TY - JOUR T1 - Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease? JO - Revista Clínica Española (English Edition) T2 - AU - Sepúlveda Loyola,W.A. AU - Vilaça Cavallari Machado,F. AU - Araújo de Castro,L. AU - Hissnauer Leal Baltus,T. AU - Rampazzo Morelli,N. AU - Landucci Bonifácio,K. AU - Morita,A.A. AU - Michelin,A.P. AU - Sabbatini Barbosa,D. AU - Probst,V.S. SN - 22548874 M3 - 10.1016/j.rceng.2019.04.009 DO - 10.1016/j.rceng.2019.04.009 UR - https://revclinesp.es/en-is-oxidative-stress-associated-with-articulo-S225488741930150X AB - ObjectiveTo investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. MethodsSeventy-four subjects were included, 39 with COPD (age 69±7 years; female 41%) and 35 for control group (age 69±7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. ResultsCOPD severity (GOLD≥3) and pulmonary function were associated with sulfhydryl group and AOPP (p≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (p=.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (p<.0001). ConclusionCOPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD. ER -