TY - JOUR T1 - Implementing pre-exposure prophylaxis could prevent most new HIV infections in transsexual women and men who have sex with men JO - Revista Clínica Española (English Edition) T2 - AU - Ayerdi Aguirrebengoa,O. AU - Vera García,M. AU - Portocarrero Nuñez,J.A. AU - Puerta López,T. AU - García Lotero,M. AU - Escalante Garcia,C. AU - Raposo Utrilla,M. AU - Estrada Pérez,V. AU - Del Romero Guerrero,J. AU - Rodríguez Martín,C. SN - 22548874 M3 - 10.1016/j.rceng.2019.02.010 DO - 10.1016/j.rceng.2019.02.010 UR - https://revclinesp.es/en-implementing-pre-exposure-prophylaxis-could-prevent-articulo-S225488741930092X AB - BackgroundPre-exposure prophylaxis (PrEP) consists of administering antiretroviral drugs to HIV-seronegative individuals who engage in high-risk practices, with the aim of reducing the probability of acquiring the infection. Despite its safety and efficacy, PrEP is still not available within Spain's public healthcare system.The aim of this study was to estimate the preventive impact of adding PrEP to the other preventive measures. We estimated the number of HIV seroconversions that could have been prevented (if PrEP had been available) among initially seronegative transsexual women and men who have sex with men. MethodsWe conducted a descriptive study of recent HIV seroconverters between 2014 and 2016 in a reference HIV/sexually transmitted infection clinic in Madrid. We analyzed the individuals who were indicated PrEP, according to the guidelines of the 2016 AIDS Study Group. The statistical analysis to estimate the HIV infections that could have been prevented (if PrEP had been available) was conducted using Stata 14. ResultsWe estimated that 195 of the 228 men who have sex with men and transsexual women, with documented HIV seroconversion, were indicated for PrEP. Considering the preventive efficacy reported in European studies, we estimated that 168 HIV seroconversions could have been prevented, which represents 73.7% of the diagnosed infections. ConclusionsThe results confirm the need to promote combined preventive programs against HIV that integrate all possible measures, including PrEP. ER -