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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="par0020" class="elsevierStylePara elsevierViewall">Las enfermedades cardiovasculares &#40;ECV&#41; son la principal causa de mortalidad en el mundo occidental<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; En Espa&#241;a&#44; la mortalidad por ECV representa el 28&#37; del total de defunciones en varones &#40;segunda causa de mortalidad&#41; y el 36&#37; en mujeres &#40;primera causa de mortalidad&#41;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; La prevalencia de ECV aumenta con la edad<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; y el aumento de la esperanza de vida incrementar&#225; esta proporci&#243;n&#46; En los &#250;ltimos a&#241;os se han promovido campa&#241;as y registros espec&#237;ficos para evaluar las diferencias por g&#233;nero en la frecuencia de ECV&#46; La mujer tiene un perfil de riesgo m&#225;s desfavorable que el var&#243;n&#44; con un uso sub&#243;ptimo de tratamientos farmacol&#243;gicos&#44; pruebas diagn&#243;sticas o medidas intervencionistas<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Las gu&#237;as cl&#237;nicas enfatizan medidas de prevenci&#243;n en el paciente con ECV<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a>&#46; Estos estudios se han efectuado mayoritariamente en la poblaci&#243;n masculina&#44; existiendo pocos ensayos que permitan extrapolar los resultados de forma inequ&#237;voca a la poblaci&#243;n femenina<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;10</span></a>&#46; Existen registros nacionales e internacionales sobre el tratamiento y control de los hipertensos con y sin ECV&#44; que incluyen datos para varones y mujeres<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;14</span></a>&#46; Algunos estudios que utilizan muestreo tienen como objetivo estudiar las diferencias por g&#233;nero<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a>&#59; otras publicaciones aportan datos sobre la prevalencia general<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#8211;20</span></a>&#46; A diferencia de estos estudios&#44; en este trabajo hemos examinado todos los pacientes hipertensos con y sin enfermedad cardiovascular para valorar la ECV que presentan&#44; el tratamiento y el cumplimiento de objetivos terap&#233;uticos en varones y mujeres atendidos en Atenci&#243;n Primaria&#46; La informaci&#243;n obtenida puede ayudar a establecer diferentes estrategias que mejoren el perfil cardiovascular en los hombres y en las mujeres&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metodolog&#237;a</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Fuente de datos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se dise&#241;&#243; un estudio transversal a partir de registros informatizados de pacientes hipertensos de ambos sexos&#44; adscritos al &#193;rea Sanitaria 6 de Madrid&#46; Esta &#225;rea tiene una poblaci&#243;n de 661&#46;611 habitantes&#44; de nivel sociocultural medio-alto&#44; &#225;mbito residencial y poblaci&#243;n urbana &#40;el 17&#44;8&#37; de la poblaci&#243;n fue atendida por 7 equipos&#41;&#44; semiurbana &#40;el 46&#44;2&#37; de la poblaci&#243;n fue atendida por 9 equipos&#41; y rural &#40;el 36&#37; del total fue atendida por 9 equipos&#41;&#44; con el 15&#37; de los pacientes mayores de 65 a&#241;os&#46; Los 25 equipos de Atenci&#243;n Primaria de esta &#225;rea son atendidos por 308 m&#233;dicos&#46; Se incluyeron pacientes diagnosticados de hipertensi&#243;n arterial &#40;HTA&#41; en tratamiento farmacol&#243;gico y que hubieran acudido a sus centros de salud en el a&#241;o 2008&#44; para revisi&#243;n y solicitar prescripciones de f&#225;rmacos antihipertensivos&#46; Se consider&#243; ECV la presencia en la historia cl&#237;nica de los diagn&#243;sticos basados en la clasificaci&#243;n internacional en Atenci&#243;n Primaria versi&#243;n 2 &#40;CIAP-2&#44; aparato circulatorio&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> y que habitualmente proceden de informes de alta procedentes de atenci&#243;n hospitalaria&#58; cardiopat&#237;a isqu&#233;mica &#40;CI&#41; &#40;K74&#44; K76&#41;&#59; insuficiencia card&#237;aca &#40;IC&#41; &#40;K77&#41;&#59; enfermedad arterial perif&#233;rica &#40;EAP&#41; &#40;K99&#41;&#59; insuficiencia renal cr&#243;nica &#40;IRC&#41; &#40;U99&#41;&#59; ictus &#40;K89&#44; K90&#41; y fibrilaci&#243;n auricular &#40;FA&#41; &#40;K78&#41;&#46; Se consider&#243; que un paciente ten&#237;a HTA &#40;K85&#44; K86&#44; K87&#41; cuando constaba este diagn&#243;stico previo en la historia cl&#237;nica&#44; o bien figuraban tres tomas de presi&#243;n arterial &#40;PA&#41; en consulta &#8805; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg en tres d&#237;as diferentes&#44; 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que es el mayoritariamente usado en Atenci&#243;n Primaria de las diferentes comunidades aut&#243;nomas de Espa&#241;a&#46; Se seleccionaron las variables&#58; edad&#44; sexo&#44; h&#225;bito tab&#225;quico&#44; cifras de presi&#243;n arterial sist&#243;lica y diast&#243;lica &#40;mmHg&#41;&#44; peso &#40;kg&#41;&#44; talla &#40;cm&#41;&#44; &#237;ndice de masa corporal &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; glucosa basal &#40;mg&#47;dL&#41;&#44; colesterol total &#40;mg&#47;dL&#41;&#44; LDL-colesterol &#40;mg&#47;dL&#41;&#44; HDL-colesterol &#40;mg&#47;dL&#41;&#44; triglic&#233;ridos &#40;mg&#47;dL&#41; y creatinina &#40;mg&#47;dL&#41;&#46; Se calcul&#243; el filtrado glomerular estimado &#40;ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#41; con la f&#243;rmula MDRD<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#46; Las variables anal&#237;ticas de laboratorio se obtuvieron mayoritariamente en los centros de salud en condiciones basales tras ayuno nocturno de 8 horas y fueron remitidas a los dos laboratorios de referencia del &#225;rea&#46; La morbilidad analizada se bas&#243; en la presencia de diagn&#243;sticos previos en la historia cl&#237;nica seg&#250;n c&#243;digos CIAP-2 para diabetes &#40;T90&#41; que considera los criterios de glucosa al azar &#62; 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL con s&#237;ntomas cl&#225;sicos de diabetes&#44; dos o m&#225;s glucemias al azar &#62; 126<span class="elsevierStyleHsp" style=""></span>mg&#47;dL y dos o m&#225;s glucemias &#62; 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL a las dos horas de la sobrecarga oral con 75 g de glucosa&#59; hiperlipemia &#40;T93&#41;&#58; colesterol total en dos determinaciones &#62; 250<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o &#62; 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL si hay diabetes&#44; enfermedad cardiovascular o riesgo cardiovascular elevado &#40;score &#62; 5&#41;&#59; obesidad &#40;T82&#41;&#58; &#237;ndice de masa corporal es &#62; 30 kg&#47;m<span class="elsevierStyleSup">2</span>&#59; 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anticoagulantes y antiagregantes &#40;B01&#41; e hipoglucemiantes &#40;A10&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis de datos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Se revisaron los datos y se comprobaron las distribuciones de frecuencia y posibles errores de codificaci&#243;n&#46; Se comprob&#243; la normalidad de las variables con la prueba de Kolmogorov-Smirnov&#44; y se usaron estad&#237;sticos b&#225;sicos de centralizaci&#243;n&#44; media aritm&#233;tica y desviaci&#243;n est&#225;ndar &#40;DE&#41; en las variables continuas y distribuci&#243;n de frecuencias relativas &#40;prevalencia&#41; en las variables categ&#243;ricas&#44; con sus intervalos de confianza al 95&#37; &#40;IC 95&#37;&#41;&#46; Para las comparaciones de medias se us&#243; la prueba de la <span class="elsevierStyleItalic">t</span> de Student-Fisher en caso de variables independientes binarias y para comparaciones de proporciones se us&#243; la prueba de la Chi-cuadrado&#46; Se consider&#243; significaci&#243;n estad&#237;stica&#44; los valores de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Para todos los an&#225;lisis se utiliz&#243; el programa estad&#237;stico SPSS 15&#46;0&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">De un total de 96&#46;528&#44; se incluyeron 92&#46;079 historias&#46; El nivel de registro&#44; seg&#250;n las diferentes variables y grupos analizados&#44; oscil&#243; entre el 95&#37; para la variable tabaco&#44; y el 75&#37; para las variables PA&#44; peso y talla&#44; y del 60&#37; para las variables de laboratorio&#46; Se desestim&#243; el an&#225;lisis de la microalbuminuria por no existir un nivel adecuado de registro&#46; De las 92&#46;079 historias con HTA&#44; 19&#46;501 ten&#237;an un diagn&#243;stico previo de ECV &#40;21&#44;2&#37;&#59; el 23&#44;9&#37; en varones y el 19&#44;1&#37; en mujeres&#41; y 72&#46;578 padec&#237;an HTA&#44; pero no ten&#237;an un diagn&#243;stico previo de ECV &#40;78&#44;8&#37;&#41;&#46; Las caracter&#237;sticas generales y el an&#225;lisis comparativo de los pacientes con y sin ECV se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; La distribuci&#243;n de factores de riesgo y morbilidad asociada fue mayor en los enfermos con ECV&#44; salvo la obesidad&#44; que se distribuy&#243; igual en ambos grupos&#46; La prescripci&#243;n de f&#225;rmacos antihipertensivos&#44; hipolipemiantes y antiagregantes fue significativamente mayor en el grupo con ECV &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El control de presi&#243;n arterial y l&#237;pidos fue mejor en los pacientes con ECV &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas generales de los pacientes con ECV y el an&#225;lisis comparativo por g&#233;nero se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; Del total de 19&#46;501 pacientes con ECV&#44; el porcentaje de varones fue similar al de mujeres &#40;49&#44;7 vs 50&#44;3&#37;&#41;&#46; La edad de las mujeres fue mayor &#40;78&#44;2 vs 71 a&#241;os&#41;&#46; El filtrado glomerular fue menor en mujeres&#44; con 35&#37; de mujeres con tasas &#60; 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> frente a 25&#44;7&#37; de varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El porcentaje de pacientes con presi&#243;n arterial &#60; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg&#44; fue 59&#44;9&#37; &#40;IC 95&#37;&#58; 59&#44;2-60&#44;6&#41;&#44; siendo algo mayor en varones &#40;60&#44;5 vs 59&#44;1&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#41; y el que ten&#237;a niveles de LDL-col &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl fue del 36&#37; &#40;IC 95&#37;&#58; 35&#44;3-36&#44;7&#41;&#44; siendo significativamente mayor en varones &#40;40&#44;4 vs 31&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se recoge la distribuci&#243;n por g&#233;nero de los diferentes diagn&#243;sticos de ECV&#46; Encontramos diferencias estad&#237;sticamente significativas en la distribuci&#243;n de estas enfermedades&#44; siendo la cardiopat&#237;a isqu&#233;mica&#44; la enfermedad arterial perif&#233;rica y la insuficiencia renal cr&#243;nica m&#225;s frecuentes en los varones y la insuficiencia card&#237;aca&#44; la fibrilaci&#243;n auricular y el ictus m&#225;s frecuentes en las mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> se presentan las tasas globales y especificas por g&#233;nero y edad &#40;&#8805; 65 y<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#41; y sexo de los diagn&#243;sticos de las diferentes ECV en los hipertensos estudiados&#46; Todas las ECV fueron m&#225;s prevalentes en los varones de ambos grupos de edad &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Fueron especialmente apreciables las diferencias en cardiopat&#237;a isqu&#233;mica e insuficiencia renal cr&#243;nica&#44; siendo pr&#225;cticamente el doble en varones que en mujeres&#44; tanto mayores como menores de 65 a&#241;os&#46; La prevalencia de fibrilaci&#243;n auricular e ictus fue mayor en varones que en mujeres menores de 65 a&#241;os &#40;2&#44;1 vs 1&#44;4&#37; para la fibrilaci&#243;n y 2&#44;4 vs 1&#44;3&#37; para ictus&#41;&#44; acort&#225;ndose&#44; en t&#233;rminos relativos&#44; estas diferencias en el grupo mayor de 65 a&#241;os &#40;10&#44;3 vs 9&#44;4&#37; para fibrilaci&#243;n auricular y 8&#44;6 vs 7&#44;1&#37; para ictus&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Los resultados del an&#225;lisis comparativo de consumo farmacol&#243;gico por g&#233;nero se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#46; Se encontr&#243; un consumo mayor de diur&#233;ticos &#40;52 vs 35&#44;3&#37;&#41; en mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El uso de antiagregantes&#47;anticoagulantes &#40;68&#44;7 vs 63&#37;&#41;&#44; betabloqueantes &#40;40 vs 26&#37;&#41;&#44; antagonistas del calcio &#40;29 vs 26&#44;8&#37;&#41;&#44; inhibidores del sistema renina angiotensina aldosterona &#40;64 vs 61&#44;5&#37;&#41; e hipolipemiantes &#40;48 vs 36&#37;&#41; fue mayor en varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; De entre los pacientes que tomaban antiagregantes&#47;anticoagulantes&#44; se encontr&#243; mayor consumo de anticoagulantes orales en mujeres &#40;36 vs 29&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Este estudio realizado a partir de casi 100&#46;000 historias cl&#237;nicas de pacientes con HTA atendidos en el &#225;mbito de la Atenci&#243;n Primaria aporta un an&#225;lisis comparativo de los enfermos que padecen o no alguna ECV &#40;prevenci&#243;n primaria y secundaria&#41; y un an&#225;lisis de diferencias por g&#233;nero en los pacientes con eventos&#46; En general&#44; los enfermos con ECV presentan una mayor edad&#44; morbilidad y tratamiento farmacol&#243;gico y mejor control de presi&#243;n arterial y l&#237;pidos en el grupo con ECV&#46; Entre los pacientes con ECV encontramos diferencias de g&#233;nero&#44; tanto cualitativas como cuantitativas&#44; con respecto a la prevalencia de las ECV&#44; prescripci&#243;n farmacol&#243;gica y objetivos terap&#233;uticos alcanzados&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Al analizar las ECV observamos que la prevalencia de IC fue del 3&#44;3&#37;&#44; claramente inferior a la de estudios previos en Espa&#241;a &#40;alrededor del 19&#37; en el estudio HICAP en poblaci&#243;n hipertensa&#41;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Esta diferencia sugiere un infradiagn&#243;stico importante&#44; tal vez porque en Atenci&#243;n Primaria no se emplean de forma sistem&#225;tica los criterios de Framingham<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>&#46; De igual forma&#44; en la EAP encontramos prevalencias muy inferiores a las reportadas por otros estudios<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> y a&#250;n menores si las comparamos con prevalencias de EAP asintom&#225;tica del estudio MERITO II &#40;30 al 50&#37; en pacientes con ECV&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#46; Este hecho sugiere&#44; que en la pr&#225;ctica