American Journal of Obstetrics and Gynecology
ResearchBasic science: ObstetricsIncidence and risk patterns of venous thromboembolism in pregnancy and puerperium—a register-based case-control study
Section snippets
Materials and Methods
From Jan. 1, 1990-Dec. 31, 2003, women with a diagnosis of VTE in pregnancy or postpartum in 18 hospitals in 11 of 19 Norwegian counties were identified through selected ICD-9 and -10 code search in the Norwegian Patient Register (Table 1 and Figure 1). In addition, ascertainment of case identification in the Norwegian Patient Register was validated for the entire study period by data on VTE in pregnancy at 3 major Norwegian hospitals (Ullevål University Hospital, Haukeland University Hospital,
Results
We identified 615 cases with objectively confirmed VTE. Five hundred and ninety-five cases were identified in the Norwegian Patient Register, and another 20 patients were only identified in the Medical Birth Registry of Norway. The incidence of pregnancy-related VTE was 1.0 per 1000 pregnancies with no difference in antenatal and postnatal incidences (Table 2). DVT was more common antenatally than postnatally (0.43 vs 0.30 per 1000 deliveries, respectively), whereas PE displayed higher
Comment
The crude incidence rate of VTE associated with pregnancy was 1.0 per 1000 deliveries. The incidences of ante- and postnatal VTE were similar, but the risk pattern differed. Antenatal risk factors seemed to be related to the woman’s constitutional conditions such as age, parity, numbers of fetuses, and way of conception, whereas postnatal risk factors seemed to be correlated to maternal morbidity and complications during and after delivery. The postnatal risk factors such as preeclampsia,
References (21)
- et al.
Pregnancy-related mortality in the United States, 1987-1990
Obstet Gynecol
(1996) - et al.
Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality
Am J Obstet Gynecol
(2006) Thrombosis in pregnancy: maternal and fetal issues
Lancet
(1999)- et al.
Incidence, clinical characteristics, and timing of objectively diagnosed venous thromboembolism during pregnancy
Obstet Gynecol
(1999) - et al.
Thrombotic risk during pregnancy: a population study
Obstet Gynecol
(1999) - et al.
Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database
BJOG
(2001) - et al.
Epidemiological observations of thrombo-embolic disease during pregnancy and in the puerperium, in 56,022 women
Int J Gynaecol Obstet
(1983) - et al.
Risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum: a population-based, case-control study
Am J Obstet Gynecol
(2001) - et al.
ICD-9-CM codes poorly indentified venous thromboembolism during pregnancy
J Clin Epidemiol
(2004) - et al.
ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium: a population-based, nested case-control study
J Thromb Haemost
(2005)
Cited by (0)
This study was supported by grants from the Norwegian Research Council (Grant 160805-V50, fellowship to A.F.J.) and the Eastern Norway Regional Health Authority Trust, Hamar, Norway.
Cite this article as: Jacobsen AF, Skjeldestad FE, Sandset PM. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium—a register-based case-control study. Am J Obstet Gynecol 2008;198:233.e1-233.e7.