TY - JOUR T1 - High doses of systemic corticosteroids in patients hospitalized for exacerbation of chronic obstructive pulmonary disease. A cohort study JO - Revista Clínica Española (English Edition) T2 - AU - Rueda-Camino,J.A. AU - Bernal-Bello,D. AU - Canora-Lebrato,J. AU - Velázquez-Ríos,L. AU - García de Viedma-García,V. AU - Guerrero-Santillán,M. AU - Duarte-Millán,M.A. AU - Cristóbal-Bilbao,R. AU - Zapatero-Gaviria,A. SN - 22548874 M3 - 10.1016/j.rceng.2017.07.003 DO - 10.1016/j.rceng.2017.07.003 UR - https://revclinesp.es/en-high-doses-systemic-corticosteroids-in-articulo-S2254887417301042 AB - ObjectivesTo assess the effect of high doses of corticosteroids in patients hospitalized for exacerbation of chronic obstructive pulmonary disease (COPD). Patients and methodsA prospective cohort study was conducted on patients hospitalized with COPD between January and March 2015, grouped according to the glucocorticoid dosage administered (cutoff, 40mg of prednisone/day). We compared the results of hospital stay, readmission and mortality at 3 months of discharge. ResultsWe analyzed 87 patients. The median daily dose was 60mg of prednisone (interquartile range, 46.67–82.33mg/day), and the administration route was intravenous in 96.6% of the cases. We established a relative risk (RR) for hospital stays longer than 8 days of 1.095 (95% CI 0.597–2.007; p=.765) when steroid dosages greater than 40mg/day were employed. In these patients, the hazard ratio (HR) for readmission in the 3 months after discharge was 0.903 (95% CI 0.392–2.082; p=.811), and the mortality was 1.832 (95% CI 0.229–16.645; p=.568). Neither the RR nor the HR varied in a statistically significant manner after adjusting for confounding factors. ConclusionsA daily dose greater than 40mg of prednisone in patients hospitalized for COPD exacerbation was not associated with a shorter hospital stay or a reduction in readmissions or mortality at 3 months. ER -