendo los criterios de la OMS &#40;hemoglobina mayor a 13<span class="elsevierStyleHsp" style=""></span>g&#47;dL en varones o 12<span class="elsevierStyleHsp" style=""></span>g&#47;dL en mujeres&#41;&#46; Se consider&#243; la presencia de FEVI preservada cuando la FE fue inferior al 50&#37; y cumpl&#237;a los criterios indicados en la Gu&#237;a Europea de IC<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se registr&#243; el tratamiento prescrito al alta incluyendo beta-bloqueantes&#44; inhibidores de la enzima convertidora de la angiotensina &#40;IECA&#41;&#44; antagonistas de los receptores de la angiotensina <span class="elsevierStyleSmallCaps">II</span> &#40;ARA II&#41;&#44; antagonistas de la aldosterona&#44; diur&#233;ticos&#44; as&#237; como la estancia del ingreso &#237;ndice y mortalidad por cualquier causa al a&#241;o&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0025" class="elsevierStylePara elsevierViewall">Se realiz&#243; un an&#225;lisis descriptivo&#44; utilizando la media y desviaci&#243;n est&#225;ndar para variables cuantitativas y porcentajes para variables categ&#243;ricas&#46; Se analizaron las diferencias entre ambos g&#233;neros en cuanto a caracter&#237;sticas de la cardiopat&#237;a&#44; comorbilidad&#44; situaci&#243;n funcional&#44; mental&#44; desencadenantes&#44; tratamiento&#44; estancia y mortalidad al a&#241;o&#46; Para comparar variables categ&#243;ricas se utilizaron los test de la Chi cuadrado y el test exacto de Fischer&#46; Para comparar variables cuantitativas se utiliz&#243; el test t-Student o el test U de Mann-Whitney en funci&#243;n de que las variables siguieran o no una distribuci&#243;n normal&#46; La normalidad de las variables se analiz&#243; mediante el test Kolmogorov-Smirnov&#46; Se analiz&#243; el valor pron&#243;stico del g&#233;nero ajustado por la edad y otros factores pron&#243;sticos&#46; Se realiz&#243; un an&#225;lisis multivariable de riesgos prorpocionales de regresi&#243;n de Cox&#44; en el cual se incluyeron las variables que se relacionaron de forma significativa en el an&#225;lisis univariante con la mortalidad y aquellas otras consideradas de valor pron&#243;stico con independencia de su asociaci&#243;n estad&#237;stica &#40;edad&#44; grado funcional de la NYHA&#44; funci&#243;n renal&#44; anemia&#44; obesidad&#44; hiponatremia&#44; FEVI&#44; uso de IECA&#44; ARA <span class="elsevierStyleSmallCaps">II</span> o beta-bloqueantes y capacidad funcional evaluada mediante el &#237;ndice de Barthel&#41;&#46; Se consideraron significativas las diferencias con un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; El an&#225;lisis estad&#237;stico fue realizado con el programa <span class="elsevierStyleItalic">Statistical Package for Social Sciences</span> &#40;versi&#243;n 15&#46;0&#44; SPSS Inc&#46; Chicago&#46;IL&#44; EE&#46; UU&#46;&#41;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se incluyeron 1772 pacientes con una edad media de 78 a&#241;os &#40;DE 8&#44;7&#41;&#44; 836 varones &#40;47&#44;2&#37;&#41; y 936 mujeres &#40;52&#44;8&#37;&#41;&#46; Las caracter&#237;sticas basales de todos los pacientes y en funci&#243;n del g&#233;nero se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Las mujeres ten&#237;an una edad media significativamente superior que los varones &#40;79&#44;3 vs&#46; 76&#44;6 a&#241;os&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; mostraron mayor prevalencia de hipertensi&#243;n &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; obesidad &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; y de enfermedad renal cr&#243;nica &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Los varones ten&#237;an con mayor frecuencia antecedentes de infarto de miocardio &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; arteriopat&#237;a perif&#233;rica &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; enfermedad pulmonar obstructiva cr&#243;nica &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; anemia &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41; y una mayor puntuaci&#243;n en el &#237;ndice de comorbilidad de Charlson &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Las mujeres mostraron peor capacidad funcional evaluada mediante el &#237;ndice de Barthel &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y peor estado mental seg&#250;n el test de Pfeiffer &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">La etiolog&#237;a de la cardiopat&#237;a m&#225;s frecuente en las mujeres fue la hipertensiva &#40;45&#44;3&#37; vs&#46; 28&#44;1&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; seguida de la valvular &#40;22&#44;6&#37; vs&#46; 13&#44;3&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; mientras que en los varones predomin&#243; la etiolog&#237;a isqu&#233;mica &#40;37&#44;1&#37;&#44; vs&#46; 19&#44;9&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Ninguna mujer se diagnostic&#243; de miocardiopat&#237;a dilatada alcoh&#243;lica&#46; En las mujeres predomin&#243; la IC con fracci&#243;n de eyecci&#243;n preservada &#40;IC-FEP&#41;&#44; a diferencia de los varones &#40;69&#44;2 vs&#46; 44&#44;6&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; La prevalencia de FA fue significativamente superior en las mujeres en relaci&#243;n a los varones &#40;56&#44;2 vs&#46; 47&#44;6&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Entre las mujeres la presi&#243;n arterial sist&#243;lica &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y la frecuencia cardiaca &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; fueron m&#225;s