cl&#237;nica solo se est&#225;n identificando a los pacientes m&#225;s graves que requieren tratamientos m&#225;s agresivos u hospitalizaciones&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En cuanto a la cardiopat&#237;a isqu&#233;mica&#44; encontramos una prevalencia del 7&#44;5&#37;&#44; concordante con estudios previos&#44; tanto en poblaci&#243;n general como hipertensa<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;29</span></a>&#46; La prevalencia de FA ofreci&#243; datos similares a otros estudios como el PREVICTUS&#44; &#40;8&#44;5&#37; en poblaci&#243;n &#62; 60 a&#241;os&#44; de base poblacional&#41; o como los estudios analizados por P&#233;rez-Villacast&#237;n que reportan prevalencias entre el 2&#44;5 y el 17&#44;6&#37; seg&#250;n el entorno analizado<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a>&#46; Tambi&#233;n el ictus mostr&#243; prevalencias similares a otros estudios previos tanto en poblaci&#243;n general como en sujetos con HTA<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;32</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">En cuanto a la prescripci&#243;n farmacol&#243;gica&#44; observamos una relativamente baja prescripci&#243;n de f&#225;rmacos con evidencia probada en prevenci&#243;n secundaria &#40;antiagregantes&#44; hipolipemiantes e inhibidores del sistema renina angiotensina aldosterona&#41;&#44; con diferencias de g&#233;nero considerables&#46; Se prescriben m&#225;s estatinas&#44; betabloqueantes&#44; inhibidores del sistema renina angiotensina aldosterona y antiagregantes en los hombres&#44; mientras que las mujeres reciben m&#225;s diur&#233;ticos&#44; antagonistas de los receptores de la angiotensina y anticoagulantes orales&#46; Destaca la mayor prescripci&#243;n de antagonistas de los receptores de la angiotensina solos o en combinaci&#243;n en mujeres&#44; lo cual pudiera deberse a la mayor prevalencia de tos que presentan las mujeres con inhibidores del sistema renina angiotensina aldosterona<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>&#46; Estos resultados son similares a los del suban&#225;lisis del estudio PRESENAP que analiza las diferencias de g&#233;nero de estas terapias en pacientes con cardiopat&#237;a isqu&#233;mica<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">El control de la PA result&#243; similar al hallado en estudios previos de prevenci&#243;n secundaria<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a>&#44; pero superior al comunicado en sujetos con HTA esencial &#40;41&#44;4&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#46; Es posible que el porcentaje de control de la PA sea incluso algo mejor&#59; al analizar tan solo las cifras de PA en consulta es posible que hayamos infraestimando el nivel de control de la PA por el efecto de bata blanca que tiende a elevar las cifras de PA en consulta<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a>&#46; Las cifras del control de l&#237;pidos &#40;36&#37;&#41; son algo superiores a las comunicadas en estudios de prevenci&#243;n secundaria en nuestro entorno &#40;26&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> y tambi&#233;n resultaron significativamente mayores en varones<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Como todos los estudios transversales y de registros&#44; el presente trabajo tiene las limitaciones propias de los mismos&#58; imposibilidad de establecer relaciones de causalidad&#46; Otros estudios han utilizado muestras de m&#233;dicos o de pacientes que acuden a consulta aleatoriamente&#46; Nosotros hemos analizado a toda la poblaci&#243;n&#44; lo que refleja mejor la realidad de la pr&#225;ctica cl&#237;nica en un &#225;rea de salud concreta&#46; Hemos incluido solamente a pacientes en tratamiento farmacol&#243;gico&#44; que no representa a toda la poblaci&#243;n hipertensa&#44; porque es previsible que este grupo tendr&#237;a una mayor calidad de registros&#46; Con respecto a la codificaci&#243;n diagn&#243;stica &#233;sta se realiza de acuerdo a una clasificaci&#243;n internacionalmente aceptada y los diagn&#243;sticos estaban habitualmente documentados por informes de ingresos hospitalarios o pruebas complementarias&#44; pero puede haberse incurrido en alg&#250;n sesgo al analizar pacientes que no han precisado ingresos&#46; Este hecho ha podido afectar especialmente a las caracter&#237;sticas de la insuficiencia renal&#44; enfermedad arterial perif&#233;rica y a la ICC en sus formas menos sintom&#225;ticas&#46; Ser&#237;a deseable que de forma institucional se promoviera la homogeneizaci&#243;n de registros inform&#225;ticos para realizar an&#225;lisis como el aqu&#237; recogido y que permitiera comparar y monitorizar resultados en el tiempo de forma global&#44; obviando as&#237; los estudios por muestreo&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; el presente estudio muestra una fotograf&#237;a exhaustiva y bastante n&#237;tida de la ECV en los pacientes con HTA atendidos en el &#225;mbito de la Atenci&#243;n Primaria&#46; La ECV afecta a los hombres a una edad m&#225;s temprana y presenta m&#225;s carga de morbilidad y factores de riesgo&#44; y los objetivos terape&#250;ticos obtenidos distan mucho de alcanzar los est&#225;ndares deseables<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">38&#8211;40</span></a><span class="elsevierStyleSup">&#46;</span> Estudios posteriores por subgrupos de las afecciones analizadas pueden ayudarnos a identificar factores asociados a la ECV susceptible de tratamiento y consecuci&#243;n de objetivos terap&#233;uticos en la pr&#225;ctica cl&#237;nica&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p id="par0110" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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            1 => "Enfermedad cardiovascular"
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            0 => "Arterial hypertension"
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            2 => "Prevalence"
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar las caracter&#237;sticas de la enfermedad cardiovascular &#40;ECV&#41;&#44; el tratamiento y cumplimiento de los objetivos terap&#233;uticos para la presi&#243;n arterial y l&#237;pidos en pacientes hipertensos atendidos en Atenci&#243;n Primaria&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de todas las historias cl&#237;nicas de pacientes hipertensos&#44; a partir de las cuales se seleccionaron los enfermos en tratamiento farmacol&#243;gico que consultaron en los 25 centros de Salud del &#193;rea 6 de Madrid&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 92&#46;079 historias&#44; 19&#46;501 enfermos &#40;21&#44;2&#37;&#41; con hipertensi&#243;n arterial &#40;HTA&#41; ten&#237;an un diagn&#243;stico previo de ECV &#40;23&#44;9&#37; eran varones y el 19&#44;1&#37; mujeres&#41;&#46; En estos hipertensos con ECV los diagn&#243;sticos m&#225;s frecuentes y su proporci&#243;n en hombres y mujeres fueron&#58; cardiopat&#237;a isqu&#233;mica&#44; 35&#44;6&#37; &#40;43&#44;7&#47;27&#44;6&#37;&#41;&#59; fibrilaci&#243;n auricular&#44; 29&#44;5&#37; &#40;25&#47;33&#44;9&#37;&#41;&#59; ictus&#44; 24&#37; &#40;22&#47;26&#44;7&#37;&#41;&#59; insuficiencia renal&#44; 15&#44;7&#37; &#40;18&#44;2&#47;13&#44;2&#37;&#41;&#59; insuficiencia card&#237;aca&#44; 15&#44;3&#37; &#40;10&#44;4&#47;20&#44;2&#37;&#41;&#59; y enfermedad arterial perif&#233;rica&#44; 7&#44;5&#37; &#40;8&#44;7&#47;6&#44;4&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; En los hombres la