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Available online 15 October 2021
Relevance of early diagnosis in polycythemia vera and essential thrombocythemia: A single center’s experience
Importancia del diagnóstico precoz en policitemia vera y trombocitemia esencial. Experiencia de un centro
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S. Lakhwani
Corresponding author
sunillakhwani@hotmail.com

Corresponding author.
, M. Pardina-Echevarría, R. Arcas-Vega, O.R. Díaz-Sánchez, M.T. Hernández-García, J.M. Raya
Servicio de Hematología y Hemoterapia, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
Received 13 March 2021. Accepted 01 July 2021
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Table 1. Characteristics of the patients with previous thrombosis.
Abstract
Objectives

This work aims to describe the proportion of patients with polycythemia vera (PV) or essential thrombocythemia (ET) and thrombosis prior to the diagnosis who had erythrocytosis or thrombocytosis prior to the thrombosis.

Patients and methods

This is a retrospective review of 63 patients with PV and 130 with ET.

Results

In regard to PV, we found prior erythrocytosis in 7 (11.1%) of the 17 cases (27%) with thrombosis prior to diagnosis. In ET, we found prior thrombocytosis in 10 (7.7%) of the 25 cases (19.2%) with thrombosis prior to diagnosis. The median time between the laboratory finding and thrombosis was 8.2 months and 11.8 months for PV and TE, respectively. In both entities, patients with thrombosis prior to diagnosis had significantly lower survival.

Conclusion

A significant proportion of patients with thrombosis prior to the diagnosis of PV and ET present with erythrocytosis or thrombocytosis prior to the episode of thrombosis. This could allow for anticipating diagnosis and treatment.

Keywords:
Polycythemia vera
Essential thrombocythemia
Chronic myeloproliferative neoplasms
Resumen
Objetivos

Describir la proporción de pacientes con policitemia vera (PV) o trombocitemia esencial (TE) y trombosis previa al diagnóstico que presentaban eritrocitosis o trombocitosis antes de la trombosis.

Pacientes y métodos

Revisión retrospectiva de 63 pacientes con PV y 130 con TE.

Resultados

En PV, encontramos eritrocitosis previa en 7 (11,1%) de los 17 casos (27%) con trombosis previa al diagnóstico. En TE, encontramos trombocitosis previa en 10 (7,7%) de los 25 casos (19,2%) con trombosis previa al diagnóstico. La mediana de tiempo entre el hallazgo analítico y la trombosis fue 8,2 meses y 11,8 meses para PV y TE respectivamente. En ambas entidades, los pacientes con trombosis previa al diagnóstico tenían una supervivencia significativamente menor.

Conclusión

Una proporción significativa de pacientes con trombosis previa al diagnóstico de PV y TE presenta eritrocitosis o trombocitosis previa al episodio de trombosis, lo que permitiría anticipar el diagnóstico y el tratamiento.

Palabras clave:
Policitemia vera
Trombocitemia esencial
Neoplasias mieloproliferativas crónicas

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