altas y su clase funcional de la NYHA&#44; peor &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41;&#44; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Tambi&#233;n se observaron diferencias en los factores desencadenantes del episodio de IC&#44; predominando en mujeres la FA &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41; y la crisis hipertensiva &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;039&#41;&#44; frente al incumplimiento terap&#233;utico y&#47;o transgresi&#243;n diet&#233;tica en varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;044&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">La mortalidad al a&#241;o global fue de un 27&#37;&#44; sin mostrar diferencias significativas en relaci&#243;n al g&#233;nero &#40;28&#44;6&#37; en varones y 25&#44;6&#37; en mujeres p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;16&#41;&#46; Sin embargo&#44; al ajustar por la edad s&#237; se observ&#243; que el sexo femenino se asoci&#243; a menor mortalidad &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; Al realizar un an&#225;lisis multivariante&#44; se observ&#243; que se manten&#237;a la menor mortalidad en mujeres ajustando por otros factores pron&#243;sticos conocidos&#44; que incluyeron adem&#225;s de la edad&#44; la presencia de anemia&#44; insuficiencia renal&#44; hiponatremia&#44; obesidad&#44; presi&#243;n arterial sist&#243;lica&#44; grado funcional de la NYHA&#44; tratamiento con beta-bloqueantes o con IECA o ARA II &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">La estancia media no difiri&#243; en funci&#243;n del g&#233;nero &#40;10&#44;1 d&#237;as en varones vs&#46; 9&#44;4 en mujeres&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;16&#41;&#44; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En cuanto al tratamiento administrado&#44; las mujeres recibieron con m&#225;s frecuencia que los varones ARA II &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y con menor frecuencia IECA &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; sin embargo&#44; el uso combinado de IECA y ARA II no difiri&#243; en funci&#243;n del g&#233;nero &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;83&#41;&#46; Tampoco se observaron diferencias entre ambos g&#233;neros en el uso de beta-bloqueantes &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;24&#41;&#46; La prescripci&#243;n de diur&#233;ticos&#44; de forma global&#44; fue similar&#44; aunque los diur&#233;ticos antagonistas de la aldosterona se utilizaron con mayor frecuencia en varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; Al considerar &#250;nicamente los pacientes con disfunci&#243;n sist&#243;lica &#40;FEVI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>50&#37;&#41;&#44; los resultados fueron similares&#44; observ&#225;ndose entre las mujeres una menor utilizaci&#243;n de IECA &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;017&#41; y de diur&#233;ticos antagonistas de la aldosterona &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;013&#41; y una tendencia a un mayor uso de ARA II &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;052&#41;&#44; pero sin diferencias en el uso combinado de IECA y ARA II &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;34&#41; y de beta-bloqueantes &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;24&#41;&#44; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0070" class="elsevierStylePara elsevierViewall">Este estudio es representativo de los pacientes que ingresan por IC en los Servicios de Medicina Interna&#46; Los datos que aporta proceden de hospitales de toda Espa&#241;a y distintos niveles asistenciales&#44; muestra una poblaci&#243;n de edad avanzada&#44; con caracter&#237;sticas diferenciales en funci&#243;n del g&#233;nero&#44; siendo las mujeres de mayor edad&#44; con m&#225;s prevalencia de hipertensi&#243;n&#44; obesidad&#44; enfermedad renal cr&#243;nica&#44; fibrilaci&#243;n auricular&#44; IC-FEP y menor mortalidad ajustada por otros factores pron&#243;sticos&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas espec&#237;ficas de la IC en la mujer han sido poco estudiadas&#46; Las mujeres han estado infrarrepresentadas en los ensayos cl&#237;nicos<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#44; mientras que en la vida real la mitad de los ingresos hospitalarios por IC acontecen en esta poblaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4&#44;6&#44;12</span></a>&#46; Posiblemente&#44; al menos en parte&#44; ello sea debido a que en la mujer la IC se presenta a edades m&#225;s avanzadas que los varones&#44; tanto en el entorno ambulatorio como hospitalario<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#8211;4&#44;10&#44;12&#44;19</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">En relaci&#243;n con la comorbilidad que presentan los pacientes con IC&#44; se han descrito diferencias en funci&#243;n del g&#233;nero&#46; Al igual que lo referido en la literatura&#44; las mujeres tienen una menor prevalencia de cardiopat&#237;a isqu&#233;mica y EPOC<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#8211;4&#44;10&#44;11&#44;19</span></a> y una mayor frecuencia de hipertensi&#243;n&#46; Existe casi unanimidad en las distintas series acerca de la mayor prevalencia de hipertensi&#243;n en la mujer<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4&#44;9&#8211;12&#44;19</span></a>&#44; con cifras m&#225;s elevadas de presi&#243;n arterial sist&#243;lica<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4&#44;9&#44;10&#44;12&#44;19</span></a> al