prescripci&#243;n de f&#225;rmacos antihipertensivos&#44; hipolipemiantes y antiagregantes fue mayor que en las mujeres&#44; y en &#233;stas predomin&#243; la prescripci&#243;n de diur&#233;ticos&#44; antagonistas de los receptores de la angiotensina y anticoagulantes &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El porcentaje de hombres y mujeres con presi&#243;n arterial<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg fue del 60&#44;5 y del 59&#44;1&#37;&#44; y de LDL-colesterol &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; 40&#44;4 y 31&#37;&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En los casi 20&#46;000 hipertensos analizados por enfermedad cardiovascular&#44; se observan diferencias apreciables de g&#233;nero en la prevalencia&#44; tratamiento y consecuci&#243;n de objetivos terap&#233;uticos en los diversas enfermedades cardiovasculares&#46; Estos resultados sugieren la conveniencia de homogeneizar los registros inform&#225;ticos&#44; como el presente&#44; para seguir los resultados en el tiempo&#44; sin necesidad de realizar estudios por muestras&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To examine the type of cardiovascular disease &#40;CVD&#41; and treatment and achievement of treatment goals in blood pressure and lipids in hypertensive patients in primary care&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A cross-sectional study of all medical records of hypertensive patients&#44; from which patients with antihypertensive treatment who visited the 25 Primary Health Care Centers of the 6<span class="elsevierStyleSup">th</span> sanitary district of Madrid during 2008 were selected&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">From a total of&#160;92&#44;079 patients&#44; 19&#44;501 &#40;21 2&#37;&#41; with an arterial hypertension had a previous diagnosis of CVD &#40;23&#46;9&#37; in males and 19&#46;1&#37; in females&#41;&#46; In hypertensive with CVD&#44; the most frequent diagnosis and their proportion in males and females were&#58; ischemic heart disease 35&#46;6&#37; &#40;43&#46;7&#37;&#47;27&#46;6&#37;&#41;&#44; atrial fibrillation 29&#46;5&#37; &#40;25&#37;&#47;33&#46;9&#37;&#41;&#44; stroke 24&#37; &#40;22&#37;&#47;26&#46;7&#37;&#41;&#44; chronic renal disease 15&#46;7&#37; &#40;18&#46;2&#37;&#47;13&#46;2&#37;&#41;&#44; heart failure 15&#46;3&#37; &#40;10&#46;4&#37;&#47;20&#46;2&#37;&#41; and peripheral artery disease 7&#46;5&#37; &#40;8&#46;7&#37;&#47;6&#46;4&#37;&#41; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; Antihypertensive drugs&#44; lipid-lowering drugs and antiplatelet therapy were used more often by males&#44; with women predominating in the prescription of diuretics and angiotensin receptor blockers and anticoagulants&#44; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;The proportion of patients with blood pressure<span class="elsevierStyleHsp" style=""></span>&#60;140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg was 60&#46;5&#37; and 59&#46;1&#37;&#44; and that of LDL-cholesterol &#60;100<span class="elsevierStyleHsp" style=""></span>mg&#47; dl was 40&#46;4&#37; y 31&#37; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;005&#41;&#44; in males and females&#44; respectively&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In almost all the 20&#44;000 patients with CVD studied&#44; substantial gender differences in the prevalence&#44; therapy and achievements of goals in the different types of CVD were observed&#46; These results suggest the convenience of homogenization of the computerized registries at the present&#44; for monitoring results over time&#44; with no need of continuous sampling-based studies&#46;</p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;6 &#40;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;1 &#40;33&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;2 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207&#44;6 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">211&#44;4 &#40;48&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;52&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL-colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;4 &#40;37&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&#44;2 &#40;82&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129 &#40;72&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL-colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;6 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;3 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;6 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triglic&#233;ridos &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130 &#40;80&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&#44;3 &#40;82&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129 &#40;72&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinina &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;91 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;86 &#40;0&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;07 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FGe &#40;&#60; 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73&#41; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAS&#47;PAD &#60; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL &#60; 100 mg&#47;dl &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diur&#233;ticos &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Betabloqueantes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antagonistas del calcio &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inhibidores SRAA &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipolipemiantes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antiagregantes&#47;anticoagulantes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;6&nbsp;\t\t\t\t\t\t\n
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                  """
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; FGe&#58; filtraci&#243;n glomerular estimada&#59; HDL-colesterol&#58; colesterol ligado a lipoprote&#237;nas de alta densidad&#59; LDL-colesterol&#58; colesterol ligado a lipoprote&#237;nas de baja densidad&#59; PA&#58; presi&#243;n arterial&#59; PAD&#58; presi&#243;n arterial diast&#243;lica&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presi&#243;n del pulso &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">58&#44;1 &#40;24&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  """
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          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n por g&#233;nero de las diferentes enfermedades cardiovasculares en los pacientes con hipertensi&#243;n arterial</p>"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">C&#46; isqu&#233;mica&#58; cardiopat&#237;a isqu&#233;mica&#59; F&#46; auricular&#58; fibrilaci&#243;n auricular&#59; I &#46;card&#237;aca&#58; insuficiencia card&#237;aca&#59; I&#46; renal&#58; insuficiencia renal&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeresn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#46;063&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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Original
Enfermedad cardiovascular en pacientes con hipertensión arterial: diferencias por género a partir de 100.000 historias clínicas
Cardiovascular disease in hypertension: gender differences in 100,000 clinical records
T. Gijón-Condea,b,
Autor para correspondencia
gijonmt@gmail.com
teresa.gijon@uam.es

Autor para correspondencia.
