TY - JOUR T1 - What do we know about the origin of COVID-19 three years later? JO - Revista Clínica Española (English Edition) T2 - AU - Zapatero Gaviria,A. AU - Barba Martin,R. SN - 22548874 M3 - 10.1016/j.rceng.2023.02.010 DO - 10.1016/j.rceng.2023.02.010 UR - https://revclinesp.es/en-what-do-we-know-about-articulo-S2254887423000395 AB - More than three years have passed since the first case of a new coronavirus infection (SARS-CoV-2) in the city of Wuhan (Hubei, China). The Wuhan Institute of Virology was founded in that city in 1956 and the country’s first biosafety level 4 laboratory opened within that center in 2015. The coincidence that the first cases of infection emerged in the city where the virology institute’s headquarters is located, the failure to 100% identify the virus’ RNA in any of the coronaviruses isolated in bats, and the lack of evidence on a possible intermediate animal host in the contagion’s transmission make it so that at present, there are doubts about the real origin of SARS-CoV-2. This article will review two theories: SARS-CoV-2 as a virus of zoonotic origin or as a leak from the high-level biosafety laboratory in Wuhan. ER -