igual que lo observado por nosotros&#46; Se ha objetivado un riesgo superior de desarrollar IC en relaci&#243;n con la hipertensi&#243;n arterial en mujeres que en varones&#46; Levy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> apreciaron que el riesgo de desarrollo de IC en pacientes hipertensos comparado con sujetos normotensos era casi el doble en varones y el triple en mujeres ajustando por la edad y otros factores&#46; De hecho&#44; la etiolog&#237;a de la IC en mujeres es predominantemente hipertensiva y valvular&#44; como se ha referido previamente<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a>&#44; mientras que la etiolog&#237;a isqu&#233;mica predomina en el var&#243;n<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4&#44;10&#44;11&#44;19</span></a>&#44; hallazgos tambi&#233;n observados en este estudio&#46; Por otra parte&#44; en nuestro estudio la obesidad fue m&#225;s frecuente en el grupo de mujeres&#44; tal y como se describe en la literatura<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">10&#44;19</span></a>&#44; aunque no de forma un&#225;nime<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;12</span></a>&#46; Con relaci&#243;n a la prevalencia de diabetes&#44; no observamos diferencias en funci&#243;n del g&#233;nero&#44; al igual que en el registro ADHERE<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a>&#46; Sin embargo&#44; en la literatura se han descrito resultados variables&#44; con mayor prevalencia de diabetes en mujeres en algunas series<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#44;10&#44;19</span></a> y menor en otras<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#46; Tampoco observamos diferencias en la prevalencia de dislipemia en funci&#243;n del g&#233;nero a diferencia de otros estudios que han constatado menor frecuencia en la mujer<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">12&#44;19</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En cuanto a la anemia&#44; la prevalencia fue menor en la poblaci&#243;n de mujeres de nuestro registro&#44; de forma similar a lo observado en el estudio ADHERE<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a>&#44; aunque otros trabajos han aportado resultados diferentes<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;11&#44;12&#44;19</span></a>&#46; En nuestro estudio&#44; a diferencia de otros&#44; la insuficiencia renal fue m&#225;s frecuente entre las mujeres<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4&#44;10&#8211;12</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Un aspecto a considerar que puede explicar la diferente prevalencia de comorbilidades en los distintos estudios es la procedencia de los pacientes&#46; Se han descrito diferencias en el perfil de comorbilidad entre los pacientes hospitalizados en los servicios de Medicina Interna y Cardiolog&#237;a&#46; Los pacientes que ingresan en Medicina Interna son con m&#225;s frecuencia mujeres&#44; con m&#225;s edad&#44; con menos cardiopat&#237;a isqu&#233;mica y con mayor prevalencia de diabetes&#44; insuficiencia renal&#44; anemia y patolog&#237;a respiratoria<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">21&#44;22</span></a>&#46; Nuestros resultados se aproximan a los descritos en el Registro ADHERE&#44; que incluye una ampl&#237;sima muestra de pacientes con IC representativos del mundo real en Estados Unidos&#46; Otras series han incluido pacientes procedentes &#250;nica o mayoritariamente de servicios de cardiolog&#237;a<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#44;19&#44;23</span></a>&#44; lo que podr&#237;a explicar algunas de las diferencias publicadas&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Las mujeres de nuestra poblaci&#243;n se encuentran en una situaci&#243;n cl&#237;nica m&#225;s evolucionada&#44; con peor capacidad funcional de la NYHA&#44; al igual que lo descrito en otras series<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#44;19&#44;23</span></a>&#44; con mayor frecuencia de IC previa&#44; y una proporci&#243;n mayor de FA&#46; Aunque la FA en la poblaci&#243;n general es m&#225;s frecuente en varones&#44; entre los pacientes con IC hay m&#250;ltiples estudios que muestran un predominio entre las mujeres<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#8211;11&#44;19&#44;23</span></a>&#44; aunque no de forma un&#225;nime<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">En las mujeres predomin&#243; la IC-FEP&#44; de forma similar a lo descrito&#44; casi un&#225;nimemente en distintas series<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#44;5&#44;9&#8211;11&#44;19&#44;23</span></a>&#46; La prevalencia de la IC-FEP va en aumento&#44; ya que su prevalencia se incrementa con la edad y es preferentemente una enfermedad de la mujer de edad avanzada<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a>&#46; Con el aumento de la esperanza de vida&#44; las mujeres suponen una mayor proporci&#243;n de los pacientes mayores&#44; lo que conlleva un aumento de la prevalencia de IC-FEP&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La capacidad de realizar las actividades b&#225;sicas de la vida diaria&#44; evaluada con escalas como el &#237;ndice de Barthel&#44; es un aspecto que no ha sido bien recogido en los grandes registros de IC americanos &#40;AFHERE&#44; GWTG-HF&#44; Optimize-HF&#41;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;4&#44;12</span></a> ni europeos &#40;EHFSII&#41;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#46; Sin embargo&#44; en los &#250;ltimos a&#241;os