, J.R. Banegasb
a Centro de Salud Universitario Cerro del Aire, Majadahonda, Madrid, España
b Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid/IdiPAZ, CIBER de Epidemiología y Salud Pública, CIBERESP, Madrid, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="par0020" class="elsevierStylePara elsevierViewall">Las enfermedades cardiovasculares &#40;ECV&#41; son la principal causa de mortalidad en el mundo occidental<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; En Espa&#241;a&#44; la mortalidad por ECV representa el 28&#37; del total de defunciones en varones &#40;segunda causa de mortalidad&#41; y el 36&#37; en mujeres &#40;primera causa de mortalidad&#41;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; La prevalencia de ECV aumenta con la edad<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; y el aumento de la esperanza de vida incrementar&#225; esta proporci&#243;n&#46; En los &#250;ltimos a&#241;os se han promovido campa&#241;as y registros espec&#237;ficos para evaluar las diferencias por g&#233;nero en la frecuencia de ECV&#46; La mujer tiene un perfil de riesgo m&#225;s desfavorable que el var&#243;n&#44; con un uso sub&#243;ptimo de tratamientos farmacol&#243;gicos&#44; pruebas diagn&#243;sticas o medidas intervencionistas<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Las gu&#237;as cl&#237;nicas enfatizan medidas de prevenci&#243;n en el paciente con ECV<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a>&#46; Estos estudios se han efectuado mayoritariamente en la poblaci&#243;n masculina&#44; existiendo pocos ensayos que permitan extrapolar los resultados de forma inequ&#237;voca a la poblaci&#243;n femenina<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;10</span></a>&#46; Existen registros nacionales e internacionales sobre el tratamiento y control de los hipertensos con y sin ECV&#44; que incluyen datos para varones y mujeres<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;14</span></a>&#46; Algunos estudios que utilizan muestreo tienen como objetivo estudiar las diferencias por g&#233;nero<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a>&#59; otras publicaciones aportan datos sobre la prevalencia general<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#8211;20</span></a>&#46; A diferencia de estos estudios&#44; en este trabajo hemos examinado todos los pacientes hipertensos con y sin enfermedad cardiovascular para valorar la ECV que presentan&#44; el tratamiento y el cumplimiento de objetivos terap&#233;uticos en varones y mujeres atendidos en Atenci&#243;n Primaria&#46; La informaci&#243;n obtenida puede ayudar a establecer diferentes estrategias que mejoren el perfil cardiovascular en los hombres y en las mujeres&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metodolog&#237;a</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Fuente de datos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se dise&#241;&#243; un estudio transversal a partir de registros informatizados de pacientes hipertensos de ambos sexos&#44; adscritos al &#193;rea Sanitaria 6 de Madrid&#46; Esta &#225;rea tiene una poblaci&#243;n de 661&#46;611 habitantes&#44; de nivel sociocultural medio-alto&#44; &#225;mbito residencial y poblaci&#243;n urbana &#40;el 17&#44;8&#37; de la poblaci&#243;n fue atendida por 7 equipos&#41;&#44; semiurbana &#40;el 46&#44;2&#37; de la poblaci&#243;n fue atendida por 9 equipos&#41; y rural &#40;el 36&#37; del total fue atendida por 9 equipos&#41;&#44; con el 15&#37; de los pacientes mayores de 65 a&#241;os&#46; Los 25 equipos de Atenci&#243;n Primaria de esta &#225;rea son atendidos por 308 m&#233;dicos&#46; Se incluyeron pacientes diagnosticados de hipertensi&#243;n arterial &#40;HTA&#41; en tratamiento farmacol&#243;gico y que hubieran acudido a sus centros de salud en el a&#241;o 2008&#44; para revisi&#243;n y solicitar prescripciones de f&#225;rmacos antihipertensivos&#46; Se consider&#243; ECV la presencia en la historia cl&#237;nica de los diagn&#243;sticos basados en la clasificaci&#243;n internacional en Atenci&#243;n Primaria versi&#243;n 2 &#40;CIAP-2&#44; aparato circulatorio&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> y que habitualmente proceden de informes de alta procedentes de atenci&#243;n hospitalaria&#58; cardiopat&#237;a isqu&#233;mica &#40;CI&#41; &#40;K74&#44; K76&#41;&#59; insuficiencia card&#237;aca &#40;IC&#41; &#40;K77&#41;&#59; enfermedad arterial perif&#233;rica &#40;EAP&#41; &#40;K99&#41;&#59; insuficiencia renal cr&#243;nica &#40;IRC&#41; &#40;U99&#41;&#59; ictus &#40;K89&#44; K90&#41; y fibrilaci&#243;n auricular &#40;FA&#41; &#40;K78&#41;&#46; Se consider&#243; que un paciente ten&#237;a HTA &#40;K85&#44; K86&#44; K87&#41; cuando constaba este diagn&#243;stico previo en la historia cl&#237;nica&#44; o bien figuraban tres tomas de presi&#243;n arterial &#40;PA&#41; en consulta &#8805; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg en tres d&#237;as diferentes&#44; en un per&#237;odo de tres meses&#44; o una PA aislada &#8805; 180&#47;110<span class="elsevierStyleHsp" style=""></span>mmHg&#46; La PA se determin&#243; en condiciones habituales de pr&#225;ctica cl&#237;nica&#44; con esfigmoman&#243;metros mayoritariamente aneroides que se calibraron de forma peri&#243;dica seg&#250;n protocolo habitual y periodicidad anual&#46; Se consider&#243; que la PA estaba controlada si la media de las dos &#250;ltimas cifras eran &#60; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;22</span></a>&#46; Se consider&#243; que los l&#237;pidos estaban controlados en el contexto de alguna enfermedad cardiovascular cuando la cifra de LDL &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Variables estudiadas</span><p id="par0035" class="elsevierStylePara elsevierViewall">Las variables analizadas fueron obtenidas del programa inform&#225;tico OMI-AP &#40;OMI-Atenci&#243;n Primaria&#41;&#44; que es el mayoritariamente usado en Atenci&#243;n Primaria de las diferentes comunidades aut&#243;nomas de Espa&#241;a&#46; Se seleccionaron las variables&#58; edad&#44; sexo&#44; h&#225;bito tab&#225;quico&#44; cifras de presi&#243;n arterial sist&#243;lica y diast&#243;lica &#40;mmHg&#41;&#44; peso &#40;kg&#41;&#44; talla &#40;cm&#41;&#44; &#237;ndice de masa corporal &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; glucosa basal &#40;mg&#47;dL&#41;&#44; colesterol total &#40;mg&#47;dL&#41;&#44; LDL-colesterol &#40;mg&#47;dL&#41;&#44; HDL-colesterol &#40;mg&#47;dL&#41;&#44; triglic&#233;ridos &#40;mg&#47;dL&#41; y creatinina &#40;mg&#47;dL&#41;&#46; Se calcul&#243; el filtrado glomerular estimado &#40;ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#41; con la f&#243;rmula MDRD<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#46; Las variables anal&#237;ticas de laboratorio se obtuvieron mayoritariamente en los centros de salud en condiciones basales tras ayuno nocturno de 8 horas y fueron remitidas a los dos laboratorios de referencia del &#225;rea&#46; La morbilidad analizada se bas&#243; en la presencia de diagn&#243;sticos previos en la historia cl&#237;nica seg&#250;n c&#243;digos CIAP-2 para diabetes &#40;T90&#41; que considera los criterios de glucosa al azar &#62; 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL con s&#237;ntomas cl&#225;sicos de diabetes&#44; dos o m&#225;s glucemias al azar &#62; 126<span class="elsevierStyleHsp" style=""></span>mg&#47;dL y dos o m&#225;s glucemias &#62; 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL a las dos horas de la sobrecarga oral con 75 g de glucosa&#59; hiperlipemia &#40;T93&#41;&#58; colesterol total en dos determinaciones &#62; 250<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o &#62; 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL si hay diabetes&#44; enfermedad cardiovascular o riesgo cardiovascular elevado &#40;score &#62; 5&#41;&#59; obesidad &#40;T82&#41;&#58; &#237;ndice de masa corporal es &#62; 30 kg&#47;m<span class="elsevierStyleSup">2</span>&#59; y tabaquismo &#40;P22&#41;&#58; consumo de cualquier cantidad de tabaco&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">El an&#225;lisis de prescripci&#243;n farmacol&#243;gica se hizo seg&#250;n clasificaci&#243;n por grupos terap&#233;uticos utilizados en OMI-AP&#44; que incorpora la clasificaci&#243;n anat&#243;mica&#44; terap&#233;utica y qu&#237;mica &#40;ATC&#41;&#44; que es el sistema europeo de codificaci&#243;n de sustancias farmac&#233;uticas y medicamentos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&#46; Se analizaron los grupos de antihipertensivos &#40;C02&#41;&#44; diur&#233;ticos &#40;C03&#41;&#44; betabloqueantes &#40;C07&#41;&#44; antagonistas del calcio &#40;C08&#41;&#44; inhibidores de la enzima convertidora de la angiotensina &#40;IECAS&#41; &#40;C09&#41; y antagonistas de los receptores de angiotensina &#40;ARA II&#41;&#44; bien solos o en combinaci&#243;n&#44; f&#225;rmacos hipolipemiantes &#40;C10&#41;&#44; anticoagulantes y antiagregantes &#40;B01&#41; e hipoglucemiantes &#40;A10&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis de datos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Se revisaron los datos y se comprobaron las distribuciones de frecuencia y posibles errores de codificaci&#243;n&#46; Se comprob&#243; la normalidad de las variables con la prueba de Kolmogorov-Smirnov&#44; y se usaron estad&#237;sticos b&#225;sicos de centralizaci&#243;n&#44; media aritm&#233;tica y desviaci&#243;n est&#225;ndar &#40;DE&#41; en las variables continuas y distribuci&#243;n de frecuencias relativas &#40;prevalencia&#41; en las variables categ&#243;ricas&#44; con sus intervalos de confianza al 95&#37; &#40;IC 95&#37;&#41;&#46; Para las comparaciones de medias se us&#243; la prueba de la <span class="elsevierStyleItalic">t</span> de Student-Fisher en caso de variables independientes binarias y para comparaciones de proporciones se us&#243; la prueba de la Chi-cuadrado&#46; Se consider&#243; significaci&#243;n estad&#237;stica&#44; los valores de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Para todos los an&#225;lisis se utiliz&#243; el programa estad&#237;stico SPSS 15&#46;0&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">De un total de 96&#46;528&#44; se incluyeron 92&#46;079 historias&#46; El nivel de registro&#44; seg&#250;n las diferentes variables y grupos analizados&#44; oscil&#243; entre el 95&#37; para la variable tabaco&#44; y el 75&#37; para las variables PA&#44; peso y talla&#44; y del 60&#37; para las variables de laboratorio&#46; Se desestim&#243; el an&#225;lisis de la microalbuminuria por no existir un nivel adecuado de registro&#46; De las 92&#46;079 historias con HTA&#44; 19&#46;501 ten&#237;an un diagn&#243;stico previo de ECV &#40;21&#44;2&#37;&#59; el 23&#44;9&#37; en varones y el 19&#44;1&#37; en mujeres&#41; y 72&#46;578 padec&#237;an HTA&#44; pero no ten&#237;an un diagn&#243;stico previo de ECV &#40;78&#44;8&#37;&#41;&#46; Las caracter&#237;sticas generales y el an&#225;lisis comparativo de los pacientes con y sin ECV se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; La distribuci&#243;n de factores de riesgo y morbilidad asociada fue mayor en los enfermos con ECV&#44; salvo la obesidad&#44; que se distribuy&#243; igual en ambos grupos&#46; La prescripci&#243;n de f&#225;rmacos antihipertensivos&#44; hipolipemiantes y antiagregantes fue significativamente mayor en el grupo con ECV &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El control de presi&#243;n arterial y l&#237;pidos fue mejor en los pacientes con ECV &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas generales de los pacientes con ECV y el an&#225;lisis comparativo por g&#233;nero se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; Del total de 19&#46;501 pacientes con ECV&#44; el porcentaje de varones fue similar al de mujeres &#40;49&#44;7 vs 50&#44;3&#37;&#41;&#46; La edad de las mujeres fue mayor &#40;78&#44;2 vs 71 a&#241;os&#41;&#46; El filtrado glomerular fue menor en mujeres&#44; con 35&#37; de mujeres con tasas &#60; 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> frente a 25&#44;7&#37; de varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El porcentaje de pacientes con presi&#243;n arterial &#60; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg&#44; fue 59&#44;9&#37; &#40;IC 95&#37;&#58; 59&#44;2-60&#44;6&#41;&#44; siendo algo mayor en varones &#40;60&#44;5 vs 59&#44;1&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#41; y el que ten&#237;a niveles de LDL-col &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl fue del 36&#37; &#40;IC 95&#37;&#58; 35&#44;3-36&#44;7&#41;&#44; siendo significativamente mayor en varones &#40;40&#44;4 vs 31&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se recoge la distribuci&#243;n por g&#233;nero de los diferentes diagn&#243;sticos de ECV&#46; Encontramos diferencias estad&#237;sticamente significativas en la distribuci&#243;n de estas enfermedades&#44; siendo la cardiopat&#237;a isqu&#233;mica&#44; la enfermedad arterial perif&#233;rica y la insuficiencia renal cr&#243;nica m&#225;s frecuentes en los varones y la insuficiencia card&#237;aca&#44; la fibrilaci&#243;n auricular y el ictus m&#225;s frecuentes en las mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> se presentan las tasas globales y especificas por g&#233;nero y edad &#40;&#8805; 65 y<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os&#41; y sexo de los diagn&#243;sticos de las diferentes ECV en los hipertensos estudiados&#46; Todas las ECV fueron m&#225;s prevalentes en los varones de ambos grupos de edad &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Fueron especialmente apreciables las diferencias en cardiopat&#237;a isqu&#233;mica e insuficiencia renal cr&#243;nica&#44; siendo pr&#225;cticamente el doble en varones que en mujeres&#44; tanto mayores como menores de 65 a&#241;os&#46; La prevalencia de fibrilaci&#243;n auricular e ictus fue mayor en varones que en mujeres menores de 65 a&#241;os &#40;2&#44;1 vs 1&#44;4&#37; para la fibrilaci&#243;n y 2&#44;4 vs 1&#44;3&#37; para ictus&#41;&#44; acort&#225;ndose&#44; en t&#233;rminos relativos&#44; estas diferencias en el grupo mayor de 65 a&#241;os &#40;10&#44;3 vs 9&#44;4&#37; para fibrilaci&#243;n auricular y 8&#44;6 vs 7&#44;1&#37; para ictus&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Los resultados del an&#225;lisis comparativo de consumo farmacol&#243;gico por g&#233;nero se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#46; Se encontr&#243; un consumo mayor de diur&#233;ticos &#40;52 vs 35&#44;3&#37;&#41; en mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El uso de antiagregantes&#47;anticoagulantes &#40;68&#44;7 vs 63&#37;&#41;&#44; betabloqueantes &#40;40 vs 26&#37;&#41;&#44; antagonistas del calcio &#40;29 vs 26&#44;8&#37;&#41;&#44; inhibidores del sistema renina angiotensina aldosterona &#40;64 vs 61&#44;5&#37;&#41; e hipolipemiantes &#40;48 vs 36&#37;&#41; fue mayor en varones &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; De entre los pacientes que tomaban antiagregantes&#47;anticoagulantes&#44; se encontr&#243; mayor consumo de anticoagulantes orales en mujeres &#40;36 vs 29&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Este estudio realizado a partir de casi 100&#46;000 historias cl&#237;nicas de pacientes con HTA atendidos en el &#225;mbito de la Atenci&#243;n Primaria aporta un an&#225;lisis comparativo de los enfermos que padecen o no alguna ECV &#40;prevenci&#243;n primaria y secundaria&#41; y un an&#225;lisis de diferencias por g&#233;nero en los pacientes con eventos&#46; En general&#44; los enfermos con ECV presentan una mayor edad&#44; morbilidad y tratamiento farmacol&#243;gico y mejor control de presi&#243;n arterial y l&#237;pidos en el grupo con ECV&#46; Entre los pacientes con ECV encontramos diferencias de g&#233;nero&#44; tanto cualitativas como cuantitativas&#44; con respecto a la prevalencia de las ECV&#44; prescripci&#243;n farmacol&#243;gica y objetivos terap&#233;uticos alcanzados&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Al analizar las ECV observamos que la prevalencia de IC fue del 3&#44;3&#37;&#44; claramente inferior a la de estudios previos en Espa&#241;a &#40;alrededor del 19&#37; en el estudio HICAP en poblaci&#243;n hipertensa&#41;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Esta diferencia sugiere un infradiagn&#243;stico importante&#44; tal vez porque en Atenci&#243;n Primaria no se emplean de forma sistem&#225;tica los criterios de Framingham<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>&#46; De igual forma&#44; en la EAP encontramos prevalencias muy inferiores a las reportadas por otros estudios<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> y a&#250;n menores si las comparamos con prevalencias de EAP asintom&#225;tica del estudio MERITO II &#40;30 al 50&#37; en pacientes con ECV&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#46; Este hecho sugiere&#44; que en la pr&#225;ctica cl&#237;nica solo se est&#225;n identificando a los pacientes m&#225;s graves que requieren tratamientos m&#225;s agresivos u hospitalizaciones&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En cuanto a la cardiopat&#237;a isqu&#233;mica&#44; encontramos una prevalencia del 7&#44;5&#37;&#44; concordante con estudios previos&#44; tanto en poblaci&#243;n general como hipertensa<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;29</span></a>&#46; La prevalencia de FA ofreci&#243; datos similares a otros estudios como el PREVICTUS&#44; &#40;8&#44;5&#37; en poblaci&#243;n &#62; 60 a&#241;os&#44; de base poblacional&#41; o como los estudios analizados por P&#233;rez-Villacast&#237;n que reportan prevalencias entre el 2&#44;5 y el 17&#44;6&#37; seg&#250;n el entorno analizado<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a>&#46; Tambi&#233;n el ictus mostr&#243; prevalencias similares a otros estudios previos tanto en poblaci&#243;n general como en sujetos con HTA<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;32</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">En