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Vol. 224. Issue 8.
Pages 510-521 (October 2024)
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Vol. 224. Issue 8.
Pages 510-521 (October 2024)
Original article
Association between serum neurofilament light chains (sNfL) and neurologic disorders in a representative sample of US adults: a cross-sectional study
Asociación entre las cadenas ligeras de neurofilamento en suero (sNfL) y los trastornos neurológicos en una muestra representativa de adultos en los Estados Unidos: un estudio transversal
Qi Xua,b,
Corresponding author
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Corresponding author.
, Jiale Wangc, Hanzhi Lia, Yuwan Gaod
a Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Nanyang Medical College, Nanyang, China
b Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China
c Department of Internal Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
d Department of Ophthalmology, The First Affiliated Hospital of Nanyang Medical College, Nanyang, China
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Tables (5)
Table 1. Demographic characteristics of NHANES 2013–2014 participants, stratified by baseline serum NfL quartiles.
Table 2. The serum NfL levels in several neurological conditions.
Table 3. Associations between PHQ-9 scores and ln serum NfL levels.
Table 4. Associations between several neurological disorders and ln serum NfL levels.
Table 5. Subgroup analysis of the association between ln serum NfL levels and depression, stroke, long-term subjective memory decline, and long sleep.
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Additional material (1)
Abstract
Background

While increased neurofilament light chain (NfL) in serum concentrations are linked to the progression of several neurological conditions, their distribution and implications within the general adult population remain largely unexplored. The current research aims to clarify the relationship between serum NfL levels and neurological disorders in a broad and representative population sample.

Methods

We utilized information gathered from 1751 adults involved in the 2013–2014 cycle of the National Health and Nutrition Examination Survey . Our analytical approach encompassed logistic regression, smoothed curve fitting, and subgroup analyses to identify potential correlations between serum NfL levels and neurological conditions, such as depression, severe hearing and visual impairments, stroke, subjective memory deficits, and sleep problems.

Results

After adjusting for all confounders, we found that higher serum NfL levels were significantly associated with increased risks of depression, stroke, subjective memory deficits, and longer sleep duration (p < 0.05). Subgroup analyses supported these findings. Additionally, BMI significantly influenced the relationship between serum NfL levels and long-term subjective memory decline.

Conclusion

Our research shows that higher serum NfL levels are strongly related to an elevated risk for several neurological disorders. These findings highlight the role of serum NfL serving as a critical marker for early detection and monitoring of neurological conditions, emphasizing its importance in both clinical and public health settings.

Keywords:
Neurological diseases
Depression
Neurofilament light chain (NfL)
Cross-Sectional study
NHANES
Resumen
Antecedentes

Mientras que el aumento de las concentraciones de la cadena ligera de neurofilamentos (NfL) en suero está relacionado con la progresión de varias afecciones neurológicas, su distribución e implicaciones dentro de la población adulta general siguen siendo en gran parte inexploradas. La presente investigación tiene como objetivo aclarar la relación entre los niveles de NfL en suero y los trastornos neurológicos en una muestra amplia y representativa de la población.

Métodos

Utilizamos información recopilada de 1751 adultos involucrados en el ciclo 2013-2014 de la Encuesta Nacional de Salud y Nutrición . Nuestro enfoque analítico incluyó regresión logística, ajuste de curvas suavizadas y análisis de subgrupos para identificar posibles correlaciones entre los niveles de NfL en suero y condiciones neurológicas, incluyendo depresión, discapacidades auditivas y visuales severas, accidente cerebrovascular, déficits de memoria subjetivos y problemas de sueño.

Resultados

Después de ajustar por todos los factores de confusión, encontramos que mayores concentraciones de NfL en suero se asociaban significativamente con un mayor riesgo de depresión, accidente cerebrovascular, déficits de memoria subjetivos y mayor duración del sueño (p < 0,05). Los análisis de subgrupos respaldaron estos hallazgos. Además, el IMC influyó significativamente en la relación entre los niveles de NfL en suero y los deterioro de la memoria subjetiva a largo plazo.

Conclusión

Nuestra investigación muestra que niveles más altos de NfL en suero están firmemente relacionados con un mayor riesgo de varios trastornos neurológicos. Estos hallazgos destacan el papel del NfL en suero como un marcador crítico para la detección temprana y el monitoreo de condiciones neurológicas, enfatizando su importancia tanto en entornos clínicos como de salud pública.

Palabras clave:
Enfermedades neurológicas
Depresión
Cadena ligera de neurofilamentos (NfL)
Estudio transversal
NHANES

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