se est&#225; constatando la importancia que tiene la situaci&#243;n funcional como factor pron&#243;stico en pacientes con IC<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">25&#8211;27</span></a>&#46; Las mujeres en nuestro estudio mostraron una peor situaci&#243;n funcional que los varones&#46; No obstante hay que considerar que ten&#237;an m&#225;s edad&#44; lo cual podr&#237;a influir en el mayor grado de incapacidad observado&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En relaci&#243;n al posible desencadenante del episodio de IC&#44; la primera causa fue la infecci&#243;n respiratoria en ambos sexos&#46; Sin embargo&#44; entre las mujeres fue m&#225;s frecuente la FA&#44; al igual que comunican otros autores<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> y las crisis hipertensivas&#44; circunstancias ambas que predominan en la mujer&#46; Aunque en algunos estudios no se observan diferencias en funci&#243;n del g&#233;nero<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a> en cuanto al incumplimiento terap&#233;utico&#44; de forma similar a lo descrito en el registro americano GWTG-HF<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a> y en el europeo EHFS-II<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#44; en nuestra serie&#44; este predomin&#243; entre los varones&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La estancia media no difiri&#243; en funci&#243;n del g&#233;nero&#44; al igual que lo recogido en otros grandes registros<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#8211;5&#44;10&#44;11&#44;19</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">La mortalidad cruda al a&#241;o fue superior en varones que en mujeres&#44; aunque las diferencias no alcanzaron significaci&#243;n&#46; Sin embargo&#44; al ajustar por la edad s&#237; se alcanz&#243; significaci&#243;n estad&#237;stica&#44; y se mantuvo tras incluir en el an&#225;lisis multivariante otros factores pron&#243;sticos&#46; Uno de los aspectos m&#225;s debatidos en la literatura es si la mujer tiene mejor pron&#243;stico que el var&#243;n&#46; As&#237;&#44; en numerosos estudios&#44; especialmente en ensayos cl&#237;nicos&#44; las mujeres han presentado mejor pron&#243;stico como muestra el metaan&#225;lisis MAGGIC<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> &#40;Meta-Analysis Global Group In Chronic Heart Failure&#41;&#44; que incluy&#243; 41949 pacientes procedentes de 31 estudios&#46; Sin embargo&#44; otros autores no han observado diferencias en la mortalidad entre ambos g&#233;neros ajustada por la edad<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;11&#44;28</span></a>&#46; Se ha sugerido como factor protector en la mujer la menor prevalencia de cardiopat&#237;a isqu&#233;mica<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">En cuanto al tratamiento&#44; estudios previos han mostrado una menor utilizaci&#243;n de los tratamientos recomendados por las gu&#237;as de pr&#225;ctica cl&#237;nica en mujeres<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a>&#46; En el registro RICA se da una menor utilizaci&#243;n de IECA pero mayor de ARA II en las mujeres respecto a los varones&#46; Varios estudios han comunicado&#44; al igual que nuestros resultados&#44; el mayor uso de IECA en varones<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#8211;5&#44;19</span></a>&#46; Quiz&#225;s la posible menor eficacia de los IECA en mujeres con disfunci&#243;n sist&#243;lica asintom&#225;tica<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;30</span></a> pueda influir en la menor prescripci&#243;n de este f&#225;rmaco&#44; que en nuestra serie se tiende a compensar con un aumento del uso de los ARA II&#46; En la literatura los datos comunicados respecto al uso de ARA II en funci&#243;n del g&#233;nero son m&#225;s variables&#46; Algunos estudios han comunicado&#44; al igual que nosotros&#44; mayor uso de ARA II en mujeres<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#44;12</span></a> &#40;ADHERE y GWTG-HF&#41;&#44; otros menor uso<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a>&#44; mientras que otros no muestran diferencias en su utilizaci&#243;n en funci&#243;n del g&#233;nero<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;10</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En relaci&#243;n a los beta-bloqueantes&#44; se ha comunicado un menor uso en mujeres<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#44;12</span></a>&#46; Sin embargo&#44; en nuestra serie no confirmamos estas diferencias en funci&#243;n del g&#233;nero&#46; Al igual que otros autores<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#44;10</span></a>&#44; apreciamos una tendencia a incrementar su utilizaci&#243;n&#44; como demuestra un reciente estudio realizado en pacientes del registro RICA<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene algunas limitaciones&#46; No se incluyeron en el registro aquellos pacientes que fallecieron durante el ingreso&#46; En segundo lugar&#44; la participaci&#243;n de los hospitales en la inclusi&#243;n de pacientes es voluntaria&#44; lo que puede suponer cierto sesgo de selecci&#243;n&#46; No obstante en el registro RICA participan 52 hospitales de todas las comunidades aut&#243;nomas del territorio nacional y las caracter&#237;sticas de la poblaci&#243;n de este registro concuerdan con los datos obtenidos previamente en el estudio SEMI-IC realizado en servicios de Medicina Interna de nuestro pa&#237;s<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; Otra limitaci&#243;n es que no se