cuanto a la prescripci&#243;n farmacol&#243;gica&#44; observamos una relativamente baja prescripci&#243;n de f&#225;rmacos con evidencia probada en prevenci&#243;n secundaria &#40;antiagregantes&#44; hipolipemiantes e inhibidores del sistema renina angiotensina aldosterona&#41;&#44; con diferencias de g&#233;nero considerables&#46; Se prescriben m&#225;s estatinas&#44; betabloqueantes&#44; inhibidores del sistema renina angiotensina aldosterona y antiagregantes en los hombres&#44; mientras que las mujeres reciben m&#225;s diur&#233;ticos&#44; antagonistas de los receptores de la angiotensina y anticoagulantes orales&#46; Destaca la mayor prescripci&#243;n de antagonistas de los receptores de la angiotensina solos o en combinaci&#243;n en mujeres&#44; lo cual pudiera deberse a la mayor prevalencia de tos que presentan las mujeres con inhibidores del sistema renina angiotensina aldosterona<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>&#46; Estos resultados son similares a los del suban&#225;lisis del estudio PRESENAP que analiza las diferencias de g&#233;nero de estas terapias en pacientes con cardiopat&#237;a isqu&#233;mica<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">El control de la PA result&#243; similar al hallado en estudios previos de prevenci&#243;n secundaria<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a>&#44; pero superior al comunicado en sujetos con HTA esencial &#40;41&#44;4&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#46; Es posible que el porcentaje de control de la PA sea incluso algo mejor&#59; al analizar tan solo las cifras de PA en consulta es posible que hayamos infraestimando el nivel de control de la PA por el efecto de bata blanca que tiende a elevar las cifras de PA en consulta<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a>&#46; Las cifras del control de l&#237;pidos &#40;36&#37;&#41; son algo superiores a las comunicadas en estudios de prevenci&#243;n secundaria en nuestro entorno &#40;26&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> y tambi&#233;n resultaron significativamente mayores en varones<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Como todos los estudios transversales y de registros&#44; el presente trabajo tiene las limitaciones propias de los mismos&#58; imposibilidad de establecer relaciones de causalidad&#46; Otros estudios han utilizado muestras de m&#233;dicos o de pacientes que acuden a consulta aleatoriamente&#46; Nosotros hemos analizado a toda la poblaci&#243;n&#44; lo que refleja mejor la realidad de la pr&#225;ctica cl&#237;nica en un &#225;rea de salud concreta&#46; Hemos incluido solamente a pacientes en tratamiento farmacol&#243;gico&#44; que no representa a toda la poblaci&#243;n hipertensa&#44; porque es previsible que este grupo tendr&#237;a una mayor calidad de registros&#46; Con respecto a la codificaci&#243;n diagn&#243;stica &#233;sta se realiza de acuerdo a una clasificaci&#243;n internacionalmente aceptada y los diagn&#243;sticos estaban habitualmente documentados por informes de ingresos hospitalarios o pruebas complementarias&#44; pero puede haberse incurrido en alg&#250;n sesgo al analizar pacientes que no han precisado ingresos&#46; Este hecho ha podido afectar especialmente a las caracter&#237;sticas de la insuficiencia renal&#44; enfermedad arterial perif&#233;rica y a la ICC en sus formas menos sintom&#225;ticas&#46; Ser&#237;a deseable que de forma institucional se promoviera la homogeneizaci&#243;n de registros inform&#225;ticos para realizar an&#225;lisis como el aqu&#237; recogido y que permitiera comparar y monitorizar resultados en el tiempo de forma global&#44; obviando as&#237; los estudios por muestreo&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; el presente estudio muestra una fotograf&#237;a exhaustiva y bastante n&#237;tida de la ECV en los pacientes con HTA atendidos en el &#225;mbito de la Atenci&#243;n Primaria&#46; La ECV afecta a los hombres a una edad m&#225;s temprana y presenta m&#225;s carga de morbilidad y factores de riesgo&#44; y los objetivos terape&#250;ticos obtenidos distan mucho de alcanzar los est&#225;ndares deseables<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">38&#8211;40</span></a><span class="elsevierStyleSup">&#46;</span> Estudios posteriores por subgrupos de las afecciones analizadas pueden ayudarnos a identificar factores asociados a la ECV susceptible de tratamiento y consecuci&#243;n de objetivos terap&#233;uticos en la pr&#225;ctica cl&#237;nica&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p id="par0110" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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            1 => "Enfermedad cardiovascular"
            2 => "Prevalencia"
            3 => "Tratamiento"
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            0 => "Arterial hypertension"
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            2 => "Prevalence"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar las caracter&#237;sticas de la enfermedad cardiovascular &#40;ECV&#41;&#44; el tratamiento y cumplimiento de los objetivos terap&#233;uticos para la presi&#243;n arterial y l&#237;pidos en pacientes hipertensos atendidos en Atenci&#243;n Primaria&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de todas las historias cl&#237;nicas de pacientes hipertensos&#44; a partir de las cuales se seleccionaron los enfermos en tratamiento farmacol&#243;gico que consultaron en los 25 centros de Salud del &#193;rea 6 de Madrid&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 92&#46;079 historias&#44; 19&#46;501 enfermos &#40;21&#44;2&#37;&#41; con hipertensi&#243;n arterial &#40;HTA&#41; ten&#237;an un diagn&#243;stico previo de ECV &#40;23&#44;9&#37; eran varones y el 19&#44;1&#37; mujeres&#41;&#46; En estos hipertensos con ECV los diagn&#243;sticos m&#225;s frecuentes y su proporci&#243;n en hombres y mujeres fueron&#58; cardiopat&#237;a isqu&#233;mica&#44; 35&#44;6&#37; &#40;43&#44;7&#47;27&#44;6&#37;&#41;&#59; fibrilaci&#243;n auricular&#44; 29&#44;5&#37; &#40;25&#47;33&#44;9&#37;&#41;&#59; ictus&#44; 24&#37; &#40;22&#47;26&#44;7&#37;&#41;&#59; insuficiencia renal&#44; 15&#44;7&#37; &#40;18&#44;2&#47;13&#44;2&#37;&#41;&#59; insuficiencia card&#237;aca&#44; 15&#44;3&#37; &#40;10&#44;4&#47;20&#44;2&#37;&#41;&#59; y enfermedad arterial perif&#233;rica&#44; 7&#44;5&#37; &#40;8&#44;7&#47;6&#44;4&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; En los hombres la prescripci&#243;n de f&#225;rmacos antihipertensivos&#44; hipolipemiantes y antiagregantes fue mayor que en las mujeres&#44; y en &#233;stas predomin&#243; la prescripci&#243;n de diur&#233;ticos&#44; antagonistas de los receptores de la angiotensina y anticoagulantes &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El porcentaje de hombres y mujeres con presi&#243;n arterial<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg fue del 60&#44;5 y del 59&#44;1&#37;&#44; y de LDL-colesterol &#60; 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; 40&#44;4 y 31&#37;&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En los casi 20&#46;000 hipertensos analizados por enfermedad cardiovascular&#44; se observan diferencias apreciables de g&#233;nero en la prevalencia&#44; tratamiento y consecuci&#243;n de objetivos terap&#233;uticos en los diversas enfermedades cardiovasculares&#46; Estos resultados sugieren la conveniencia de homogeneizar los registros inform&#225;ticos&#44; como el presente&#44; para seguir los resultados en el tiempo&#44; sin necesidad de realizar estudios por muestras&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To examine the type of cardiovascular disease &#40;CVD&#41; and treatment and achievement of treatment goals in blood pressure and lipids in hypertensive patients in primary care&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A cross-sectional study of all medical records of hypertensive patients&#44; from which patients with antihypertensive treatment who visited the 25 Primary Health Care Centers of the 6<span class="elsevierStyleSup">th</span> sanitary district of Madrid during 2008 were selected&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">From a total of&#160;92&#44;079 patients&#44; 19&#44;501 &#40;21 2&#37;&#41; with an arterial hypertension had a previous diagnosis of CVD &#40;23&#46;9&#37; in males and 19&#46;1&#37; in females&#41;&#46; In hypertensive with CVD&#44; the most frequent diagnosis and their proportion in males and females were&#58; ischemic heart disease 35&#46;6&#37; &#40;43&#46;7&#37;&#47;27&#46;6&#37;&#41;&#44; atrial fibrillation 29&#46;5&#37; &#40;25&#37;&#47;33&#46;9&#37;&#41;&#44; stroke 24&#37; &#40;22&#37;&#47;26&#46;7&#37;&#41;&#44; chronic renal disease 15&#46;7&#37; &#40;18&#46;2&#37;&#47;13&#46;2&#37;&#41;&#44; heart failure 15&#46;3&#37; &#40;10&#46;4&#37;&#47;20&#46;2&#37;&#41; and peripheral artery disease 7&#46;5&#37; &#40;8&#46;7&#37;&#47;6&#46;4&#37;&#41; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; Antihypertensive