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Vol. 218. Num. 5.June - July 2018
Pages 215-270
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Vol. 218. Num. 5.June - July 2018
Pages 215-270
Review
DOI: 10.1016/j.rceng.2018.01.004
Treatment and prevention of invasive pneumococcal disease
Tratamiento y prevención de la enfermedad neumocócica invasiva
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A.R. Domínguez-Alegríaa,
Corresponding author
alegria.rda@gmail.com

Corresponding author.
, V. Pintadob, I. Barbollaa
a Servicio de Medicina Interna, Hospital Ramón y Cajal, Madrid, Spain
b Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
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Tables (4)
Table 1. Resistance of pneumococcus to the main antimicrobials.
Table 2. Risk factors for infection by antibiotic-resistant S. pneumoniae.
Table 3. Influence of combined antibiotic therapy on mortality in pneumococcal infections.
Table 4. Indications for pneumococcal vaccination in adults.
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Abstract

Invasive pneumococcal disease is a severe infection that mainly affects patients with associated comorbidity. The pediatric conjugate vaccination has resulted in a change in the adult vaccination strategy. The antibiotic resistance of pneumococcus is not currently a severe problem. Nevertheless, the World Health Organisation has included pneumococcus among the bacteria whose treatment requires the introduction of new drugs, such as ceftaroline and ceftobiprole. Although the scientific evidence is still limited, the combination of beta-lactams and macrolides is recommended as empiric therapy for bacteraemic pneumococcal pneumonia.

Keywords:
Streptococcus pneumoniae
Invasive pneumococcal disease
Resistance
Combined therapy
Vaccine
Resumen

La enfermedad neumocócica invasiva es una infección grave que afecta principalmente a pacientes con comorbilidad asociada. El beneficio de la vacuna conjugada infantil ha condicionado un cambio de la estrategia de vacunación en el adulto. La resistencia a antibióticos no supone un problema grave en la actualidad, a pesar de lo cual la Organización Mundial de la Salud ha incluido al neumococo entre las bacterias cuyo tratamiento requiere la introducción de nuevos fármacos, como ceftarolina y ceftobiprol. Aunque la evidencia científica es todavía limitada, se recomienda la asociación de betalactámicos y macrólidos como terapia empírica de la neumonía neumocócica bacteriémica.

Palabras clave:
Streptococcus pneumoniae
Enfermedad neumocócica invasiva
Resistencia
Terapia combinada
Vacuna

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