registr&#243; el n&#250;mero de pacientes portadores de marcapasos de resincronizaci&#243;n o desfibrilador autom&#225;tico implantable&#44; aunque el n&#250;mero de pacientes con estos dispositivos es muy escaso y probablemente sin influencia en los resultados finales&#46; Por el contrario&#44; una de las fortalezas del estudio es haber analizado una poblaci&#243;n con IC del mundo real&#44; trat&#225;ndose de pacientes de edad avanzada&#44; con comorbilidad&#44; y predominio de mujeres&#44; que muestra diferencias en relaci&#243;n a los varones en cuanto a edad&#44; comorbilidad situaci&#243;n funcional y pron&#243;stico&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; en esta amplia muestra de pacientes de la vida real se confirma la existencia de diferencias en los pacientes hospitalizados por IC&#44; dependientes del g&#233;nero&#46; As&#237;&#44; la IC en la mujer se presenta a edad m&#225;s avanzada&#44; la etiolog&#237;a m&#225;s frecuente es la hipertensiva y valvular&#44; predomina la FEVI preservada&#44; una peor situaci&#243;n funcional&#44; un diferente perfil de comorbilidad y desencadenantes y una menor mortalidad ajustada por la edad&#46; El conocimiento de estas caracter&#237;sticas es importante para apoyar la toma de decisiones en esta poblaci&#243;n&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicto de intereses</span><p id="par0145" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar las caracter&#237;sticas cl&#237;nicas diferenciales en funci&#243;n del sexo en pacientes con insuficiencia cardiaca &#40;IC&#41; en cuanto a etiolog&#237;a&#44; comorbilidad&#44; desencadenantes&#44; tratamiento&#44; estancia hospitalaria y mortalidad global al a&#241;o&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se utilizaron los datos del registro RICA&#44; cohorte prospectiva multic&#233;ntrica de pacientes hospitalizados en servicios de Medicina Interna por IC con seguimiento de un a&#241;o&#46; Se analizaron las diferencias de g&#233;nero en cuanto a la etiolog&#237;a de la cardiopat&#237;a&#44; comorbilidad&#44; factor desencadenante&#44; fracci&#243;n de eyecci&#243;n de ventr&#237;culo izquierdo&#44; situaci&#243;n funcional&#44; estado mental&#44; tratamiento&#44; estancia y mortalidad al a&#241;o&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 1772 pacientes &#40;47&#44;2&#37; varones&#41;&#46; Las mujeres eran mayores que los varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; ten&#237;an mayor prevalencia de hipertensi&#243;n&#44; obesidad&#44; enfermedad renal cr&#243;nica&#44; fibrilaci&#243;n auricular y fracci&#243;n de eyecci&#243;n de ventr&#237;culo izquierdo preservada &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Entre los varones predominaban los antecedentes de infarto de miocardio&#44; enfermedad pulmonar obstructiva cr&#243;nica&#44; arteriopat&#237;a perif&#233;rica &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y anemia &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; En las mujeres predomin&#243; la etiolog&#237;a hipertensiva&#44; seguida de la valvular&#46; Los principales desencadenantes fueron la hipertensi&#243;n y fibrilaci&#243;n auricular&#46; El tratamiento con beta-bloqueantes&#44; IECA y&#47;o ARA II no difiri&#243; en funci&#243;n del sexo&#46; Las mujeres ten&#237;an peor capacidad funcional &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; seg&#250;n el &#237;ndice de Barthel&#46; Tras ajustar por edad y otros factores pron&#243;sticos&#44; la mortalidad al a&#241;o fue menor entre las mujeres RR<span class="elsevierStyleHsp" style=""></span>&#58;<span class="elsevierStyleHsp" style=""></span>0&#44;69 &#40;IC 95&#37; 0&#44;53-0&#44;89&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La IC en la mujer se presenta a edad m&#225;s avanzada y con diferente comorbilidad&#46; Predomina la etiolog&#237;a hipertensiva y valvular&#44; con fracci&#243;n de eyecci&#243;n de ventr&#237;culo izquierdo preservada&#44; y la mortalidad ajustada por la edad es menor que en el var&#243;n&#46;</p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">History and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze the differential clinical characteristics according to gender of patients with heart failure in terms of etiology&#44; comorbidity&#44; triggers&#44; treatment&#44; hospital stay and overall mortality at one year&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We employed data from the RICA registry&#44; a multicenter prospective cohort of patients hospitalized in internal medicine departments for heart failure&#44; with a follow-up of one year&#46; We analyzed the differences between the gender in terms of the etiology of the heart disease&#44; comorbidity&#44; triggers&#44; left ventricle ejection fraction&#44; functional state&#44; mental condition&#44; treatment&#44; length of stay and mortality at 1 year&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 1772 patients &#40;47&#46;2&#37; men&#41; were included&#46; The women were older than the men &#40;p&#60;&#46;001&#41; and had a higher prevalence of hypertension&#44; obesity&#44; chronic kidney disease&#44; atrial fibrillation and preserved left ventricle ejection fraction &#40;p&#60;&#46;001&#41;&#46; The men&#39;s medical history had a predominance of myocardial infarction&#44; chronic obstructive pulmonary disease&#44; peripheral arteriopathy &#40;p&#60;&#46;001&#41; and anemia &#40;p&#61;&#46;02&#41;&#46; In the women&#44; a hypertensive etiology was predominant&#44; followed by valvular&#46; The main triggers were hypertension