Journal Information
Vol. 217. Issue 8.
Pages 439-445 (November 2017)
Share
Share
Download PDF
More article options
Vol. 217. Issue 8.
Pages 439-445 (November 2017)
Original article
Tp-e interval and Tp-e/QT ratio in patients with celiac disease
Intervalo Tp-e y ratio Tp-e/QT en pacientes con celiaquía
K. Demirtaşa, Ç. Yaylaa,
Corresponding author
cagriyayla@gmail.com

Corresponding author.
, M. Yükselb, B. Açara, S. Ünala, A.G. Ertema, M. Kaplana, M.Y. Akpinarb, Z.M.Y. Kiliçb, E. Kayaçetinb
a Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey
b Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (2)
Table 1. Basal characteristics and laboratory parameters of the study population.
Table 2. Electrocardiographic and echocardiographic characteristics of the study population.
Show moreShow less
Abstract
Objectives

Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease.

Material and methods

This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects). Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram.

Results

Tp-e interval (64.2±11.0 vs. 44.5±6.0; p<0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.13±0.02; p<0.001) and Tp-e/QTc ratio (0.16±0.02 vs. 0.11±0.01; p<0.001) were significantly higher in patients with celiac disease than control subjects. There was a significant positive correlation between Tp-e/QTc ratio and disease duration in patients with celiac disease (r=0.480, p=0.003) and also there was a significant positive correlation between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p<0.001).

Conclusions

Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with celiac disease. Whether these changes increase the risk of ventricular arrhythmia deserve further studies.

Keywords:
Celiac disease
Tp-e interval
Tp-e/QT ratio
Resumen
Objetivos

La enfermedad celíaca (EC) o celiaquía, es una enfermedad crónica del intestino delgado inmuno-mediada. Es bien sabido que la cardiomiopatía dilatada y la cardiopatía isquémica se han hecho frecuentes en los pacientes celíacos. El objetivo de este estudio fue evaluar el intervalo Tp-e y el ratio Tp-e/QT ratio en los pacientes con celiaquía.

Material y métodos

Este estudio se realizó en un único centro, en colaboración con los clínicos de gastroenterología y cardiología. Entre enero de 2014 y junio de 2015 se incluyeron a un total de 76 pacientes consecutivos (38 pacientes con celiaquía y 38 sujetos control). Se midieron el intervalo Tp-e y los ratios Tp-e/QT y Tp-e/QTc a partir del electrocardiograma de 12 derivaciones.

Resultados

El intervalo Tp-e (64,2±11 vs. 44,5±6; p<0,001), el ratio Tp-e/QT (0,18±0,02 vs. 0,13±0,02; p<0,001) y el ratio Tp-e/QTc (0,16±0,02 vs. 0,11±0,01; p<0,001) fueron significativamente superiores en los sujetos celíacos con respecto a los controles. Se observó una correlación significativa entre el ratio Tp-e/QTc y la duración de la enfermedad en los pacientes celíacos (r=0,48; p=0,003), y también una correlación positiva significativa entre el ratio Tp-e/QTc y la tasa de sedimentación eritrocitaria (r=0,434; p<0,001).

Conclusiones

Nuestro estudio reflejó que el intervalo Tp-e y los ratios Tp-e/QT y Tp-e/QTc se incrementaron en los pacientes celíacos. El hecho de que dichos cambios incrementen o no el riesgo de arritmia ventricular justifica la realización de estudios futuros.

Palabras clave:
Celiaquía
Intervalo Tp-e
Ratio Tp-e/QT

Article

These are the options to access the full texts of the publication Revista Clínica Española (English Edition)
Member
Si es usted socio de FESEMI siga los siguientes pasos:

Diríjase desde aquí a la web de la >>>FESEMI<<< e inicie sesión mediante el formulario que se encuentra en la barra superior, pulsando sobre el candado.

Una vez autentificado, en la misma web de FESEMI, en el menú superior, elija la opción deseada.

>>>FESEMI<<<

Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Clínica Española (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Revista Clínica Española (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?