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DOI: 10.1016/j.rceng.2021.06.005
Available online 14 October 2021
Alpha-gal syndrome. Allergy to red meat and gelatin
Síndrome de alfa-gal. Alergia a carne roja y gelatina
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L. Zurbano-Azquetaa,
Corresponding author
laurazurbano@hotmail.com

Corresponding author.
, E. Antón-Casasb, S. Duque-Gómezb, I. Jiménez-Gómezb, L. Fernández-Pellóna, J. López-Gutiérrezb
a Servicio de Alergología, Hospital Sierrallana, Torrelavega (Cantabria), Spain
b Servicio de Alergología, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Received 18 March 2021. Accepted 17 June 2021
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Table 1. Demographic and clinical data.
Table 2. Allergy study.
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Abstract
Introduction

Alpha-gal syndrome is a potentially severe food allergy caused by the presence of alpha-gal-specific IgE. The aim of this study is to describe our series of 13 patients.

Material and methods

This work is a retrospective study of patients diagnosed in 2016 and 2017. Skin tests were performed with commercial extract and gelaspan as well as specific IgE determination for alpha-gal and different types of meat.

Results

Thirteen patients diagnosed with alpha-gal syndrome were analyzed; 9 of them had anaphylaxis, 6 of whom had been diagnosed with idiopathic anaphylaxis. All had a positive skin test with gelaspan, though this was not true with the commercial extracts, whose results were less conclusive.

Conclusions

We believe that a diagnosis of idiopathic anaphylaxis may prevent the identification of patients with alpha-gal syndrome. The gelaspan skin test is more useful than commercial extracts.

Keywords:
Anaphylaxis
Red meat
Alpha-gal
Gelatin
Resumen
Introducción

El síndrome de alfa-gal es una alergia alimentaria potencialmente grave producido por la presencia de IgE específica para alfa-gal. El objetivo de este estudio es describir nuestra serie de 13 pacientes.

Material y métodos

Estudio retrospectivo de pacientes diagnosticados entre 2016 y 2017. Se realizaron pruebas cutáneas con extracto comercial y gelaspan así como determinación de IgE específica para alfa-gal y diferentes tipos de carne.

Resultados

Se analizó a 13 pacientes diagnosticados de síndrome de alfa-gal, 9 de ellos con anafilaxia, de los cuales 6 habían sido diagnosticados de anafilaxia idiopática. Todos presentaron prueba cutánea con gelaspan positiva, y no así con los extractos comerciales, cuyos resultados fueron menos concluyentes.

Conclusiones

Creemos que la anafilaxia idiopática puede esconder pacientes con síndrome de alfa-gal. La prueba cutánea con gelaspan es más útil que los extractos comerciales.

Palabras clave:
Anafilaxia
Carne roja
Alfa-gal
Gelatina

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