and atrial fibrillation&#46; Treatment with beta-blockers&#44; ACEIs and&#47;or ARBs did not differ by sex&#46; The women had poorer functional capacity &#40;p&#60;&#46;001&#41;&#44; according to the Barthel index&#46; After adjusting for age and other prognostic factors&#44; the mortality at one year was lower among the women &#40;RR&#58; 0&#46;69&#59; 95&#37; CI 0&#46;53-0&#46;89&#59; p&#61;&#46;004&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">HF in women occurs at a later age and with different comorbidities&#46; The hypertensive and valvular etiology is predominant&#44; with preserved left ventricle ejection fraction&#44; and the age-adjusted mortality is lower than in men&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "History and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Patients and method"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0150" class="elsevierStylePara elsevierViewall">Anarte L&#44; Aramburu O&#44; Ar&#233;valo-Lorido JC&#44; Arkuch E&#44; Armengou A&#44; Bas F&#44; Carrera M&#44; Cerqueiro JM&#44; Conde A&#44; D&#225;vila MF&#44; D&#237;ez J&#44; Epelde F&#44; Formiga F&#44; Franco J&#44; Gallego J&#44; Gonz&#225;lez A&#44; Guisado ME&#44; Herrero A&#44; Llacer P&#44; L&#243;pez G&#44; Manzano L&#44; Montero M&#44; Muela A&#44; Murado I&#44; Oropesa R&#44; P&#233;rez J&#44; P&#233;rez Calvo JI&#44; Quesada MA&#44; Quir&#243;s R&#44; Roca B&#44; Ruiz R&#44; Ruiz Laiglesia F&#44; Salamanca P&#44; S&#225;nchez M&#44; Satu&#233; JA&#44; Serrado A&#44; Serrano M&#44; Su&#225;rez I&#44; Trull&#224;s JC&#46;</p>"
            "etiqueta" => "Ap&#233;ndice"
            "titulo" => "Miembros del Registro RICA&#58;"
            "identificador" => "sec0035"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">ACV&#58; accidente cerebrovascular&#59; EPOC&#58; enfermedad pulmonar obstructiva cr&#243;nica&#59; FGe&#58; filtrado glomerular estimado&#46; Se considera enfermedad renal cr&#243;nica cuando es<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#59; ICT&#58; isquemia cerebral transitoria&#59; IM&#58; infarto de miocardio&#59; IMC&#58; &#237;ndice de masa corporal&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TotalN<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Varonesn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>836 &#40;47&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mujeresn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>936 &#40;52&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Edad media a&#241;os &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#44;0 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#44;6 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79&#44;3 &#40;7&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hipertensi&#243;n n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1515 &#40;85&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">675 &#40;80&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">840 &#40;89&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diabetes n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">801 &#40;45&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">370 &#40;44&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">431 &#40;46&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Dislipemia n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">821 &#40;46&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">387 &#40;46&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">434 &#40;46&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Obesidad &#40;IMC <span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30&#41; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">656 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">253 &#40;30&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">403 &#40;43&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Anemia<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a> n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1021 &#40;57&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">514 &#40;61&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">507 &#40;54&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">IM previo n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">393 &#40;22&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">242 &#40;28&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">151 &#40;16&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ACV o ICT previo n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">240 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">122 &#40;14&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">118 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Enfermedad arterial perif&#233;rica n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">230 &#40;13&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">186 &#40;22&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">FGe&#60; 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1048 &#40;59&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">443 &#40;53&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">605 &#40;64&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">EPOC n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">481 &#40;27&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">361 &#40;43&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">120 &#40;12&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Demencia n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">113 