TY - JOUR T1 - Spanish multidisciplinary clinical practice guidelines for Anderson–Fabry disease in adults. I. Method and recommendations JO - Revista Clínica Española (English Edition) T2 - AU - Calderón Sandubete,E.J. AU - Briones Pérez de la Blanca,E. AU - Alonso-Ortiz del Río,C. AU - Santamaría Olmo,R. AU - López Mendoza,M. AU - Barcos Martínez,M. AU - Márquez Infante,C. AU - Marín-León,I. SN - 22548874 M3 - 10.1016/j.rceng.2019.02.001 DO - 10.1016/j.rceng.2019.02.001 UR - https://revclinesp.es/en-spanish-multidisciplinary-clinical-practice-guidelines-articulo-S2254887419300268 AB - Anderson–Fabry disease is a severe progressive multisystem condition of genetic origin that affects men and women, reducing their life expectancy and quality of life. The considerable variability in its clinical expression, the difficulties in diagnosing the condition and the current availability of several alternatives for its treatment represent a considerable challenge that justifies the development of evidence-based clinical practice guidelines that can help health professionals in the decision-making process for managing these patients. To develop these guidelines, we conducted a systematic search of the main reference databases using strategies adapted to each of the 32 clinical questions considered. We prepared documents to synthesize the evidence and assess its quality for each of the questions. The methodology employed is based on the Spanish methodology manual for preparing clinical practice guidelines, incorporating the GRADE methodology in the assessment of the scientific evidence and the preparation of the recommendations, considering the quality of the evidence, the risk-benefit balance, patient values and preferences, equity and use of resources. For the definitive preparation of the recommendations, we conducted a structured consensus process based on the Delphi-RAND methodology in 2 rounds, with an expert panel proposed by various scientific societies, research centers and patient associations. Ultimately, we developed 92 specific recommendations for managing Fabry disease. ER -