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Available online 19 September 2021
Impact of the mutation profile on thrombotic risk in cancer patients
Impacto del perfil mutacional sobre el riesgo trombótico en pacientes con cáncer
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J.A. Páramo
Corresponding author
japaramo@unav.es

Corresponding author.
, M. Marcos-Jubilar, R. Lecumberri
Servicio de Hematología, Clínica Universidad de Navarra, Pamplona, Spain
Received 05 January 2021. Accepted 16 April 2021
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Tables (3)
Table 1. Risk factors of VTE in patients with cancer.
Table 2. Risk scales of VTE in patients with cancer.
Table 3. Molecular alterations associated with an increase in thrombotic risk.
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Abstract

Patients with cancer present with an elevated risk of thrombosis, which entails high morbidity and mortality. Various predictive scales that incorporate clinical and biological data have been developed to identify those at high risk of thrombosis, but, in general, they do not allow for the optimal selection of subjects who are candidates for thromboprophylaxis. Recent studies have demonstrated that the mutation profile has a high impact on the risk of thrombosis; this will facilitate developing new predictive models of thrombosis in patients with cancer.

Keywords:
Mutation profile
Thrombosis
Cancer
Thromboprophylaxis
Resumen

Los pacientes con cáncer presentan un riesgo elevado de trombosis, que condiciona una elevada morbimortalidad. Se han desarrollado diversas escalas predictivas para la identificación de aquellos con alto riesgo trombótico, incorporando datos clínicos y biológicos, pero, en general, no permiten una selección óptima de los sujetos candidatos para recibir tromboprofilaxis. Estudios recientes demuestran que el perfil mutacional tiene un alto impacto sobre el riesgo trombótico, lo que va a facilitar el desarrollo de nuevos modelos predictivos de trombosis en pacientes con cáncer.

Palabras clave:
Perfil mutacional
Trombosis
Cáncer
Tromboprofilaxis

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