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">&#205;ndice de Charlson &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">&#205;ndice de Barthel &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">86&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Test de Pfeiffer &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Institucionalizado en residencian&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">186 &#40;10&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">91 &#40;10&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95 &#40;10&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Estancia hospitalaria en d&#237;as&#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;1 &#177;8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Mortalidad n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">239 &#40;28&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">240 &#40;25&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Varones n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>836 &#40;47&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mujeres n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>936 &#40;52&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">FEVI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">354 &#40;44&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">600 &#40;69&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">PAS mmHg&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">140&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">142&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">PAD mmHg&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">FC lpm&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">87&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">NYHA</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">I</span>-<span class="elsevierStyleSmallCaps">II</span> n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1014 &#40;58&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">513 &#40;62&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">501&#40;55&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="center" valign="middle">0&#44;002</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">III</span>- <span class="elsevierStyleSmallCaps">IV</span> n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">715 &#40;41&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">309 &#40;37&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">406 &#40;44&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">IC de debut&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">551 &#40;31&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">282&#40;33&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">269 &#40;28&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;023&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">921 &#40;52&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">397 &#40;47&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">524 &#40;56&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Etiolog&#237;a n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IC previa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1098 &#40;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">498 &#40;59&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">600 &#40;64&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Etiolog&#237;a hipertensiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">659 &#40;37&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">235 &#40;28&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">424 &#40;45&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Etiolog&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">496 &#40;28&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">310 &#40;37&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">186 &#40;19&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Etiolog&#237;a valvular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">323 &#40;18&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">111 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">212 &#40;22&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Miocardiopat&#237;a alcoh&#243;lica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;2&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;4&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Miocardiopat&#237;a hipertr&#243;fica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45 &#40;5&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;3&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;023&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Desencadenantes n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span> FA con respuesta ventricular r&#225;pida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">336 &#40;19&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139 &#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">197 &#40;21&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infecci&#243;n respiratoria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">490 &#40;27&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">227 &#40;27&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">263 &#40;28&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Urgencia hipertensiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">102 &#40;5&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38 &#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64 &#40;6&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;039&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mal