drugs&#44; lipid-lowering drugs and antiplatelet therapy were used more often by males&#44; with women predominating in the prescription of diuretics and angiotensin receptor blockers and anticoagulants&#44; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;The proportion of patients with blood pressure<span class="elsevierStyleHsp" style=""></span>&#60;140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg was 60&#46;5&#37; and 59&#46;1&#37;&#44; and that of LDL-cholesterol &#60;100<span class="elsevierStyleHsp" style=""></span>mg&#47; dl was 40&#46;4&#37; y 31&#37; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;005&#41;&#44; in males and females&#44; respectively&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In almost all the 20&#44;000 patients with CVD studied&#44; substantial gender differences in the prevalence&#44; therapy and achievements of goals in the different types of CVD were observed&#46; These results suggest the convenience of homogenization of the computerized registries at the present&#44; for monitoring results over time&#44; with no need of continuous sampling-based studies&#46;</p>"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; ECV&#58; enfermedad cardiovascular&#59; FGe&#58; filtraci&#243;n glomerular estimada&#59; HDL-colesterol&#58; colesterol ligado a lipoprote&#237;nas de baja densidad&#59; IMC&#58; &#237;ndice de masa corporal&#59; LDL-colesterol&#58; colesterol ligado a lipoprote&#237;nas de alta densidad&#59; NS&#58; no significativo&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#59; PAD&#58; presi&#243;n arterial diast&#243;lica&#59; SRAA&#58; sistema renina angiotensina aldosterona&#46;</p>"
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                  \t\t\t\t">42&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mujeres &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hiperlipemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obesidad &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabaquismo &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IMC &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;4 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;8 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;3 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;035&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAS &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&#44;8 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&#44;2 &#40;34&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132&#44;2 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAD &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#44;3 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;2 &#40;20&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presi&#243;n del pulso &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;6 &#40;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;1 &#40;33&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;2 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207&#44;6 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">211&#44;4 &#40;48&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;52&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL-colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;4 &#40;37&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&#44;2 &#40;82&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129 &#40;72&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL-colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;6 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;3 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;6 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triglic&#233;ridos &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130 &#40;80&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&#44;3 &#40;82&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129 &#40;72&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinina &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;91 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;86 &#40;0&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">FGe &#40;&#60; 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73&#41; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hiperlipemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obesidad &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabaquismo &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAS &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132&#44;2 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#44;6 &#40;25&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132&#44;8 &#40;26&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAD &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44; 8 &#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;4 &#40;17&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#44;6 &#40;17&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presi&#243;n del pulso &#40;mmHg&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;2 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;2 &#40;27&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#44;1 &#40;24&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;52&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&#44;7 &#40;60&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">202&#44;8 &#40;62&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL-colesterol &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114&#44;8 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&#44;2 &#40;34&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&#44;1 &#40;36&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL-colesterol&#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;6 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;8 &#40;13&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;6 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triglic&#233;ridos &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129 &#40;72&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#44;8 &#40;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&#44;1 &#40;64&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinina &#40;mg&#47;dl&#41; &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;07 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;2 &#40;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;96 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FG &#40;&#60; 60 ml&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#41; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PA &#40;&#60; 140&#47;90 mmHg&#41; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prevalencian<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>51&#46;044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#8805; 65 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Varonesn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&#46;725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeresn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;310&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Varonesn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#46;981&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeresn<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#46;063&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#46; isqu&#233;mica &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&#46; card&#237;aca &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#46; auricular &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">10&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ictus &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">8&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">7&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&#46; renal &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arteriopat&#237;a &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">&#191;Qu&#233; sab&#237;amos antes de realizar este estudio&#63;</span><p id="par0010" class="elsevierStylePara elsevierViewall">La prevalencia de diferentes condiciones englobadas como &#171;enfermedad cardiovascular&#187; &#40;ECV&#41; es diferente en hombres y en mujeres&#44; pero desconocemos el alcance de estas diferencias en nuestro medio&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">&#191;Qu&#233; hemos aprendido&#63;</span><p id="par0015" class="elsevierStylePara elsevierViewall">El 21&#37; de los enfermos con hipertensi&#243;n arterial &#40;HTA&#41;&#44; del &#225;mbito de la Atenci&#243;n Primaria&#44; presentaron alguna enfermedad cardiovascular&#46; Existen diferencias significativas en cuanto a las diferentes enfermedades cardiovasculares&#44; prescripci&#243;n de f&#225;rmacos y consecuci&#243;n de objetivos de presi&#243;n arterial y l&#237;pidos en hombres y en mujeres&#46;</p></span></span>"
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ISSN: 00142565
Idioma original: Español
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