cumplimiento terap&#233;utico y&#47;o transgresi&#243;n diet&#233;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">147 &#40;8&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81 &#40;9&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Isquemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">112 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ingesta de AINE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Tratamiento n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IECA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">935 &#40;52&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">481 &#40;57&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">454 &#40;48&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ARA II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">595 &#40;33&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">238 &#40;28&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">357 &#40;38&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IECA o ARA II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1425 &#40;80&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">674 &#40;80&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">751 &#40;80&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Beta-bloqueantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1113 &#40;62&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">537 &#40;64&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">576 &#40;61&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diur&#233;ticos de asa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1639 &#40;92&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">778 &#40;93&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">861 &#40;92&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diur&#233;ticos antagonistas de la aldosterona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">624 &#40;35&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">317 &#40;37&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">307 &#40;32&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diur&#233;ticos tiaz&#237;dicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">211 &#40;11&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">96 &#40;11&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">115 &#40;12&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Tratamiento &#40;pacientes con FEVI</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">50&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IECA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">431 &#40;61&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">283 &#40;65&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">148 &#40;55&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ARA II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">180 &#40;25&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">101 &#40;23&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79 &#40;29&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IECA o ARA II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">563 &#40;79&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">355 &#40;80&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">208 &#40;77&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Beta-bloqueantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">511 &#40;72&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">311 &#40;70&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">200 &#40;74&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diur&#233;ticos antagonistas de la aldosterona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">309 &#40;32&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">208 &#40;47&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">101 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Anemia&#58; Hb<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>13<span class="elsevierStyleHsp" style=""></span>g&#47;dL en el var&#243;n y Hb<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>g&#47;dL en la mujer&#59; ARA II&#58; inhibidores de los receptores de la angiotensina II&#59; FEVI&#58; fracci&#243;n de eyecci&#243;n de ventr&#237;culo izquierdo&#59; Hiponatremia &#40;Na&#60; 135 meq&#47;L&#41;&#59; IECA&#58; inhibidores de la enzima convertidora de la angiotensina&#59; MDRD&#58; Modification of Diet in Renal Disease&#59; NYHA&#58; New York Heart Association&#59; Obesidad &#40;IMC&#62; 30&#41;&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">An&#225;lisis univariante</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">An&#225;lisis multivariante</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;05 &#40;1&#44;04-1&#44;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;02 &#40;1&#44;01-1&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sexo &#40;mujer&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;86 &#40;0&#44;70-1&#44;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;69 &#40;0&#44;53-0&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Anemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;70 &#40;1&#44;37-2&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;37 &#40;1&#44;06 -1&#44;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MDRD IV<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;99 &#40;1&#44;68-2&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;84 &#40;1&#44;42-2&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
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